Preview

Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»

Расширенный поиск

Диагностика и лечение церебрального венозного тромбоза

https://doi.org/10.23934/2223-9022-2021-10-1-122-134

Полный текст:

Аннотация

 АКТУАЛЬНОСТЬ    Данная статья посвящена обсуждению жизнеугрожающего и трудно диагностируемого заболевания — церебрального венозного тромбоза (ЦВТ). В статье указаны клинические проявления, особенности диагностики и лечения ЦВТ. Церебральный венозный тромбоз — неотложное состояние, требующее быстрого принятия решения о начале терапии с целью предотвращения развития венозного инфаркта мозга, внутричерепного кровоизлияния, тяжелой инвалидизации и смерти. Церебральные венозные тромбозы являются редкой и достаточно сложно распознаваемой формой острого нарушения мозгового кровообращения (ОНМК). Учитывая вариабельность клинической и радиологической картины, а также большое количество факторов риска, ЦВТ представляют сложную медицинскую задачу. Несмотря на то, что ЦВТ составляют менее 1% от всех ОНМК, значительные различия в лечении обуславливают необходимость максимально ранней дифференциальной диагностики ЦВТ с артериальным инсультом. Диагноз нередко устанавливают с опозданием по причине широкого спектра клинических проявлений, подострого начала заболевания, а также низкой настороженности специалистов в отношении ЦВТ. У пациентов с криптогенным инсультом необходимо исключить ЦВТ как потенциальную причину ОНМК. Помимо всего прочего, в случае ЦВТ, как и при тромбозах церебральных артерий, установление ведущего этиологического фактора является одной из приоритетных задач, решение которой позволяет выбрать оптимальное средство вторичной профилактики. 

ЦЕЛЬ РАБОТЫ    Повышение информированности врачей многопрофильных стационаров о клинических проявлениях, методах диагностики и лечения ЦВТ. 

МАТЕРИАЛ И МЕТОДЫ    Для достижения поставленной цели были проанализированы результаты отечественных и зарубежных научных исследований, посвященных диагностике и лечению ЦВТ. Поиск литературы проводили в электронных поисковых системах Scopus, eLibrary, PubMed по ключевым словам: церебральные венозные тромбозы, криптогенный инсульт, внутримозговое кровоизлияние, антикоагулянтная терапия, нейровизуализация при церебральном венозном тромбозе. Для анализа были отобраны научные статьи, опубликованные в период с 1828 по 2020 год. 30% проанализированных работ, посвященных теме ЦВТ, не старше 5 лет. 

ЗАКЛЮЧЕНИЕ    В связи с различными клиническими проявлениями и отсутствием патогномоничных симптомов, ведущая роль в установлении диагноза принадлежит нейровизуализации. Ранняя диагностика церебрального венозного тромбоза и применение антикоагулянтов приводит к снижению инвалидизации и летальности. 

Об авторах

Г. Р. Рамазанов
ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»
Россия

кандидат медицинских наук, заведующий научным отделением неотложной неврологии и восстановительного лечения

Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3



Х. В. Коригова
ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»
Россия

врач-невролог неврологического отделения для больных с острыми нарушениями мозгового кровообращения

Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3



С. С. Петриков
Неврологическое отделение для больных с острыми нарушениями мозгового кровообращения, ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»
Россия

член-корреспондент РАН, доктор медицинских наук, директор  

Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3



Список литературы

1. Глебов М.В., Максимова М.Ю., Домашенко М.А., Брюхов В.В. Тромбозы церебральных венозных синусов. Анналы клинической и экспериментальной неврологии. 2011;5(1):4–10.

2. Максимова М.Ю., Дубовицкая Ю.И. Брюхов В.В., Кротенкова М.В. Диагностика тромбоза мозговых вен и венозных синусов. РМЖ. 2017;(21):1595–1601.

3. Чуканова Е.И., Чуканова А.С., Мамаева Х.И. Церебральные венозные тромбозы. Журнал неврологии и психиатрии им. С.С. Корсакова. 2016;116(10):4–10. https://doi.org/10.17116/jnevro20161161014-10

4. Daif A, Awada A, Al-Rajeh S, Abduljabbar M, Al Tahan AR, Obeid T, et al. Cerebral Venous Thrombosis in Adults. A Study of 40 Cases from Saudi Arabia. Stroke. 1995;26(7):1193–1195. PMID: 7604412 https://doi.org/10.1161/01.str.26.7.1193

5. Abercrombie J. Pathological and Practical Researches on Diseases of the Brain and Spinal Cord. Edinburgh: Waugh and Innes; 1828.

