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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nmp</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Sklifosovsky Journal "Emergency Medical Care"</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-9022</issn><issn pub-type="epub">2541-8017</issn><publisher><publisher-name>“N.V. Sklifosovsky Research Institute for Emergency Medicine”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23934/2223-9022-2017-6-3-238-245</article-id><article-id custom-type="elpub" pub-id-type="custom">nmp-388</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS OF LITERATURE</subject></subj-group></article-categories><title-group><article-title>ПРЕИМУЩЕСТВА И ОПАСНОСТИ РАННЕГО ОСТЕОСИНТЕЗА БЕДРЕННОЙ КОСТИ ПРИ ПОЛИТРАВМЕ С ПОВРЕЖДЕНИЯМИ ГРУДИ</article-title><trans-title-group xml:lang="en"><trans-title>ADVANTAGES AND DANGERS OF EARLY OSTEOSYNTHESIS OF FEMUR IN POLYTRAUMA WITH CHEST INJUR</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шапкин</surname><given-names>Ю. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Shapkin</surname><given-names>Y. G.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Селиверстов</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Seliverstov</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Селиверстов Павел Андреевич, кандидат медицинских наук, ассистент кафедры общей хирургии ФГБОУ ВО Саратовский ГМУ им. В.И. Разумовского Минздрава России</p></bio><bio xml:lang="en"><p>Cand. Med. Sci., Assistant of General Surgery Department, Saratov State Medical University named after V.I. Razumovsky</p></bio><email xlink:type="simple">seliwerstov.pl@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУ ВО «Саратовский государственный медицинский университет имени В.И. Разумовского» Министерства здравоохранения Российской Федерации<country>Россия</country></aff><aff xml:lang="en">«Saratov State Medical University named after V.I. Razumovsky», Ministry of Health Care, Russian Federation, Saratov<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>11</day><month>10</month><year>2017</year></pub-date><volume>6</volume><issue>3</issue><fpage>238</fpage><lpage>245</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шапкин Ю.Г., Селиверстов П.А., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Шапкин Ю.Г., Селиверстов П.А.</copyright-holder><copyright-holder xml:lang="en">Shapkin Y.G., Seliverstov P.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jnmp.ru/jour/article/view/388">https://www.jnmp.ru/jour/article/view/388</self-uri><abstract><p>В обзоре представлены результаты экспериментальных и клинических исследований влияния раннего остеосинтеза при переломе бедренной кости на развитие системных осложнений и исхода политравмы с повреждениями груди. Рассмотрена роль сочетания торакальных повреждений с переломом бедренной кости, а также ее интрамедуллярного остеосинтеза в механизмах формирования местной и системной воспалительной реакции, коагулопатии, жировой и тромбоэмболии в легких, дыхательной недостаточности. Изложены концепции «немедленной тотальной помощи», «контроля ортопедических повреждений» применительно к переломам бедренной кости, сочетанных с травмой груди. Приведены критерии относительной безопасности выполнения окончательного остеосинтеза бедренной кости при политравме с торакальными повреждениями</p></abstract><trans-abstract xml:lang="en"><p>The review presents the results of experimental and clinical studies of the effect of early osteosynthesis in the femoral fracture on the development of systemic complications and the outcome of polytrauma with chest injuries. We explored the role of combination of thoracic injuries with a fracture of the femur, as well as its intramedullary osteosynthesis in the mechanisms of local and systemic inflammatory reaction formation, coagulopathy, fatty embolism and pulmonary embolism, respiratory failure. The concepts of “immediate total care” and “orthopedic damage control” are described with reference to fractures of the femur, combined with a chest trauma. The criteria for the relative safety of osteosynthesis of the femur in polytrauma with thoracic injuries are given.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>политравма</kwd><kwd>перелом бедренной кости</kwd><kwd>повреждения груди</kwd><kwd>легочные осложнения</kwd><kwd>«второй удар»</kwd><kwd>воспалительный ответ</kwd><kwd>коагулопатия</kwd><kwd>контроль скелетных повреждений</kwd><kwd>интрамедуллярный остеосинтез</kwd></kwd-group><kwd-group xml:lang="en"><kwd>polytrauma</kwd><kwd>femoral fracture</kwd><kwd>chest injuries</kwd><kwd>pulmonary complications</kwd><kwd>«second hit»</kwd><kwd>inflammatory response</kwd><kwd>coagulopathy</kwd><kwd>orthopedic damage control</kwd><kwd>intramedullary osteosynthesis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Pfeifer R., Pape H.C. Diagnostics and treatment strategies for multiple trauma patients. Chirurg. 2016; 87(2): 165–175. PMID: 26830303. DOI: 10.1007/s00104-015-0139-0.</mixed-citation><mixed-citation xml:lang="en">Pfeifer R., Pape H.C. Diagnostics and treatment strategies for multiple trauma patients. Chirurg. 