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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nmp</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Sklifosovsky Journal "Emergency Medical Care"</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-9022</issn><issn pub-type="epub">2541-8017</issn><publisher><publisher-name>“N.V. Sklifosovsky Research Institute for Emergency Medicine”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23934/2223-9022-2019-8-1-68-73</article-id><article-id custom-type="elpub" pub-id-type="custom">nmp-589</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS OF LITERATURE</subject></subj-group></article-categories><title-group><article-title>Анемия у больных с хронической сердечной недостаточностью: современное состояние проблемы</article-title><trans-title-group xml:lang="en"><trans-title>Anemia in Patients with Heart Failure: Current State of the Problem</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8505-1848</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гиляревский</surname><given-names>С. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Gilyarevsky</surname><given-names>S. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гиляревский Сергей Руджерович – доктор медицинских наук, профессор кафедры клинической фармакологии и терапии РМАНПО</p><p>125993 Москва, ул. Баррикадная, д. 2/1 </p></bio><bio xml:lang="en"><p>Sergey R. Gilyarevsky – Dr. Med. Sci., Professor of the Department of Clinical Pharmacology and Therapy of RMACPE</p><p>2/1 Barrikadnaya St., Moscow 125993</p></bio><email xlink:type="simple">sgilarevsky@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9865-4998</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голшмид</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Golshmid</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Голшмид Мария Владимировна – кандидат медицинских наук, доцент кафедры клинической фармакологии и терапии РМАНПО</p><p>125993 Москва, ул. Баррикадная, д. 2/1 </p></bio><bio xml:lang="en"><p>Maria V. Golshmid  – Cand. Med. Sci., Associate Professor of the Department of Clinical Pharmacology and Therapy of RMACPE</p><p>2/1 Barrikadnaya St., Moscow 125993</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9458-7305</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузьмина</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuzmina</surname><given-names>I. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кузьмина Ирина Михайловна – кандидат медицинских наук, ведущий научный сотрудник отделения неотложной кардиологии</p><p>129090 Москва, Б. Сухаревская пл., д. 3 </p></bio><bio xml:lang="en"><p>Irina M. Kuzmina  – Cand. Med. Sci., Leading Researcher, Department of Emergency Cardiology</p><p>3 Bolshaya Sukharevskaya Square, Moscow 129090</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3102-1958</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бенделиани</surname><given-names>Н. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Bendeliani</surname><given-names>N. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бенделиани Нана Георгиевна – доктор медицинских наук, старший научный сотрудник научно-консультативного отделения института коронарной и сосудистой хирургии (ИКиСХ) консультативно-диагностического центра (КДЦ) Федерального государственного бюджетного учреждения «Национальный медицинский исследовательский центр сердечно-сосудистой хирургии имени А.Н. Бакулева» Министерство здравоохранения РФФГБУ «НМИЦССХ им. А.Н.Бакулева» Минздрава России</p><p>121552 Москва, Рублевское ш., д. 135</p></bio><bio xml:lang="en"><p>Nana G. Bendeliani  – Dr. Med. Sci., Senior Researcher of Scientifc Advisory Department of the Institute of Coronary and Vascular Surgery (ICVS)Consultative and Diagnostic Center (CDC), A.N. Bakulev NMRCCVS of the Ministry of Health of Russian Federation</p><p>8 Leninsky Ave., Moscow 117931</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare Department</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>«Национальный медицинский исследовательский центр сердечно-сосудистой хирургии имени А.