ABSTRACT Introduction Nosocomial infection of the central nervous system (NI-CNS) is a serious complication in neurocritical patients that leads to deterioration of patient’s condition, worsening of outcomes and increased cost of treatment. The timely diagnosis of NI-CNS is a relevant problem and the search for new reliable markers of NI-CNS is an important issue.

MATERIAL AND METHODS The prospective observational study consisted of two parts. The aim of the frst part was to defne normal ranges of cerebral spinal presepsin (CSF PSP). The aim of the second part was investigation of CSF PSP in neurocritical patients. We studied CSF sampling obtained during spinal anesthesia for elective urologic surgery in order to defne the normal CSF PSP. The following data was collected in neurocritical patients: CSF cell count, glucose, lactate, PSP, microbiological tests, polymerase chain reaction (PCR), when it was possible. Blood tests included complete blood count, C-reactive protein (CRP), procalcitonin (PCT), PSP. IBM SPSS Statistics (version 23.0) was used for statistical analysis.

RESULTS Fifteen CSF samplings were obtained for investigation of normal CSF PSP ranges, which was 50–100 pg/ml. Nineteen neurocritical patients were included. Sixty-three pairs of CSF and blood samplings were obtained. All pairs were divided into the 4 groups in accordance with presence/absence of NI-CNS or systemic infection. In cases without both NI-CNS and systemic infection (group 4) CSF PSP was 406±203.1 pg/ml. In cases without NI-CNS and with systemic infection (group 2) CSF PSP was 614.9±315 pg/ml. In cases with NI-CNS and without systemic infection (group 3) CSF PSP was 547.8±264.3 pg/ml. In cases with both NI-CNS and systemic infection (group 1) CSF PSP was 731.1±389.7 pg/ml. The ROC analysis showed that in neurocritical patients without systemic infection CSF PSP 537 pg/ml meant NI-CNS with sensitivity 68.8% and specifcity 85.7%.

CONCLUSION The normal value of the CSF PSP is 50-100 pg/ml. CSF PSP more than 537 pg/ml in neurocritical patients without systemic infection meant NI-CNS with 688% sensitivity and 857% specifcity. CSF PSP may be used for diagnosing NI-CNS in neurocritical patients as an additional marker only. CSF may be used as an additional diagnostic criterion, but further research is needed.

INTRODUCTION Bleedings after endoscopic removal of gastric polyps continue to be a relevant issue. A technique has been developed for infltrating the base of polyps with a new hemostatic agent Hemoblock to prevent bleedings during polypectomy. The purpose of this study was to assess the effectiveness of this technique.

MATERIALS AND METHODS We present the results of the use of Hemoblock in 63 patients with 129 removed polyps. The results were compared with data in the control group, where 267 polyps were removed in 142 patients. In the control group, 0.9% sodium chloride solution, 5% aminocaproic acid solution were used for submucosa injection. We also compared the effectiveness of endoscopic hemostasis for bleeding that occurred after the removal of polyps in both groups. In the main group, hemostasis was performed by irrigation and puncturing using Hemoblock. In the control group the injection method (0.9% sodium chloride solution, 5% aminocaproic acid solution) and electrocoagulation were performed.

RESULTS The study showed that the use of Hemoblock during endoscopic removal of polyps for infltration of their base provided a more effective prevention of bleeding, and with the development of bleeding from a thermal defect after polypectomy, the use of irrigation/puncturing of the same drug provides reliable hemostasis.

CONCLUSION The use of hemostatic agent Hemoblock in the endoscopic removal of gastric polyps provides prevention of bleeding and radical intervention. With the development of bleeding after polypectomy, irrigation/puncturing hemostatic agent Hemoblock allows to achieve reliable hemostasis.

BACKGROUND Benign vascular lesions of the skin, hemangiomas and pyogenic granulomas are quite common in pediatric patients, which are complicated with bleeding in 7.5% of cases.

MATERIAL AND METHODS In 2016–2018, 17 children with cavernous hemangiomas and pyogenic granulomas complicated with bleeding were operated on an emergency basis at the Research Institute of Emergency Children’s Surgery and Traumatology. Surgical intervention for all patients was performed using the method of interstitial selective laser photodestruction developed by the RIECST, which took out the utility patent. This method was implemented using two wave laser surgical device IPG “IRE-Polus” (Russia), generating two wavelengths of laser radiation of 0.97 μm and 1.56 μm.

