nmpЖурнал им. Н.В. Склифосовского «Неотложная медицинская помощь»Russian Sklifosovsky Journal "Emergency Medical Care"2223-90222541-8017“N.V. Sklifosovsky Research Institute for Emergency Medicine”10.23934/2223-9022-2020-9-1-85-95nmp-908Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSНейропротективные свойства ксенона по данным экспериментальных исследованийNeuroprotective Properties of Xenon According to Experimental Studieshttps://orcid.org/0000-0001-9045-6017ГребенчиковО. А.GrebenchikovO. A.

Гребенчиков Олег Александрович, доктор медицинских наук, главный научный сотрудник

Oleg A. Grebenchikov, Dr. Med. Sci., Senior Researcher

oleg.grebenchikov@yandex.ruhttps://orcid.org/0000-0001-8520-9468МолчановИ. В.MolchanovI. V.

доктор медицинских наук, профессор, руководитель НИИ общей реаниматологии

Dr. Med. Sci., Professor, Director of Research Institute of General Resuscitation

igormol46@mail.ruhttps://orcid.org/0000-0002-4652-3259ШпичкоА. И.ShpichkoA. I.

кандидат медицинских наук, ведущий научный сотрудник лаборатории органопротекции при критических состояниях

Cand. Med. Sci., Leading Researcher

shpichko.a@yandex.ruhttps://orcid.org/0000-0002-0832-3272ЕвсеевА. К.YevseyevA. K.

доктор химических наук, ведущий научный сотрудник отделения общей реанимации

Dr. Chem. Sci., Leading Researcher of the Department of General Resuscitation

anatolevseev@gmail.comhttps://orcid.org/0000-0002-3417-2682ШабановА. К.ShabanovA. K.

доктор медицинских наук, главный научный сотрудник лаборатории клинической патофизиологии при критических состояниях; зам. главного врача по анестезиологии и реаниматологии

Dr. Med. Sci., Senior Researche; Deputy Chief Physician for Anesthesiology and Resuscitation

aslan_s@mail.ruhttps://orcid.org/0000-0002-3177-8929ХусаиновШ. Ж.KhusainovS. Z.

врач анестезиолог-реаниматолог

Anesthesiologist and Resuscitator

shamilkhusainov1989@gmail.comhttps://orcid.org/0000-0003-3292-8789ПетриковС. С.PetrikovS. S.

член-корр. РАН, доктор медицинских наук, профессор, директор

Corresponding Member of RAS, Dr. Med. Sci., Director

sklif@zdrav.mos.ruЛаборатория органопротекции при критических состояниях, ФГБНУ «Федеральный научно-клинический центр реаниматологии и реабилитологии»РоссияLaboratory for Organ Protection in Critical Conditions, Federal Scientific and Clinical Center for Resuscitation and RehabilitationRussian FederationГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»РоссияN.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health DepartmentRussian FederationЛаборатория органопротекции при критических состояниях, ФГБНУ «Федеральный научно-клинический центр реаниматологии и реабилитологии»; ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»РоссияLaboratory for Organ Protection in Critical Conditions, Federal Scientific and Clinical Center for Resuscitation and Rehabilitation; N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health DepartmentRussian Federation202018102020918595Copyright © Гребенчиков О.А., Молчанов И.В., Шпичко А.И., Евсеев А.К., Шабанов А.К., Хусаинов Ш.Ж., Петриков С.С., 20202020Гребенчиков О.А., Молчанов И.В., Шпичко А.И., Евсеев А.К., Шабанов А.К., Хусаинов Ш.Ж., Петриков С.С.Grebenchikov O.A., Molchanov I.V., Shpichko A.I., Yevseyev A.K., Shabanov A.K., Khusainov S.Z., Petrikov S.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jnmp.ru/jour/article/view/908

АННОТАЦИЯ. Увеличение числа пациентов с тяжелым повреждением мозга различной этиологии определяет необходимость совершенствования технологий нейропротекции. Обзор посвящен современным взглядам на механизмы защиты головного мозга, а также основным процессам, лежащим в основе повреждения нейронов. В статье обсуждаются результаты наиболее важных экспериментальных исследований в этой области с использованием инертного газа ксенона. Авторами про- веден анализ ряда работ, освещающих нейропротективные свойства ингаляционного анестетика ксенона в исследованиях in vitro и in vivo. Показаны основные механизмы гибели нейронов в зависимости от типа повреждения, продемонстрированы точки приложения защитного эффекта ксенона на головной мозг и перспективы дальнейших исследований в этой области.

ABSTRACT. An increase in the number of patients with severe brain damage of various etiologies determines the need to improve neuroprotection technologies. The review is devoted to modern views on the mechanisms of brain protection, as well as the basic processes underlying damage to neurons. The article discusses the results of the most important experimental studies in this area using inert xenon gas. The authors analyzed a number of works highlighting neurotective properties of the xenon inhalation anesthetic in studies performed in vitro and in vivo. The main mechanisms of neuronal death depending on the type of damage are shown, the points of application of the protective effect of xenon on the brain and the prospects for further research in this area are demonstrated in the article.

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The authors declare that there are no conflicts of interest present.