Immunological Aspects of the Pathogenesis of Cicatricial Tracheal Stenosis
https://doi.org/10.23934/2223-9022-2023-12-3-428-434
Abstract
Cicatricial tracheal stenosis is a fairly common complication that occurs after tracheal intubation or tracheostomy. However, critical tracheal stenosis is a rare case, sometimes not associated with trauma, and is probably due to the peculiarities of the patient’s immune response during the development of stenosis. In this regard, the study of the immune mechanisms of the development of inflammation in the upper respiratory tract is a very relevant and promising direction. This review is devoted to the analysis of the immunological mechanisms of tracheal stricture formation, and presents modern data on the immunopathogenesis of the disease.
Clarification of some pathogenetic mechanisms of the immune response during the formation of tracheal strictures of various origins can help in identifying laboratory markers as risk factors for tracheal stricture and timely prevention of such complications.
About the Authors
E. S. Vladimirova
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Elizaveta S. Vladimirova - Doctor of Medical Sciences, Scientific Consultant, Thoracic Surgical Department,
3, B. Sukharevskaya Sq., 129090, Moscow
V. P. Nikulina
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Valentina P. Nikulina - Candidate of Medical Sciences, Senior Researcher, Laboratory of Clinical Immunology,
3, B. Sukharevskaya Sq., 129090, Moscow
M. A. Godkov
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Mikhail A. Godkov - Doctor of Medical Sciences, Senior Researcher, Department of Laboratory Diagnostics,
3, B. Sukharevskaya Sq., 129090, Moscow
E. A. Kasholkina
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Elena A. Kasholkina - Specialist in Clinical Laboratory Diagnostics,
3, B. Sukharevskaya Sq., 129090, Moscow
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For citations:
Vladimirova E.S., Nikulina V.P., Godkov M.A., Kasholkina E.A. Immunological Aspects of the Pathogenesis of Cicatricial Tracheal Stenosis. Russian Sklifosovsky Journal "Emergency Medical Care". 2023;12(3):428-434. https://doi.org/10.23934/2223-9022-2023-12-3-428-434
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