2016; 87(2): 165–175. PMID: 26830303. DOI: 10.1007/s00104-015-0139-0.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Соколов В.А. Множественные и сочетанные травмы. М.: ГЭОТАР- Медиа, 2006. 512 с.</mixed-citation><mixed-citation xml:lang="en">Sokolov V.A. Multiple and associated injuries. Moscow: GEOTAR-Media Publ., 2006. 512 р. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Бондаренко А.В., Герасимова О.А., Лукьянов В.В., и др. Состав, структура повреждений, летальность и особенности оказания помощи у пострадавших на этапах лечения политравмы. Политравма. 2014; (1): 15–28.</mixed-citation><mixed-citation xml:lang="en">Bondarenko A.V., Gerasimova O.A., Luk’yanov V.V., et al. Composition, structure of injuries, mortality and features of rendering assistance for patients during treatment of polytrauma. Politravma. 2014; (1): 15–28. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Самохвалов И.М., Рудь А.А., Петров А.Н., и др. Инфекционные осложнения у пострадавших с политравмой. Здоровье. Медицинская экология. Наука. 2012; 47–48(1–2): 98–99.</mixed-citation><mixed-citation xml:lang="en">Samokhvalov I.M., Rud’ A.A., Petrov A.N., et al. Infectious complications in patients with multiple injuries. Zdorov’e. Meditsinskaya ekologiya. Nauka. 2012; 47–48(1–2): 98–99. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Агаджанян В.В., Кравцов С.А., Шаталин А.В., Левченко Т.В. Госпитальная летальность при политравме и основные направления ее снижения. Политравма. 2015; (1): 6–15.</mixed-citation><mixed-citation xml:lang="en">Agadzhanyan V.V., Kravtsov S.A., Shatalin A.V., Levchenko T.V. Hospital mortality in polytrauma and main directions for its decrease. Politravma. 2015; (1): 6–15. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Liu X., Jiang M., Yi C.L., et al. Early intramedullary nailing for femoral fractures in patients with severe thoracic trauma: A systemic review and meta-analysis. Chin. J. Traumatol. 2016; 19(3): 160–163. PMID: 27321297.</mixed-citation><mixed-citation xml:lang="en">Liu X., Jiang M., Yi C.L., et al. Early intramedullary nailing for femoral fractures in patients with severe thoracic trauma: A systemic review and meta-analysis. Chin J Traumatol. 2016; 19(3): 160–163. PMID: 27321297.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Huber S., Biberthaler P., Delhey P., et al. Predictors of poor outcomes after significant chest trauma in multiply injured patients: a retrospective analysis from the German Trauma Registry (Trauma Register DGU®). Scand. J. Trauma Resusc. Emerg. Med. 2014; 22: 52 PMID: 25204466. DOI: 10.1186/s13049-014-0052-4.</mixed-citation><mixed-citation xml:lang="en">Huber S., Biberthaler P., Delhey P. et al. Predictors of poor outcomes after significant chest trauma in multiply injured patients: a retrospective analysis from the German Trauma Registry (Trauma Register DGU®). Scand J Trauma Resusc Emerg Med. 2014; 22: 52 PMID: 25204466. DOI: 10.1186/ s13049-014-0052-4.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Песчанский Р.Е., Танцюра В.П., Дудин А.М., Ярощак В.В. Принципы хирургического лечения пострадавших с сочетанной травмой груди и конечностей. Вестник неотложной и восстановительной медицины. 2012; 13(3): 384–386.</mixed-citation><mixed-citation xml:lang="en">Peschanskiy R.E., Tantsyura V.P., Dudin A.M., Yaroshchak V.V. Principles of surgical treatment of patients with combined trauma of chest and extremities. Vestnik neotlozhnoy i vosstanovitel’noy meditsiny. 2012; 13(3): 384–386. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Willett K., Al-Khateeb H., Kotnis R., et al. Risk of mortality: the relationship with associated injuries and fracture treatment methods in patients with unilateral or bilateral femoral shaft fractures. J. Trauma. 2010; 69(2): 405–410. PMID: 20699750. DOI: 10.1097/ TA.0b013e3181e6138a.</mixed-citation><mixed-citation xml:lang="en">Willett K., Al-Khateeb H., Kotnis R., et al. Risk of mortality: the relationship with associated injuries and fracture treatment methods in patients with unilateral or bilateral femoral shaft fractures. J Trauma. 2010; 69(2): 405–410. PMID: 20699750. DOI: 10.1097/TA.0b013e3181e6138a.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Godzik J., McAndrew C.M., Morshed S., et al. Multiple lower-extremity and pelvic fractures increase pulmonary embolus risk. Orthopedics. 2014; 37(6): e517–524. PMID: 24972431. DOI: 10.3928/01477447- 20140528-50.</mixed-citation><mixed-citation xml:lang="en">Godzik J., McAndrew C.M., Morshed S. et al. Multiple lower-extremity and pelvic fractures increase pulmonary embolus risk. Orthopedics. 2014; 37(6): e517–524. PMID: 24972431. DOI: 10.3928/01477447-20140528-50.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Радевская Н.С., Овчинников Л.В. Профилактика синдрома жировой эмболии при тяжелых сочетанных травмах. Евразийский Союз Ученых. 2015; (11–1): 159–162.</mixed-citation><mixed-citation xml:lang="en">Radevskaya N.S., Ovchinnikov L.V. Prevention of fat embolism syndrome with severe concomitant injuries. Evraziyskiy Soyuz Uchenykh. 2015; (11–1): 159–162. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Панков И.О. Анализ причин летальных исходов пострадавших с тяжелой скелетной политравмой. Практическая медицина. 