The Use of Autologous Leucocyte Labelling in Patients With Fever Of Unknown Origin
https://doi.org/10.23934/2223-9022-2025-14-1-123-131
Abstract
RELEVANCE. Patients with a systemic reaction to inflammation are often observed after adequate surgical intervention and/or treatment of the underlying disease. Laboratory tests indicate the presence of a pronounced inflammatory process, and instrumental diagnostic methods (ultrasound, computed tomography, radiography) do not always help in detecting the source of inflammation.
THE AIM OF THE STUDY. Is to present the possibilities of radionuclide imaging (RI) using labelled autologous leucocytes to identify the source of infection.
MATERIAL AND METHODS. 95 patients with fever of unknown origin were examined by the radionuclide diagnostic method. The data of computed tomography (CT), ultrasound, radiography (RG), laboratory tests (CRP, PCT, IL-6), the results of morphological examination in comparison with the results of RI were analyzed. Clinical examples are presented.
RESULTS. With the help of RI, foci of inflammation were identified. Based on the data obtained, the treatment was adjusted, which contributed to the recovery of 80 patients. In 15 patients, because of generalized infection, a systemic inflammatory reaction and sepsis developed, leading to a fatal outcome.
CONCLUSION. Radionuclide imaging (RI) using labelled autologous leucocytes in patients with fever of unknown origin allows us to obtain reliable visualization of areas of pathological infiltration and physiological distribution of cells. Based on the data obtained, it is possible to adjust the therapy, which helps increase treatment effectiveness.
About the Authors
E. V. Migunova
N.V. Sklifosovsky Research Institute for Emergency Medicine; Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
Екаterina V. Migunova - Doctor of Medical Sciences, Leading Researcher, Department of Diagnostic Radiology, N.V. Sklifosovsky Research Institute for Emergency Medicine; Full Professor, Academicians A.S. Pavlov and F.G. Krotkov Department of Radiology, Radiotherapy, Radiation Hygiene and Radiation Safety, Russian Medical Academy of Continuous Professional Education.
Bolshaya Sukharevskaya Sq. 3, Moscow, 129090; Barrikadnaya Str. 2/1, bldg. 1, Moscow, 125993
G. A. Nefedova
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Galina A. Nefedova - Candidate of Medical Sciences, Leading Researcher, Department of Pathological Anatomy, N.V. Sklifosovsky Research Institute for Emergency Medicine.
Bolshaya Sukharevskaya Sq. 3, Moscow, 129090
V. P. Nikulina
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Valentina P. Nikulina - Candidate of Medical Sciences, Senior Researcher, Laboratory of Clinical Immunology, N.V. Sklifosovsky Research Institute for Emergency Medicine.
Bolshaya Sukharevskaya Sq. 3, Moscow, 129090
S. S. Petrikov
N.V. Sklifosovsky Research Institute for Emergency Medicine; Russian University of Medicine, N.D. Yushchuk Scientific and Educational Institute of Continuous Professional Education
Russian Federation
Russian Federation
Sergey S. Petrikov - Corresponding Member of the RAS, Professor, Doctor of Medical Sciences, Director, N.V. Sklifosovsky Research Institute for Emergency Medicine; Head, Department of Anesthesiology, Resuscitation and Emergency Medicine, N.D. Yushchuk Scientific and Educational Institute of Continuous Professional Education, Russian University of Medicine.
Bolshaya Sukharevskaya Sq. 3, Moscow, 129090; Dolgorukovskaya Str.4, Moscow, 127006
L. T. Khamidova
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Layla T. Khamidova - Doctor of Medical Sciences, Head of the Department of Diagnostic Radiology, N.V. Sklifosovsky Research Institute for Emergency Medicine.
Bolshaya Sukharevskaya Sq. 3, Moscow, 129090
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Review
For citations:
Migunova E.V., Nefedova G.A., Nikulina V.P., Petrikov S.S., Khamidova L.T. The Use of Autologous Leucocyte Labelling in Patients With Fever Of Unknown Origin. Russian Sklifosovsky Journal "Emergency Medical Care". 2025;14(1):123-131. (In Russ.) https://doi.org/10.23934/2223-9022-2025-14-1-123-131
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