nmpЖурнал им. Н.В. Склифосовского «Неотложная медицинская помощь»Russian Sklifosovsky Journal "Emergency Medical Care"2223-90222541-8017“N.V. Sklifosovsky Research Institute for Emergency Medicine”nmp-321Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWS OF LITERATUREСУПЕРОКСИДДИСМУТАЗА В СОСТАВЕ АНТИОКСИДАНТНОЙ ТЕРАПИИ: СОСТОЯНИЕ ВОПРОСА И ПЕРСПЕКТИВЫ (ОБЗОР ЛИТЕРАТУРЫ)SUPEROxIDE DISMUTASE AS A COMPONENT OF ANTIOxIDANT THERAPY: CURRENT STATE OF THE ISSUE AND PROSPECTS. A LITERATURE REVIEWПушкинаТ. А.PushkinaT. A.

ассистент кафедры восстановительной медицины, спортивной медицины, курортологии и физиотерапии с курсом сестринского дела,

Москва

Teaching Assistant at the Department of Rehabilitation and Resort Medicine with Nursing Care,

Moscow

Pushkina18@yandex.ruТокаевЭ. С.TokayevE. S.

Москва

Moscow

ПоповаТ. С.PopovaT. S.

Москва

Moscow

БородинаЕ. Н.BorodinaE. N.

Москва

Moscow

ФГБУ «Государственный научный центр РФ — Федеральный медицинский биофизический центр им. А.И. Бурназяна» ФМБА РоссииРоссияFederal Medical and biophysical Center n.a. A.I. burnazyanRussian FederationООО «Академия-Т»РоссияOOO (LLC) Academia-TRussian FederationГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»РоссияN.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare DepartmentRussian Federation201624122016044247Copyright © Пушкина Т.А., Токаев Э.С., Попова Т.С., Бородина Е.Н., 20162016Пушкина Т.А., Токаев Э.С., Попова Т.С., Бородина Е.Н.Pushkina T.A., Tokayev E.S., Popova T.S., Borodina E.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jnmp.ru/jour/article/view/321

Оксидативный стресс, развивающийся при многих заболеваниях, является нарушением баланса между прооксидантами и антиоксидантными защитными механизмами организма. Антиоксидантные ферменты, такие как супероксиддисмутаза (СОД), играют ключевую роль в снижении оксидативного стресса в естественных условиях. Таким образом, уменьшение образования активных форм кислорода, а также активации процессов перекисного окисления липидов за счет экзогенного поступления СОД могло бы стать эффективным методом профилактики и лечения ряда заболеваний. В данной работе мы предлагаем обзор результатов экспериментальных и клинических исследований по использованию внутривенно вводимых препаратов и пищевых добавок, содержащих СОД, при лечении воспалительных, инфекционных, сердечно-сосудистых и нейродегенеративных заболеваний. В результате введения СОД большинство авторов наблюдали увеличение содержания эндогенных антиоксидантных ферментов (СОД, каталазы, глутатионпероксидазы), т.е. стимуляцию эндогенной антиоксидантной защиты, и, следовательно, снижение уровня оксидативного стресса, что может объяснять механизмы положительных наблюдаемых эффектов.

Oxidative stress, developing in many diseases, is an imbalance between pro-oxidants and antioxidant defense mechanisms of the body. Antioxidant enzymes such as superoxide dismutase (SOD) play a key role in reduction of oxidative stress in vivo. Thus, a decrease in formation of reactive oxygen species (ROS), as well as activation of lipid peroxidation (LPO) due to exogenous SOD intake could be an effective method of prevention and treatment of some diseases. In this paper, we provide an overview of the results of experimental and clinical studies on the use of intravenous drugs and dietary supplements, containing SOD, in the treatment of inflammatory, infectious, cardiovascular and neurodegenerative diseases. As a result of SOD administration, the majority of authors observed an increase in the content of endogenous antioxidant enzymes (SOD, catalase, glutathione peroxidase), i.e., stimulation of endogenous antioxidant defence and consequent reduction of oxidative stress, which may explain mechanisms of positive effects observed.

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The authors declare that there are no conflicts of interest present.