2015; 1(4): 157–160.</mixed-citation><mixed-citation xml:lang="en">Pankov I.O. Analysis of the causes of deaths of patients with severe skeletal polytrauma. Prakticheskaya meditsina. 2015; 1(4): 157–160. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Самохвалов И.М., Гаврилин С.В., Супрун А.Ю., и др. Роль ушиба лёгких в патогенезе дыхательных расстройств при тяжёлой соче- танной травме груди. Вестник анестезиологии и реаниматологии. 2011; 8(5): 11–16.</mixed-citation><mixed-citation xml:lang="en">Samokhvalov I.M., Gavrilin S.V., Suprun A.Yu., et al. Implication of pulmonary contusion in the pathogenesis of respiratory disorders in severe concomitant chest trauma. Vestnik anesteziologii i reanimatologii. 2011; 8(5): 11–16. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Lane M.K., Nahm N.J., Vallier H.A. Morbidity and mortality of bilateral femur fractures. Orthopedics. 2015; 38(7): e588–592. PMID: 26186320. DOI: 10.3928/01477447-20150701-56.</mixed-citation><mixed-citation xml:lang="en">Lane M.K., Nahm N.J., Vallier H.A. Morbidity and mortality of bilateral femur fractures. Orthopedics. 2015; 38(7): e588–592. PMID: 26186320. DOI: 10.3928/01477447-20150701-56.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Vallier H.A., Wang X., Moore T.A., et al. Timing of orthopaedic surgery in multiple trauma patients: development of a protocol for early appropriate care. J. Orthop. Trauma. 2013; 27(10): 543–551. PMID: 23760182. DOI: 10.1097/BOT.0b013e31829efda1.</mixed-citation><mixed-citation xml:lang="en">Vallier H.A., Wang X., Moore T.A., et al. Timing of orthopaedic surgery in multiple trauma patients: development of a protocol for early appropriate care. J Orthop Trauma. 2013; 27(10): 543–551. PMID: 23760182. DOI: 10.1097/BOT.0b013e31829efda1.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Nahm N.J., Como J.J., Wilber J.H., Vallier H.A. Early appropriate care: definitive stabilization of femoral fractures within 24 hours of injury is safe in most patients with multiple injuries. J. Trauma. 2011; 71(1): 175–185. PMID: 21336198. DOI: 10.1097/TA.0b013e3181fc93a2.</mixed-citation><mixed-citation xml:lang="en">Nahm N.J., Como J.J., Wilber J.H., Vallier H.A. Early appropriate care: definitive stabilization of femoral fractures within 24 hours of injury is safe in most patients with multiple injuries. J Trauma. 2011; 71(1): 175–185. PMID: 21336198. DOI: 10.1097/TA.0b013e3181fc93a2.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Dienstknecht T., Rixen D., Giannoudis P., Pape H.C. Do parameters used to clear noncritically injured polytrauma patients for extremity surgery predict complications? Clin. Orthop. Relat. Res. 2013; 471(9): 2878–2884. PMID: 23512748. DOI: 10.1007/s11999-013-2924-8.</mixed-citation><mixed-citation xml:lang="en">Dienstknecht T., Rixen D., Giannoudis P., Pape H.C. Do parameters used to clear noncritically injured polytrauma patients for extremity surgery predict complications? Clin Orthop Relat Res. 2013; 471(9): 2878–2884. PMID: 23512748. DOI: 10.1007/s11999-013-2924-8.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Fröhlich M., Lefering R., Probst C., et al. Epidemiology and risk factors of multiple-organ failure after multiple trauma: an analysis of 31,154 patients from the Trauma Register DGU. J. Trauma Acute Care Surg. 2014; 76(4): 921–928. PMID: 24662853. DOI: 10.1097/TA.0000000000000199.</mixed-citation><mixed-citation xml:lang="en">Fröhlich M., Lefering R., Probst C., et al. Epidemiology and risk factors of multiple-organ failure after multiple trauma: an analysis of 31,154 patients from the Trauma Register DGU. J Trauma Acute Care Surg. 2014; 76(4): 921–928. PMID: 24662853. DOI: 10.1097/TA.0000000000000199.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Cannada L.K., Taghizadeh S., Murali J., et al. Retrograde intramedullary nailing in treatment of bilateral femur fractures. J. Orthop. Trauma. 2008; 22(8): 530–534. PMID: 18758283. DOI: 10.1097/ BOT.0b013e318183eb48.</mixed-citation><mixed-citation xml:lang="en">Cannada L.K., Taghizadeh S., Murali J., et al. Retrograde intramedullary nailing in treatment of bilateral femur fractures. J Orthop Trauma. 2008; 22(8): 530–534. PMID: 18758283. DOI: 10.1097/BOT.0b013e318183eb48.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Seitz D.H., Perl M., Liener U.C., et al. Inflammatory alterations in a novel combination model of blunt chest trauma and hemorrhagic shock. J. Trauma. 2011; 70(1): 189–196. PMID: 20495485. DOI: 10.1097/ TA.0b013e3181d7693c.</mixed-citation><mixed-citation xml:lang="en">Seitz D.H., Perl M., Liener U.C., et al. Inflammatory alterations in a novel combination model of blunt chest trauma and hemorrhagic shock. J Trauma. 2011; 70(1): 189–196. PMID: 20495485. DOI: 10.1097/ TA.0b013e3181d7693c.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Mommsen P., Zeckey C., Andruszkow H., et al. Comparison of different thoracic trauma scoring systems in regards to prediction of posttraumatic complications and outcome in blunt chest trauma. J. Surg. Res. 2012; 176(1): 239–247. PMID: 22099585. DOI: 10.1016/ j.jss.2011.09.018.