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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nmp</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Sklifosovsky Journal "Emergency Medical Care"</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-9022</issn><issn pub-type="epub">2541-8017</issn><publisher><publisher-name>“N.V. Sklifosovsky Research Institute for Emergency Medicine”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23934/2223-9022-2025-14-3-571-57</article-id><article-id custom-type="elpub" pub-id-type="custom">nmp-2213</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>осложнения у больных инфарктом миокарда с подъёмом сегмента ST. данные исследования</article-title><trans-title-group xml:lang="en"><trans-title>ST-segment Elevation Myocardial Infarction. Study Data</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9458-7305</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузьмина</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuzmina</surname><given-names>I. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кузьмина Ирина Михайловна, кандидат медицинских наук, врач-кардиолог, заведующая научным отделением неотложной кардиологии для больных инфарктом миокарда,</p><p>129090, Москва, Большая Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Irina M. Kuzmina, Candidate of Medical Sciences, Cardiologist, Head of the Scientific Department of Emergency Cardiology for Patients with Myocardial Infarction,</p><p>Bolshaya Sukharevskaya Sq. 3, Moscow, 129090</p></bio><email xlink:type="simple">kuzminaim@sklif.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гвинджилия</surname><given-names>Т. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Gvindzhilia</surname><given-names>T. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гвинджилия Тамара Романовна, младший научный сотрудник отделения неотложной кардиологии для больных инфарктом миокарда,</p><p>129090, Москва, Большая Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Tamara R. Gvindzhilia, Junior Researcher, Department of Emergency Cardiology for Patients with Myocardial Infarction,</p><p>Bolshaya Sukharevskaya Sq. 3, Moscow, 129090</p></bio><email xlink:type="simple">gvindzhiliatr@sklif.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1002-6629</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мурадян</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Muradyan</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мурадян Нина Араиковна, врач-кардиолог, научный сотрудник отделения неотложной кардиологии для больных инфарктом миокарда,</p><p>129090, Москва, Большая Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Nina A. Muradyan, Cardiologist, Researcher, Emergency Cardiology Department for Patients with Myocardial Infarction, </p><p>Bolshaya Sukharevskaya Sq. 3, Moscow, 129090</p></bio><email xlink:type="simple">muradyanna@sklif.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0746-1884</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хубутия</surname><given-names>М. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Khubutiya</surname><given-names>M. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хубутия Могели Шалвович, академик РАН, профессор, доктор медицинских наук, президент,</p><p>129090, Москва, Большая Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Mogeli Sh. Khubutiya, Academician of the Russian Academy of Sciences, Professor, Doctor of Medical Sciences, President,</p><p>Bolshaya Sukharevskaya Sq. 3, Moscow, 129090</p></bio><email xlink:type="simple">khubutiyams@sklif.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1493-4544</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Загребельный</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zagrebelny</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Загребельный Александр Васильевич, кандидат медицинских наук, врач кардиолог отделения неотложной кардиологии для больных инфарктом миокарда,</p><p>129090, Москва, Большая Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Aleksandr V. Zagrebelny, Candidate of Medical Sciences, Cardiologist, Emergency Cardiology Department for Patients with Myocardial Infarction, </p><p>Bolshaya Sukharevskaya Sq. 3, Moscow, 129090</p></bio><email xlink:type="simple">zagrebelniav@sklif.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ломакин</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lomakin</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ломакин Никита Валерьевич, доцент, доктор медицинских наук, заведующий кардиологическим отделением № 2 (для проведения рентгенхирургических методов лечения) (с палатами реанимации и интенсивной терапии), 121359, Москва, ул. Маршала Тимошенко, д. 15;</p><p>заведующий кафедрой кардиологии, 123242, Москва, ул. Баррикадная, д. 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Nikita V. Lomakin, Docent, Doctor of Medical Sciences, Head of Cardiology Department No. 2 (for carrying out X-ray surgical treatment methods) (with intensive care and resuscitation wards), Marshal Timoshenko Str. 15, Moscow, 121359;</p><p>Barrikadnaya Str. 2/1, bldg. 1, Moscow, 123242</p></bio><email xlink:type="simple">lomakinnikita@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»<country>Россия</country></aff><aff xml:lang="en">N.V. Sklifosovsky Research Institute for Emergency Medicine<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБУ «Центральная клиническая больница с поликлиникой» УДП РФ;&#13;
 ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» МЗ РФ<country>Россия</country></aff><aff xml:lang="en">Central Clinical Hospital with a Polyclinic;&#13;
