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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nmp</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Sklifosovsky Journal "Emergency Medical Care"</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-9022</issn><issn pub-type="epub">2541-8017</issn><publisher><publisher-name>“N.V. Sklifosovsky Research Institute for Emergency Medicine”</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">nmp-221</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>ОЦЕНКА АДЕКВАТНОСТИ МУЛЬТИМОДАЛЬНОЙ АНАЛГЕЗИИ В ПЕРИОПЕРАЦИОННОМ ПЕРИОДЕ ПРИ ДЛИТЕЛЬНЫХ ТРАВМАТИЧНЫХ ОПЕРАТИВНЫХ ВМЕШАТЕЛЬСТВАХ</article-title><trans-title-group xml:lang="en"><trans-title>ESTIMATION OF MULTI-MODAL ANALGESIA ADEQUACY IN THE PERIOPERATIVE PERIOD AT LONG-TERMED TRAUMATIZING ABDOMINAL OPERATIVE INTERVENTIONS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шарипова</surname><given-names>В. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Sharipova</surname><given-names>V. Kh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., заведующая</p><p>операционно-анестезиологическое отделение</p></bio><email xlink:type="simple">visolat_78@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Республиканский научный центр экстренной медицинской помощи, Ташкент<country>Узбекистан</country></aff><aff xml:lang="en">Republic Research Center of Emergency Medical Care, Tashkent<country>Uzbekistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>03</day><month>04</month><year>2016</year></pub-date><volume>0</volume><issue>3</issue><fpage>16</fpage><lpage>22</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шарипова В.Х., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Шарипова В.Х.</copyright-holder><copyright-holder xml:lang="en">Sharipova V.K.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jnmp.ru/jour/article/view/221">https://www.jnmp.ru/jour/article/view/221</self-uri><abstract><sec><title>ЦЕЛЬ ИССЛЕДОВАНИЯ</title><p>ЦЕЛЬ ИССЛЕДОВАНИЯ. Совершенствование методов периоперационной мультимодальной аналгезии при длительных травматичных абдоминальных оперативных вмешательствах с оценкой их эффективности.</p></sec><sec><title>МАТЕРИАЛ И МЕТОДЫ</title><p>МАТЕРИАЛ И МЕТОДЫ. Обследованы 86 больных, которых разделили на три группы в зависимости от метода анестезии и послеоперационного обезболивания.</p></sec><sec><title>РЕЗУЛЬТАТЫ</title><p>РЕЗУЛЬТАТЫ. Выявлена эффективность периоперационной мультимодальной аналгезии с применением средств, воздействующих на все звенья патогенеза боли. Выявлены минимальное напряжение параметров центральной и периферической гемодинамики, менее выраженный болевой синдром в послеоперационном периоде, а также экономический эффект, проявляющийся снижением потребления наркотических анальгетиков как в интра­, так и в послеоперационном периоде.</p></sec><sec><title>ЗАКЛЮЧЕНИЕ</title><p>ЗАКЛЮЧЕНИЕ. Разработана схема периоперационной мультимодальной аналгезии при длительных травматичных абдоминальных оперативных вмешательствах, позволяющая улучшить качество анестезиологического пособия и послеоперационного обезболивания. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>PURPOSE OF THE STUDY</title><p>PURPOSE OF THE STUDY. Improvement of perioperative multimodal analgesia at long­termed traumatizing abdominal interventions with estimation of its effectiveness.</p></sec><sec><title>MATERIALS AND METHODS</title><p>MATERIALS AND METHODS. Eighty six patients have been examined and divided into 3 groups depending on anesthesia and postoperative pain relief methods.