</mixed-citation><mixed-citation xml:lang="en">Mommsen P., Zeckey C., Andruszkow H., et al. Comparison of different thoracic trauma scoring systems in regards to prediction of post-traumatic complications and outcome in blunt chest trauma. J Surg Res. 2012; 176(1): 239–247. PMID: 22099585. DOI: 10.1016/j.jss.2011.09.018.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Jin H., Tang L.Q., Pan Z.G., et al. Ten-year retrospective analysis of multiple trauma complicated by pulmonary contusion. Mil. Med. Res. 2014; 1: 7. PMID: 25722865. DOI: 10.1186/2054-9369-1-7.</mixed-citation><mixed-citation xml:lang="en">Jin H., Tang L.Q., Pan Z.G., et al. Ten-year retrospective analysis of multiple trauma complicated by pulmonary contusion. Mil Med Res. 2014; 1: 7. PMID: 25722865. DOI: 10.1186/2054-9369-1-7.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Horst K., Eschbach D., Pfeifer R., et al. Local inflammation in fracture hematoma: results from a combined trauma model in pigs. Mediators Inflamm. 2015; 2015: 126060. PMID: 25694748. DOI: 10.1155/2015/126060.</mixed-citation><mixed-citation xml:lang="en">Horst K., Eschbach D., Pfeifer R., et al. Local inflammation in fracture hematoma: results from a combined trauma model in pigs. Mediators Inflamm. 2015; 2015: 126060. PMID: 25694748. DOI: 10.1155/2015/126060.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Pfeifer R., Darwiche S., Kohut L., et al. Cumulative effects of bone and soft tissue injury on systemic inflammation: a pilot study. Clin. Orthop. Relat. Res. 2013; 471 (9): 2815–2821. PMID: 23479238. DOI: 10.1007/ s11999-013-2908-8.</mixed-citation><mixed-citation xml:lang="en">Pfeifer R., Darwiche S., Kohut L., et al. Cumulative effects of bone and soft tissue injury on systemic inflammation: a pilot study. Clin Orthop Relat Res. 2013; 471 (9): 2815–2821. PMID: 23479238. DOI: 10.1007/s11999-013- 2908-8.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Denk S., Wiegner R., Hönes F.M., et al. Early detection of junctional adhesion molecule-1 (JAM-1) in the circulation after experimental and clinical polytrauma. Mediators Inflamm. 2015; 2015: 463950. PMID: 26556956. DOI: 10.1155/2015/463950.</mixed-citation><mixed-citation xml:lang="en">Denk S., Wiegner R., Hönes F.M., et al. Early detection of junctional adhesion molecule-1 (JAM-1) in the circulation after experimental and clinical polytrauma. Mediators Inflamm. 2015; 2015: 463950. PMID: 26556956. DOI: 10.1155/2015/463950.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Dai H., Xu L., Tang Y., et al. Treatment with a neutralising antirat interleukin-17 antibody after multiple-trauma reduces lung inflammation. Injury 2015; 46(8): 1465–1470. PMID: 26100210. DOI: 10.1016/j.injury.2015.05.016.</mixed-citation><mixed-citation xml:lang="en">Dai H., Xu L., Tang Y., et al. Treatment with a neutralising anti-rat interleukin-17 antibody after multiple-trauma reduces lung inflammation. Injury. 2015; 46(8): 1465–1470. PMID: 26100210. DOI: 10.1016/ j.injury.2015.05.016.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Gan L., Chen X., Sun T., et al. Significance of serum mtDNA concentration in lung injury induced by hip fracture. Shock. 2015; 44(1): 52–57. PMID: 25705859. DOI: 10.1097/SHK.0000000000000366.</mixed-citation><mixed-citation xml:lang="en">Gan L., Chen X., Sun T., et al. Significance of serum mtDNA concentration in lung injury induced by hip fracture. Shock. 2015; 44(1): 52–57. PMID: 25705859. DOI: 10.1097/SHK.0000000000000366.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Li. H., Itagaki K., Sandler N., et al. Mitochondrial damage-associated molecular patterns from fractures suppress pulmonary immune responses via formyl peptide receptors 1 and 2. J. Trauma Acute Care Surg. 2015; 78(2): 272–281. PMID: 25757111. DOI: 10.1097/ TA.0000000000000509.</mixed-citation><mixed-citation xml:lang="en">Li. H., Itagaki K., Sandler N., et al. Mitochondrial damage-associated molecular patterns from fractures suppress pulmonary immune responses via formyl peptide receptors 1 and 2. J Trauma Acute Care Surg. 2015; 78(2): 272–281. PMID: 25757111. DOI: 10.1097/TA.0000000000000509.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Бочаров С.Н., Кулинский В.И., Лебедь М.Л., и др. Состояние системы глутатиона внутренних органов в условиях множественной скелетной травмы в эксперименте. Фундаментальные исследования. 2014; (10-1): 32–36.</mixed-citation><mixed-citation xml:lang="en">Bocharov S.N., Kulinskiy V.I., Lebed’ M.L. et al. Glutathione system of internal organs in the presence of multiple skeletal trauma in experiment. Fundamental’nye issledovaniya. 2014; (10-1): 32–36. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Gandhi R.R., Overton T.L., Haut E.R., et al. Optimal timing of femur fracture stabilization in polytrauma patients: A practice management guideline from the Eastern Association for the Surgery of Trauma. J. Trauma Acute Care Surg. 2014; 77(5): 787–795. PMID: 25494434. DOI: 10.1097/TA.0000000000000434.</mixed-citation><mixed-citation xml:lang="en">Gandhi R.R., Overton T.L., Haut E.R. et al. Optimal timing of femur fracture stabilization in polytrauma patients: A practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg. 2014; 77(5): 787–795. PMID: 25494434. DOI: 10.1097/TA.0000000000000434.