Treatment of Patients with Thrombosis of the Arteries of the Lower Extremities and Coronavirus Infection
https://doi.org/10.23934/2223-9022-2022-11-3-506-512
Abstract
The course of severe coronavirus infection is accompanied by hypercoagulability with micro- and macroangiopathy, which may be the cause of arterial and venous thrombosis. In March, 2021 — May 2021, 14 patients with COVID-19 and acute ischemia of the lower extremities due to arterial thrombosis were operated in the Infectious Pavilion of the N.V. Sklifosovsky Research Institute for Emergency Medicine. Retrombosis in the immediate postoperative period developed in 4 patients (26.7%). The amputation at the level of the thigh was performed in 2 patients (13.3%) due to the development of ischemic gangrene. The mortality was 71.4%, 10 patients died. The main cause of death was the progression of multiple organ failure in the course of severe viral-bacterial pneumonia. The best results were obtained with a combination of open surgery and endovascular technique, performing hybrid operations.
About the Authors
G. A. IsayevRussian Federation
Georgy A. Isayev Candidate of Medical Sciences, Senior Lecturer, Cardiovascular Surgeon
129090, Moscow, B. Suharevskaya Sq., 3
I. P. Mikhailov
Russian Federation
Igor P. Mikhailov Doctor of Medical Sciences, Professor, Scientific Director
129090, Moscow, B. Suharevskaya Sq., 3
I. A. Yeroshkin
Russian Federation
Ivan A. Yeroshkin Doctor of Medical Sciences, Scientific Supervisor of the Department of X-ray Endovascular Diagnosis and Treatment Methods
129090, Moscow, B. Suharevskaya Sq., 3
L. S. Kokov
Russian Federation
Leonid S. Kokov Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Head of the Department of Emergency Cardiology and Cardiovascular Surgery
129090, Moscow, B. Suharevskaya Sq., 3
References
1. Cheruiyot I, Kipkorir V, Ngure B, Misiani M, Munguti J, Ogeng’o J. Arterial Thrombosis in Coronavirus disease 2019 (COVID-19) Patients: A Rapid Systematic Review. Ann Vasc Surg. 2021;70:273–281. PMID:32866574 https://doi.org/10.1016/j.avsg.2020.08.087
2. Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020;395(10234):1417–1418. PMID:32325026 https://doi.org/10.1016/S0140-6736(20)30937-5
3. Lippi G, Favaloro EJ. D-dimer is associated with severity of coronavirus disease 2019: a 292 pooled analysis. Thromb Haemost. 2020;120(5):876–878. PMID:32246450 https://doi.org/10.1055/s-0040-1709650
4. Henry BM, De Oliveira MH, Benoit S, Plebani M, Lippi G. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chemi Lab Med. 2020;58(7):1021–1028. PMID:32286245 https://doi.org/10.1515/cclm-2020-0369
5. Perini P, Nabulsi B, Massoni CB, Azzarone M, Freyrie A. Acute limb ischaemia in two young, non-atherosclerotic patients with COVID-19. Lancet. 2020;395(10236):1546. PMID:32423583 https://doi.org/10.1016/S0140-6736(20)31051-5
6. Favaloro EJ, Franchini M, Lippi G. Aging hemostasis: changes to laboratory markers of hemostasis as we age – a narrative review. Semin Thromb Hemost. 2014;40(6):621–633. PMID:25099191 https://doi.org/10.1055/s-0034-1384631
7. Mari D, Ogliari G, Castaldi D, Vitale G, Bollini EM, Lio D. Hemostasis and ageing. Immun Ageing. 2008;5:12. PMID:18947391 https://doi.org/10.1186/1742-4933-5-12
8. Meng Y, Wu P, Lu W, Liu K, Ma K, Huang L, et al. Sex-specific clinical characteristics and prognosis of coronavirus disease-19 infection in Wuhan, China: A retrospective study of 168 severe patients. PLoS Pathog. 2020;16(4):e1008520. PMID:32343745 https://doi.org/10.1371/journal.ppat.1008520
9. Du R-H, Liang L-R, Yang C-Q, Wang W, Cao T-Z, Li M, et al. Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV2: a prospective cohort study. Eur Respir J. 2020;55(5):2000524. PMID:32269088 https://doi.org/10.1183/13993003.00524-2020
10. Etkin Y, Conway AM, Silpe J, Qato K, Carroccio A, Manvar-Singh P, et al. Acute Arterial Thromboembolism in Patients with COVID-19 in the New York City Area. Ann Vasc Surg. 2021;70:290–294. PMID:32866580 https://doi.org/10.1016/j.avsg.2020.08.085
11. Hemingway J, Emanuels D, Aarabi S, Quirogaet E, Tran N, Starnesal B, et al. Safety of transfer, type of procedure, and factors predictive of limb salvage in a modern series of acute limb ischemia. J Vasc Surg. 2019;69(4):1174–1179. PMID:30777685 https://doi.org/10.1016/j.jvs.2018.08.174
Review
For citations:
Isayev G.A., Mikhailov I.P., Yeroshkin I.A., Kokov L.S. Treatment of Patients with Thrombosis of the Arteries of the Lower Extremities and Coronavirus Infection. Russian Sklifosovsky Journal "Emergency Medical Care". 2022;11(3):506-512. https://doi.org/10.23934/2223-9022-2022-11-3-506-512