Н. Бакулева»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.N. Bakulev National Medical Research Center of Cardiovascular Surgery</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>23</day><month>04</month><year>2019</year></pub-date><volume>8</volume><issue>1</issue><fpage>68</fpage><lpage>73</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гиляревский С.Р., Голшмид М.В., Кузьмина И.М., Бенделиани Н.Г., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Гиляревский С.Р., Голшмид М.В., Кузьмина И.М., Бенделиани Н.Г.</copyright-holder><copyright-holder xml:lang="en">Gilyarevsky S.R., Golshmid M.V., Kuzmina I.M., Bendeliani N.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jnmp.ru/jour/article/view/589">https://www.jnmp.ru/jour/article/view/589</self-uri><abstract><p>В статье рассмотрена современная тактика лечения больных с хронической сердечной недостаточностью и сопутствующей анемией. Обсуждаются результаты наиболее важных рандомизированных клинических исследований, которые стали основанием для разработки подходов к лечению анемии в таких случаях. Уделяется внимание и нерешенным проблемам лечения анемии у больных с сердечной недостаточностью (СН). Приводятся данные о внутривенном введении препаратов железа как наиболее эффективном подходе к лечению анемии у больных с сердечной недостаточностью при наличии дефицита железа. Рассматриваются основные положения современных клинических рекомендаций по тактике ведения больных с СН и анемией.</p></abstract><trans-abstract xml:lang="en"><p>The article reports the modern tactics of treating patients with chronic heart failure and concomitant anemia. The results of the most important randomized clinical trials that are the basis for developing approaches to the treatment of anemia in such cases are discussed. Attention is also paid to unresolved problems in the treatment of anemia in patients with heart failure. The data on the intravenous administration of iron preparations as the most effective approach to the treatment of anemia in patients with heart failure in the presence of iron defciency are given. The main provisions of modern clinical guidelines on the management of patients with heart failure and anemia are considered.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая сердечная недостаточность</kwd><kwd>анемия</kwd><kwd>препараты железа</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic heart failure</kwd><kwd>anemia</kwd><kwd>iron preparations</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Grote Beverborg N., van Veldhuisen D.J., van der Meer P. Anemia in Heart Failure. Still Relevant? ACC Heart Fail. 2018; 6(3): 201–208. PMID: 29128254. DOI: 10.1016/j.jchf.2017.08.023.</mixed-citation><mixed-citation xml:lang="en">Grote Beverborg N., van Veldhuisen D.J., van der Meer P. Anemia in Heart Failure. Still Relevant? ACC Heart Fail. 2018; 6(3): 201–208. PMID: 29128254. DOI: 10.1016/j.jchf.2017.08.023.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">van Veldhuisen D.J., Anker S.D., Ponikowski P., Macdougall I.C. Anemia and iron deficiency in heart failure: mechanisms and therapeutic approaches. Nat. Rev. Cardiol. 2011; 8(9): 485-493. PMID: 21629210. DOI: 10.1038/nrcardio.2011.77.</mixed-citation><mixed-citation xml:lang="en">van Veldhuisen D.J., Anker S.D., Ponikowski P., Macdougall I.C. Anemia and iron deficiency in heart failure: mechanisms and therapeutic approaches. Nat Rev Cardiol. 2011; 8(9): 485–493. PMID: 21629210. DOI: 10.1038/nrcardio.2011.77.