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Vallier H.A., Super D.M., Moore T.A., Wilber J.H. Do patients with multiple system injury benefit from early fixation of unstable axial fractures? The effects of timing of surgery on initial hospital course. J. Orthop. Trauma. 2013; 27(7): 405–412. PMID: 23287766. DOI: 10.1097/ BOT.0b013e3182820eba.</mixed-citation><mixed-citation xml:lang="en">Vallier H.A., Super D.M., Moore T.A., Wilber J.H. Do patients with multiple system injury benefit from early fixation of unstable axial fractures? The effects of timing of surgery on initial hospital course. J Orthop Trauma. 2013; 27(7): 405–412. PMID: 23287766. DOI: 10.1097/ BOT.0b013e3182820eba.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Harvin J.A., Harvin W.H., Camp E., et al. Early femur fracture fixation is associated with a reduction in pulmonary complications and hospital charges: a decade of experience with 1,376 diaphyseal femur fractures. J. Trauma Acute Care Surg. 2012; 73(6): 1442–1449. PMID: 23188236. DOI: 10.1097/TA.0b013e3182782696.</mixed-citation><mixed-citation xml:lang="en">Harvin J.A., Harvin W.H., Camp E. et al. Early femur fracture fixation is associated with a reduction in pulmonary complications and hospital charges: a decade of experience with 1,376 diaphyseal femur fractures. J Trauma Acute Care Surg. 2012; 73(6): 1442–1449. PMID: 23188236. DOI: 10.1097/TA.0b013e3182782696.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Шабанова А.Ю. Тактика лечения пострадавших с политравмой в остром периоде травматической болезни. Пермский медицинский журнал. 2015; 32(3): 22–28.</mixed-citation><mixed-citation xml:lang="en">Shabanova A. Yu. Management tactics for sufferers with polytrauma in acute period of traumatic disease. Permskiy meditsinskiy zhurnal. 2015; 32(3): 22–28. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Cantu R.V., Graves S.C., Spratt K.F. In-hospital mortality from femoral shaft fracture depends on the initial delay to fracture fixation and Injury Severity Score: a retrospective cohort study from the NTDB 2002-2006. J. Trauma Acute Care Surg. 2014; 76(6): 1433–1440. PMID: 24854312. DOI: 10.1097/TA.0000000000000230.</mixed-citation><mixed-citation xml:lang="en">Cantu R.V., Graves S.C., Spratt K.F. In-hospital mortality from femoral shaft fracture depends on the initial delay to fracture fixation and Injury Severity Score: a retrospective cohort study from the NTDB 2002-2006. J Trauma Acute Care Surg. 2014; 76(6): 1433–1440. PMID: 24854312. DOI: 10.1097/TA.0000000000000230.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Morshed S., Mikhail C., Miclau Iii T. Timing of femoral shaft fracture fixation affects length of hospital stay in patients with multiple injuries. Open Orthop. J. 2015; 9: 324–331. PMID: 26312117. DOI: 10.2174/1874325001509010324.</mixed-citation><mixed-citation xml:lang="en">Morshed S., Mikhail C., Miclau Iii T. Timing of femoral shaft fracture fixation affects length of hospital stay in patients with multiple injuries. Open Orthop J. 2015; 9: 324–331. PMID: 26312117. DOI: 10.2174/18743250 01509010324.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Nicola R. Early total care versus damage control: current concepts in the orthopedic care of polytrauma patients. ISRN Orthop. 2013; 2013: 329452. PMID: 24959356. DOI: 10.1155/2013/329452.</mixed-citation><mixed-citation xml:lang="en">Nicola R. Early total care versus damage control: current concepts in the orthopedic care of polytrauma patients. ISRN Orthop. 2013; 2013: 329452. PMID: 24959356. DOI: 10.1155/2013/329452.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Hietbrink F., Koenderman L., Leenen L.P. Intramedullary nailing of the femur and the systemic activation of monocytes and neutrophils. World J. Emerg. Surg. 2011; 6: 34. PMID: 22040874. DOI: 10.1186/1749-7922- 6-34.</mixed-citation><mixed-citation xml:lang="en">Hietbrink F., Koenderman L., Leenen L.P. Intramedullary nailing of the femur and the systemic activation of monocytes and neutrophils. World J Emerg Surg. 2011; 6: 34. PMID: 22040874. DOI: 10.1186/1749-7922-6-34.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Husebye E.E., Lyberg T., Opdahl H., et al. Intramedullary nailing of femoral shaft fractures in polytraumatized patients. a longitudinal, prospective and observational study of the procedure-related impact on cardiopulmonary- and inflammatory responses. Scand. J. Trauma Resusc. Emerg. Med. 2012; 20: 2. PMID: 22221511. DOI: 10.1186/1757- 7241-20-2.</mixed-citation><mixed-citation xml:lang="en">Husebye E.E., Lyberg T., Opdahl H., et al. Intramedullary nailing of femoral shaft fractures in polytraumatized patients. a longitudinal, prospective and observational study of the procedure-related impact on cardiopulmonaryand inflammatory responses. Scand J Trauma Resusc Emerg Med. 2012; 20: 2. PMID: 22221511. DOI: 10.1186/1757-7241-20-2.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Gan L., Zhong J., Zhang R., et al. The immediate intramedullary nailing surgery increased the mitochondrial DNA release that aggravated systemic inflammatory response and lung injury induced by elderly hip fracture. Mediators Inflamm. 