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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nmp</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Sklifosovsky Journal "Emergency Medical Care"</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-9022</issn><issn pub-type="epub">2541-8017</issn><publisher><publisher-name>“N.V. Sklifosovsky Research Institute for Emergency Medicine”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23934/2223-9022-2025-14-4-714-723</article-id><article-id custom-type="elpub" pub-id-type="custom">nmp-2282</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Разработка и валидация прогностической модели диагностики острого аппендицита у детей</article-title><trans-title-group xml:lang="en"><trans-title>Development and Validation of a Predictive Model for the Diagnosis of Acute Appendicitis in Children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-6993-2463</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пайзе</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Paise</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пайзе Ольга Николаевна, врач детский хирург хирургического отделения </p><p>432063, Ульяновск, ул. 3 Интернационала, д. 7</p></bio><bio xml:lang="en"><p>Olga N. Paize, Pediatric Surgeon, Surgical Department</p><p>3rd International Str. 7, Ulyanovsk, 432063</p></bio><email xlink:type="simple">helga@blamange.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8590-2350</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тонеев</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Toneev</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тонеев Евгений Александрович, кандидат медицинских наук, врач-торакальный хирург хирургического отделения торакальной онкологии ГУЗ ОКОД; доцент кафедры госпитальной хирургии им. В.И. Мидленко, ординатор кафедры акушерства и гинекологии медицинского факультета им. Т.З. Биктимирова Института медицины, экологии и физической культуры ФГБОУ ВО УлГУ</p><p>432017, Ульяновск, ул. Льва Толстого, д. 42,</p><p>432017, Ульяновск, ул. 12 Сентября, д. 90</p></bio><bio xml:lang="en"><p>Evgeny A. Toneev, Candidate of Medical Sciences, Thoracic Surgeon, Thoracic Oncology Surgical Department, Ulyanovsk Regional Oncological Dispensary; Associate Professor, V.I. Midlenko Department of Hospital Surgery; Resident, Obstetrics and Gynecology Department, T.Z. Biktimirov Faculty of Medicine, Institute of Medicine, Ecology, and Physical Culture, Ulyanovsk State University</p><p>1 Tolstoy Str. 42, Ulyanovsk, 432017,</p><p>12 September Str. 90, Ulyanovsk, 432017</p></bio><email xlink:type="simple">e.toneev@inbox.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-0218-666X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шагдалеев</surname><given-names>Р. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Shagdaleev</surname><given-names>R. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шагдалеев Роман Фатыхович, ассистент кафедры физиологии и патофизиологии, ординатор кафедры акушерства и гинекологии Института медицины, экологии и физической культуры ФГБОУ ВО УлГУ; врачторакальный хирург хирургического отделения торакальной онкологии ГУЗ ОКОД</p><p>432017, Ульяновск, ул. Льва Толстого, д. 42,</p><p>432017, Ульяновск, ул. 12 Сентября, д. 90</p></bio><bio xml:lang="en"><p>Roman F. Shagdaleev, Assistant Professor, Department of Physiology and Pathophysiology; Resident, Department of Obstetrics and Gynecology, Institute of Medicine, Ecology, and Physical Culture, Ulyanovsk State University; Thoracic Surgeon, Thoracic Oncology Surgical Department, Ulyanovsk Regional Oncological Dispensary</p><p>1 Tolstoy Str. 42, Ulyanovsk, 432017,</p><p>12 September Str. 90, Ulyanovsk, 432017</p></bio><email xlink:type="simple">roman.shagdaleev@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5724-6034</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Благовестнов</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Blagovestnov</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Благовестнов Дмитрий Алексеевич, профессор, доктор медицинских наук, заведующий кафедрой неотложной и общей хирургии имени профессора А.С. Ермолова </p><p>125993, Москва, ул. Баррикадная, д. 