RECENT ADVANCES OF HYPERMETABOLIC RESPONSE MODULATION IN SEVERE THERMAL TRAUMA
Abstract
The review focuses on key aspects of complex hypermetabolic response modulation which improve treatment outcomes in patients with severe thermal trauma: pharmacologic and non-pharmacologic approaches, early enteral feeding and micronutrients, physiatrics, estimation of individual nutritional requirements and monitoring of the nutritional support adequacy.
About the Authors
M. Y. Ilynsky
N.V. Sklifosovsky Researh Institute for Emergency Medicine, Moscow
Russian Federation
Russian Federation
Y. N. Lyashchenko
N.V. Sklifosovsky Researh Institute for Emergency Medicine, Moscow
Russian Federation
Russian Federation
A. A. Ryk
N.V. Sklifosovsky Researh Institute for Emergency Medicine, Moscow
Russian Federation
Russian Federation
D. E. Bocharov
N.V. Sklifosovsky Researh Institute for Emergency Medicine, Moscow
Russian Federation
Russian Federation
References
1. Peck M.D. Epidemiology of burns throughout the world. Part I: Distribution and risk factors. Burns. 2011;37(7):1087–1100.
2. Brusselaers N., Monstrey S., Vogelaers D., et al. Severe burn injury in Europe: a systematic review of the incidence, etiology, morbidity, and mortality. Crit Care. 2010;14(5):188.
3. Wolf S. Critical Care in the Severely burned: organ support and management of complications. In: ed. Herndon D.N. Total burn care. 3rd ed. London: Saunders Elsevier, 2007. 454–476.
4. Smirnov S.V., Lyashchenko Yu.N., Spiridonova T.G., Ryk A.A. Enteral and parenteral nutrition patients with thermal injury. In: eds. Khubutiya M.Sh., Popova T.S., Saltanov A.I. Parenteral and enteral nutrition: national leadership. Moscow: GEOTAR-Media Publ., 2014. 351–370. (In Russian).
5. Herndon D.N., Tompkins R.G. Support of the metabolic response to burn injury. Lancet. 2004;363:1895–1902.
6. Gerasimova L.I. Thermal burns. In: ed. Ermolov A.S., Abakumov M.M. Artificial nutrition in emergency surgery and traumatology. Moscow: NII SP im. N.V. Sklifosovskogo Publ., 2001. 239–264. (In Russian).
7. Sheridan R.L. A great constitutional disturbance. N Engl J Med. 2001;345(17):1271–1272.
8. Yu Y.M., Tompkins R.G., Ryan C.M., Young V.R. The metabolic basis of the increase in energy expenditure in severely burned patients. J Parenter Enteral Nutr. 1999;23(3):160–168.
9. Demling R., Seigne P. Metabolic management of patients with severe burns. World J Surg. 2000;24(6):673–680.
10. Newsome T., Mason A., Pruitt B. Weight loss following thermal injury. Ann Surg. 1973;178(2):215–217.
11. Wilmore D.W. Nutrition and metabolism following thermal injury. Clin Plast Surg. 1974;1(4):603–619.
12. Jeschke M.G., Mlcak R.P., Finnerty C.C., et al. Burn size determines the inflammatory and hypermetabolic response. Crit Care. 2007;11(4):90.
13. Norbury W.B., Herndon D.N. Modulation of the hypermetabolic response after burn injury. In: ed. Herndon D.N. Total burn care. 3rd ed. New York: Saunders Elsevier, 2007. 420–433.
14. Zawacki B.E., Spitzer K.W., Mason A.D. Jr., et al. Does increased evaporative water loss cause hypermetabolism in burned patients? Ann Surg. 1970;171(2):236–240.
15. Wilmore D.W., Mason A.D. Jr., Johnson D.W., Pruitt B.A. Effect of ambient temperature on heat production and heat loss in burn patients. J Appl Physiol. 1975;38(4):593–597.
16. Williams F.N., Jeschke M.G., Chinkes D.L., et al. Modulation of the hypermetabolic response to trauma: temperature, nutrition, and drugs. J Am Coll Surg. 2009;208(4):489–502.
