A Case of Mass Poisoning with Thallium
https://doi.org/10.23934/2223-9022-2019-8-3-332-336
Abstract
We report the results of studies of clinical manifestations, chemical and toxico-logical tests, efficacy of complex treatment, which included antidote therapy, intestinal lavage and symptomatic treatment in patients with acute thallium poisoning, who were admitted to the Department of Acute Poisonings Treatment of the N.V. Sklifosovsky Research Institute for Emergency Medicine or underwent outpatient treatment.
About the Authors
M. M. PotskhveriyaRussian Federation
Mikhail M. Potskhveriya - Candidate of Medical Sciences, Head of the Department of Acute Poisonings Treatment and Somatopsychiatric Disorders
3 Bolshaya Sukharevskaya Square, Moscow 129090
Yu. N. Ostapenko
Russian Federation
Yuri N. Ostapenko - Candidate of Medical Sciences, Leading Researcher of the Department of Acute Poisonings Treatment and Somatopsychiatric Disorders, N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department
3 Bolshaya Sukharevskaya Square, Moscow 129090,
7, 3 Bolshaya Sukharevskaya Square, Moscow 129090
S. S. Petrikov
Russian Federation
Sergey S. Petrikov - Doctor of Medical Sciences, Professor of the Russian Academy of Sciences, Director of N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department, Head of the Department of Anesthesiology, Intensive Care and Emergency Medicine of A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation
3 Bolshaya Sukharevskaya Square, Moscow 129090,
20 building 1 Delegatskaya St., Moscow 127473
A. Yu. Simonova
Russian Federation
Anastasia Yu. Simonova - Candidate of Medical Sciences, Leading Researcher of the Department of Acute Poisonings Treatment and Somatopsychiatric Disorders, N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department
3 Bolshaya Sukharevskaya Square, Moscow 129090,
7, 3 Bolshaya Sukharevskaya Square, Moscow 129090
L. B. Zavaliy
Russian Federation
Lesya B. Zavaliy - Candidate of Medical Sciences, Senior Researcher
3 Bolshaya Sukharevskaya Square, Moscow 129090
K. K. Ilyashenko
Russian Federation
Kapitalina K. Ilyashenko - Doctor of Medical Sciences, Professor, Scientific Consultant of the Department of Acute Poisonings Treatment and Somatopsychiatric Disorders, N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department
3 Bolshaya Sukharevskaya Square, Moscow 129090,
7, 3 Bolshaya Sukharevskaya Square, Moscow 129090
T. I. Dikaya
Russian Federation
Tatyana I. Dikaya - Candidate of Medical Sciences, Senior Researcher of the Department of Acute Poisonings Treatment and Somatopsychiatric Disorders
3 Bolshaya Sukharevskaya Square, Moscow 129090
M. V. Gayduk
Russian Federation
Maria V. Gayduk - Clinical Resident of the Department of Acute Poisonings Treatment and Somatopsychiatric Disorders
3 Bolshaya Sukharevskaya Square, Moscow 129090
References
1. Otravlenie soedineniyami talliya (klinika, diagnostika, lechenie): metodicheskie rekomendatsii. No 44–10. Moscow: FGUN Institut toksikologii Publ.; 2010. (in Russ.)
2. Osorio-Rico L, Santamaria A, Galván-Arzate S. Thallium Toxicity: General Issues, Neurological Symptoms, and Neurotoxic Mechanisms. Adv Neurobiol. 2017;18:345–353. PMID: 28889276 http://doi.org/10.1007/978-3-319-60189-2_17
3. Rodrıguez-Mercado JJ, Altamirano-Lozano MA. Genetic toxicology of thallium: A review. Drug Chem Toxicol. 2013;36(3):369–383. PMID: 22970858 http://doi.org/10.3109/01480545.2012.710633
4. Cavanagh JB. What have we learnt from Graham Frederick Young? Reflections on the mechanism of thallium neurotoxicity. Neuropathol Appl Neurobiol. 1991;17(1):3–9 PMID: 2057049
5. Jha S, Kumar R, Kumar R. Thallium poisoning presenting as paresthesias, paresis, psychosis and pain in abdomen. J Assoc Physicians India. 2006;54:53–55. PMID: 16649741
6. Hoffman RS. Thallium toxicity and the role of Prussian blue in therapy. Toxicol Rev. 2003;22(1):29–40. PMID: 14579545
7. Saddique A, Peterson CD. Thallium poisoning: a review. Vet Hum Toxicol. 1983;25(1):16–22. PMID: 6338655
8. Avtsyn AP, Zhavoronkov AA, Rish MA, Strochkova LS. Mikroelementozy cheloveka (etiologiya, klassifikatsiya, organopatologiya). Moscow: Meditsina Publ.; 1991. (in Russ.)
9. Livanov GA, Batotsyrenov BV, Ostapenko YuN, Shestova GV, Rutkovsky GV, Malygin AYu. Acute Severe Thallium Poisoning: Early Diagnosis and Treatment. General Reanimatology. 2013;(3):35–40. (in Russ.)
10. Hoffman RS, Nelson LS, Howland MA, Lewis NA, Flomenbaum NE, Goldfrank LR. (eds.) Goldfrank’s Manual of Toxicologic Emergencies. New York: McGraw-Hill Medical; 2007. (Russ. ed.: Khoffman R, Nel’son L, Khauland M-E, L’yuin N, Flomenbaum N., Goldfrank L. Ekstrennaya meditsinskaya pomoshch’ pri otravleniyakh. Moscow: Praktika Publ.; 2010.)
11. ANP van Heijst MD. Thallium. International Programme on Chemical Safety. Poisons Information Monograph 525. 1990; Avaible at: http://www.inchem.org/documents/pims/chemical/pim525.htm [Accessed Aug 13, 2019]
12. Thallium and thallium compounds: health and safety guide. World Health Organization; 1996.
13. Luzhnikov EA, Sukhodolova GN. Ostrye otravleniya u vzroslykh i detey. Moscow: Eksmo Publ.; 2009. (in Russ.)
14. Matkevich VA, Luzhnikov EA, Belova MV, Yevdokimova NV, Syromyatnikova ED, Kurilkin YA. The Role of Intestinal Translocation in the Origin of Endotoxemia in Acute Poisoning and Detoxification Effect of Intestinal Lavage. Russian Sklifosovsky Journal “Emergency Medical Care”. 2015;(4):16–21. (In Russ.)
15. Khazhikhanova EV. Osobennosti porazheniya nervnoy sistemy pri ostrom peroral’nom otravlenii solyami talliya: cand. med. sci. diss. synopsis. SaintPeterburg; 2006. (In Russ.)
16. Izmerenie massovykh kontsentratsiy khimicheskikh elementov v biosredakh (krov’, mocha) metodom mass-spektrometrii s induktivno svyazannoy plazmoy. МУК 4.1.3230-14. Moscow; 2013. (In Russ.)
Review
For citations:
Potskhveriya M.M., Ostapenko Yu.N., Petrikov S.S., Simonova A.Yu., Zavaliy L.B., Ilyashenko K.K., Dikaya T.I., Gayduk M.V. A Case of Mass Poisoning with Thallium. Russian Sklifosovsky Journal "Emergency Medical Care". 2019;8(3):332-336. https://doi.org/10.23934/2223-9022-2019-8-3-332-336