СУПЕРОКСИДДИСМУТАЗА В СОСТАВЕ АНТИОКСИДАНТНОЙ ТЕРАПИИ: СОСТОЯНИЕ ВОПРОСА И ПЕРСПЕКТИВЫ (ОБЗОР ЛИТЕРАТУРЫ)
Аннотация
Оксидативный стресс, развивающийся при многих заболеваниях, является нарушением баланса между прооксидантами и антиоксидантными защитными механизмами организма. Антиоксидантные ферменты, такие как супероксиддисмутаза (СОД), играют ключевую роль в снижении оксидативного стресса в естественных условиях. Таким образом, уменьшение образования активных форм кислорода, а также активации процессов перекисного окисления липидов за счет экзогенного поступления СОД могло бы стать эффективным методом профилактики и лечения ряда заболеваний. В данной работе мы предлагаем обзор результатов экспериментальных и клинических исследований по использованию внутривенно вводимых препаратов и пищевых добавок, содержащих СОД, при лечении воспалительных, инфекционных, сердечно-сосудистых и нейродегенеративных заболеваний. В результате введения СОД большинство авторов наблюдали увеличение содержания эндогенных антиоксидантных ферментов (СОД, каталазы, глутатионпероксидазы), т.е. стимуляцию эндогенной антиоксидантной защиты, и, следовательно, снижение уровня оксидативного стресса, что может объяснять механизмы положительных наблюдаемых эффектов.
Об авторах
Т. А. Пушкина
ФГБУ «Государственный научный центр РФ — Федеральный медицинский биофизический центр им. А.И. Бурназяна» ФМБА России
Россия
Россия
ассистент кафедры восстановительной медицины, спортивной медицины, курортологии и физиотерапии с курсом сестринского дела,
Москва
Э. С. Токаев
ООО «Академия-Т»
Россия
Москва
Россия
Москва
Т. С. Попова
ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»
Россия
Москва
Россия
Москва
Е. Н. Бородина
ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»
Россия
Москва
Россия
Москва
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Рецензия
Для цитирования:
Пушкина Т.А., Токаев Э.С., Попова Т.С., Бородина Е.Н. СУПЕРОКСИДДИСМУТАЗА В СОСТАВЕ АНТИОКСИДАНТНОЙ ТЕРАПИИ: СОСТОЯНИЕ ВОПРОСА И ПЕРСПЕКТИВЫ (ОБЗОР ЛИТЕРАТУРЫ). Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь». 2016;(4):42-47.
For citation:
Pushkina T.A., Tokayev E.S., Popova T.S., Borodina E.N. SUPEROxIDE DISMUTASE AS A COMPONENT OF ANTIOxIDANT THERAPY: CURRENT STATE OF THE ISSUE AND PROSPECTS. A LITERATURE REVIEW. Russian Sklifosovsky Journal "Emergency Medical Care". 2016;(4):42-47. (In Russ.)
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