EARLY PARENTERAL USE OF PROTON PUMP INHIBITORS IN THE COMPLEx TREATMENT OF ACUTE POISONING WITH CAUTERANT AGENTS

BACKGROUND. Acute poisonings with cauterant agents are accompanied by an increase in acid­forming function of the stomach in more than half of the cases. It slows reparative processes in the gastric wall and increases the risk of complications.

MATERIALS AND METHODS. The study involved 40 patients with chemical burns of the stomach grade III­IV who had underwent standard therapy. The complex therapy for 20 patients included 5 days of intravenous Rabeloc, 20 mg daily.

RESULTS. Rabeloc included into the complex of therapeutic measures in patients with chemical burns of the stomach grade III–IV helped reduce the length of stay in the ICU by 1.5 times and inpatient treatment by 1.8 times, reduce the frequency of early secondary hemorrhage and decompensated cicatricial narrowing of the stomach.

CONCLUSION. Early parenteral use of Rabeloc increases the effectiveness of complex therapy for acute poisoning with cauterant substances. 

1. Медицинская токсикология: нац. рук-во / под ред. Е.А.Лужникова. – М.: ГЭОТАР-Медиа, 2012. – 928 с. Luzhnikov E.A., ed. Meditsinskaya toksikologiya [Medical toxicology]. Moscow: GEOTAR-MediaPubl., 2012. 928 p. (In Russian).

2. Волков С.В. Химические ожоги пищевода и желудка (Эндоскопическая диагностика и лазеротерапия) / С.В. Волков, А.С. Ермолов, Е.А. Лужников. – М: МЕДПРАКТИКА-М, 2005. – 120 с. Volkov S.V., Ermolov A.S., Luzhnikov E.A. Khimicheskie ozhogi pishchevoda i zheludka (Endoskopicheskaya diagnostika i lazeroterapiya) [Chemical burns of the esophagus and stomach (Endoscopic diagnostics and laser therapy)]. Moscow: MEDPRAKTIKA-M Publ., 2005. 120 p. (In Russian).

3. Песня–Прасолова Е.А., Ильяшенко К.К., Пинчук Т.П. и др. Нарушения кислотообразующей функции желудка у больных с отравлениями прижигающими жидкостями // Анестезиология и реаниматология. – 2005. – № 6. – С. 64–67. Pesnya–Prasolova E.A., Il’yashenko K.K., Pinchuk T.P. et al. Narusheniya kislotoobrazuyushchey funktsii zheludka u bol’nykh s otravleniyami prizhigayushchimi zhidkostyami [Impaired gastric acid secretion in patients poisoned by cauterizing liquids]. Anesteziologiya ireanimatologiya. 2005; 6: 64–67. (In Russian).

4. Андреев Д.Н., Дичева Д.Т., Лебедева Е.Г., Парцваниа-Виноградова Е.В. Фармакологические основы применения ингибиторов протонной помпы // Фарматека. – 2014. – № 14. – С. 62–69. Andreev D.N., Dicheva D.T., Lebedeva E.G., Partsvania-Vinogradova E. V. Farmakologicheskie osnovy primeneniya ingibitorov protonnoy pompy [Pharmacological basis for the use of proton pump inhibitors]. Farmateka. 2014; 14: 62–69. (In Russian).

5. Wolfe M.M., Sachs G. Acid suppression: Optimizing therapy for gastroduodenal healing, gastroesophageal reflux disease, and stress-related erosive syndrome // Gastroenterology. – 2000. –Vol. 118, N. 2. Suppl. 1. – S. 9–31.

6. Welage L.S. Overview of pharmacologic agents for acid suppression in critically ill patients // Am. J. Health Syst. Pharm. – 2005. – Vol. 62, N. 10. Suppl. 2. – S. 4–10.

7. Khuroo M.S., Yattoo G.N., Javid G. et al. A comparison of omeprazole and placebo for bleeding peptic ulcer // N. Engl. J. Med. – 1997. – Vol. 336, N. 15. – P. 1054–1058.

8. Щербаков П. Л., Михеева О.М., Васнев О.С. Использование инъекционных форм кислотоподавляющих препаратов в гастроэнтерологии // Лечащий врач. – 2008. – № 6. – С. 27–30. Shcherbakov P. L., Mikheeva O.M., Vasnev O.S. Ispol’zovanie in”ektsionnykh form kislotopodavlyayushchikh preparatov v gastroenterologii [The use of injectable acid-suppresseddrugs in gastroenterology]. Lechashchiy vrach. 2008; 6: 27–30. (In Russian).

9. Пасечников В.Д. Ключи к выбору оптимального ингибитора протонной помпы для терапии кислотозависимых заболеваний // Российский журнал гастроэнтерологии, гепатологии, колопроктологии. – 2004. – № 3. – С. 32–40. Pasechnikov V.D. Klyuchi k vyboru optimal’nogo ingibitora protonnoy pompy dlya terapii kislotozavisimykh zabolevaniy [Keys to select the optimal proton pump inhibitor for treatment of acid-related diseases]. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii. 2004; 3: 32–40. (In Russian).

10. Horn J. Review article relationship between the metabolism and efficacy of proton pump inhibitors – focus on rabeprazole // Aliment. Pharmacol. Ther. – 2004. – Vol. 20, Suppl. 6. – S. 11–19.

11. Лужников Е.А. Клиническая токсикология: учебник. – 3-е изд., парераб. и доп. – М.: Медицина, 1999. – 416 с. Luzhnikov E.A. Klinicheskaya toksikologiya: uchebnik [Clinical toxicology]. 3rd ed., ed. and exp. Moscow: Meditsina Publ., 1999. 416 p. (In Russian).

12. Green F.W., Kaplan M.M., Curtis L.E., Levine P.H. Effect of acid and pepsin on blood coagulation and platelet aggregation: A possible contributor to prolonged gastroduodenal mucosal hemorrhage // Gastroenterology. – 1978. –Vol. 74, N. 1. – P. 38–43.

13. Fennerty M.B. Pathophysiology of the upper gastrointestinal tract in the critically ill patient: Rationale for therapeutic benefits of acid suppression // Crit. Care Med. – 2002. – Vol. 30, N. 6. – S. 351–355.