RESULTS The analysis of the long-term results of treatment in 17 pediatric patients who were operated on an emergency basis for hemangioma and pyogenic granuloma complicated by bleeding showed that all 17 patients (100%) had a good clinical and aesthetic result. The method of interstitial selective laser photodestruction provided a radical removal with guaranteed hemostasis of the indicated benign vascular lesions of the skin complicated with bleeding illustrate the effectiveness of this method in clinical practice, as well as the possibility of its use in inpatient and outpatient conditions.

CONCLUSION To prevent the large blood loss in hemangiomas complicated by bleeding and pyogenic granulomas of the skin in children, emergency surgical treatment has been performed using interstitial selective laser photodestruction. This method ensures the radical photodestruction of tissues of a pathological vascular formation and reliable hemostasis, which guarantees the achievement of a good clinical and aesthetic result of treatment in inpatient and outpatient conditions in all cases.

BACKGROUND Coronary heart disease is one of the main causes of the population’s disability and mortality in Russia and abroad. Revascularization with coronary stents in the course of the most suitable drug therapy is one of the most important treatments of coronary heart disease. It is essential to pay special attention to the research results of using modern stents, in particular, the frst Russian drug-eluting stent “CALYPSO”.

AIM OF STUDY To study immediate and medium-term results of Limus-eluting stents procedure in patients with acute coronary syndrome.

MATERIAL AND METHODS 304 patients with acute coronary syndrome were included into the research and were divided into 2 groups. The frst group consisted of 156 patients with CALYPSO stent (Angioline, Russia). The other group consisted of 148 patients who had undergone revascularization with the XIENCE stent (Abbot Vascular, USA). Their health state was monitored via phone 3, 6, 9 and 12 months later. After the discharge from the hospital, the drug therapy was prescribed, and instrumental procedures of diagnostics were planned for the period of 9–12 months. According to the results of the examination, patients with suspected or confrmed myocardial ischemia underwent follow-up coronary angiography.

RESULTS The success of implantation was 98.63% in the frst group, and 99.4% in the second group. One fatal outcome occurred in both groups during hospitalization (thus making 0.64% и 0.67%). The placement of the CALYPSO stent in distal parts of coronary arteries requested signifcantly less time and contrast. Medium-term results of stenting in both groups appeared to be comparable (thus, all cause death 3 (1.92%) and 2 (1.35%), restenosis >50% 3 (1.92%) and 3 (2 %), late thrombosis — 0 in both groups, cardiac death — 0 in both groups. End points (MACE) in both groups were 1.28% and 0.67%.

CONCLUSION Taking into consideration immediate and medium-term results it can be concluded that domestic stents (CALYPSO) are comparable to stents XIENCE. The CALYPSO stent is more advantageous than the XIENCE in the delivery to the lesion focus while performing the procedure in distal flow.

 BACKGROUND The liver’s function is impaired above all others in the mechanical jaundice, which leads to the progression of endogenous intoxication and the damage of different organs and systems, including the brain. The development of hepatic encephalopathy undoubtedly aggravates the course of the disease, which requires its timely management.

AIM OF STuDy: to evaluate the effcacy of the low-intensity laser therapy when managing the cerebral dysfunction in mechanical jaundice of non-tumor origin.

MATERIAL AND METHODS A comprehensive study of 60 patients with obstructive jaundice of non-tumor origin was performed. The patients were divided into 2 groups: I (comparison) — the standard therapy (n=30); II (studied) group — inclusion of low-intensity laser irradiation of blood (n=30). On check dates (day 1 and 7), the severity of cerebral dysfunction was assessed in all patients using the psychometric tests (“Point in Circle, “Labyrinth”). The microcirculation was assessed with LACC 02 device (Russia). The coagulation/lysis system of blood was studied with TEG 5000 thrombelastograph (USA).

RESULTS In patients with obstructive jaundice, disorders of the functional state of the liver were noted, which resulted in the growth of total bilirubin, alanine and aspartic aminotransferases, and toxic products. All this was accompanied by cerebral dysfunction, which was shown by results of the psychometric study and extended performance of tests, in particular (“Point in Circle”, “Labyrinth”). Signifcant changes and disorders of the hemostatic system were revealed in patients. The complex treatment of obstructive jaundice, which included laser therapy, allowed a relatively rapid recovery of the functional state of the brain to be observed, as evidenced by the shortening of the test time for the tests being studied. The positive effect of this kind of therapy was accompanied by a decrease in the severity of the syndrome of endogenous intoxication, improved microcirculation and hemostasis.

