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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nmp</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Sklifosovsky Journal "Emergency Medical Care"</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-9022</issn><issn pub-type="epub">2541-8017</issn><publisher><publisher-name>“N.V. Sklifosovsky Research Institute for Emergency Medicine”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23934/2223-9022-2020-9-1-148-158</article-id><article-id custom-type="elpub" pub-id-type="custom">nmp-915</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group></article-categories><title-group><article-title>Синдром Такоцубо у пациентки со злокачественным новообразованием почки</article-title><trans-title-group xml:lang="en"><trans-title>Takotsubo Syndrome in a Patient With a Malignant Tumor of the Kidney</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8829-0481</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рутковская</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rutkovskaya</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рутковская Наталья Витальевна, доктор медицинских наук, руководитель центра кардиологии</p></bio><bio xml:lang="en"><p>Natalya V. Rutkovskaya, Doctor of Medical Sciences, Head of the Center for Cardiology, Head</p></bio><email xlink:type="simple">wenys@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9958-5026</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лазаренко</surname><given-names>Я. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Lazarenko</surname><given-names>Y. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>клинический ординатор кафедры «Терапия» Медико-биологического университета инноваций и непрерывного образования</p></bio><bio xml:lang="en"><p>Clinical Resident of the Department of Therapy of the Biomedical University of Innovation and Continuing Education</p></bio><email xlink:type="simple">stav-yana@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3268-4665</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Штин</surname><given-names>С. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Shtin</surname><given-names>S. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, заведующая отделением реанимации и интенсивной терапии, врач-анестезиолог-реаниматолог</p></bio><bio xml:lang="en"><p>Candidate of Medical Sciences, Head of the Intensive Care Unit, Anesthesiologist and Resuscitator</p></bio><email xlink:type="simple">sabinochka85@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9241-7238</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Самойлов</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Samoylov</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор РАН, доцент, генеральный директор</p></bio><bio xml:lang="en"><p>Doctor of Medical Sciences, Professor of the Russian Academy of Sciences, Associate Professor, General Director</p></bio><email xlink:type="simple">asamoilov@fmbcfmba.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7240-8273</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сотников</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sotnikov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, руководитель центра анестезиологии, реаниматологии и интенсивной терапии, заведующий отделением анестезиологии-реанимации №2</p></bio><bio xml:lang="en"><p>Doctor of Medical Sciences, Head of the Center for Anesthesiology, Resuscitation and Intensive Care, Head of the Department of Anesthesiology and Reanimation No. 2</p></bio><email xlink:type="simple">abcv@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9523-5966</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Праскурничий</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Praskurnichy</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, заведующий кафедрой «Терапия» Медико-биологического университета инноваций и непрерывного образования</p></bio><bio xml:lang="en"><p>Doctor of Medical Sciences, Professor, Head of the Department of Therapy, Medical and Biological University of Innovation and Continuing Education</p></bio><email xlink:type="simple">praskumichey@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2370-170X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Паринов</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Parinov</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, заместитель главного врача по терапии, заведующий терапевтическим отделением, врач-гастроэнтеролог</p></bio><bio xml:lang="en"><p>Candidate of Medical Sciences, Deputy Chief Physician for Therapy, Head of the Therapeutic Department, Gastroenterologist</p></bio><email xlink:type="simple">parinov75@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9739-8478</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Удалов</surname><given-names>Ю. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Udalov</surname><given-names>Y. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, доцент, заместитель генерального директора по медицинской части</p></bio><bio xml:lang="en"><p>Candidate of Medical Sciences, Associate Professor, Deputy General Director for Medicine</p></bio><email xlink:type="simple">udalov@fmbcfmba.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Кардиологическое отделение, ФГБУ «Государственный научный центр Российской Федерации — Федеральный медицинский биофизический центр им. А.