2015; 2015: 587378. PMID: 26273137. DOI: 10.1155/2015/587378.</mixed-citation><mixed-citation xml:lang="en">Gan L., Zhong J., Zhang R., et al. The immediate intramedullary nailing surgery increased the mitochondrial DNA release that aggravated systemic inflammatory response and lung injury induced by elderly hip fracture. Mediators Inflamm. 2015; 2015: 587378. PMID: 26273137. DOI: 10.1155/2015/587378.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Husebye E.E., Lyberg T., Opdahl H., Røise O. Intravasation of bone marrow content. Can its magnitude and effects be modulated by low pressurereaming in a porcine model? Injury. 2010; 41 (Suppl. 2): S9–15. PMID: 21144936. DOI: 10.1016/S0020-1383(10)70003-6.</mixed-citation><mixed-citation xml:lang="en">Husebye E.E., Lyberg T., Opdahl H., Røise O. Intravasation of bone marrow content. Can its magnitude and effects be modulated by low pressurereaming in a porcine model? Injury. 2010; 41 (Suppl 2): S9–15. PMID: 21144936. DOI:10.1016/S0020-1383(10)70003-6. 41. Volgas D.A., Burch T., Stannard J.P., et al. Fat embolus in femur fractures: a comparison of two reaming systems. Injury. 2010;</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Volgas D.A., Burch T., Stannard J.P., et al. Fat embolus in femur fractures: a comparison of two reaming systems. Injury. 2010; 41 (Suppl 2): S90–93. PMID: 21144937. DOI: 10.1016/S0020-1383(10)70017-6.</mixed-citation><mixed-citation xml:lang="en">(Suppl 2): S90–93. PMID: 21144937. DOI: 10.1016/S0020-1383(10)70017-6.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Blankstein M., Byrick R.J., Nakane M., et al. Amplified inflammatory response to sequential hemorrhage, resuscitation, and pulmonary fat embolism: an animal study. J. Bone Joint Surg. Am. 2010; 92(1): 149–161. PMID: 20048107. DOI: 10.2106/JBJS.H.01141.</mixed-citation><mixed-citation xml:lang="en">Blankstein M., Byrick R.J., Nakane M., et al. Amplified inflammatory response to sequential hemorrhage, resuscitation, and pulmonary fat embolism: an animal study. J. Bone Joint Surg. Am. 2010; 92(1): 149–161. PMID: 20048107. DOI: 10.2106/JBJS.H.01141.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Aoki S., Yokoyama K., Itoman M. Effects of reamed or unreamed intramedullary nailing under non-damaged conditions on pulmonary function in sheep. J. Trauma. 2005; 59(3): 647–658. PMID: 16361908.</mixed-citation><mixed-citation xml:lang="en">Aoki S., Yokoyama K., Itoman M. Effects of reamed or unreamed intramedullary nailing under non-damaged conditions on pulmonary function in sheep. J Trauma. 2005; 59(3): 647–658. PMID: 16361908.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Blankstein M., Byrick R.J., Nakane M., et al. A preliminary study of platelet activation after embolization of marrow contents. J. Orthop. Trauma. 2012; 26(11): e214–220. PMID: 22473062. DOI: 10.1097/ BOT.0b013e3182410560.</mixed-citation><mixed-citation xml:lang="en">Blankstein M., Byrick R.J., Nakane M., et al. A preliminary study of platelet activation after embolization of marrow contents. J Orthop Trauma. 2012; 26(11): e214–220. PMID: 22473062. DOI: 10.1097/ BOT.0b013e3182410560.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Giannoudis P.V., van Griensven M., Hildebrand F., et al. Femoral nailingrelated coagulopathy determined by first-hit magnitude: an animal study. Clin. Orthop. Relat. Res. 2008; 466(2): 473–480. PMID: 18196434. DOI: 10.1007/s11999-007-0066-6.</mixed-citation><mixed-citation xml:lang="en">Giannoudis P.V., van Griensven M., Hildebrand F., et al. Femoral nailingrelated coagulopathy determined by first-hit magnitude: an animal study. Clin Orthop Relat Res. 2008; 466(2): 473–480. PMID: 18196434. DOI: 10.1007/s11999-007-0066-6.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Neunaber C., Oestern S., Andruszkow H., et al. Cytokine productive capacity of alveolar macrophages and Kupffer cells after femoral fracture and blunt chest trauma in a murine trauma model. Immunol. Lett. 2013; 152(2): 159–166. PMID: 23735227. DOI: 10.1016/j.imlet.2013.05.012.</mixed-citation><mixed-citation xml:lang="en">Neunaber C., Oestern S., Andruszkow H., et al. Cytokine productive capacity of alveolar macrophages and Kupffer cells after femoral fracture and blunt chest trauma in a murine trauma model. Immunol Lett. 2013; 152(2): 159–166. PMID: 23735227. DOI: 10.1016/j.imlet.2013.05.012.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Handolin L., Pajarinen J., Lassus J., Tulikoura I. Early intramedullary nailing of lower extremity fracture and respiratory function in polytraumatized patients with a chest injury: a retrospective study of 61 patients. Acta Orthop. Scand. 2004; 75(4): 477–480. PMID: 15370594.</mixed-citation><mixed-citation xml:lang="en">Handolin L., Pajarinen J., Lassus J., Tulikoura I. Early intramedullary nailing of lower extremity fracture and respiratory function in polytraumatized patients with a chest injury: a retrospective study of 61 patients. Acta Orthop Scand. 2004; 75(4): 477–480. PMID: 15370594.