CONCLUSION The presence of pancreatic obstructive jaundice lead to the development of florid syndrome of endogenous intoxication, which was reflected in the growth of ALT, AST, amylase, and total bilirubin. During the entire period of the study, a decrease in studied blood parameters was observed in patients who had underwent low-intensity laser therapy sessions. Conducting a psychometric study in the initial periods revealed some violations, such as extended performance of tests (“Point in Circle”, “Labyrinth”).

Rapid recognition of cardiac arrest based on the data reported by a bystander, and delivering telephone cardiopulmonary resuscitation instructions by emergency medical services (EMS) dispatcher promote timely provision of frst aid by people who witness the emergency, and this may signifcantly influence the outcome of out-of-hospital cardiac arrest (OHCA). This review is aimed to analyze the up-to-date scientifc literature on EMS dispatcher recognition of OHCA. In particular, general concept and experience of algorithm-based diagnosis of cardiac arrest, diffculties of telephone OHCA recognition, approaches for dispatcher diagnosis quality evaluation and assurance are discussed herein. Based on the analysis results, recommendations on organizing and improving the effectiveness of EMS dispatcher recognition of cardiac arrest are formulated. The review is designed primarily for EMS and public health specialists.

The article reports the modern tactics of treating patients with chronic heart failure and concomitant anemia. The results of the most important randomized clinical trials that are the basis for developing approaches to the treatment of anemia in such cases are discussed. Attention is also paid to unresolved problems in the treatment of anemia in patients with heart failure. The data on the intravenous administration of iron preparations as the most effective approach to the treatment of anemia in patients with heart failure in the presence of iron defciency are given. The main provisions of modern clinical guidelines on the management of patients with heart failure and anemia are considered.

Colorectal cancer is one of the most common oncological diseases. In 40–60% of cases, patients with colorectal cancer enter general surgical hospitals with complications. Obstructive colonic obstruction is the most common complication of colorectal cancer. The radical operation against the background of colonic obstruction is associated with a high postoperative lethality, ranging from 5% to 34%. To improve the results of surgical treatment of patients with colorectal cancer complicated by obturation colonic obstruction, various minimally invasive methods of temporary decompression have been proposed, followed by radical surgery, which signifcantly reduce the risk of complications and mortality. 

Among complications of malignant neoplasms of the heart, tumor exudative pericarditis requires emergency surgical measures with the development of chronic tamponade. At the frst stage, puncture drainage of the pericardial cavity is advisable. In case of a common tumor process and the impossibility of radical surgical treatment by the second stage, it is advisable to perform video assisted thoracoscopic pericardial fenestration with biopsy and pleurodesis, if necessary. This tactic improves the quality of life in patients and complies with modern standards of treatment of this disease.

 BACKGROUND In 12–47% of patients, there is a need to repeat the aortic valve replacement due to various valve-related complications in the immediate and late postoperative period. The standard operation of repeated aortic valve replacement is a complex procedure and it is associated with an increased risk due to adhesions in the pericardial cavity, previously performed coronary bybass surgery, diffculties of excision of the previously implanted prosthesis, narrow fbrous aortic valve ring and aorta. In 2007, the sutureless Perceval S aortic valve bioprosthesis (Sorin Group, Italy) was introduced into clinical practice. One of the advantages of such a prosthesis is the convenience of its anatomical positioning during repeated operations and the absence of the need to fx the prosthesis with sutures. The aim of study was to summarize the experience of sutureless implantation of the aortic valve prosthesis during repeated replacement.

MATERIAL AND METHODS We report the results of treatment in 3 patients with valve-associated complications, who underwent aortic valve repeated replacement with the Perceval S sutureless prosthesis.

RESULTS There were no hospital mortality and paraprosthetic regurgitation in the repeated replacement of the aortic valve with the Perceval S sutureless prosthesis. Two patients required implantation of a permanent pacemaker due to the development of a complete atrioventricular block, which was not related to the model of the prosthesis used.

CONCLUSION The use of aortic valve prosthesis in cardiac surgery, which does not require fxation with sutures, allows non-standard decisions to be made in the surgical treatment of patients with various complications of previously performed aortic valve replacement and provides good immediate results if repeated replacement is necessary.