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Russian Sklifosovsky Journal "Emergency Medical Care"

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BIOSPECIFIC HEMOSORBENTS. THE SUCCESSES AND PROBLEMS

Abstract

Understanding the leading role of the endogenous proteolysis activation in a number of serious diseases has existed for a long time, the large group of antifermental drugs has been created and widely used. The hemosorbent, capable of selectively removing from the blood the most significant class of serine proteases in purulent septic pathology, was developed and tested in the clinic. The nature of the hemosorbents` therapeutic effect and the status of the proteins metabolism certain parts in connection with the application for haemosorption with biospecific antiproteinase hemosorbents has been studied in patients with diffuse purulent peritonitis of appendicular origin.

About the Authors

V. V. Kirkovsky
Belarusian state medical university
Belarus
Minsk


I. G. Kolesnikova
Belarusian state medical university
Belarus
Minsk


G. A. Lobacheva
Belarusian state medical university
Belarus
Minsk


E. L. Sedjolkina
Belarusian state medical university
Belarus
Minsk


References

1. Lopukhin Yu.M., Molodenkov M.N. Gemosorbtsiya [Hemosorption]. 2nd ed., rev. and exp. Moscow: Meditsina Publ., 1985. 287 p. (In Russian)

2. Nikolaev V.G. Metod gemokarboperfuzii v eksperimente i klinike [Hemocarboperfusion in experiment and clinic]. Kiev: Naukova dumka Publ., 1983. 359 p. (In Russian)

3. Nikolaychik V.V. Molekulyarnye mekhanizmy razvitiya endogennoy intoksikatsii i sovershenstvovanie putey detoksikatsii: avtoref. dis. … d-ra med. nauk [Molecular mechanisms of development of endogenous intoxication and to improve detoxification: Dr. med. sci. diss. synopsis]. Moscow, 1984. 44 p. (In Russian)

4. Kirkovskiy V.V. Primenenie gemosorbtsii v kompleksnom lechenii sindroma endogennoy intoksikatsii u bol’nykh s peritonitom i ozhogovoy bolezn’yu: avtoref. dis. ... kand. med. nauk [The use of hemosorption in the complex treatment of the syndrome of endogenous intoxication in patients with peritonitis, and burn disease: Cand. med. sci. diss. synopsis]. Minsk, 1983. 21 p. (In Russian)

5. Napalkov P.N., Shekhtel’ V.V. Razvitie khirurgii pankreatita v SSSR [The development of pancreatitis surgery in the USSR]. Vestnik khirurgii. 1977; 11: 17–24. (In Russian)

6. Plate N., Kirkovsky V., Antiperovich O., et al. Biospecific haemosorbents based on proteinase inhibitor: II. Efficiency of biospecific antiproteinase haemosorbent “Ovosorb” in complex treatment of experimental generalized purulent peritonitis and acute destructive pancreatitis. Biomaterials. 1994; 15 (4): 285–288.

7. Kirkovsky V., Antiperovich O., Valueva T., et al. Biospecific haemosorbents based proteinase inhibitor: III Biospecific antiproteinase haemosorbent “Ovosorb” in complex therapy of acute destructive pancreatitis. Biomaterials. 1994. 15 (5): 334–336.


Review

For citations:


Kirkovsky V.V., Kolesnikova I.G., Lobacheva G.A., Sedjolkina E.L. BIOSPECIFIC HEMOSORBENTS. THE SUCCESSES AND PROBLEMS. Russian Sklifosovsky Journal "Emergency Medical Care". 2016;(2):16-19.

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ISSN 2223-9022 (Print)
ISSN 2541-8017 (Online)