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Anwar I.A., Battistella F.D., Neiman R., et al. Femur fractures and lung complications: a prospective randomized study of reaming. Clin. Orthop. Relat. Res. 2004; (422): 71–76. PMID: 15187836.</mixed-citation><mixed-citation xml:lang="en">Anwar I.A., Battistella F.D., Neiman R., et al. Femur fractures and lung complications: a prospective randomized study of reaming. Clin Orthop Relat Res. 2004; (422): 71–76. PMID: 15187836.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Weresh M.J., Stover M.D., Bosse M.J., et al. Pulmonary gas exchange during intramedullary fixation of femoral shaft fractures. J. Trauma. 1999; 46(5): 863–868. PMID: 10338404.</mixed-citation><mixed-citation xml:lang="en">Weresh M.J., Stover M.D., Bosse M.J., et al. Pulmonary gas exchange during intramedullary fixation of femoral shaft fractures. J Trauma. 1999; 46(5): 863–868. PMID: 10338404.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Jiang M., Li C., Yi C., Tang S. Early intramedullary nailing of femoral shaft fracture on outcomes in patients with severe chest injury: A meta-analysis. Sci Rep. 2016; 6: 30566. PMID: 27457468. DOI: 10.1038/ srep30566.</mixed-citation><mixed-citation xml:lang="en">Jiang M., Li C., Yi C., Tang S. Early intramedullary nailing of femoral shaft fracture on outcomes in patients with severe chest injury: A meta-analysis. Sci Rep. 2016; 6: 30566. PMID: 27457468. DOI: 10.1038/srep30566.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Bone L.B., Giannoudis P. Femoral shaft fracture fixation and chest injury after polytrauma. J Bone Joint Surg. Am. 2011; 93(3): 311–317. PMID: 21266645. DOI: 10.2106/JBJS.J.00334.</mixed-citation><mixed-citation xml:lang="en">Bone L.B., Giannoudis P. Femoral shaft fracture fixation and chest injury after polytrauma. J Bone Joint Surg Am. 2011; 93(3): 311–317. PMID: 21266645. DOI: 10.2106/JBJS.J.00334.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Bone L.B., Anders M.J., Rohrbacher B.J. Treatment of femoral fractures in the multiply injured patient with thoracic injury. Clin. Orthop. Relat. Res. 1998; (347): 57–61. PMID: 9520875.</mixed-citation><mixed-citation xml:lang="en">Bone L.B., Anders M.J., Rohrbacher B.J. Treatment of femoral fractures in the multiply injured patient with thoracic injury. Clin Orthop Relat Res. 1998; (347): 57–61. PMID: 9520875.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Aufmkolk M., Neudeck F., Voggenreiter G., et al. Effect of primary femoral plate osteosynthesis on the course of polytrauma patients with or without thoracic trauma. Unfallchirurg. 1998; 101(6): 433–439. PMID: 9677841.</mixed-citation><mixed-citation xml:lang="en">Aufmkolk M., Neudeck F., Voggenreiter G., et al. Effect of primary femoral plate osteosynthesis on the course of polytrauma patients with or without thoracic trauma. Unfallchirurg. 1998; 101(6): 433–439. PMID: 9677841.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Sír M., Pleva L., Procházka V. Multiple trauma — treatment of skeletal injuries with damage control orthopaedics. Rozhl Chir. 2014; 93(5): 287–291. PMID: 24891247.</mixed-citation><mixed-citation xml:lang="en">Sír M., Pleva L., Procházka V. Multiple trauma – treatment of skeletal injuries with damage control orthopaedics. Rozhl Chir. 2014; 93(5): 287– 291. PMID: 24891247.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Recknagel S., Bindl R., Wehner T., et al. Conversion from external fixator to intramedullary nail causes a second hit and impairs fracture healing in a severe trauma model. J. Orthop. Res. 2013; 31(3): 465–471. PMID: 23070742. DOI: 10.1002/jor.22242.</mixed-citation><mixed-citation xml:lang="en">Recknagel S., Bindl R., Wehner T., et al. Conversion from external fixator to intramedullary nail causes a second hit and impairs fracture healing in a severe trauma model. J Orthop Res. 2013; 31(3): 465–471. PMID: 23070742. DOI: 10.1002/jor.22242.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Kobbe P., Micansky F., Lichte P., et al. Increased morbidity and mortality after bilateral femoral shaft fractures: myth or reality in the era of damage control? Injury 2013; 44(2): 221–225. PMID: 23040674. DOI: 10.1016/j.injury.2012.09.011.</mixed-citation><mixed-citation xml:lang="en">Kobbe P., Micansky F., Lichte P., et al. Increased morbidity and mortality after bilateral femoral shaft fractures: myth or reality in the era of damage control? Injury. 2013; 44(2): 221–225. PMID: 23040674. DOI: 10.1016/ j.injury.2012.09.011.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">OʼToole R.V., Lindbloom B.J., Hui E., et al. Are bilateral femoral fractures no longer a marker for death? J. Orthop. Trauma. 2014; 28(2): 77–82. PMID: 23981901. DOI: 10.1097/BOT.0b013e3182a83fdf.</mixed-citation><mixed-citation xml:lang="en">OʼToole R.V., Lindbloom B.J., Hui E., et al. Are bilateral femoral fractures no longer a marker for death? J Orthop Trauma. 2014; 28(2): 77–82. PMID: 23981901. DOI: 10.1097/BOT.0b013e3182a83fdf.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Tiansheng S., Xiaobin C., Zhi L., et al. Is damage control orthopedics essential for the management of bilateral femoral fractures associated or complicated with shock? An animal study. J. Trauma. 