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Adlbrecht C., Kommata S., Hülsmann M., et al. Chronic heart failure leads to an expanded plasma volume and pseudoanaemia, but does not lead to a reduction in the body’s red cell volume. Eur. Heart J. 2008; 29(19): 2343–2350. PMID: 18701467. DOI: 10.1093/eurheartj/ehn359.</mixed-citation><mixed-citation xml:lang="en">Adlbrecht C., Kommata S., Hülsmann M., et al. Chronic heart failure leads to an expanded plasma volume and pseudoanaemia, but does not lead to a reduction in the body’s red cell volume. Eur Heart J. 2008; 29(19): 2343–2350. PMID: 18701467. DOI: 10.1093/eurheartj/ehn359.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Grote Beverborg N., Verweij N., Klip I.T., et al. Erythropoietin in the general population: reference ranges and clinical, biochemical and genetic correlates. PLoS One. 2015; 10(4): e0125215. PMID: 25915923. DOI: 10.1371/journal.pone.0125215.</mixed-citation><mixed-citation xml:lang="en">Grote Beverborg N., Verweij N., Klip I.T., et al. Erythropoietin in the general population: reference ranges and clinical, biochemical and genetic correlates. PLoS One. 2015; 10(4): e0125215. PMID: 25915923. DOI: 10.1371/journal.pone.0125215.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Groenveld H.F., Januzzi J.L., Damman K., et al. Anemia and mortality in heart failure patients. a systematic review and meta-analysis. J. Am. Coll. Cardiol. 2008; 52(10): 818–827. PMID: 18755344. DOI: 10.1016/j.jacc.2008.04.061.</mixed-citation><mixed-citation xml:lang="en">Groenveld H.F., Januzzi J.L., Damman K., et al. Anemia and mortality in heart failure patients. a systematic review and meta-analysis. J Am Coll Cardiol. 2008; 52(10): 818–827. PMID: 18755344. DOI: 10.1016/j.jacc.2008.04.061.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Tang W.H., Tong W., Jain A., et al. Evaluation and long-term prognosis of new-onset, transient, and persistent anemia in ambulatory patients with chronic heart failure. J. Am. Coll. Cardiol. 2008; 51(5): 569–576. PMID: 18237687. DOI: 10.1016/j.jacc.2007.07.094.</mixed-citation><mixed-citation xml:lang="en">Tang W.H., Tong W., Jain A., et al. Evaluation and long-term prognosis of new-onset, transient, and persistent anemia in ambulatory patients with chronic heart failure. J Am Coll Cardiol. 2008; 51(5): 569–576. PMID: 18237687. DOI: 10.1016/j.jacc.2007.07.094.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Waldum B., Westheim A.S., Sandvik L., et al. Baseline anemia is not a predictor of all-cause mortality in outpatients with advanced heart failure or severe renal dysfunction. Results from the Norwegian Heart Failure Registry. J. Am. Coll. Cardiol. 2012; 59(4): 371–378. MID: 22261159. DOI: 10.1016/j.jacc.2011.10.864.</mixed-citation><mixed-citation xml:lang="en">Waldum B., Westheim A.S., Sandvik L., et al. Baseline anemia is not a predictor of all-cause mortality in outpatients with advanced heart failure or severe renal dysfunction. Results from the Norwegian Heart Failure Registry. J Am Coll Cardiol. 2012; 59(4): 371–378. PMID: 22261159. DOI: 10.1016/j.jacc.2011.10.864.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Klip I.T., Comin-Colet J., Voors A.A., et al. Iron deficiency in chronic heart failure: an international pooled analysis. Am. Heart J. 2013; 165(4): 575–582.e3. PMID: 23537975. DOI: 10.1016/j.ahj.2013.01.017.</mixed-citation><mixed-citation xml:lang="en">Klip I.T., Comin-Colet J., Voors A.A., et al. Iron deficiency in chronic heart failure: an international pooled analysis. Am Heart J. 2013; 165(4): 575–582.e3. PMID: 23537975. DOI: 10.1016/j.ahj.2013.01.017.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Okonko D.O., Mandal A.K., Missouris C.G., Poole- Wilson P.A. Disordered iron homeostasis in chronic heart failure: prevalence, predictors, and relation to anemia, exercise capacity, and survival. J. Am. Coll. Cardiol. 2011; 58(12): 1241–1251. PMID: 21903058. DOI: 10.1016/j.jacc.2011.04.040.