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Dmitry A. Blagovestnov, Professor, Doctor of Medical Sciences, Head, A.S. Ermolov Department of Emergency and General Surgery</p><p>Barrikadnaya Str. 2/1, bldg. 1, Moscow, 125993</p></bio><email xlink:type="simple">sklifkafedra@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6512-9361</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Староконь</surname><given-names>П. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Starokony</surname><given-names>P. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Староконь Павел Михайлович, профессор, доктор медицинских наук, старший преподаватель кафедры хирургии с курсом онкологии и лучевой диагностики филиала </p><p>107392, Москва, ул. Малая Черкизовская, д. 7</p></bio><bio xml:lang="en"><p>Pavel M. Starokony, Professor, Doctor of Medical Sciences, Senior Lecturer, Department of Surgery with a Course in Oncology and Diagnostic Radiology</p><p>Malaya Cherkizovskaya Str. 7, Moscow, 107392</p><p> </p></bio><email xlink:type="simple">oldhorse.pm@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0428-7454</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шабаев</surname><given-names>Р. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Shabaev</surname><given-names>R. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шабаев Рамис Маратович, кандидат медицинских наук, хирург-онколог (маммолог), пластический хирург, врач ультразвуковой диагностики, научный сотрудник кафедры неотложной и общей хирургии имени профессора А.С. Ермолова </p><p>125993, Москва, ул. Баррикадная, д. 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Ramis M. Shabaev, Candidate of Medical Sciences, Surgical Oncologist (Mammologist), Plastic Surgeon, Top-Category Physician, Sonographer, Researcher, A.S. Ermolov Department of Emergency and General Surgery</p><p>Barrikadnaya Str. 2/1, bldg. 1, Moscow, 125993 </p></bio><email xlink:type="simple">kampramis@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2781-6184</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Belova</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Белова Мария Александровна, студентка 5-го курса медицинского факультета им. Т.З. Биктимирова Института медицины, экологии и физической культуры </p><p>432017, Ульяновск, ул. Льва Толстого, д. 42</p></bio><bio xml:lang="en"><p>Mariia A. Belova, 5th-year Student, T.Z. Biktimirov Faculty of Medicine, Institute of Medicine, Ecology, and Physical Culture</p><p>1 Tolstoy Str. 42, Ulyanovsk, 432017</p></bio><email xlink:type="simple">belovamaria5102@gmail.com</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-0939-2287</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Терягова</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Teriagova</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Терягова Анастасия Дмитриевна, студентка 5-го курса медицинского факультета им. Т.З. Биктимирова Института медицины, экологии и физической культуры </p><p>432017, Ульяновск, ул. Льва Толстого, д. 42</p></bio><bio xml:lang="en"><p>Аnastasiia D. Teriagova, 5th-year Student, T.Z. Biktimirov Faculty of Medicine, Institute of Medicine, Ecology, and Physical Culture</p><p>1 Tolstoy Str. 42, Ulyanovsk, 432017</p></bio><email xlink:type="simple">tnastya1706med@mail.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-0617-2408</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куликова</surname><given-names>М. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulikova</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Куликова Минзалия Шевкетовна, студентка 5-го курса медицинского факультета им. Т.З. Биктимирова Института медицины, экологии и физической культуры </p><p>432017, Ульяновск, ул. Льва Толстого, д. 42</p></bio><bio xml:lang="en"><p>Minzaliya Sh. Kulikova, 5th-year Student, T.Z. Biktimirov Faculty of Medicine, Institute of Medicine, Ecology, and Physical Culture</p><p>1 Tolstoy Str. 42, Ulyanovsk, 432017</p></bio><email xlink:type="simple">minzalia16@gmail.com</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-5532-9112</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васильева</surname><given-names>К. Я.