6. Stam J. Thrombosis of the cerebral veins and sinuses. N Engl J Med. 2005;352(17):1791–1798. PMID: 15858188 https://doi.org/10.1056/NEJMra042354

7. Coutinho JM, Zuurbier SM, Aramideh M, Stam J. The incidence of cerebral venous thrombosis: a cross-sectional study. Stroke. 2012;43(12):3375-3377. PMID: 22996960 https://doi.org/10.1161/STROKEAHA.112.671453

8. Gunes HN, Cokal BG, Guler SK, Yoldas TK, Malkan UY, Demircan CS, et al. Clinical associations, biological risk factors and outcomes of cerebral venous sinus thrombosis. J Int Med Res. 2016;44(6):1454–1461. PMID: 28222615 https://doi.org/10.1177/0300060516664807

9. Lanska DJ, Kryscio RJ. Risk factors for peripartum and postpartum stroke and intracranial venous thrombosis. Stroke. 2000;31(6):1274–1282. PMID: 10835444 https://doi.org/10.1161/01.str.31.6.1274

10. Bousser MG, Ferro JM. Cerebral venous thrombosis: an update. Lancet Neurol. 2007;6(2):162–170. PMID: 17239803 https://doi.org/10.1016/S1474-4422(07)70029-7

11. Canhão P, Ferro JM, Lindgren AG, Bousser MG, Stam J, Barinagarrementeria F; ISCVT Investigators. Causes and predictors of death in cerebral venous thrombosis. Stroke. 2005;36(8):1720–1725. PMID: 16002765 https://doi.org/10.1161/01.STR.0000173152.84438.1c

12. Ruiz-Sandoval JL, Chiquete E, Bañuelos-Becerra LJ, Torres-Anguiano C, González-Padilla Ch, Arauz A, et al. Cerebral venous thrombosis in a Mexican multicenter registry of acute cerebrovascular disease: the RENAMEVASC study. J Stroke Cerebrovasc Dis. 2012;21(5):395–400. PMID: 21367622 https://doi.org/10.1016/j.jstrokecerebrovasdis.2011.01.001

13. Janghorbani M, Zare M, Saadatnia M, Mousavi SA, Mojarrad M, Asgari E. Cerebral vein and dural sinus thrombosis in adults in Isfahan, Iran: frequency and seasonal variation. Acta Neurol Scand. 2008;117(2):117–121. PMID: 18184347 https://doi.org/10.1111/j.1600-0404.2007.00915.x

14. Towbin A. The syndrome of latent cerebral venous thrombosis: its frequency and relation to age and congestive heart failure. Stroke. 1973;4(3):419–430. PMID: 4713031 https://doi.org/10.1161/01.str.4.3.419

15. Ferro JM, Canhao P, Stam J, Bousser M-G, Barinagarrementeria F; ISCVT Investigators. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke. 2004;35(3):664–670. PMID: 14976332 https://doi.org/ 10.1161/01.STR.0000117571.76197.26

16. Sassi SB, Touati N, Baccouche H, Drissi C, Romdhane NB, Hentati F. Cerebral Venous Thrombosis: A Tunisian Monocenter Study on 160 Patients. Clin Appl Thromb Hemost. 2017;23(8):1005–1009. PMID: 27582021 https://doi.org/10.1177/1076029616665168

17. Sidhom Y, Mansour M, Messelmani M, Derbali H, Fekih-Mrissa N, Zaouali J, et al. Cerebral venous thrombosis: clinical features, risk factors, and long-term outcome in a Tunisian cohort. J Stroke Cerebrovasc Dis. 2014;23(6):1291–1295. PMID: 24462460 https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.10.025

18. Prakash C, Bansal BC. Cerebral venous thrombosis. J Indian Acad Clin Med. 2000;5(1):55–61. Available at: http://medind.nic.in/jac/t00/i1/jact00i1p55.pdf [Accessed Jul 13, 2020].

