Gastrointestinal Bleeding in Patients With New Coronavirus Infection COVID-19
https://doi.org/10.23934/2223-9022-2023-12-3-458-463
Abstract
Currently, the issue of coronavirus infection COVID-19 remains extremely relevant, and the SARS-CoV-2 virus also affects the gastrointestinal tract, and in some cases, coronavirus infection can be complicated by gastrointestinal bleeding. Up to 13% of COVID-19 patients have this complication. At the same time, the issue of determining risk factors for the development of gastrointestinal bleeding in patients with COVID-19 remains unresolved in the world literature. There is no single standardized approach to the treatment of gastrointestinal bleeding in patients with COVID-19. The above reasons served as prerequisites for this literature review. The purpose of the literature review is to establish risk factors and groups for gastrointestinal bleeding in patients with a new coronavirus infection, and to determine current and effective methods of treating this disease.
About the Authors
V. D. Anosov
O.I. Filatov City Clinical Hospital No. 15
Russian Federation
Russian Federation
Viktor D. Anosov - Candidate of Medical Sciences, Deputy Chief Physician for Surgery,
23, Veshnyakovskaya St., 111539, Moscow
S. A. Domrachev
A.S. Loginov Moscow Clinical Scientific and Practical Center
Russian Federation
Russian Federation
Sergey A. Domrachev - Doctor of Medical Sciences, Leading Researcher,
86, Entuziastov Hwy, 111123, Moscow
S. V. Ovchinnikov
O.I. Filatov City Clinical Hospital No. 15
Russian Federation
Russian Federation
Sergey V. Ovchinnikov - Surgeon,
23, Veshnyakovskaya St., 111539, Moscow
N. O. Solovyov
A.S. Loginov Moscow Clinical Scientific and Practical Center
Russian Federation
Russian Federation
Nikita O. Solovyov - Clinical resident,
86, Entuziastov Hwy, 111123, Moscow
References
1. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. https://doi.org/10.1016/S0140-6736(20)30183-5 PMID: 31986264
2. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054–1062. https://doi.org/10.1016/S0140-6736(20)30566-3 PMID: 32171076
3. Openshaw PJ. Crossing barriers: infections of the lung and the gut. Mucosal Immunol. 2009;2(2):100–102. https://doi.org/10.1038/mi.2008.79 PMID: 19129753
4. Marasco G, Maida M, Morreale GC, Licata M, Renzulli M, Cremon C, et al. Gastrointestinal Bleeding in COVID-19 Patients: A Systematic Review with Meta-Analysis. Can J Gastroenterol Hepatol. 2021;2021:2534975. https://doi.org/10.1155/2021/2534975 eCollection 2021. PMID: 34513750
5. Iqbal U, Anwar H, Siddiqui HU, Khan MA, Kamal F, Confer BD, et al. Acute Gastrointestinal Bleeding in COVID-19 Patients: A Systematic Review and Meta-Analysis. Clin Endosc. 2021;54(4):534–541. https://doi.org/10.5946/ce.2021.071 PMID: 34176255
6. Negro A, Villa G, Rolandi S, Lucchini A, Bambi S. Gastrointestinal Bleeding in COVID-19 Patients: A Rapid Review. Gastroenterol Nurs. 2022;45(4):267–275. https://doi.org/10.1097/SGA.0000000000000676 PMID: 35833732
7. Yang F, Shi S, Zhu J, Shi J, Dai K, Chen X. Analysis of 92 deceased patients with COVID-19. J Med Virol. 2020;92(11):2511–2515. https://doi.org/10.1002/jmv.25891 PMID: 32293741
8. Lin L, Jiang X, Zhang Z, Huang S, Zhang Z, Fang Z, et al. Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection. Gut. 2020;69(6):997–1001. https://doi.org/10.1136/gutjnl-2020-321013 PMID: 32241899
9. Mao R, Qiu Y, He JS, Tan JY, Li XH, Liang J, et al. Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: A systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2020;5(7):667–678. https://doi.org/10.1016/S2468-1253(20)30126-6 PMID: 32405603
10. Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270–273. https://doi.org/10.1038/s41586-020-2012-7 PMID: 32015507
11. Trindade AJ, Izard S, Coppa K, Hirsch JS, Lee C, Satapathy SK; Northwell COVID-19 Research Consortium. Gastrointestinal bleeding in hospitalized COVID-19 patients: a propensity score matched cohort study. J Intern Med. 2021;289(6):887–894. https://doi.org/10.1111/joim.13232 PMID: 33341978
12. Blackett JW, Kumta NA, Dixon RE, David Y, Nagula S, DiMaio CJ, et al. Characteristics and Outcomes of Patients Undergoing Endoscopy During the COVID-19 Pandemic: A Multicenter Study from New York City. Dig Dis Sci. 2021;66(8):2545–2554. https://doi.org/10.1007/s10620-020-06593-9 PMID: 32930898