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasilieva</surname><given-names>K. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Васильева Ксения Ярославовна, студентка 5-го курса медицинского факультета им. Т.З. Биктимирова Института медицины, экологии и физической культуры </p><p>432017, Ульяновск, ул. Льва Толстого, д. 42</p></bio><bio xml:lang="en"><p>Kseniya Y. Vasilieva, 5th-year Student, T.Z. Biktimirov Faculty of Medicine, Institute of Medicine, Ecology, and Physical Culture</p><p>1 Tolstoy Str. 42, Ulyanovsk, 432017</p></bio><email xlink:type="simple">ksenya.ksyus.vasileva@mail.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-6167-4861</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крымская</surname><given-names>Ж. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Krymskaya</surname><given-names>Z. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Крымская Жанна Игоревна, студентка 5-го курса медицинского факультета им Т.З. Биктимирова, Институт медицины, экологии и физической культуры </p><p>432017, Ульяновск, ул. Льва Толстого, д. 42</p></bio><bio xml:lang="en"><p>Zhanna I. Krymskaya, 5th-year Student, T.Z. Biktimirov Faculty of Medicine, Institute of Medicine, Ecology, and Physical Culture</p><p>1 Tolstoy Str. 42, Ulyanovsk, 432017</p></bio><email xlink:type="simple">zhanna_krymskaya@mail.ru</email><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ГУЗ «Ульяновская областная детская клиническая больница имени политического и общественного деятеля Ю.Ф. Горячева»<country>Россия</country></aff><aff xml:lang="en">Ulyanovsk Regional Children’s Clinical Hospital<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБОУ ВО «Ульяновский государственный университет»;&#13;
ГУЗ «Областной клинический онкологический диспансер»<country>Россия</country></aff><aff xml:lang="en">Ulyanovsk State University;&#13;
Regional Oncology Dispensary<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» МЗ РФ<country>Россия</country></aff><aff xml:lang="en">Russian Medical Academy of Continuing Professional Education<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">Филиал ФГБВОУ ВО «Военно-медицинской академии имени С.М. Кирова» МО РФ<country>Россия</country></aff><aff xml:lang="en">Branch of the S. M. Kirov Military Medical Academy<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru">ФГБОУ ВО «Ульяновский государственный университет»<country>Россия</country></aff><aff xml:lang="en">Ulyanovsk State University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>30</day><month>01</month><year>2026</year></pub-date><volume>14</volume><issue>4</issue><fpage>714</fpage><lpage>723</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Пайзе О.Н., Тонеев Е.А., Шагдалеев Р.Ф., Благовестнов Д.А., Староконь П.М., Шабаев Р.М., Белова М.А., Терягова А.Д., Куликова М.Ш., Васильева К.Я., Крымская Ж.И., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Пайзе О.Н., Тонеев Е.А., Шагдалеев Р.Ф., Благовестнов Д.А., Староконь П.М., Шабаев Р.М., Белова М.А., Терягова А.Д., Куликова М.Ш., Васильева К.Я., Крымская Ж.И.</copyright-holder><copyright-holder xml:lang="en">Paise O.N., Toneev E.A., Shagdaleev R.F., Blagovestnov D.A., Starokony P.M., Shabaev R.M., Belova M.A., Teriagova A.D., Kulikova M.S., Vasilieva K.Y., Krymskaya Z.I.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jnmp.ru/jour/article/view/2282">https://www.jnmp.ru/jour/article/view/2282</self-uri><abstract><sec><title>Цель</title><p>Цель. Построить прогностическую модель прогнозирования наличия острого аппендицита (ОА) у пациентов детского возраста.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Исследование проведено на базе хирургического отделения ГУЗ «Ульяновская областная детская клиническая больница» в период с 01.09.2023 по 01.06.2024, в анализ были включены пациенты, которые поступили в стационар с подозрением на ОА. Всего в исследование были включены 400 пациентов, 300 из которых имели подтверждённый диагноз ОА и 100 — с другими дифференцируемыми заболеваниями. Была проведена оценка характеристик исследуемых пациентов по единому разработанному протоколу.