19. Nasr DM, Brinjikji W, Cloft HJ, Saposnik G, Rabinstein AA. Mortality in cerebral venous thrombosis: results from the national inpatient sample database. Cerebrovasc Dis. 2013;35(1):40–44. PMID: 23428995 https://doi.org/10.1159/000343653

20. Krayenbuhl HA. Cerebral venous and sinus thrombosis. Neurol Med Chir. 1968;10:1–24. PMID: 4194573 https://doi.org/10.2176/nmc.10.1

21. Hiltunen S, Putaala J, Haapaniemi E, Tatlisumak T. Long-term outcome after cerebral venous thrombosis: analysis of functional and vocational outcome, residual symptoms, and adverse events in 161 patients. J Neurol. 2016;263(3):477–484. PMID: 26725090 https://doi.org/10.1007/s00415-015-7996-9

22. Palazzo P, Agius P, Ingrand P, Ciron J, Lamy M, Berthomet A, et al. Venous Thrombotic Recurrence After Cerebral Venous Thrombosis A Long-Term Follow-Up Study. Stroke. 2017;48(2):321–326. PMID: 27980127 https://doi.org/10.1161/STROKEAHA.116.015294

23. Liberman AL, Merkler AE, Gialdini G, Messé SR, Lerario MP, Murthy SB, et al. Risk of Pulmonary Embolism after Cerebral Venous Thrombosis. Stroke. 2017;48(3):563–567. PMID: 28228575 https://doi.org/10.1161/STROKEAHA.116.016316

24. Piazza G. Cerebral Venous Thrombosis. Circulation. 2012;125(13):1704–1709. PMID: 22474313 https://doi.org/10.1161/CIRCULATIONAHA.111.067835

25. Guenther G, Arauz A. Cerebral venous thrombosis: A diagnostic and treatment update. Neurología. 2011;26(8):488–498. PMID: 21163216 https://doi.org/10.1016/j.nrl.2010.09.013

26. Ferro JM, Canhão P, Stam J, Bousser MG, Barinagarrementeria F, Massaro A, et al. Delay in the diagnosis of cerebral vein and dural sinus thrombosis: influence on outcome. Stroke. 2009;40(9):3133–3138. PMID: 19608994 https://doi.org/10.1161/STROKEAHA.109.553891

27. Paciaroni M, Palmerini F, Bogousslavsky J. Clinical presentations of cerebral vein and sinus thrombosis. Front Neurol Neurosci. 2008;23:77-88. PMID: 18004054 https://doi.org/10.1159/000111262

28. Wasay M, Bakshi R, Bobustuc G, Kojan S, Sheikh Z, Dai A, et al. Cerebral venous thrombosis: analysis of a multicenter cohort from the United States. J Stroke Cerebrovasc Dis. 2008;17(2):49–54. PMID: 18346644 https://doi.org/10.1016/j.jstrokecerebrovasdis.2007.10.001

29. Uzar E, Ekici F, Acar A, Yucel Y, Bakir S, Tekbas G, et al. Cerebral venous sinus thrombosis: an analyses of 47 patients. Eur Rev Med Pharmacol Sci. 2012;16(11):1499–1505. PMID: 23111961

30. Agostoni E. Headache in cerebral venous thrombosis. Neurol Sci. 2004;25(Suppl 3):S206–210. PMID: 15549538 https://doi.org/10.1007/s10072-004-0287-3

31. Cumurciuc R, Crassard I, Sarov M, Valade D, Bousser MG. Headache as the only neurological sign of cerebral venous thrombosis: a series of 17 cases. J Neurol Neurosurg Psychiatry. 2005;76(8):1084–1087. PMID: 16024884 https://doi.org/10.1136/jnnp.2004.056275

32. Timóteo Â, Inácio N, Machado S, Pinto AA, Parreira E. Headache as the sole presentation of cerebral venous thrombosis: a prospective study. J Headache Pain. 2012;13(6):487–490. PMID: 22592865 https://doi.org/10.1007/s10194-012-0456-3

33. Saposnik G, Barinagarrementeria F, Brown RD Jr, Bushnell CD, Cucchiara B, Cushman M, et al. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42(4):1158–1192. PMID: 21293023 https://doi.org/10.1161/STR.0b013e31820a8364

34. Botta R, Donirpathi S, Yadav R, Kulkarni GB, Veerendra M K, Nagaraja D. Headache Patterns in Cerebral Venous Sinus Thrombosis. J Neurosci Rural Pract. 2017;8(Suppl 1):S72–S77. PMID: 28936075 https://doi.org/10.4103/jnrp.jnrp_339_16

