FORECAST OF CLINICAL TOXICOLOGY DEVELOPMENT IN RUSSIA
Abstract
BACKGRO UN D. The lack of scientific papers on the forecast of clinical toxicology development.
MATERIAL. Diagnostic, medical and organizational technologies in different periods of clinical toxicology development in Russia.
METHODS. Historical, predictive and analytical.
RESULTS. We analyzed trends and research results in the field of clinical toxicology and other sections of science (knowledge about the natural mechanisms of detoxification, adopted detoxification methods and its monitoring, individualization of detoxification effects, state of the toxicological aid organization to the population).
CONCLUSIO N. The fundamental positive shift in the development of clinical toxicology occurred due to introduction of the complex detoxification therapy and creation of Toxicology Services in Russia. Further improvement of urgent care delivery in acute poisonings is associated with the progress of all its units: diagnostic, therapeutic, organizational, legal, and educational. Also, it will be related with timely implementation of advanced medical technologies based on the achievements of the world scientific and technical progress.About the Authors
M. S. KhubutiyaRussian Federation
S. A. Kabanova
Russian Federation
Y. S. Goldfarb
Russian Federation
V. A. Matkevich
Russian Federation
P. M. Bogopolsky
Russian Federation
A. V. Badalyan
Russian Federation
References
1. Methodical recommendations on formation of forecasts of development of medical science. Moscow: RAMN Publ., 2006. 36 p. (In Russian).
2. A Glossary of key terms: Scientific forecasting. Available at: http://philosophy_of_science.academic.ru/218 (Accessed 28 Aug 2016). (In Russian).
3. Mirskiy M.B. Surgery from ancient times to the present. Moscow: Nauka Publ., 2000. 797 p. (In Russian).
4. Zabludovskiy P.E., Kryuchok G.R., Kuz’min M.K., Levit M.M. History of medicine. Moscow: Meditsina Publ., 1981. 352 p. (In Russian).
5. Bogopol’skiy P.M., Kabanova S.A., Gol’dfarb Yu.S. On the criteria of the periodization of the history of particular fields of medicine. Problemy sotsial’noy gigieny, zdravookhraneniya i istorii meditsiny. 2015;4:58–61. (In Russian).
6. Luzhnikov E.A., Kabanova S.A., Gol’dfarb Yu.S., et al. To the periodization of the history of clinical toxicology in Russia. Toksikologicheskiy vestnik. 2015;5:2–9. (In Russian).
7. Gal’perin Yu.M. Paresis, paralysis and functional bowel obstruction. Moscow: Meditsina Publ., 1975. 219 p. (In Russian).
8. Matkevich V.A., Lisovik Zh.E., Luzhnikov E.A., Aleksandrovskiy V.N. Toxicokinetics of organophosphate insecticides in acute oral poisoning and rational tactics of detoxification of the body. Toksikologicheskiy vestnik. 2010;6:6–10. (In Russian).
9. Matkevich V.A. Intestinal lavage. In: Ed. Luzhnikov E.A. Medical toxicology. Moscow: GEOTAR-Media, 2012. Ch. 4. 162–186. (Series Natsional’nye rukovodstva). (In Russian).
10. Freydlin I.S., Nazarov P.G. The Regulatory functions of inflammatory cytokines and acute phase proteins. Vestnik RAMN. 1999;5:28–32. (In Russian).
11. Foster J.R. The functions of cytokines and their uses in toxicology. Int J Exp Path. 2001;82(3):171–192.
12. Granik V.G. Toxicology of drugs. Moscow: Vuzovskaia kniga Publ., 2009. 440 p. (In Russian).
13. Bagnenko S.F., Shilov V.V., Pivovarova L.P., et al. The status of antimicrobial resistance in patients with acute neurotropic substances poisonings severe. Toksikologicheskii vestnik. 2013;4:4–7. (In Russian).
14. Goldin M.M., Volkov A.G., Goldfarb Y.S., Goldin Mik.M. Electrochemical Aspects of Hemosorption. J Electrochem Soc. 2006;153(8):J91–J99.
15. Khubutiia M.Sh., Tsivadze A.Iu., Gol’din M.M., et al. Electrochemicallycontrolled methods of removal of endoand ecotoxicants of biological environments. Rossiyskiy khimicheskiy zhurnal. 2013;5–6:30–42. (In Russian).
16. Gol’dfarb Yu.S. Physico-chemical methods of haemotherapy with exogenous and endotoxemia (review). Anesteziologiya i reanimatologiya. 1995;3:48–55. (In Russian).
17. Luzhnikov E.A., Gol’dfarb Yu.S., Musselius S.G. Detoxification therapy. Saint Petersburg: Lan’, 2000. 192 p. (In Russian).
18. Luzhnikov E.A., Gol’dfarb Yu.S. Physiohaemotherapy of acute poisoning. Moscow: Medpraktika-M Publ.; 2002. 200 p. (In Russian).