</p></sec><sec><title>Результаты</title><p>Результаты. Однофакторный статистический анализ показал, что наиболее часто приходится дифференцировать данные патологии у детей 6–12 лет. Логистический регрессионный анализ показал, что наличие тошноты (ОШ 11,586; 95% ДИ 3,347– 40,125), количество лейкоцитов в крови (ОШ 1,52; 95% ДИ 1,343–1,721), количество лимфоцитов в крови (ОШ 0,59; 95% ДИ 0,371–0,939), возраст (ОШ 1,207; 95% ДИ 1,079–1,350), диаметр аппендикса более 6 мм (ОШ 32,691; 95% ДИ 12,846–83,179), наличие рвоты (ОШ 0,121; 95% ДИ 0,03–0,487) были независимыми факторами риска ОА у детей в проведении дифференциальной диагностики. Указанные переменные в логистическом регрессионном анализе включены в модель номограммы. Результаты проверки показали, что площадь под ROC-кривой составила 0,967±0,008 с 95% ДИ: 0,951–0,983. Полученная модель была статистически значимой (p&lt;0,001).</p></sec><sec><title>Вывод</title><p>Вывод. Разработана номограмма и прогностический интерактивный калькулятор для прогнозирования наличия острого аппендицита у детей при проведении дифференциальной диагностики с другими заболеваниями.</p></sec></abstract><trans-abstract xml:lang="en"><p>Objective To develop a predictive model for diagnosing acute appendicitis in pediatric patients.</p><p>Material and methods The study was conducted at the Surgical Department of Ulyanovsk Regional Children’s Clinical Hospital from September 1, 2023, to June 1, 2024. The analysis included patients admitted with suspected acute appendicitis. A total of 400 patients were included in the study, of which 300 were diagnosed with acute appendicitis, and 100 had functional bowel disorders. Patient characteristics were assessed using a standardized protocol.</p><p>Results Univariate statistical analysis showed that the differential diagnosis of these conditions is most frequently required in children aged 6–12 years. Logistic regression analysis indicated that nausea (OR 11.586; 95% CI 3.347–40.125), white blood cell count (OR 1.52; 95% CI 1.343–1.721), lymphocyte count (OR 0.59; 95% CI 0.371–0.939), age (OR 1.207; 95% CI 1.079–1.350), appendix diameter of &gt;6 mm (OR 32.691; 95% CI 12.846–83.179), and vomiting (OR 0.121; 95% CI 0.03–0.487) were independent risk factors for acute appendicitis in children during differential diagnosis. The identified variables were included in a nomogram using logistic regression analysis. The validation results showed that the area under the ROC curve was 0.967±0.008, with a 95% CI of 0.951–0.983. The developed model was statistically significant (p&lt;0.001).</p><p>Conclusion A nomogram and an interactive prognostic calculator were developed for predicting the presence of acute appendicitis in children, which can be used for differential diagnosis with functional bowel disorders.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>острый аппендицит у детей</kwd><kwd>дифференциальная диагностика острого аппендицита</kwd><kwd>функциональное расстройство кишечника</kwd><kwd>номограмма</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pediatric acute appendicitis</kwd><kwd>differential diagnosis of acute appendicitis</kwd><kwd>functional bowel disorder</kwd><kwd>nomogram</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ревишвили А.Ш. Хирургическая помощь в Российской Федерации. Москва; 2023. URL: https://главный хирург.рф/publication.html [Дата обращения 18.11.2025 г.]</mixed-citation><mixed-citation xml:lang="en">Revishvili ASh. Khirurgicheskaya pomoshch’ v Rossiyskoy Federatsii v 2023 godu. Moscow; 2023. (In Russ.) Available at: https://xn--80aebcyfls3aa6av0f.xn--p1ai/publication.html [Accessed Nov 18, 2025]</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Almaramhy HH. Acute appendicitis in young children less than 5 years: review article. Ital J Pediatr. 2017;43(1):15. PMID: 28257658 https://doi.org/10.1186/s13052-017-0335-2</mixed-citation><mixed-citation xml:lang="en">Almaramhy HH. Acute appendicitis in young children less than 5 years: review article. Ital J Pediatr. 