Acute Poisoning with Ethyl Alcohol (Alcoholic Coma)
https://doi.org/10.23934/2223-9022-2018-7-4-357-365
Abstract
The article summarizes years of the authors experience in the diagnosis and treatment of acute poisonings with ethyl alcohol and presents data on the epidemiology of poisoning with ethyl alcohol, as well as modern terminology and systematization of poisoning with alcohols in accordance with the international classification of diseases ICD 10.
We analyzed the pharmacokinetics and pharmacodynamics of ethyl alcohol in its toxic effects.
The original clinical classification of alcoholic coma, confirmed by electrophysiological studies of the brain is given in the article. We also determined the involvement of deep structures of the brain in the pathogenesis of acute alcohol poisoning.
The emergency therapeutic measures in acute alcohol intoxication and its complications, primarily related to accelerated detoxification of the body by forced diuresis are reported. The importance of effective correction of acid-base blood disorders and prevention of acute renal failure is emphasized.
The article might provide a more accurate diagnosis of acute alcohol poisoning, accompanied by the development of alcoholic coma, and to improve the quality of treatment of this disease in the intensive care and toxicology departments.
About the Authors
V. N. Alexandrovsky
Scientific and Practical Toxicology Center of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Alexandrovsky Vladimir Naumovich - Dr. Med. Sci., Senior Researcher, Scientific and Practical Toxicology Center of the Federal Medical and Biological Agency of Russia.
3 Bolshaya Sukharevskaya Square, b. 7, Moscow 129090
Y. N. Ostapenko
Scientific and Practical Toxicology Center of the Federal Medical and Biological Agency of Russia; N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare Department; Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
Ostapenko Yuri Nikolaevich - Cand. Med. Sci., Head of Research Department of the Federal Bank for Acute Chemical Pathology, SPTCFMBAR.
3 Bolshaya Sukharevskaya Square, b. 7, Moscow 129090; 3 Bolshaya Sukharevskaya Square, Moscow 129090; 2/1 Barrikadnaya St., b. 1, Moscow 125993
Y. S. Goldfarb
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare Department; Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
Goldfarb Yuri Semenovich - Dr. Med. Sci., Full Professor, Head of the Department of Clinical Toxicology, RMA CPE.
3 Bolshaya Sukharevskaya Square, Moscow 129090; 2/1 Barrikadnaya St., b. 1, Moscow 125993
M. M. Potskhveriya
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare Department; Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
Potskhveriya Мikhail Мikhailovich - Cand. Med. Sci., Head of the Scientific Department of Acute Poisonings and Somatopsychic Disorders, N.V. Sklifosovsky RIEM.
3 Bolshaya Sukharevskaya Square, Moscow 129090; 2/1 Barrikadnaya St., b. 1, Moscow 125993
M. V. Kareva
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare Department; Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
Kareva Naria Vladimirovna - Cand. Med. Sci., Head of the Admission Department of the Center of Acute Poisonings for Mental Patients, N.V. Sklifosovsky RIEM.
3 Bolshaya Sukharevskaya Square, Moscow 129090; 2/1 Barrikadnaya St., b. 1, Moscow 125993References
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Review
For citations:
Alexandrovsky V.N., Ostapenko Y.N., Goldfarb Y.S., Potskhveriya M.M., Kareva M.V. Acute Poisoning with Ethyl Alcohol (Alcoholic Coma). Russian Sklifosovsky Journal "Emergency Medical Care". 2018;7(4):357-365. https://doi.org/10.23934/2223-9022-2018-7-4-357-365
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