Liver Abscesses in Patients Who Have Had a New Coronavirus Infection
https://doi.org/10.23934/2223-9022-2024-13-1-72-78
Abstract
Aim of study To analyze clinical, laboratory, instrumental and microbiological data in patients with diagnosed liver abscesses who had previously had a new coronavirus infection.
Material and methods An analysis of the work carried out with 13 patients who received treatment at the surgical clinic of the Botkin Hospital in the emergency surgical department No. 76 from September 2021 to October 2022 for liver abscesses and previous COVID-19 is presented.
Results All presented patients were comprehensively examined. Surgical intervention was performed — transcutaneous drainage of liver abscesses under ultrasound guidance. Positive changes were revealed in the course of complex therapy, including antibacterial (based on the Results of a microbiological study with determination of the sensitivity of the flora to antibacterial drugs), anti-inflammatory, and daily sanitation of the abscess cavity. All patients were discharged for outpatient follow-up treatment in stable, satisfactory condition. Nine patients (69.2%) were discharged with drain under the supervision of clinic doctors. In 5 patients (30.8%) with regression of the abscess cavity, drainage from the abscess cavity was removed before discharge.
Conclusion Patients with previous COVID-19 may develop liver abscesses. It is important to conduct thorough diagnostic measures in patients who present with fever and (or) abdominal pain after a coronavirus infection. Further prospective studies are needed, including morphological assessment of liver changes (upon autopsy in case of death).
About the Authors
Z. A. BagateliaRussian Federation
Zurab A. Bagatelia - Doctor of Medical Sciences, Deputy Chief Physician for the Medical Department, S.P. Botkin City Clinical Hospital, Professor of the Department of Surgery, RMA of Postgraduate Education.
2nd Botkinsky Dr., Moscow 125284; 2/11, bldg. 1, Barrikadnaya Str., Moscow 125933
V. V. Bedin
Russian Federation
Vladimir V. Bedin - Doctor of Medical Sciences, Deputy Chief Physician for Surgery, S.P. Botkin City Clinical Hospital, Professor of the Department of Surgery.
2nd Botkinsky Dr., Moscow 125284; 2/11, bldg. 1, Barrikadnaya Str., Moscow 125933
G. M. Chechenin
Russian Federation
Grigory M. Chechenin - Candidate of Medical Sciences, Surgeon, Department of Hepatopancreatobiliary Surgery No. 50, S.P. Botkin City Clinical Hospital, Associate Professor of the Department of Surgery, RMA of Postgraduate Education.
2nd Botkinsky Dr., Moscow 125284; 2/11, bldg. 1, Barrikadnaya Str., Moscow 125933
M. Z. Eminov
Russian Federation
Makhir Z. Eminov - Candidate of Medical Sciences, Surgeon, Department of Emergency Surgical Care No. 76, S.P. Botkin City Clinical Hospital, Associate Professor of the Department of Surgery, RMA of Postgraduate Education.
2nd Botkinsky Dr., Moscow 125284; 2/11, bldg. 1, Barrikadnaya Str., Moscow 125933
A. A. Kolotilshchikov
Russian Federation
Andrey A. Kolotilshchikov - Candidate of Medical Sciences, Head of the Department of Emergency Surgical Care No. 76.
2nd Botkinsky Dr., Moscow 125284
S. V. Gorbanev
Russian Federation
Sergey V. Gorbanev -Surgeon, Department of Emergency Surgical Care No. 76.
2nd Botkinsky Dr., Moscow 125284
L. N. Voloschenko
Russian Federation
Leonid N. Voloschenko - Surgeon, Department of Emergency Surgical Care No. 76.
2nd Botkinsky Dr., Moscow 125284
References
1. Bogoch II, Watts A, Thomas-Bachli A, Huber C, Kraemer MUG, Khan K. Potential for global spread of a novel coronavirus from China. J Travel Med. 2020;27(2):taaa011. PMID: 31985790 https://doi.org/10.1093/jtm/taaa011
2. Nardo AD, Schneeweiss-Gleixner M, Bakail M, Dixon ED, Lax SF, Trauner M. Pathophysiological mechanisms of liver injury in COVID-19. Liver Int. 2021;41(1):20–32. PMID: 33190346 https://doi.org/10.1111/liv.14730
3. Xie M, Chen Q. Insight into 2019 novel coronavirus - an updated interim review and lessons from SARS-CoV and MERS-CoV. Int J Infect Dis. 2020;94:119–124. PMID: 32247050 https://doi.org/10.1016/j.ijid.2020.03.071
4. Li R, Qiao S, Zhang G. Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV. J Infect. 2020;80(4):469–496. PMID: 32092392 https://doi.org/10.1016/j.jinf.2020.02.013
5. Chai X, Hu L, Zhang Y, Han W, Lu Z, Ke A, et al. Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage after 2019-nCoV Infection. bioRxiv. 2020. https://doi.org/10.1101/2020.02.03.931766
6. Sun J, Aghemo A, Forner A, Valenti L. COVID-19 and liver disease. Liver Int. 2020;40(6):1278–1281. PMID: 32251539 https://doi.org/10.1111/liv.14470
7. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia
8. in Wuhan, China: a descriptive study. Lancet. 2020;395(10223) 507–513. PMID: 32007143 https://doi.org/10.1016/S0140-6736(20)30211-7 8. Weng J, Li Y, Li J, Shen L, Zhu L, Liang Y, et al. Gastrointestinal sequelae 90 days after discharge for COVID-19, Lancet Gastroenterol. Hepatol. 2021;6(5):344–346. PMID: 33711290 https://doi.org/10.1016/S24681253(21)00076-5
9. Ferri FA, Emberton E, Simpfendorfer CH, Roy M, Wexner SD. COVID-19 Testing as a Contributory Cause of Delayed Treatment of a Pyogenic Liver Abscess. Am Surg. 2023;89(4):1202–1205. PMID: 33380168 https://doi.org/10.1177/0003134820983201
10. Liemarto AK, Budiono BP, Chionardes MA, Oliviera I, Rahmasiwi A. Liver abscess with necrosis in post COVID-19: A case report. Ann Med Surg (Lond). 2021;72:103107. PMID: 34840781 https://doi.org/10.1016/j.amsu.2021.103107
11. Zhong P, Xu J, Yang D, Shen Y, Wang L, Feng Y, et al. COVID-19associated gastrointestinal and liver injury: clinical features and potential mechanisms. Signal Transduct Target Ther. 2020;5(1):256. PMID: 33139693 https://doi.org/10.1038/s41392-020-00373-7
12. Grillet F, Behr J, Calame P, Aubry S, Delabrousse E. Acute pulmonary embolism associated with COVID-19 pneumonia detected with pulmonary CT angiography. Radiology. 2020;296(3):E186–E188. PMID: 32324103 https://doi.org/10.1148/radiol.2020201544
Review
For citations:
Bagatelia Z.A., Bedin V.V., Chechenin G.M., Eminov M.Z., Kolotilshchikov A.A., Gorbanev S.V., Voloschenko L.N. Liver Abscesses in Patients Who Have Had a New Coronavirus Infection. Russian Sklifosovsky Journal "Emergency Medical Care". 2024;13(1):72-78. https://doi.org/10.23934/2223-9022-2024-13-1-72-78