</mixed-citation><mixed-citation xml:lang="en">Okonko D.O., Mandal A.K., Missouris C.G., Poole-Wilson P.A. Disordered iron homeostasis in chronic heart failure: prevalence, predictors, and relation to anemia, exercise capacity, and survival. J Am Coll Cardiol. 2011; 58(12): 1241–1251. PMID: 21903058. DOI: 10.1016/j.jacc.2011.04.040.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Nanas J.N., Matsouka C., Karageorgopoulos D., et al. Etiology of anemia in patients with advanced heart failure. J. Am. Coll. Cardiol. 2006; 48(12): 2485–2489. PMID: 17174186. DOI: 10.1016/j.jacc.2006.08.034.</mixed-citation><mixed-citation xml:lang="en">Nanas J.N., Matsouka C., Karageorgopoulos D., et al. Etiology of anemia in patients with advanced heart failure. J Am Coll Cardiol. 2006; 48(12): 2485–2489. PMID: 17174186. DOI: 10.1016/j.jacc.2006.08.034.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">van der Meer P., Lok D.J., Januzzi J.L., et al. Adequacy of endogenous erythropoietin levels and mortality in anaemic heart failure patients. Eur. Heart J. 2008; 29(12): 1510–1515. PMID: 18495690. DOI: 10.1093/eurheartj/ehn205.</mixed-citation><mixed-citation xml:lang="en">van der Meer P., Lok D.J., Januzzi J.L., et al. Adequacy of endogenous erythropoietin levels and mortality in anaemic heart failure patients. Eur Heart J. 2008; 29(12): 1510–1515. PMID: 18495690. DOI: 10.1093/eurheartj/ehn205.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Westenbrink B.D., Visser F.W., Voors A.A., et al. Anaemia in chronic heart failure is not only related to impaired renal perfusion and blunted erythropoietin production, but to fluid retention as well. Eur. Heart J. 2007; 28(2): 166–171. PMID: 17158825. DOI: 10.1093/eurheartj/ehl419.</mixed-citation><mixed-citation xml:lang="en">Westenbrink B.D., Visser F.W., Voors A.A., et al. Anaemia in chronic heart failure is not only related to impaired renal perfusion and blunted erythropoietin production, but to fluid retention as well. Eur Heart J. 2007; 28(2): 166–171. PMID: 17158825. DOI: 10.1093/eurheartj/ehl419.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Westenbrink B.D., Voors A.A., De Boer R.A., et al. Bone marrow dysfunction in chronic heart failure patients. Eur. J. Heart Fail. 2010; 12(7): 676–684. PMID: 20427614. DOI: 10.1093/eurjhf/hfq061.</mixed-citation><mixed-citation xml:lang="en">Westenbrink B.D., Voors A.A., De Boer R.A., et al. Bone marrow dysfunction in chronic heart failure patients. Eur J Heart Fail. 2010; 12(7): 676–684. PMID: 20427614. DOI: 10.1093/eurjhf/hfq061.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">van der Meer P., Voors A.A., Lipsic E., et al. Prognostic value of plasma erythropoietin on mortality in patients with chronic heart failure. J. Am. Coll. Cardiol. 2004; 44(1): 63–67. PMID: 15234408. DOI: 10.1016/j.jacc.2004.03.052.</mixed-citation><mixed-citation xml:lang="en">van der Meer P., Voors A.A., Lipsic E., et al. Prognostic value of plasma erythropoietin on mortality in patients with chronic heart failure. J Am Coll Cardiol. 2004; 44(1): 63–67. PMID: 15234408. DOI: 10.1016/j.jacc.2004.03.052.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">van der Meer P., Lipsic E., Westenbrink B.D., et al. Levels of hematopoiesis inhibitor N-acetyl-seryl-aspartyl-lysyl-proline partially explain the occurence of anemia in heart failure. Circulation. 2005; 112(12): 1743– 1747. PMID: 16172283. DOI: 10.1161/CIRCULATIONAHA.105.549121.</mixed-citation><mixed-citation xml:lang="en">van der Meer P., Lipsic E., Westenbrink B.D., et al. Levels of hematopoiesis inhibitor N-acetyl-seryl-aspartyl-lysyl-proline partially explain the occurence of anemia in heart failure. Circulation. 2005; 112(12): 1743– 1747. PMID: 16172283. DOI: 10.1161/CIRCULATIONAHA.105.549121.