35. Wasay M, Kojan S, Dai AI, Bobustuc G, Sheikh Z. Headache in Cerebral Venous Thrombosis: incidence, pattern and location in 200 consecutive patients. J Headache Pain. 2010;11(2):137–139. PMID: 20112042 https://doi.org/10.1007/s10194-010-0186-3

36. Luo Y, Tian X, Wang X. Diagnosis and Treatment of Cerebral Venous Thrombosis: A Review. Front Aging Neurosci. 2018;10:2. PMID: 29441008 https://doi.org/10.3389/fnagi.2018.00002

37. Masuhr F, Busch M, Amberger N, Ortwein H, Weih M, Neumann K, et al. Risk and predictors of early epileptic seizures in acute cerebral venous and sinus thrombosis. Eur J Neurol. 2006;13(8):852–856. PMID: 16879295 https://doi.org/10.1111/j.1468-1331.2006.01371.x

38. Ferro JM, Canhão P, Bousser MG, Stam J, Barinagarrementeria F; ISCVT Investigators. Early seizures in cerebral vein and dural sinus thrombosis: risk factors and role of antiepileptics. Stroke. 2008;39(4):1152–1158. PMID: 18309177 https://doi.org/10.1161/STROKEAHA.107.487363

39. Mahale R, Mehta A, John AA, Buddaraju K, Shankar AK, Javali M, et al. Acute seizures in cerebral venous sinus thrombosis: what predicts it? Epilepsy Res. 2016;123:1–5. PMID: 27023399 https://doi.org/10.1016/j.eplepsyres.2016.01.011

40. Kalita J, Chandra S, Misra UK. Significance of seizure in cerebral venous sinus thrombosis. Seizure. 2012;21(8):639–642. PMID: 22840965 https://doi.org/10.1016/j.seizure.2012.07.005

41. Uluduz D, Midi I, Duman T. Epileptic seizures in cerebral venous sinus thrombosis: Subgroup analysis of VENOST study. Seizure. 2020;78:113–117. PMID: 32353818 https://doi.org/10.1016/j.seizure.2020.02.017

42. Korathanakhun P, Petpichetchian W, Sathirapanya P, Geater SL. Cerebral venous thrombosis: comparing characteristics of infective and non-infective aetiologies: a 12-year retrospective study. Postgrad Med J. 2015;91(1082):670–674. PMID: 26499451 https://doi.org/10.1136/postgradmedj-2015-133592

43. Sparaco M, Feleppa M, Bigal ME. Cerebral Venous Thrombosis and Headache. A Case-Series. Headache. 2015;55(6):806–814. PMID: 26084237 https://doi.org/10.1111/head.12599

44. Ameri A, Bousser MG. Cerebral venous thrombosis. Neurol Clin. 1992;10(1):87–111. PMID: 1557011

45. Thammishetti V, Dharanipragada S, Basu D, Ananthakrishnan R, Surendiran D. A Prospective Study of the Clinical Profile, Outcome and Evaluation of D-dimer in Cerebral Venous Thrombosis. J Clin Diagn Res. 2016;10(6):OC07-10. PMID: 27504325 https://doi.org/10.7860/JCDR/2016/19114.7926

46. Das A, Huxlin KR. New approaches to visual rehabilitation for cortical blindness: outcomes and putative mechanisms. Neuroscientist. 2010;16(4):374–387. PMID: 20103505 https://doi.org/10.1177/1073858409356112

47. Messouak O, Alaoui Faris M, Benabdejlil M, Tizniti S, Belahsen F. Cerebral venous thrombosis secondary to essential thrombocythemia. Rev Neurol (Paris). 2007;163(5):596–598. PMID: 17571029 https://doi.org/10.1016/s0035-3787(07)90467-1

48. O’Connor L, Croxson G, McCluskey P, Halmagyi GM. A 43-year-old woman presenting with subacute, bilateral, sequential facial nerve palsies, then developing pseudotumour cerebri. BMJ Case Rep. 2015;2015:bcr2015211399. PMID: 26604227 https://doi.org/10.1136/bcr-2015-211399