19. Gol’dfarb Yu.S., Chukina E.A., Korotitskiy A.V., et al. First experience of EHF haemotherapy upon haemorheological disorders toxic etiology. Proceedings of XIII Conf. The Moscow society of hemapheresis, Moscow, 2005, 30 May–1 June. Moscow, 2005. 98–99. (In Russian).
20. Luzhnikov E.A., Gol’dfarb Yu.S., Petrov S.I., et al. Haemorheological aspects of detoxification in acute poisoning. Health Capital 2011: Abstracts. X Moscow Assembly, 15–16 Dec 2011. Moscow: GEOS Publ., 2011. 213–214. (In Russian).
21. Goldin M.M., Volkov A.G., Goldfarb Yu.S., Luzhnikov E.A. Electrochemical generation of active oxygen into aqueous solutions for organism detoxification. Toxicology in vitro. 2004;18:791–795.
22. Kutusov M.V.; patentee Germanov E.P., Kutusov M.V. System correction biological fluid. Pat. RU 2252037 (51) Int.Cl. 7 А61М1/34 (2006.01). No. 2003130214/14; Stat. 14.10.2003; publ. 20.05.2005.
23. Kutushov M.V. Magnetically operated absorbent and method for the production thereof. Pat. 20070071977 A1 United States, Int.Cl. H01F 1/00; B32B 1/00; B32B 9/00 (2006.01) N 10/575,830; stat. 20.09.2004; publ. 14.04.2006.
24. Komissarova L.Kh., Kuznetsov A.A., Filippov V.I., et al. Detoxification of the body by using magnetically controlled sorbents. Application of biomagnetic carriers in medicine: proceedings of the Symp. Moscow, 2002, November 19–20. Moscow: IBKhF RAN Publ., 2002. p. 68–76. (In Russian).
25. Kosonogov L.F., Shapovalova N.V., Strukov M.A., et al. An artificial circulatory support, efferent detoxification and hyperbaric oxygenation in the treatment of exotoxic shock. Anesteziologiya i reanimatologiya. 1995;3:26–29. (In Russian).
26. Strukov M.A. Auxiliary blood circulation and hyperbaric oxygenation in complex resuscitation at exotoxic shock: Dr. med. sci. diss. synopsis. Voronezh, 1998. 34 p. (In Russian).
27. Luzhnikov E.A., Gol’dfarb Yu.S., Marupov A.M. Endotoxemia in acute exogenous poisonings. Moscow: BINOM Publ., 2008. 200 p. (In Russian).
28. Il’yashenko K.K., Luzhnikov E.A. Toxic damage of respiratory system in acute poisoning. Moscow: Medpraktika Publ., 2004. 176 p. (In Russian).
29. Narzikulov R.A. Features of the development and course of endotoxemia in patients with acute severe poisoning drugs neurotropic using efferent methods of detoxification: Cand. med. sci. diss. synopsis. Saint Petersburg, 2000. 22 p. (In Russian).
30. Kostyuchenko A.L., Kostin E.D, Kurygin A.A. Enteral artificial nutrition in intensive medicine. Saint Petersburg: Spetsial’naya literature Publ., 1996. 330 p. (In Russian).
31. Matkevich V.A Enteral detoxication of the organism in case of acute oral poisoning. Dr. med. sci. diss. synopsis. Saint Petersburg, 2013. 49 p. (In Russian).
32. Kurygina A., Stoyko Yu., Bagnenko C. Motor-evacuation disorders of the small intestine in the early postoperative period. Available at: http:// www.medactiv.ru/ysurg/gastro-090004.shtml (Accessed 28 Aug 2016). (In Russian).
33. Matkevich V.A., Luzhnikov E.A., Il’yashenko K.K., et al. The effect of intestinal lavage for the development of pneumonia in patients with acute poisoning by psychopharmacological agents. Obshchaya reanimatologiya. 2011;2:20–24. (In Russian).
34. Matkevich V.A., Luzhnikov E.A., Belova M.V., et al. The role of intestinal translocation in the origin of endotoxemia in acute poisoning and detoxification effect of intestinal lavage. Sklifosovsky Journal of Emergency Medical Care. 2015;4:16–21. (In Russian).
35. Lapshin V.P., Gol’dfarb Yu.S., Krasil’nikov A.M., et al. Transcranial electric stimulation therapy in emergency conditions. Range of application and perspectives of development. Fizioterapiya, bal’neologiya, reabilitatsiya. 2007;1:45–47. (In Russian).
36. Gol’dfarb Yu.S., Krasil’nikov A.M., Lapshin V.P., et al. Effect MDM-therapy on the course of endotoxemia in acute poisoning by psychopharmacological drugs. Actual aspects of extracorporeal blood purification in Intensive Care: abs. VI Intern. conf, Moscow, 2008 May 29–30. Moscow, 2008. 43–44. (In Russian).