2017;43(1):15. PMID: 28257658 https://doi.org/10.1186/s13052-017-0335-2</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Glass CC, Rangel SJ Overview and diagnosis of acute appendicitis in children. Semin Pediatr Surg. 2016;25(4):198–203. https://doi.org/10.1053/j.sempedsurg.2016.05.001</mixed-citation><mixed-citation xml:lang="en">Glass CC, Rangel SJ Overview and diagnosis of acute appendicitis in children. Semin Pediatr Surg. 2016;25(4):198–203. https://doi.org/10.1053/j.sempedsurg.2016.05.001</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Haijanen J, Sippola S, Tuominen R, Grönroos J, Paajanen H, Rautio T, et al. Cost analysis of antibiotic therapy versus appendectomy for treatment of uncomplicated acute appendicitis: 5-year results of the APPAC randomized clinical trial. PLoS One. 2019;14(7):e0220202. PMID: 31344073 https://doi.org/10.1371/journal.pone.0220202</mixed-citation><mixed-citation xml:lang="en">Haijanen J, Sippola S, Tuominen R, Grönroos J, Paajanen H, Rautio T, et al. Cost analysis of antibiotic therapy versus appendectomy for treatment of uncomplicated acute appendicitis: 5-year results of the APPAC randomized clinical trial. PLoS One. 2019;14(7):e0220202. PMID: 31344073 https://doi.org/10.1371/journal.pone.0220202</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Awayshih MMA, Nofal MN, Yousef AJ, et al. Evaluation of Alvarado score in diagnosing acute appendicitis. Pan Afr Med J. 2019:34:15. PMID: 31762884 https://doi.org/10.11604/pamj.2019.34.15.17803</mixed-citation><mixed-citation xml:lang="en">Awayshih MMA, Nofal MN, Yousef AJ, et al. Evaluation of Alvarado score in diagnosing acute appendicitis. Pan Afr Med J. 2019:34:15. PMID: 31762884 https://doi.org/10.11604/pamj.2019.34.15.17803</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Пайзе О.Н., Тонеев Е.А., Шагдалеев Р.Ф., Прохоров Д.Д., Белова М. А., Терягова А.Д. База данных острого аппендицита у детей по данным регионального учреждения здравоохранения. Свидетельство о государственной регистрации базы данных № 2024623069 Российская Федерация. Заявка № 2024622892: заявл. 04.07.2024: опубл. 12.07.2024</mixed-citation><mixed-citation xml:lang="en">Payze O.N., Toneev E.A., Shagdaleev R.F., Prokhorov D.D., Belova M.A., Teryagova A.D. Baza dannykh ostrogo appenditsita u detey po dannym regional’nogo uchrezhdeniya zdravookhraneniya. Certificate of state registration of the database No 2024623069 RU. No 2024622892: decl. 04.07.2024: publ. 12.07.2024</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Гаркави Л.Х. Адаптационные реакции и резистентность организма. Ростов-на-Дону: Издательство Ростовского университета;1990.</mixed-citation><mixed-citation xml:lang="en">Garkavi LKh. Adaptatsionnye reaktsii i rezistentnost’ organizma. Rostov-on-Don: Izdatel’stvo Rostovskogo universiteta Publ.;1990. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Разумовский А.Ю., Дронов А.Ф., Смирнов А.Н., Голованев М.А. Острый аппендицит у детей. Клинические рекомендации. Российский вестник детской хирургии, анестезиологии и реаниматологии. 2013;3(4):125–131.</mixed-citation><mixed-citation xml:lang="en">Razumovsky AY, Dronov AF, Smirnov AN, Golovanev MA. Acute Appendicitis in Children. Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care. 2013;3(4):125–131. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Пайзе О.Н., Тонеев Е.А., Шагдалее Р.Ф., Прохоров Д.Д., Белова М.А., Терягова А.Д. Способ прогнозирования риска наличия острого аппендицита у детей. Патент 2838313 C1 Российская Федерация, МПК G01N 33/48, A61B 17/00. заявл. 06.08.2024: опубл. 14.04.2025. URL: https://patents.google.com/patent/RU2838313C1/ [Дата обращения 18.11.2025 г.]</mixed-citation><mixed-citation xml:lang="en">Payze ON, Toneev EA, Shagdalee RF, Prokhorov DD, Belova MA, Teryagova AD. Sposob prognozirovaniya riska nalichiya ostrogo appenditsita u detey. Patent 2838313 C1 RU, IPC G01N 33/48, A61B 17/00. decl. 06.08.2024: publ. 14.04.2025. (In Russ.) Available at: https://patents.google.com/patent/RU2838313C1/ [Accessed Nov 18, 2025]</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Пайзе О.Н., Тонеев Е.А., Шагдалеев Р.Ф., Прохоров Д.Д., Белова М. А., Терягова А.Д. Калькулятор прогнозирования острого аппендицита у детей. Свидетельство о государственной регистрации программы для ЭВМ № 2024666386 Российская Федерация. Заявка № 2024665762; заявлено 02.07.2024: опубликовано 12.07.2024</mixed-citation><mixed-citation xml:lang="en">Payze ON, Toneev EA, Shagdaleev RF, Prokhorov DD, Belova MA, Teryagova AD. Kal’kulyator prognozirovaniya ostrogo appenditsita u detey. Certificate of state registration of a software No 2024666386 RU. No 2024665762; decl. 02.07.2024: publ. 12.07.2024.