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ishani A., Weinhandl E., Zhao Z., et al. Angiotensin-converting enzyme inhibitor as a risk factor for the development of anemia, and the impact of incident anemia on mortality in patients with left ventricular dysfunction. J. Am. Coll. Cardiol. 2005; 45(3): 391–399. PMID: 15680718. DOI: 10.1016/j.jacc.2004.10.038.</mixed-citation><mixed-citation xml:lang="en">Ishani A., Weinhandl E., Zhao Z., et al. Angiotensin-converting enzyme inhibitor as a risk factor for the development of anemia, and the impact of incident anemia on mortality in patients with left ventricular dysfunction. J Am Coll Cardiol. 2005; 45(3): 391–399. PMID: 15680718. DOI: 10.1016/j.jacc.2004.10.038.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Komajda M., Anker S.D., Charlesworth A., et al. The impact of new onset anaemia on morbidity and mortality in chronic heart failure: results from COMET. Eur. Heart J. 2006; 27(12): 1440–1446. PMID: 16717081. DOI: 10.1093/eurheartj/ehl012.</mixed-citation><mixed-citation xml:lang="en">Komajda M., Anker S.D., Charlesworth A., et al. The impact of new onset anaemia on morbidity and mortality in chronic heart failure: results from COMET. Eur Heart J. 2006; 27(12): 1440–1446. PMID: 16717081. DOI: 10.1093/eurheartj/ehl012.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Weiskopf R.B., Viele M.K., Feiner J., et al. Human cardiovascular and metabolic response to acute, severe isovolemic anemia. JAMA. 1998; 279(3): 217–221. PMID: 9438742.</mixed-citation><mixed-citation xml:lang="en">Weiskopf R.B., Viele M.K., Feiner J., et al. Human cardiovascular and metabolic response to acute, severe isovolemic anemia. JAMA. 1998; 279(3): 217—221. PMID: 9438742.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ebner N., Jankowska E.A., Ponikowski P., et al. The impact of iron deficiency and anaemia on exercise capacity and outcomes in patients with chronic heart failure. Results from the studies investigating comorbidities aggravating heart failure. Int. J. Cardiol. 2016; 205: 6–12. PMID: 26705670. DOI: 10.1016/j.ijcard.2015.11.178.</mixed-citation><mixed-citation xml:lang="en">Ebner N., Jankowska E.A., Ponikowski P., et al. The impact of iron deficiency and anaemia on exercise capacity and outcomes in patients with chronic heart failure. Results from the studies investigating comorbidities aggravating heart failure. Int J Cardiol. 2016; 205: 6–12. PMID: 26705670. DOI: 10.1016/j.ijcard.2015.11.178.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Klip I.T., Jankowska E.A., Enjuanes C., et al. The additive burden of iron deficiency in the cardiorenal-anaemia axis: scope of a problem and its consequences. Eur. J. Heart Fail. 2014; 16(6): 655–662. PMID: 24644024. DOI: 10.1002/ejhf.84.</mixed-citation><mixed-citation xml:lang="en">Klip I.T., Jankowska E.A., Enjuanes C., et al. The additive burden of iron deficiency in the cardiorenal-anaemia axis: scope of a problem and its consequences. Eur J Heart Fail. 2014; 16(6): 655–662. PMID: 24644024. DOI: 10.1002/ejhf.84.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Garty M., Cohen E., Zuchenko A., et al. Blood transfusion for acute decompensated heart failure–friend or foe? Am. Heart J. 2009; 158(4): 653–658. PMID: 19781427. DOI: 10.1016/j.ahj.2009.08.001.</mixed-citation><mixed-citation xml:lang="en">Garty M., Cohen E., Zuchenko A., et al. Blood transfusion for acute decompensated heart failure — friend or foe? Am Heart J. 2009; 158(4): 653–658. PMID: 19781427. DOI: 10.1016/j.ahj.2009.08.001.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Kao D.P., Kreso E., Fonarow G.C., Krantz M.J. Characteristics and outcomes among heart failure patients with anemia and renal insufficiency with and without blood transfusions (public discharge data from California 2000–2006). Am. J. Cardiol. 2011; 107(1): 69–73. PMID: 21146689. DOI: 10.1016/j.amjcard.2010.08.046.