17. Munster A.M., Smith-Meek M., Sharkey P. The effect of early surgical intervention on mortality and cost-effectiveness in burn care, 1978–1991. Burns. 1994;20(1):61–64.
18. Ramzy P.I., Barret J.P., Herndon D.N. Thermal injury. Crit Care Clin. 1999;15(2):333–352.
19. Hart D.W., Wolf S.E., Chinkes D.L., et al. Determinants of skeletal muscle catabolism after severe burn. Ann Surg. 2000;232(4):455–465.
20. Cucuzzo N.A., Ferrando A., Herndon D.N. The effects of exercise programming vs traditional outpatient therapy in the rehabilitation of severely burned children. J Burn Care Rehabil. 2001;22(3):214–220.
21. Murphy K.D., Lee J.O., Herndon D.N. Current pharmacotherapy for the treatment of severe burns. Expert Opin Pharmacother. 2003;4(3):369–384.
22. Herndon D.N., Rodriguez N.A., Diaz E.C., et al. Long-term propranolol use in severely burned pediatric patients: a randomized controlled study. Ann Surg. 2012;256(3):402–411.
23. Herndon D.N., Hart D.W., Wolf S.E., et al. Reversal of catabolism by beta-blockade after severe burns. N Engl J Med. 2001;345(17):1223–1229.
24. Ali A., Herndon D.N., Mamachen A., et al. Propranolol attenuates hemorrhage and accelerates wound healing in severely burned adults. Crit Care. 2015;19:217.
25. Hart D.W., Wolf S.E., Ramzy P.I., et al. Anabolic effects of oxandrolone after severe burn. Ann Surg. 2001;233(4):556–564.
26. Suman O.E., Thomas S.J., Wilkins J.P., et al. Effect of exogenous growth hormone and exercise on lean mass and muscle function in children with burns. J Appl Physiol. 2003;94(6):2273–2281.
27. Branski L.K., Herndon D.N., Barrow R.E., et al. Randomized controlled trial to determine the efficacy of long-term growth hormone treatment in severely burned children. Ann Surg. 2009;250(4):514–523.
28. Takala J., Ruokonen E., Webster N.R., et al. Increased mortality associated with growth hormone treatment in critically ill adults. N Engl J Med. 1999;341(11):785–792.
29. Moller S., Jensen M., Svensson P., Skakkebaek N.E. Insulin-like growth factor 1 (IGF-1) in burn patients. Burns. 1991;17(4):279–281.
30. Langouche L., Van den Berghe G. Glucose metabolism and insulin therapy. Crit Care Clin. 2006;22(1):119–129.
31. Gauglitz G.G., Herndon D.N., Kulp G.A., et al. Abnormal insulin sensitivity persists up to three years in pediatric patients post-burn. J Clin Endocrinol Metab. 2009;94(5):1656–1664.
32. Gornik I., Vujaklija-Brajkovic A., Renar I.P., et al. A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent development of type 2 diabetes. Crit Care. 2010;14(4):130.
33. Pidcoke H.F., Wade C.E., Wolf S.E. Insulin and the burned patient. Crit Care Med. 2007;35(9 Suppl):S524–S530.
34. Jeschke M.G., Klein D., Herndon D.N. Insulin treatment improves the systemic inflammatory reaction to severe trauma. Ann Surg. 2004;239(4):553–560.
35. Ferrando A.A., Chinkes D.L., Wolf S.E., et al. A submaximal dose of insulin promotes net skeletal muscle protein synthesis in patients with severe burns. Ann Surg. 1999;229:11–18.
36. Dellinger R.P., Levy M.M., Rhodes A., et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013;41(2):580–637.
37. Gore D.C., Wolf S.E., Herndon D.N., et al. Metformin blunts stressinduced hyperglycemia after thermal injury. J Trauma. 2003;54(3):555–561.
38. Gore D.C., Herndon D.N., Wolfe R.R. Comparison of peripheral metabolic effects of insulin and metformin following severe burn injury. J Trauma. 2005;59(2):316–322.