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Mekitarian Filho E, Horita SM, Dos Santos COG, Pelosi CS, Laurentino LP, Galotti BL. Management of Acute Appendicitis in Children in a University Hospital. Pediatr Emerg Care. 2023;39(11):832–835. PMID: 37902652 https://doi.org/10.1097/PEC.0000000000003059</mixed-citation><mixed-citation xml:lang="en">Mekitarian Filho E, Horita SM, Dos Santos COG, Pelosi CS, Laurentino LP, Galotti BL. Management of Acute Appendicitis in Children in a University Hospital. Pediatr Emerg Care. 2023;39(11):832–835. PMID: 37902652 https://doi.org/10.1097/PEC.0000000000003059</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Téoule P, Laffolie J, Rolle U, Reissfelder C. Acute Appendicitis in Childhood and Adulthood. Dtsch Arztebl Int. 2020;117(45):764–774. PMID: 33533331 https://doi.org/10.3238/arztebl.2020.0764</mixed-citation><mixed-citation xml:lang="en">Téoule P, Laffolie J, Rolle U, Reissfelder C. Acute Appendicitis in Childhood and Adulthood. Dtsch Arztebl Int. 2020;117(45):764–774. PMID: 33533331 https://doi.org/10.3238/arztebl.2020.0764</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Soundappan SS, Karpelowsky J, Lam A, Lam L, Lawrence TM, Cass D. Diagnostic accuracy of surgeon performed ultrasound (SPU) for appendicitis in children. J Pediatr Surg. 2018;53(10):2023–2027. https://doi.org/10.1016/j.jpedsurg.2018.05.014</mixed-citation><mixed-citation xml:lang="en">Soundappan SS, Karpelowsky J, Lam A, Lam L, Lawrence TM, Cass D. Diagnostic accuracy of surgeon performed ultrasound (SPU) for appendicitis in children. J Pediatr Surg. 2018;53(10):2023–2027. https://doi.org/10.1016/j.jpedsurg.2018.05.014</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Virmani S, Prabhu PS, Sundeep PT, Kumar V. Role of laboratory markers in predicting severity of acute appendicitis. Afr J Paediatr Surg. 2018;15(1):1–4. PMID: 30829300 https://doi.org/10.4103/ajps.AJPS_47_16</mixed-citation><mixed-citation xml:lang="en">Virmani S, Prabhu PS, Sundeep PT, Kumar V. Role of laboratory markers in predicting severity of acute appendicitis. Afr J Paediatr Surg. 2018;15(1):1–4. PMID: 30829300 https://doi.org/10.4103/ajps.AJPS_47_16</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Dooki ME, Nezhadan M, Mehrabani S, Osia S, Hadipoor A, Hajiahmadi M, et al. Diagnostic accuracy of laboratory markers for diagnosis of acute appendicitis in children. Wien Med Wochenschr. 2022;172(13–14):303–307. PMID: 35006517 https://doi.org/10.1007/s10354-021-00898-8</mixed-citation><mixed-citation xml:lang="en">Dooki ME, Nezhadan M, Mehrabani S, Osia S, Hadipoor A, Hajiahmadi M, et al. Diagnostic accuracy of laboratory markers for diagnosis of acute appendicitis in children. Wien Med Wochenschr. 2022;172(13–14):303–307. PMID: 35006517 https://doi.org/10.1007/s10354-021-00898-8</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Jiang J, Wu Y, Tang Y, Shen Z, Chen G, Huang Y, et al. A novel nomogram for the differential diagnosis between advanced and early appendicitis in pediatric patients. Biomark Med. 2019;13(14):1157–1173. PMID: 31559834 https://doi.org/10.2217/bmm-2019-0036</mixed-citation><mixed-citation xml:lang="en">Jiang J, Wu Y, Tang Y, Shen Z, Chen G, Huang Y, et al. A novel nomogram for the differential diagnosis between advanced and early appendicitis in pediatric patients. Biomark Med. 2019;13(14):1157–1173. PMID: 31559834 https://doi.org/10.2217/bmm-2019-0036</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Blok G, Burger H, van der Lei J, Berger M, Holtman G. Development and validation of a clinical prediction rule for acute appendicitis in children in primary care. Eur J Gen Pract. 2023;29(1):2233053. PMID: 37578416 https://doi.org/doi:10.1080/13814788.2023.2233053</mixed-citation><mixed-citation xml:lang="en">Blok G, Burger H, van der Lei J, Berger M, Holtman G. Development and validation of a clinical prediction rule for acute appendicitis in children in primary care. Eur J Gen Pract. 2023;29(1):2233053. PMID: 37578416 https://doi.org/doi:10.1080/13814788.2023.2233053</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