Russian Medical Academy of Continuous Professional Education<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>24</day><month>09</month><year>2025</year></pub-date><volume>14</volume><issue>3</issue><fpage>571</fpage><lpage>577</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кузьмина И.М., Гвинджилия Т.Р., Мурадян Н.А., Хубутия М.Ш., Загребельный А.В., Ломакин Н.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Кузьмина И.М., Гвинджилия Т.Р., Мурадян Н.А., Хубутия М.Ш., Загребельный А.В., Ломакин Н.В.</copyright-holder><copyright-holder xml:lang="en">Kuzmina I.M., Gvindzhilia T.R., Muradyan N.A., Khubutiya M.S., Zagrebelny A.V., Lomakin N.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jnmp.ru/jour/article/view/2213">https://www.jnmp.ru/jour/article/view/2213</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность.  Сердечно-сосудистые заболевания остаются лидирующей причиной инвалидизации и смертности населения разного возраста не только в России, но и в других развитых странах. Смерть при инфаркте миокарда (ИМ) наступает от его осложнений. Создание сосудистых центров в Российской Федерации, а также применение современных технологий для оказания специализированной помощи при остром коронарном синдроме (ОКС) однозначно привели к снижению случаев осложнённого течения ИМ и показателей летальности в целом. Вместе с тем ещё достаточно частая встречаемость этих опасных для жизни состояний требует дальнейших усилий для повышения качества их диагностики и лечения.</p></sec><sec><title>Цель</title><p>Цель. Изучить течение осложнённого ИМ и оценить частоту его ранних и поздних осложнений.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В исследование включены 2172 пациента, которые находились на лечении в отделении неотложной кардиологии для больных ИМ НИИ СП им. Н.В. Склифосовского за период с 2011 по 2021 год с осложнённым ИМ. Данная когорта составила 79% от общего числа госпитализированных (n=2741) за указанный период наблюдения. Всем больным были выполнены необходимые методы диагностики и проведено лечение на современном уровне.</p></sec><sec><title>Результаты</title><p>Результаты. В статье приведены сведения о результатах лечения пациентов с осложнённым течением ИМ за период с 2011 по 2021 год. Проведен анализ частоты развития различных осложнений ИМ, учитывая современный подход к оказанию специализированной помощи пациентам с ОКС в рамках регионального сосудистого центра. В результате выполненного исследования изучены осложнения при остром ИМ, частота их развития и разработаны алгоритмы оптимизации современного подхода к диагностике, профилактике и лечению этих осложнений. В ходе проведенного исследования отмечено в большей части случаев статистически значимое уменьшение частоты таких осложнений в 1,5–15 раз, особенно ранней постинфарктной стенокардии, формирования аневризмы левого желудочка, механических повреждений миокарда (разрывы миокарда), а также развития синдрома Дресслера.</p></sec><sec><title>Заключение</title><p>Заключение. Установлено, что по мере совершенствования оказания специализированной помощи пациентам с острым коронарным синдромом с подъёмом сегмента ST в рамках деятельности сети сосудистых центров наблюдается снижение количества осложнений на разных сроках заболевания и смертности в целом. Однако такие осложнения, как кардиогенный шок, сердечная недостаточность диктуют необходимость дальнейшего изучения и разработки современных методов их профилактики и лечения.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. Kardiovascular diseases remain the leading cause of disability and mortality among people of all ages, not only in Russia, but also in other developed countries. Death from myocardial infarction occurs from its complications. The creation of vascular centers in the Russian Federation, as well as the use of modern technologies for the provision of specialized care for acute coronary syndrome (ACS) have clearly led to a decrease in cases of complicated myocardial infarction and mortality rates from them in general. At the same time, the still fairly frequent occurrence of these life-threatening conditions requires further efforts to improve the quality of their diagnosis and treatment.</p></sec><sec><title>Aim of Study</title><p>Aim of Study. To study the course of complicated myocardial infarction (MI) and assess the frequency of its early and late complications.</p></sec><sec><title>Material and Methods</title><p>Material and Methods. The study included 2,172 patients who were treated in the emergency cardiology department for patients with MI of the N.V. Sklifosovsky Research Institute for Emergency Medicine for the period from 2011 to 2021 with complicated MI. This cohort accounted for 79% of the total number of hospitalized patients (n=2,741) during the specified observation period. All patients underwent the necessary diagnostic methods and received treatment at a modern level.</p></sec><sec><title>Results</title><p>Results. The article presents information on the treatment outcomes of patients with complicated MI for the period from 2011 to 2021. The frequency of various MI complications was analyzed, taking into account the modern approach to providing specialized care to patients with ACS within the regional vascular center. As a result of the study, complications in acute myocardial infarction, their frequency of development were studied and algorithms for optimizing the modern approach to diagnosis, prevention and treatment of these complications were developed. The study noted a statistically significant decrease in the frequency of such complications by 1.5–15 times in most cases, especially early post-infarction angina, left ventricular aneurysm formation, mechanical myocardial damage (myocardial ruptures), as well as the development of Dressler syndrome.</p></sec><sec><title>Conclusion</title><p>Conclusion. It has been established that as specialized care for patients with acute coronary syndrome with ST segment elevation improves within the framework of the network of vascular centers, a decrease in the number of complications at different stages of the disease and mortality in general is observed. However, complications such as cardiogenic shock and heart failure dictate the need for further study and development of modern methods for their prevention and treatment.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>острый инфаркт миокарда</kwd><kwd>осложнения</kwd><kwd>разрыв миокарда</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute myocardial infarction</kwd><kwd>complications</kwd><kwd>myocardial rupture</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Сыркин А.Л., Новикова Н.А., Терехин С.А. Острый коронарный синдром. Москва: МИА, 2010.</mixed-citation><mixed-citation xml:lang="en">Syrkin AL, Novikova NA, Terekhin SA. Ostryy koronarnyy sindrom. Moscow: MIA Publ., 2010. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Семакина С.В., Сайгитов Р.Т., Глезер М.Г. 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