39. Luft D., Schmulling R.M., Eggstein M. Lactic acidosis in biguanidetreated diabetics: a review of 330 cases. Diabetologia. 1978;14(2):75–87.
40. Bailey C.J., Turner R.C. Metformin. N Engl J Med. 1996;334(9):574–579.
41. Williams F.N., Branski L.K., Jeschke M.G., et al. What, How, and How Much Should Patients with Burns be Fed? Surg Clin North Am. 2011;91(3):609–629.
42. Smirnov S.V., Lyashchenko Yu.N., Ryk A.A., Khvatov V.B. Modern approaches to nutritional support in intensive care patients with thermal injuries in a hospital emergency room. Skoraya meditsinskaya pomoshch’. 2010;1:25–38. (In Russian).
43. Rousseau A.F., Losser M.R., Ichai C., Berger M.M. ESPEN endorsed recommendations: nutritional therapy in major burns. Clin Nutr. 2013;32(4):497–502.
44. Deitch E.A. Intestinal permeability is increased in burn patients shortly after injury. Surgery. 1990;107(4):411–416.
45. Mochizuki H., Trocki O., Dominioni L., et al. Mechanism of prevention of postburn hypermetabolism an catabolism by early enteral feeding. Ann Surg. 1984;200(3):297–310.
46. Chiarelli A., Enzi G., Casadei A., et al. Very early nutrition supplementation in burned patients. Am J Clin Nutr. 1990;51(6):1035–1039.
47. McDonald W.S., Sharp C.W. Jr. Deitch E.A. Immediate enteral feeding in burn patients is safe and effective. Ann Surg. 1991;213(2):177–183.
48. Venter M., Rode H., Sive A., Visser M. Enteral resuscitation and early enteral feeding in children with major burns–Effect on McFarlane response to stress. Burns. 2007;33(4):464–471.
49. Barton R., Craft W., Mone M.C., Saffle J. Chemical paralysis reduces energy expenditure in mechanically ventilated trauma patients. J Burn Care Rehabil. 1997;18(5):461–468.
50. Saffle J., Medina E., Raymond J., et al. Use of indirect calorimetry in the nutritional management of burn patients. J Trauma. 1985;25(1):32–39.
51. Swinamer D., Phang P., Jones R., et al. Twenty-four hour energy expenditure in critically ill patient. Crit Care Med. 1987;15(7):637–641.
52. Shaw-Delanty S., Elwyn D., Askanazi J., et al. Resting energy expenditure in injured, septic, and malnourished adult patients on intravenous diets. Clin Nutr. 1990;9(6):305–312.
53. Hester D., Lawson K. Suggested guidelines for use by dietitians in the interpretation of indirect calorimetry data. J Amer Diet Assoc. 1989;89(1):100–101.
54. Rimdeika R., Gudaviciene D., Adamonis K., et al. The effectiveness of caloric value of enteral nutrition in patients with major burns. Burns. 2006;32(1):83–86.
55. Berger M.M., Revelly J.P., Wasserfallen J.B., et al. Impact of a computerized information system on quality of nutritional support in the ICU. Nutrition. 2006;22(3):221–229.
56. Masters B., Aarabi S., Sidhwa F., Wood F. High-carbohydrate, high-protein, low-fat versus low-carbohydrate, high-protein, high-fat enteral feeds for burns. Cochrane Database Syst Rev. 2012;1:CD006122.
57. Gibson B.R., Galiatsatos P., Rabiee A., et al. Intensive insulin therapy confers a similar survival benefit in the burn intensive care unit to the surgical intensive care unit. Surgery. 2009;146(5):922–930.
58. Pham T.N., Warren A.J., Phan H.H., et al. Impact of tight glycemic control in severely burned children. J Trauma. 2005;59(5):1148–1154.
59. Pidcoke H.F., Wanek S.M., Rohleder L.S., et al. Glucose variability is associated with high mortality after severe burn. J Trauma. 2009;67(5):990–995.