</mixed-citation><mixed-citation xml:lang="en">Kao D.P., Kreso E., Fonarow G.C., Krantz M.J. Characteristics and outcomes among heart failure patients with anemia and renal insufficiency with and without blood transfusions (public discharge data from California 2000–2006). Am J Cardiol. 2011; 107(1): 69–73. PMID: 21146689. DOI: 10.1016/j.amjcard.2010.08.046.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Qaseem A., Humphrey L.L., Fitterman N., et al. Clinical Guidelines Committee of the American College of Physicians. Treatment of anemia in patients with heart disease: a clinical practice guideline from the American College of Physicians. Ann. Intern. Med. 2013; 159(11): 770– 779. PMID: 24297193. DOI: 10.7326/0003-4819-159-11-201312030-00009.</mixed-citation><mixed-citation xml:lang="en">Qaseem A., Humphrey L.L., Fitterman N., et al. Clinical Guidelines Committee of the American College of Physicians. Treatment of anemia in patients with heart disease: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2013; 159(11): 770– 779. PMID: 24297193. DOI: 10.7326/0003-4819-159-11-201312030-00009.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Swedberg K., Young J.B., Anand I.S., et al. Treatment of anemia with darbepoetin alfa in systolic heart failure. N. Engl. J. Med. 2013; 368(13): 1210–1219. PMID: 23473338. DOI: 10.1056/NEJMoa1214865.</mixed-citation><mixed-citation xml:lang="en">Swedberg K., Young J.B., Anand I.S., et al. Treatment of anemia with darbepoetin alfa in systolic heart failure. N Engl J Med. 2013; 368(13): 1210–1219. PMID: 23473338. DOI: 10.1056/NEJMoa1214865.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Bello N.A., Lewis E.F., Desai A.S., et al. Increased risk of stroke with darbepoetin alfa in anaemic heart failure patients with diabetes and chronic kidney disease. Eur. J. Heart Fail. 2015; 17(11): 1201–1207. PMID: 26423928. DOI: 10.1002/ejhf.412.</mixed-citation><mixed-citation xml:lang="en">Bello N.A., Lewis E.F., Desai A.S., et al. Increased risk of stroke with darbepoetin alfa in anaemic heart failure patients with diabetes and chronic kidney disease. Eur J Heart Fail. 2015; 17(11): 1201–1207. PMID: 26423928. DOI: 10.1002/ejhf.412.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Lewis G.D., Semigran M.J., Givertz M.M., et al. Oral iron therapy for heart failure with reduced ejection fraction: design and rationale for oral iron repletion effects on oxygen uptake in heart failure. Circ. Heart Fail. 2016; 9(5): pii: e000345. PMID: 27140203. DOI: 10.1161/CIRCHEARTFAILURE.115.000345.</mixed-citation><mixed-citation xml:lang="en">Lewis G.D., Semigran M.J., Givertz M.M., et al. Oral iron therapy for heart failure with reduced ejection fraction: design and rationale for oral iron repletion effects on oxygen uptake in heart failure. Circ Heart Fail. 2016; 9(5): pii: e000345. PMID: 27140203. DOI: 10.1161/CIRCHEARTFAILURE.115.000345.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Toblli J.E., Lombrana A., Duarte P., Di Gennaro F. Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency. J. Am. Coll. Cardiol. 2007; 50(17): 1657–1665. PMID: 17950147. DOI: 10.1016/j.jacc.2007.07.029.</mixed-citation><mixed-citation xml:lang="en">Toblli J.E., Lombraña A., Duarte P., Di Gennaro F. Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency. J Am Coll Cardiol. 2007; 50(17): 1657–1665. PMID: 17950147. DOI: 10.1016/j.jacc.2007.07.029.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Okonko D.O., Grzeslo A., Witkowski T., et al. Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial. J. Am. Coll. Cardiol. 2008; 51(2): 103–112. PMID: 18191732. DOI: 10.1016/j.jacc.2007.09.036.</mixed-citation><mixed-citation xml:lang="en">Okonko D.O., Grzeslo A., Witkowski T., et al. Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial. J Am Coll Cardiol. 2008; 51(2): 103–112. PMID: 18191732. DOI: 10.1016/j.jacc.2007.09.036.