И. Бурназяна» ФМБА России<country>Россия</country></aff><aff xml:lang="en">Cardiology Department, State Scientific Center of A.I. Burnazyan Federal Medical Biophysical Center of the Federal Medical and Biological Agency<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБУ «Государственный научный центр Российской Федерации — Федеральный медицинский биофизический центр им. А.И. Бурназяна» ФМБА России<country>Россия</country></aff><aff xml:lang="en">State Scientific Center of A.I. Burnazyan Federal Medical Biophysical Center of the Federal Medical and Biological Agency<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>19</day><month>10</month><year>2020</year></pub-date><volume>9</volume><issue>1</issue><fpage>148</fpage><lpage>158</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Рутковская Н.В., Лазаренко Я.Н., Штин С.Р., Самойлов А.С., Сотников А.В., Праскурничий Е.А., Паринов О.В., Удалов Ю.Д., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Рутковская Н.В., Лазаренко Я.Н., Штин С.Р., Самойлов А.С., Сотников А.В., Праскурничий Е.А., Паринов О.В., Удалов Ю.Д.</copyright-holder><copyright-holder xml:lang="en">Rutkovskaya N.V., Lazarenko Y.N., Shtin S.R., Samoylov A.S., Sotnikov A.V., Praskurnichy E.A., Parinov O.V., Udalov Y.D.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jnmp.ru/jour/article/view/915">https://www.jnmp.ru/jour/article/view/915</self-uri><abstract><sec><title>АКТУАЛЬНОСТЬ</title><p>АКТУАЛЬНОСТЬ. Возрастающая доступность инвазивных методик оценки коронарного русла способствует увеличению случаев диагностики повреждений миокарда при интактных коронарных артериях. Одним из наименее изученных заболеваний, имитирующих течение инфаркта миокарда, является синдром Такоцубо (СТ), который в реальной клинической практике довольно часто остается недиагностированным. Медико-экономическое значение данного заболевания определяется высоким риском развития жизнеугрожающих осложнений и необходимостью оказания экстренной специализированной медицинской помощи.</p></sec><sec><title>ЦЕЛЬ ИССЛЕДОВАНИЯ</title><p>ЦЕЛЬ ИССЛЕДОВАНИЯ. В работе представлен аналитический обзор научной медицинской литературы с позиций иллюстрации современных представлений о наиболее распространенных факторах риска, этиопатогенезе, диагностике и лечении СТ. Также приведено клиническое наблюдение пациентки с верифицированным вторичным СТ на фоне злокачественного новообразования почки.</p></sec><sec><title>ВЫВОДЫ</title><p>ВЫВОДЫ. Для детального понимания потенциальных механизмов развития СТ, определения наиболее информативных методов его диагностики, разработки эффективных стратегий оказания медицинской помощи и критериев отдаленного прогноза необходимы дальнейшие масштабные исследования. Повышение уровня информированности врачей о СТ, в свою очередь, позволит своевременно выявлять данное заболевание, что улучшит прогноз для пациентов и позволит минимизировать экономические затраты на лечение. Исключение возможности гипердиагностики также будет способствовать определению истинной распространенности данного заболевания.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>RELEVANCE</title><p>RELEVANCE. The increasing availability of invasive methods for assessing the coronary vessels contributes to the growth in the diagnosis of myocardial damage in intact coronary arteries. One of the least studied diseases that mimic the course of myocardial infarction is Takotsubo syndrome, which quite often remains undiagnosed in real clinical practice. The medical and economic significance of this disease is determined by the high risk of developing life-threatening complications and the need to provide emergency specialized medical care.</p></sec><sec><title>AIM OF STUDY</title><p>AIM OF STUDY. The paper presents an analytical review of scientific medical literature from the perspective of illustrating modern concepts of the most common risk factors, etiopathogenesis, diagnosis and treatment of Takotsubo syndrome. A clinical observation of a patient with verified secondary Takotsubo syndrome against a malignant neoplasm of the kidney is also presented.</p></sec><sec><title>CONCLUSIONS</title><p>CONCLUSIONS. For a detailed understanding of the potential mechanisms for the development of Takotsubo syndrome, determining the most informative methods for its diagnosis, developing effective strategies for providing medical care and criteria for long-term prognosis, further large-scale studies are needed. Raising the level of awareness of doctors about Takotsubo syndrome, in turn, will allow timely detection of this disease, which will improve the prognosis for patients and minimize the economic costs of treatment. The exclusion of the possibility of overdiagnosis will also help determine the true prevalence of this disease.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>синдром Такоцубо</kwd><kwd>острый коронарный синдром</kwd><kwd>коронарные артерии</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Takotsubo syndrome</kwd><kwd>acute coronary syndrome</kwd><kwd>coronary arteries</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lyon A, Bossone E, Schneider B, Sechtem U, Citro R, Underwood SR, et al. Current state of knowledge on Takotsubo syndrome: a position statement from the taskforce on Takotsubo syndrome of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2016;18(1):8–27. 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