49. Coutinho JM, Gerritsma JJ, Zuurbier SM, Stam J. Isolated cortical vein thrombosis: systematic review of case reports and case series. Stroke. 2014;45(6):1836–1838. PMID: 24743438 https://doi.org/ 10.1161/STROKEAHA.113.004414

50. O’Rourke TL, Slagle WS, Elkins M, Eckermann D, Musick A. Papilloedema associated with dural venous sinus thrombosis. Clin Exp Optom. 2014;97(2):133–139. PMID: 23865959 https://doi.org/10.1111/cxo.12092

51. Ferro JM, Lopes MG, Rosas MJ, Fontes J, VENOPORT Investigators. Delay in hospital admission of patients with cerebral vein and dural sinus thrombosis. Cerebrovasc Dis. 2005;19(3):152–156. PMID: 15644627 https://doi.org/10.1159/000083248

52. Terazzi E, Mittino D, Rudà R, Cerrato P, Monaco F, Sciolla R, et al. Cerebral venous thrombosis: a retrospective multicentre study of 48 patients. Neurol Sci. 2005;25(6):311–315. PMID: 15729493 https://doi.org/10.1007/s10072-004-0363-8

53. Pfefferkorn T, Crassard I, Linn J, Dichgans M, Boukobza M, Bousser MG. Clinical features, course and outcome in deep cerebral venous system thrombosis: an analysis of 32 cases. J Neurol. 2009;256(11):1839-1845. PMID: 19536581 https://doi.org/10.1007/s00415-009-5206-3

54. Kowoll CM, Kaminski J, Weiß V, Bösel J, Dietrich W, Jüttler E, et al. Severe Cerebral Venous and Sinus Thrombosis: Clinical Course, Imaging Correlates, and Prognosis. Neurocrit Care. 2016;25(3):392-399. PMID: 27000641 https://doi.org/10.1007/s12028-016-0256-8

55. Крылов В.В., Петриков С.С., Солодов А.А. Внутричерепная гипертензия. Москва: Бином; 2016. ISBN: 978-5-9518-0664-2

56. Leach JL, Fortuna RB, Jones BV, Gaskill-Shipley MF. Imaging of Cerebral Venous Thrombosis: Current Techniques, Spectrum of Findings, and Diagnostic Pitfalls. RadioGraphics. 2006;26(Suppl 1):S19–S43. PMID: 17050515 https://doi.org/ 10.1148/rg.26si055174

57. Kulkarni GB, Mustare V, Abbas MM. Profile of patients with cerebral venous sinus thrombosis with cerebellar involvement. J Stroke Cerebrovasc Dis. 2014;23(5):1106–1111. PMID: 24231137 https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.09.022

58. Hassan KM, Kumar D. Reversible diencephalic dysfunction as presentation of deep cerebral venous thrombosis due to hyperhomocysteinemia and protein S deficiency: Documentation of a case. J Neurosci Rural Pract. 2013;4(2):193–196. PMID: 23914104 https://doi.org/10.4103/0976-3147.112767

59. Xue SF, Ma QF, Ma X, Jia JP. Isolated cortical vein thrombosis: a widely variable clinicoradiological spectrum. Eur Neurol. 2013;69(6):331–335. PMID: 23549196 https://doi.org/10.1159/000346813

60. Sharma RC, Kainth A, Sharma S. Transient Global Amnesia as a Presenting Manifestation of Cerebral Venous Thrombosis. J Neuropsychiatry Clin Neurosci. 2015;27(3):e209–210. PMID: 26222971 https://doi.org/10.1176/appi.neuropsych.14110354

61. Pons Y, Vérillaud B, Ukkola-Pons E, Sauvaget E, Kania R, Herman P. Pulsatile tinnitus and venous cerebral thrombosis: report of a case and literature review. Rev Laryngol Otol Rhinol (Bord). 2012;133(3):163–164. PMID: 23590107

62. Caso V, Agnelli G, Paciaroni M (eds). Handbook on Cerebral Venous Thrombosis. Front Neurol Neurosci. Basel: Karger; 2008. vol 23. pp 96–111.