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Anker S.D., Comin Colet J., Filippatos G., et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N. Engl. J. Med. 2009; 361(25): 2436–2448. PMID: 19920054. DOI: 10.1056/NEJMoa0908355.</mixed-citation><mixed-citation xml:lang="en">Anker S.D., Comin Colet J., Filippatos G., et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med. 2009; 361(25): 2436–2448. PMID: 19920054. DOI: 10.1056/NEJMoa0908355.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Ponikowski P., Van Veldhuisen D.J., Comin-Colet J., et al. Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency. Eur. Heart J. 2015; 36(11): 657–668. PMID: 25176939. DOI: 10.1093/eurheartj/ehu385.</mixed-citation><mixed-citation xml:lang="en">Ponikowski P., Van Veldhuisen D.J., Comin-Colet J., et al. Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency. Eur Heart J. 2015; 36(11): 657–668. PMID: 25176939. DOI: 10.1093/eurheartj/ehu385.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">van Veldhuisen D.J., Ponikowski P., van der Meer P., et al. Effect of ferric carboxymaltose on exercise capacity in patients with chronic heart failure and iron deficiency. Circulation. 2017; 136(15): 1374–1383. PMID: 28701470. DOI: 10.1161/CIRCULATIONAHA.117.027497.</mixed-citation><mixed-citation xml:lang="en">van Veldhuisen D.J., Ponikowski P., van der Meer P., et al. Effect of ferric carboxymaltose on exercise capacity in patients with chronic heart failure and iron deficiency. Circulation. 2017; 136(15): 1374–1383. PMID: 28701470. DOI: 10.1161/CIRCULATIONAHA.117.027497.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Grote Beverborg N., van der Meer P., Klip T., Voors A. Definition of iron deficiency based on the gold standard of bone marrow iron staining in heart failure patients Circulation Heart Fail. 2018; 11(2): e004519. DOI: 10.1161/CIRCHEARTFAILURE.117.004519.</mixed-citation><mixed-citation xml:lang="en">Grote Beverborg N., van der Meer P., Klip T., Voors A. Definition of iron deficiency based on the gold standard of bone marrow iron staining in heart failure patients. Circulation Heart Fail. 2018; 11(2): e004519. PMID: 29382661. DOI: 10.1161/CIRCHEARTFAILURE.117.004519.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Anker S.D., Kirwan B.A., van Veldhuisen D.J., et al. Effects of ferric carboxymaltose on hospital- isations and mortality rates in irondeficient heart failure patients: an individual patient data metaanalysis. Eur. J. Heart Fail. 2018; 20(1): 125–133. PMID: 28436136. DOI: 10.1002/ejhf.823.</mixed-citation><mixed-citation xml:lang="en">Anker S.D., Kirwan B.A., van Veldhuisen D.J., et al. Effects of ferric carboxymaltose on hospital- isations and mortality rates in irondeficient heart failure patients: an individual patient data metaanalysis. Eur J Heart Fail. 2018; 20(1): 125–133. PMID: 28436136. DOI: 10.1002/ejhf.823.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Ponikowski P., Voors A.A., Anker S.D., et al. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur. Heart J. 2016; 37(2): 2129–2200. PMID: 27206819. DOI: 10.1093/eurheartj/ehw128.</mixed-citation><mixed-citation xml:lang="en">Ponikowski P., Voors A.A., Anker S.D., et al. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016; 37(2): 2129–2200. PMID: 27206819. DOI: 10.1093/eurheartj/ehw128.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Yancy C.W., Jessup M., Bozkurt B., et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J. Am. Coll. Cardiol. 2013; 62(16): e147–239. PMID: 23747642. DOI: 10.1016/j.jacc.2013.05.019.</mixed-citation><mixed-citation xml:lang="en">Yancy C.W., Jessup M., Bozkurt B., et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013; 62(16): e147–239. PMID: 23747642. DOI: 10.1016/j.jacc.2013.05.019.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