37. Badalyan A.V., Borovkova N.V., Gol’dfarb Yu.S., et al. Violations of cellular component of toxemia and their correction in acute poisoning in the rehabilitation period. Toksikologicheskiy vestnik. 2015;6:2–9. (In Russian).
38. Gladkikh V.D., Sarmanaeva S.Kh., Ostapenko Yu.N., eds. Antidote therapy of poisonings with highly toxic substances in emergency situations. Moscow: Kommentariy Publ., 2014. 270 p. (In Russian).
39. Rumack B.H., Bateman D.N. Acetaminophen and acetylcysteine dose and duration: Past, present and future. Clin Toxicol (Phila). 2012;50(2):91–98. (In Russian).
40. Gromov A.E. Method for assessment of some physico-chemical properties of the blood in diseases of chemical etiology. Established all-Union conference on toxicology: abstracts, Moscow, 1980, November 25–27. Moscow, 1980. 141–142. (In Russian).
41. Chemical composition, morphology and physical properties of diamond. Available at: www.ural-almaz.com.ru (Accessed 28 Aug 2016). (In Russian).
42. Grosz H.J., Farmer B.B. Reduction-Oxidation Potential of Blood as a Function of Partial Pressure of Oxygen. Nature. 1967;213:717–718.
43. Jellinek M., Chandel B., Abdulla R., et al. The effect of shock on blood oxidation-reduction potential. Experientia. 1992;48(10):980–985.
44. Rao S.K., Palazzo R.S., Metz H.N., et al. Redox potential measurements of plasma in patients undergoing coronary artery bypass graft and its clinical significance. J Pharmacol Toxicol Methods. 1997;38(3):151–156.
45. Essex D.W., Li M. Redox Control of Platelet Aggregation. Biochemistry. 2003.42(1):129–136.
46. Goldin М.М., Khubutia M.Sh., Evseev А.К., et al. Noninvasive Diagnosis of Dysfunctions in Patients After Organ Transplantation by Monitoring the Redox Potential of Blood Serum. Transplantation. 2015;99(6):1288–1292.
47. Luzhnikov E.A., Leonov B.I., Evseev A.K., et al. Changing the redox potential of the plasma in the treatment of acute poisoning with sodium hypochlorite psychotropic drugs. Topical Issues of extracorporeal therapy: proceedings, Moscow, 2007, May 23–24. Мoscow, 2007. 129–130.
48. The scientist, who did not wash for 12 years, said that the purified bacteria. Available at: http://naked-science.ru/article/media/ne-myvshiisya-12let-uchenyi-z (Accessed 28 Aug 2016). (In Russian).
49. Methods for removing rust. Available at: http://novochem.ru/products/proizvodimye-produkty/antirzhavin/sposoby-udaleniya-rzhavchiny (Accessed 28 Aug 2016). (In Russian).
50. Pharmacological directory: Normoflorin L and B. Available at: http://www.gastroportal.ru/php/content.php?id=106743&pr=27 (Accessed 28 Aug 2016). (In Russian).
51. Maksimov G.K., Sinitsin A.N. Statistical modeling of multidimensional systems in medicine. Leningrad: Meditsina Publ., 1983. 144 p. (In Russian).
52. El’kov A.N., Il’yashenko K.K., Gol’dfarb Yu.S., et al. Experience with the use of factor analysis in clinical toxicology. Preprint (127). Moscow: IPM im MV Keldysha RAN Publ., 2005. 32 p. (In Russian).
53. Badalyan A.V., Luzhnikov E.A., Gol’dfarb Yu.S., et al. Multivariate statistical analysis of acute poisoning by psychopharmacological agents and cauterizing liquids in the rehabilitation period: Pro. Health Capital 2014: Abstracts. XIII Moscow Assembly. Moscow, 2014, Nov 20–21. Moscow, 2014. 176–177. (In Russian).
54. Khal’fin R.A. Sentsov V.G., Nozhkina N.V. The organization and experience of the service for the treatment of acute poisoning. Ekaterinburg: Ural. Un. Publ., 2004. 162 p. (In Russian).
55. Toxicology services in Russian Federation. Sklifosovsky Journal of Emergency Medical Care. 2014;3:7–10. (In Russian).
56. Khubutiya M.Sh., Luzhnikov E.A., Tadzhiev I.Ya., et al. Normative legal regulation of national service clinical toxicology. Vestnik RAMN. 2013;11:66–72. (In Russian).
Review
For citations:
Khubutiya M.S., Kabanova S.A., Goldfarb Y.S., Matkevich V.A., Bogopolsky P.M., Badalyan A.V. FORECAST OF CLINICAL TOXICOLOGY DEVELOPMENT IN RUSSIA. Russian Sklifosovsky Journal "Emergency Medical Care". 2016;(3):26-33. (In Russ.)