60. Jeschke M.G., Kulp G.A., Kraft R., et al. Intensive insulin therapy in severely burned pediatric patients: a prospective randomized trial. Am J Respir Crit Care Med. 2010;182(3):351–359.
61. van Zanten A.R., Dhaliwal R., Garrel D., et al. Enteral glutamine supplementation in critically ill patients: a systematic review and metaanalysis. Crit Care. 2015;19:294.
62. Coudray-Lucas C., LeBever H., Cynober L., et al. Ornithine aketoglutarate improves wound healing in severe burn patients: a prospective randomized double-blind trial versus isonitrogenous controls. Crit Care Med. 2000;28(6):1772–1776.
63. Yan H., Peng X., Huang Y., et al. Effects of early enteral arginine supplementation on resuscitation of severe burn patients. Burns. 2007;33(2):179–184.
64. Gamliel Z., DeBiasse M., Demling R. Essential microminerals and their response to burn injury. J Burn Care Rehabil. 1996;17(3):264–272.
65. Gottschlich M., Warden G. Vitamin supplementation in the patient with burns. J Burn Care Rehabil. 1990;11(3):275–279.
66. Mayes T., Gottschlich M., Warden G. Clinical nutrition protocols for continuous quality improvement in the outcomes of patients with burns. J Burn Care Rehabil. 1997;18(4):365–368.
67. Barbosa E., Faintuch J., Machado Moreira E.A., et al. Supplementation of vitamin E, vitamin C, and zinc attenuates oxidative stress in burned children: a randomized, double-blind, placebo-controlled pilot study. J Burn Care Res. 2009;30(5):859–866.
68. Tanaka H., Matsuda T., Miyagantani Y., et al. Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration. Arch. Surg. 2000;135(3):326–331.
69. Falder S., Silla R., Phillips M., et al. Thiamine supplementation increases serum thiamine and reduces pyruvate and lactate levels in burn patients. Burns. 2010;36(2):261–269.
70. Klein G.L., Herndon D.N., Chen T.C., et al. Standard multivitamin supplementation does not improve vitamin D insufficiency after burns. J Bone Miner Metab. 2009;27(4):502–506.
71. Berger M.M., Baines M., Raffoul W., et al. Trace element supplements after major burns modulate antioxidant status andclinical course by way of increased tissue trace element concentration. Am J Clin Nutr. 2007;85(5):1293–300.
72. Magnotti L., Deitch E. Burns, bacterial translocation, gut barrier function, and failure. J Burn Care Rehabil. 2005;26(5):383–391.
73. Fong Y., Marano M., Barber E., et al. Total parenteral nutrition and bowel rest modify the metabolic response to endotoxin in humans. Ann Surg. 1989;210(4):449–454.
74. Barret J.P., Jeschke M.G., Herndon D.N. Fatty infiltration of the liver in severely burned pediatric patients: autopsy findings and clinical implications. J Trauma. 2001;51(4):736–739.
75. Andel H., Rab M., Andel D., et al. Impact of duodenal feeding on the oxygen balance of the splanchnic region during different phases of severe burn injury. Burns. 2002;28(1):60–64.
76. Saito H., Trocki O., Alexander J., et al. The effect of route of nutrient administration on the nutritional state, catabolic hormone secretion and gut mucosal integrity after burn injury. JPEN. 1987;11(1):1–7.
77. Stroud M., Duncan H., Nightingale J., et al. Guidelines for enteral feeding in adult hospital patients. Gut. 2003;52(Suppl 7):vii1-vii12.
78. Kowal-Vern A., McGill V., Gamelli R. Ischemic necrotic bowel disease in thermal injury. Arch Surg. 1997;132(4):440–443.
79. Markell K.W., Renz E.M., White C.E., et al. Abdominal complications after severe burns. J Am Coll Surg. 2009;208(5):940–947.
80. Eisenberg P. Causes of diarrhea in tube-fed patients: a comprehensive approach to diagnosis and management. Nutr Clin Pract. 1993;8(3):119–123.