13. Martin TA, Wan DW, Hajifathalian K, Tewani S, Shah SL, Mehta A, et al. Gastrointestinal Bleeding in Patients with Coronavirus Disease 2019: A Matched Case-Control Study. Am J Gastroenterol. 2020;115(10):1609– 1616. https://doi.org/10.14309/ajg.0000000000000805 PMID: 32796176
14. Mauro A, De Grazia F, Lenti MV, Penagini R, Frego R, Ardizzone S, et al. Upper gastrointestinal bleeding in COVID-19 inpatients: Incidence and management in a multicenter experience from Northern Italy. Clin Res Hepatol Gastroenterol. 2021;45(3):101521. https://doi.org/10.1016/j.clinre.2020.07.025 PMID: 32888875
15. Cavaliere K, Levine C, Wander P, Sejpal DV, Trindade AJ. Management of upper GI bleeding in patients with COVID-19 pneumonia. Gastrointest Endosc. 2020;92(2):454–455. https://doi.org/10.1016/j.gie.2020.04.028 PMID: 32325065
16. Melazzini F, Lenti MV, Mauro A, De Grazia F, Di Sabatino A. Peptic Ulcer Disease as a Common Cause of Bleeding in Patients with Coronavirus Disease 2019. Am J Gastroenterol. 2020;115(7):1139–1140. https://doi.org/10.14309/ajg.0000000000000710 PMID: 32618672
17. González González R, Jacob J, Miró Ò, Llorens P, Jiménez S, González Del Castillo J, et al.; Spanish Investigators on Emergency Situations TeAm (SIESTA) Network. Incidence, Clinical Characteristics, Risk Factors, and Outcomes of Upper Gastrointestinal Bleeding in Patients with COVID-19: Results of the UMC-19-S12. J Clin Gastroenterol. 2022;56(1):e38–e46. https://doi.org/10.1097/MCG.0000000000001465 PMID: 33252555
18. Iqbal U, Patel PD, Pluskota CA, Berger AL, Khara HS, Confer BD. Outcomes of Acute Gastrointestinal Bleeding in Patients With COVID19: A Case-Control Study. Gastroenterology Res. 2022;15(1):13–18. https://doi.org/10.14740/gr1483 PMID: 35369679
19. Nakamura J, Tsujino I, Yachi S, Takeyama M, Nishimoto Y, Konno S, et al. Incidence, risk factors, and clinical impact of major bleeding in hospitalized patients with COVID-19: a sub-analysis of the CLOTCOVID Study. Thromb J. 2022;20(1):53. https://doi.org/10.1186/s12959-022-00414-x PMID: 36127738
20. Popa P, Iordache S, Florescu DN, Iovanescu VF, Vieru A, Barbu V, et al. Mortality Rate in Upper Gastrointestinal Bleeding Associated with Anti-Thrombotic Therapy Before and During Covid-19 Pandemic. J Multidiscip Healthc. 2022;15:2679–2692. https://doi.org/10.2147/JMDH.S380500 eCollection 2022. PMID: 36425876
21. Holzwanger EA, Bilal M, Stallwood CG, Sterling MJ, Yacavone RF. Acute lower gastrointestinal bleeding during the COVID-19 pandemic – less is more! Endoscopy. 2020;52(9):816–817. https://doi.org/10.1055/a-1194-4864 PMID: 32846443
22. Abulawi A, Al-Tarbsheh A, Leamon A, Feustel P, Chopra A, Batool A. Clinical Characteristics of Hospitalized COVID-19 Patients who Have Gastrointestinal Bleeds Requiring Intervention: A Case-Control Study. Cureus. 2022;14(7):e26538. https://doi.org/10.7759/cureus.26538 eCollection 2022 Jul. PMID: 35936188
23. Shalimar, Vaishnav M, Elhence A, Kumar R, Mohta S, Palle C, et al. Outcome of Conservative Therapy in Coronavirus disease-2019 Patients Presenting with Gastrointestinal Bleeding. J Clin Exp Hepatol. 2021;11(3):327–333. https://doi.org/10.1016/j.jceh.2020.09.007 PMID: 33519132
24. Prasoppokakorn T, Kullavanijaya P, Pittayanon R. Risk factors of active upper gastrointestinal bleeding in patients with COVID-19 infection and the effectiveness of PPI prophylaxis. BMC Gastroenterol. 2022;22(1):465. https://doi.org/10.1186/s12876-022-02568-4 PMID: 36397007
25. Ierardi AM, Del Giudice C, Coppola A, Carnevale A, Giganti M, Renzulli M, et al. Gastrointestinal Hemorrhages in Patients with COVID-19 Managed with Transarterial Embolization. Am J Gastroenterol. 2021;116(4):838– 840. https://doi.org/10.14309/ajg.0000000000000978 PMID: 33982964
Review
For citations:
Anosov V.D., Domrachev S.A., Ovchinnikov S.V., Solovyov N.O. Gastrointestinal Bleeding in Patients With New Coronavirus Infection COVID-19. Russian Sklifosovsky Journal "Emergency Medical Care". 2023;12(3):458-463. https://doi.org/10.23934/2223-9022-2023-12-3-458-463
Views:
491
Email this article 