Neuroprotective Properties of Xenon According to Experimental Studies
O. A. Grebenchikov,
I. V. Molchanov,
A. I. Shpichko,
A. K. Yevseyev,
A. K. Shabanov,
S. Z. Khusainov,
S. S. Petrikov https://doi.org/10.23934/2223-9022-2020-9-1-85-95
Abstract
ABSTRACT. An increase in the number of patients with severe brain damage of various etiologies determines the need to improve neuroprotection technologies. The review is devoted to modern views on the mechanisms of brain protection, as well as the basic processes underlying damage to neurons. The article discusses the results of the most important experimental studies in this area using inert xenon gas. The authors analyzed a number of works highlighting neurotective properties of the xenon inhalation anesthetic in studies performed in vitro and in vivo. The main mechanisms of neuronal death depending on the type of damage are shown, the points of application of the protective effect of xenon on the brain and the prospects for further research in this area are demonstrated in the article.
About the Authors
O. A. Grebenchikov
Laboratory for Organ Protection in Critical Conditions, Federal Scientific and Clinical Center for Resuscitation and Rehabilitation
Russian Federation
Oleg A. Grebenchikov, Dr. Med. Sci., Senior Researcher
Russian Federation
Oleg A. Grebenchikov, Dr. Med. Sci., Senior Researcher
I. V. Molchanov
Laboratory for Organ Protection in Critical Conditions, Federal Scientific and Clinical Center for Resuscitation and Rehabilitation
Russian Federation
Dr. Med. Sci., Professor, Director of Research Institute of General Resuscitation
Russian Federation
Dr. Med. Sci., Professor, Director of Research Institute of General Resuscitation
A. I. Shpichko
Laboratory for Organ Protection in Critical Conditions, Federal Scientific and Clinical Center for Resuscitation and Rehabilitation
Russian Federation
Cand. Med. Sci., Leading Researcher
Russian Federation
Cand. Med. Sci., Leading Researcher
A. K. Yevseyev
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department
Russian Federation
Dr. Chem. Sci., Leading Researcher of the Department of General Resuscitation
Russian Federation
Dr. Chem. Sci., Leading Researcher of the Department of General Resuscitation
A. K. Shabanov
Laboratory for Organ Protection in Critical Conditions, Federal Scientific and Clinical Center for Resuscitation and Rehabilitation; N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department
Russian Federation
Dr. Med. Sci., Senior Researche; Deputy Chief Physician for Anesthesiology and Resuscitation
Russian Federation
Dr. Med. Sci., Senior Researche; Deputy Chief Physician for Anesthesiology and Resuscitation
S. Z. Khusainov
Laboratory for Organ Protection in Critical Conditions, Federal Scientific and Clinical Center for Resuscitation and Rehabilitation; N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department
Russian Federation
Anesthesiologist and Resuscitator
Russian Federation
Anesthesiologist and Resuscitator
S. S. Petrikov
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department
Russian Federation
Corresponding Member of RAS, Dr. Med. Sci., Director
Russian Federation
Corresponding Member of RAS, Dr. Med. Sci., Director
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Grebenchikov O.A., Molchanov I.V., Shpichko A.I., Yevseyev A.K., Shabanov A.K., Khusainov S.Z., Petrikov S.S. Neuroprotective Properties of Xenon According to Experimental Studies. Russian Sklifosovsky Journal "Emergency Medical Care". 2020;9(1):85-95. https://doi.org/10.23934/2223-9022-2020-9-1-85-95
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