63. Ford K, Sarwar M. Computed tomography of dural sinus thrombosis. AJNR Am J Neuroradiol. 1981;2(6):539–543. PMID: 6797278

64. Girot M, Ferro JM, Canhão P, Stam J, Bousser MG, Barinagarrementeria F, et al. Predictors of outcome in patients with cerebral venous thrombosis and intracerebral hemorrhage. Stroke. 2007;38(2):337–342. PMID: 17204682 https://doi.org/10.1161/01.STR.0000254579.16319.35

65. Coutinho JM, van den Berg R, Zuurbier SM, VanBavel E, Troost D, Majoie CB, et al. Small Juxtacortical Hemorrhages in Cerebral Venous Thrombosis. Ann Neurol. 2014;75(6):908–916. PMID: 24816819 https://doi.org/10.1002/ana.24180

66. Oppenheim C, Domigo V, Gauvrit JY, Lamy C, Mackowiak-Cordoliani MA, Pruvo JP, et al. Subarachnoid hemorrhage as the initial presentation of dural sinus thrombosis. AJNR Am J Neuroradiol. 2005;26(3):614–617. PMID: 15760875

67. Levine HR, Ha KY, O’Rourke B, Owens FD, Doughty KE, Opatowsky MJ. A pictorial review of complications of acute coalescent mastoiditis. Proc (Bayl Univ Med Cent). 2012;25(4):372–373. PMID: 23077392 https://doi.org/10.1080/08998280.2012.11928882

68. Rao KCVG, Knipp HC, Wajner EJ. CT findings in cerebral sinus and venous thrombosis. Radiology. 1981;140(2):391–398. PMID: 7255715 https://doi.org/10.1148/radiology.140.2.7255715

69. Virapongse C, Cazenave C, Quisling R, Sarwar M, Hunter S. The empty delta sign: frequency and significance in 76 cases of dural sinus thrombosis. Radiology. 1987;162(3):779–785. PMID: 3809494 https://doi.org/10.1148/radiology.162.3.3809494

70. Vijay RK. The cord sign. Radiology. 2006;240(1):299–300. PMID: 16793988 https://doi.org/10.1148/radiol.2401031739

71. Teasdale E. Cerebral venous thrombosis: making the most of imaging. J R Soc Med. 2000;93(5):234–237. PMID: 10884765 https://doi.org/10.1177/014107680009300505

72. Masuhr F, Mehraein S, Einhäupl K. Cerebral venous and sinus thrombosis. J Neurol. 2004;251(1):11–23. PMID: 14999484 https://doi.org/10.1007/s00415-004-0321-7

73. Provenzale JM, Joseph GJ, Barboriak DP. Dural sinus thrombosis: findings on CT and MR imaging and diagnostic pitfalls. AJR Am J Roentgenol. 1998;170(3):777–783. PMID: 9490973 https://doi.org/10.2214/ajr.170.3.9490973

74. Avsenik J, Oblak JP, Popovic KS. Non-contrast computed tomography in the diagnosis of cerebral venous sinus thrombosis. Radiol Oncol. 2016;50(3):263–268. PMID: 27679541 https://doi.org/ 10.1515/raon-2016-0026

75. Haage P, Krings T, Schmitz-Rode T. Nontraumatic vascular emergencies: imaging and intervention in acute venous occlusion. Eur Radiol. 2002;12(11):2627–2643. PMID: 12386751 https://doi.org/10.1007/s00330-002-1615-8

76. Buyck P, De Keyzer F, Vanneste D,Wilms G, Thijs V, Demaerel P. CT density measurement and H:H ratio are useful in diagnosing acute cerebral venous sinus thrombosis. Am J Neuroradiol. 2013;34(8):1568–1572. PMID: 23471024 https://doi.org/10.3174/ajnr.A3469

77. Neal E, Sturgeon J. Hypodense cerebral venous sinus thrombosis on unenhanced CT: A potential pitfall. Report of a case and review of the literature. Radiol Case Rep. 2020;15(1):35–38. PMID: 31737143 https://doi.org/10.1016/j.radcr.2019.10.012

78. Einhäupl KM, Masuhr F. Cerebral venous and sinus thrombosis – an update. Eur J Neurol. 1994;1(2):109–126. PMID: 24283479 https://doi.org/10.1111/j.1468-1331.1994.tb00059.x

79. Bousser MG. Cerebral Venous Thrombosis. Nothing, Heparin, or Local Thrombolysis? Stroke. 1999;30(3):481–483. PMID: 10066839 https://doi.org/10.1161/01.str.30.3.481

80. Ozsvath RR, Casey SO, Lustrin ES, Alberico RA, Hassankhani A, Patel M. Cerebral Venography: Comparison of CT and MR Projection Venography. AJR Am J Roentgenol. 1997;169(6):1699–1707. PMID: 9393193 https://doi.org/ 10.2214/ajr.169.6.9393193

81. Alvis-Miranda HH, Castellar-Leones SM, Alcala-Сerra G, Moscote-Salazar LR. Cerebral sinus venous thrombosis. J Neurosci Rural Pract. 2013;4(4):427–438.