2009; 67(6): 1402–1411. PMID: 20009694. DOI: 10.1097/TA.0b013e3181a7462d.</mixed-citation><mixed-citation xml:lang="en">Tiansheng S., Xiaobin C., Zhi L.. et al. Is damage control orthopedics essential for the management of bilateral femoral fractures associated or complicated with shock? An animal study. J Trauma. 2009; 67(6): 1402– 1411. PMID: 20009694. DOI: 10.1097/TA.0b013e3181a7462d.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Gray A.C., White T.O., Clutton E., et al. The stress response to bilateral femoral fractures: a comparison of primary intramedullary nailing and external fixation. J. Orthop. Trauma. 2009; 23(2): 90–99. PMID: 9169099. DOI: 10.1097/BOT.0b013e31819194c6.</mixed-citation><mixed-citation xml:lang="en">Gray A.C., White T.O., Clutton E. et al. The stress response to bilateral femoral fractures: a comparison of primary intramedullary nailing and external fixation. J Orthop Trauma. 2009; 23(2): 90–99. PMID: 9169099. DOI: 10.1097/BOT.0b013e31819194c6.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Steinhausen E., Lefering R., Tjardes T., et al. A risk-adapted approach is beneficial in the management of bilateral femoral shaft fractures in multiple trauma patients: an analysis based on the trauma registry of the German Trauma Society. J. Trauma Acute Care Surg. 2014; 76(5): 1288–1293. PMID: 24747462. DOI: 10.1097/TA.0000000000000167.</mixed-citation><mixed-citation xml:lang="en">Steinhausen E., Lefering R., Tjardes T., et al. A risk-adapted approach is beneficial in the management of bilateral femoral shaft fractures in multiple trauma patients: an analysis based on the trauma registry of the German Trauma Society. J Trauma Acute Care Surg. 2014; 76(5): 1288–1293. PMID: 24747462. DOI: 10.1097/TA.0000000000000167.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Хмара А.Д., Норкин И.А., Хмара Т.Г. Выбор лечебной тактики у пациентов с сочетанными повреждениями груди и сегментов конечностей. Фундаментальные исследования. 2013; (12–1): 89– 92.</mixed-citation><mixed-citation xml:lang="en">Khmara A.D., Norkin I.A., Khmara T.G. Select treatment policy in patients with combined chest injuries and limb segments. Fundamental’nye issledovaniya. 2013; (12–1): 89–92. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Richards J.E., Matuszewski P.E., Griffin S.M., et al. The role of elevated lactate as a risk factor for pulmonary morbidity after early fixation of femoral shaft fractures. J. Orthop. Trauma. 2016; 30(6): 312–318. PMID: 27206261. DOI: 10.1097/BOT.0000000000000528.</mixed-citation><mixed-citation xml:lang="en">Richards J.E., Matuszewski P.E., Griffin S.M., et al. The role of elevated lactate as a risk factor for pulmonary morbidity after early fixation of femoral shaft fractures. J Orthop Trauma. 2016; 30(6): 312–318. PMID: 27206261. DOI: 10.1097/BOT.0000000000000528.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Morshed S., Corrales L.A., Lin K., Miclau T. Femoral nailing during serum bicarbonate-defined hypo-perfusion predicts pulmonary organ dysfunction in multi-system trauma patients. Injury. 2011 Jul; 42(7): 643–649. PMID: 20678765. DOI: 10.1016/j.injury.2010.07.244.</mixed-citation><mixed-citation xml:lang="en">Morshed S., Corrales L.A., Lin K., Miclau T. Femoral nailing during serum bicarbonate-defined hypo-perfusion predicts pulmonary organ dysfunction in multi-system trauma patients. Injury. 2011 Jul; 42(7): 643–649. PMID: 20678765. DOI: 10.1016/j.injury.2010.07.244.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Easton R., Balogh Z.J. Peri-operative changes in serum immune markers after trauma: a systematic review. Injury. 2014; 45(6): 934–941. PMID: 24388280. DOI: 10.1016/j.injury.2013.12.002.</mixed-citation><mixed-citation xml:lang="en">Easton R., Balogh Z.J. Peri-operative changes in serum immune markers after trauma: a systematic review. Injury. 2014; 45(6): 934–941. PMID: 24388280. DOI: 10.1016/j.injury.2013.12.002.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Lumsdaine W., Easton R.M., Lott N.J., et al. Neutrophil oxidative burst capacity for peri-operative immune monitoring in trauma patients. Injury. 2014; 45(8): 1144–1148. PMID: 24815374. DOI: 10.1016/ j.injury.2014.04.019.</mixed-citation><mixed-citation xml:lang="en">Lumsdaine W., Easton R.M., Lott N.J. et al. Neutrophil oxidative burst capacity for peri-operative immune monitoring in trauma patients. Injury. 2014; 45(8): 1144–1148. PMID: 24815374. DOI: 10.1016/ j.injury.2014.04.019.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Childs B.R., Nahm N.J., Moore T.A., Vallier H.A. Multiple procedures in the initial surgical setting: when do the benefits outweigh the risks in patients with multiple system trauma? J. Orthop. Trauma. 2016; 30(8): 420–425. PMID: 27441760. DOI: 10.1097/BOT.0000000000000556.</mixed-citation><mixed-citation xml:lang="en">Childs B.R., Nahm N.J., Moore T.A., Vallier H.A. Multiple procedures in the initial surgical setting: when do the benefits outweigh the risks in patients with multiple system trauma? J Orthop Trauma. 2016; 30(8): 420–425. PMID: 27441760. DOI: 10.1097/BOT.0000000000000556.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