81. Kealey G., Aguillar J., Lewis R., et al. Cadaver skin allografts and transmission of human cytomegalovirus to burn patients. J Am Coll Surg. 1996;182(3):201–205.
82. Grube B.J., Heimbach D.M., Marvin J.A. Clostridium difficile diarrhea in critically ill burned patients. Arch Surg. 1987;122(6):655–661.
83. Gottschlich M., Warden G., Michel M., et al. Diarrhea in tube-fed burn patients: incidence, etiology, nutritional impact, and prevention. JPEN. 1988;12(4):338–345.
84. Whelan K., Schneider S.M. Mechanisms, prevention, and management of diarrhea in enteral nutrition. Curr Opin Gastroenterol. 2011;27(2):152–159.
85. Scaife C.L., Saffle J.R., Morris S.E. Intestinal obstruction secondary to enteral feedings in burn trauma patients. J Trauma. 1999;47(5):859–863.
86. Gump F., Kinney J. Energy balance and weight loss in burned patients. Arch Surg. 1971;103(4):442–448.
87. Zdolsek H.J., Lindahl O.A., Angquist K.A., Sjöberg F. Non-invasive assessment of intercompartmental fluid shifts in burn victims. Burns. 1998;24(3):233–240.
88. Streat S., Beddoe A., Hill G. Aggressive nutritional support does not prevent protein loss despite fat gain in septic intensive care patients. J Trauma. 1987;27(3):262–266.
89. Hart D.W., Wolf S.E., Herndon D.N., et al. Energy expenditure and caloric balance after burn: Increased feeding leads to fat rather than lean mass accretion. Ann Surg. 2002;235(1):152–161.
90. Graves C., Saffle J., Morris S. Comparison of urine urea nitrogen collection times in critically ill patients. Nutr Clin Pract. 2005;20(2):271–275.
91. Konstantinides F., Radmer W., Becker W., et al. Inaccuracy of nitrogen balance determinations in thermal injury with calculated total urinary nitrogen. J Burn Care Rehabil. 1992;13(2)Pt1:254–260.
92. LeBlanc A., Gogia P., Schneider V., et al. Calf muscle area and strength changes after five weeks of horizontal bed rest. Am J Sports Med. 1988;16(6):624–629.
93. Greenhalgh D.G., Housinger T.A., Kagan R.J., et al. Maintenance of serum albumin levels in pediatric burn patients: a prospective, randomized trial. J Trauma. 1995;39(1):67–73.
94. Sheridan R.L., Prelack K., Cunningham J.J. Physiologic hypoalbuminemia is well tolerated by severely burned children. J Trauma. 1997;43(3):448–452.
95. Rettmer R., Williamson J., Labbe R., et al. Laboratory monitoring of nutrition status in burn patients. Clin Chem. 1992;38(3):334–337.
96. Cynober L., Prugnaud O., Lioret H., et al. Serum transtyretin levels in patients with burn injury. Surgery. 1991;109(5):640–644.
97. Manelli J., Abdetii C., Botti G., et al. A reference standard for plasma proteins is required for nutritional assessment of adult burn patients. Burns. 1998;24(4):337–345.
98. Saffrey J.R., Graves C., Cochran A. Nutritional support of the burned patient. In: ed. Herndon D.N. Total burn care. 4th ed. New York: Saunders Elsevier, 2012. 348–349.
99. Kyle U.G., Nicod L., Raguso C., et al. Fat-free mass change to weight change ratio during refeeding following lung transplantation. Acta Diabetol. 2003;40Suppl1:S165–S167.
100. Bachrach L.K. Dual energy X-ray absorptiometry (DEXA) measurements of bone density and body composition: promise and pitfalls. J Pediatr Endocrinol Metab. 2000;13Suppl2:S983–S988.
Review
For citations:
Ilynsky M.Y., Lyashchenko Y.N., Ryk A.A., Bocharov D.E. RECENT ADVANCES OF HYPERMETABOLIC RESPONSE MODULATION IN SEVERE THERMAL TRAUMA. Russian Sklifosovsky Journal "Emergency Medical Care". 2016;(3):55-64. (In Russ.)
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