82. Gokce E, Pınarbas T, Acu B, Fırat MM, Erkorkmaz U. Torcular Herophili classification and evaluation of dural venous sinus variations using digital subtraction angiography and magnetic resonance venographies. Surg Radiol Anat. 2014;36(6):527–536. PMID: 24154635 https://doi.org/10.1007/s00276-013-1223-0

83. Choi HJ, Cho CW, Kim YS, Cha JH. Giant Arachnoid Granulation Misdiagnosed as Transverse Sinus Thrombosis. J Korean Neurosurg Soc. 2008;43(1):48–50. PMID: 19096547 https://doi.org/10.3340/jkns.2008.43.1.48

84. Tokiguchi S, Hayashi S, Takahashi H, Okamoto K, Ito J. CT of the pacchionian body. Neuroradiology. 1993;35(5):347–348. PMID: 8327108 https://doi.org/10.1007/BF00588366

85. Leach JL, Jones BV, Tomsick TA, Stewart CA, Balko MG. Normal appearance of arachnoid granulations on contrast-enhanced CT and MR of the brain: differentiation from dural sinus disease. AJNR Am J Neuroradiol. 1996;17(8):1523–1532. PMID: 8883652

86. Wasay M, Azeemuddin M. Neuroimaging of cerebral venous thrombosis. J Neuroimaging. 2005;15(2):118–128. PMID: 15746223 https://doi.org/10.1177/1051228404272883

87. Tokiguchi S. Investigation of fat in the dural sinus. Nihon Igaku Hoshasen Gakkai Zasshi. 1991;51(8):871–882. PMID: 1945768

88. Selim M, Fink J, Linfante I, Kumar S, Schlaug G, Caplan LR. Diagnosis of cerebral venous thrombosis with echo-planar T2*SW-weighted magnetic resonance imaging. Arch Neurol. 2002;59(6):1021–1026. PMID: 12056941 https://doi.org/10.1001/archneur.59.6.1021

89. Cakmak S, Hermier M, Montavont A, Derex L, Mauguière F, Trouillas P, et al. T2*SW-weighted MRI in cortical venous thrombosis. Neurology. 2004;63(9):1698. PMID: 15534258 https://doi.org/10.1212/01.wnl.0000138502.59539.cb

90. Idbaih A, Boukobza M, Crassard I, Porcher R, Bousser MG, Chabriat H. MRI of clot in cerebral venous thrombosis high diagnostic value of susceptibility-weighted images. Stroke. 2006;37(4):991–995. PMID: 16484607 https://doi.org/ 10.1161/01.STR.0000206282.85610.ae

91. Linn J, Michl S, Bochmann K, Pfefferkorn T, Wiesmann M, Hartz S, et al. Cortical vein thrombosis: the diagnostic value of different imaging modalities. Neuroradiology. 2010;52(10):899–911. PMID: 20107776 https://doi.org/10.1007/s00234-010-0654-0

92. Patel D, Machnowska M, Symons S, Yeung R, Fox AJ, Aviv RI, et al. Diagnostic performance of routine brain MRI sequences for dural sinus thrombosis. Am J Neuroradiol. 2016;37(11):2026–2032. PMID: 27313130 https://doi.org/10.3174/ajnr.A4843

93. Coutinho J, de Bruijn SFTM, deVeber G, Stam J. Anticoagulation for cerebral venous sinus thrombosis. Stroke. 2012;43(4):e41-e42. PMID: 22567669 https://doi.org/ 10.1161/strokeaha.111.648162

94. de Bruijn SF, Stam J. Randomized, placebo-controlled trial of anticoagulant treatment with low-molecularweight heparin for cerebral sinus thrombosis. Stroke. 1999;30(3):484–488. PMID: 10066840 https://doi.org/10.1161/01.str.30.3.484

95. Einhaupl KM, Villringer A, Meister W, Mehraein S, Garner C, Pellkofer M, et al. Heparin treatment in sinus venous thrombosis. Lancet. 1991;338:597–600. PMID: 1679154 https://doi.org/10.1016/0140-6736(91)90607-q

96. Misra UK, Kalita J, Chandra S, Kumar B, Bansal V. Low molecular weight heparin versus unfractionated heparin in cerebral venous sinus thrombosis: a randomized controlled trial. Eur J Neurol. 2012;19(7):1030–1036. PMID: 22416902 https://doi.org/10.1111/j.1468-1331.2012.03690.x

97. Ferro JM, Bousserc MG, Canhao P, Coutinhod JM, Crassardc I, Dentalie F, et al. European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis – endorsed by the European Academy of Neurology. Eur J Neurol. 2017;24(10):1203–1213. PMID: 28833980 https://doi.org/10.1111/ene.13381

98. Ferro M., Coutinho M., Dentali F, Kobayashi A, Alasheev A, Canhão P, et al. Safety and Efficacy of Dabigatran Etexilate vs Dose-Adjusted Warfarin in Patients with Cerebral Venous Thrombosis. A Randomized Clinical Trial. JAMA Neurol. 2019;76(12):1457–1465. PMID: 31479105 https://doi.org/10.1001/jamaneurol.2019.2764

99. Study of Rivaroxaban for CeREbral Venous Thrombosis (SECRET). Available at: https://clinicaltrials.gov/ct2/show/NCT03178864 [Accessed Jul 13, 2020].

100. Yii IYL, Mitchell PJ, Dowling RJ, Yan B. Imaging Predictors of Clinical Deterioration in Cerebral Venous Thrombosis. J Clin Neurosci. 2012;19(11):1525–1529. PMID: 22796274 https://doi.org/10.1016/j.jocn.2012.02.005

101. Coutinho JM, Zuurbier SM, Bousser MG, Ji X, Canhão P, Roos YB, et al. Effect of Endovascular Treatment with Medical Management vs Standard Care on Severe Cerebral Venous Thrombosis: The TO-ACT Randomized Clinical Trial. JAMA Neurol. 2020 May 18;e201022. Online ahead of print. PMID: 32421159 https://doi.org/10.1001/jamaneurol.2020.1022

102. Hatemi G, Silman A, Bang D, Bodaghi B, Chamberlain AM, Gul A, et al. Management of Behcet disease: a systematic literature review for the European League Against Rheumatism evidence-based recommendations for the management of Behcet disease. Ann Rheum Dis. 2009;68(10):1528–1534. PMID: 18420940 https://doi.org/10.1136/ard.2008.087957

103. Ferro JM, Crassard I, Coutinho JM, Canhão P, Barinagarrementeria F, Cucchiara B, et al. Decompressive surgery in cerebrovenous thrombosis: a multicenter registry and a systematic review of individual patient data. Stroke. 2011;42(10):2825–2831. PMID: 21799156 https://doi.org/10.1161/STROKEAHA.111.615393

104. Raza E, Shamim MS, Wadiwala MF, Ahmed B, Kamal AK. Decompressive surgery for malignant cerebral venous sinus thrombosis: a retrospective case series from Pakistan and comparative literature review. J Stroke Cerebrovasc Dis. 2014;23(1):e13–e22. PMID: 24119368 https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.07.045

105. Theaudin M, Crassard I, Bresson D, Saliou G, Favrole P, Vahedi K, et al. Should decompressive surgery be performed in malignant cerebral venous thrombosis? Stroke. 2010;41(4):727–731. PMID: 20185780 https://doi.org/10.1161/STROKEAHA.109.572909


Для цитирования:


Рамазанов Г.Р., Коригова Х.В., Петриков С.С. Диагностика и лечение церебрального венозного тромбоза. Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь». 2021;10(1):122-134. https://doi.org/10.23934/2223-9022-2021-10-1-122-134

For citation:


Ramazanov G.R., Korigova Kh.V., Petrikov S.S. Diagnostics and Treatment of Cerebral Venous Thrombosis. Russian Sklifosovsky Journal "Emergency Medical Care". 2021;10(1):122-134. (In Russ.) https://doi.org/10.23934/2223-9022-2021-10-1-122-134

Просмотров: 231


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 2223-9022 (Print)
ISSN 2541-8017 (Online)