</p></sec><sec><title>RESULTS</title><p>RESULTS. The effectiveness of perioperative multi­modal analgesia using methods affecting the whole pathogenesis of pain has been revealed. Minimal stress of central and peripheral hemodynamics parameters, less evident pain syndrome in the post­operative period, economic effect shown up by the decrease of the use of narcotic analgesics both in intra­ and post­operative period have been observed.</p></sec><sec><title>CONCLUSION</title><p>CONCLUSION. Algorithm of perioperative multi­modal analgesia at long­termed and traumatizing abdominal operative interventions has been developed. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>мультимодальная аналгезия</kwd><kwd>боль</kwd><kwd>эпидуральная блокада</kwd></kwd-group><kwd-group xml:lang="en"><kwd>multimodal analgesia</kwd><kwd>pain</kwd><kwd>epidural block</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гилдасио С. Оливейра, Дипти Агаруал, Бензон Онорио Т. Периоперационное введение однократной дозы кеторолака предупреждает развитие болевого синдрома в послеоперационном периоде: метаанализ рандомизированных клинических испытаний // Регионар. анест. и лечение острой боли. – 2012. – № 2. – С. 16–31. De Oliveyra G.S., Agarual D., Benzon O.T. Perioperatsionnoe vvedenie odnokratnoy dozy ketorolaka preduprezhdaet razvitie bolevogo sindroma v posleoperatsionnom periode: metaanaliz randomizirovannykh klinicheskikh ispytaniy [Perioperative single dose Ketorolac prevents the development of pain syndrome in the postoperative period: a metaanalysis of randomized clinical trials]. Regionarnaya anesteziya i lechenie ostroy boli. 2012; 2 (16-31). (In Russian).</mixed-citation><mixed-citation xml:lang="en">Гилдасио С. Оливейра, Дипти Агаруал, Бензон Онорио Т. Периоперационное введение однократной дозы кеторолака предупреждает развитие болевого синдрома в послеоперационном периоде: метаанализ рандомизированных клинических испытаний // Регионар. анест. и лечение острой боли. – 2012. – № 2. – С. 16–31. De Oliveyra G.S., Agarual D., Benzon O.T. Perioperatsionnoe vvedenie odnokratnoy dozy ketorolaka preduprezhdaet razvitie bolevogo sindroma v posleoperatsionnom periode: metaanaliz randomizirovannykh klinicheskikh ispytaniy [Perioperative single dose Ketorolac prevents the development of pain syndrome in the postoperative period: a metaanalysis of randomized clinical trials]. Regionarnaya anesteziya i lechenie ostroy boli. 2012; 2 (16-31). (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kishore K., Agarwal A., Gaur A. Acute pain service // Saudi J. Anaesth. – 2011. – Vol. 5, N. 2. – P. 123–124.</mixed-citation><mixed-citation xml:lang="en">Kishore K., Agarwal A., Gaur A. Acute pain service // Saudi J. Anaesth. – 2011. – Vol. 5, N. 2. – P. 123–124.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Форрест, Дж. Б., Камю Ф., Гриени И.А. и др. Кеторолак, диклофенак и кетопрофен одинаково безопасны при лечении боли после обширных хирургических вмешательств // Регионар. анест. и лечение острой боли. – 2013. – № 4. – С. 35–43. Forrest, Dzh. B., Kamyu F., Grieni I.A., et al. Ketorolak, diklofenak i ketoprofen odinakovo bezopasny pri lechenii boli posle obshirnykh khirurgicheskikh vmeshatel’stv [Ketorolac, diclofenac and Ketoprofen are equally safe in the treatment of pain after extensive surgery]. Regionarnaya anesteziya i lechenie ostroy boli. 2013; 4: 35–43. (In Russian).</mixed-citation><mixed-citation xml:lang="en">Форрест, Дж. Б., Камю Ф., Гриени И.А. и др. Кеторолак, диклофенак и кетопрофен одинаково безопасны при лечении боли после обширных хирургических вмешательств // Регионар. анест. и лечение острой боли. – 2013. – № 4. – С. 35–43. Forrest, Dzh. B., Kamyu F., Grieni I.A., et al. Ketorolak, diklofenak i ketoprofen odinakovo bezopasny pri lechenii boli posle obshirnykh khirurgicheskikh vmeshatel’stv [Ketorolac, diclofenac and Ketoprofen are equally safe in the treatment of pain after extensive surgery]. Regionarnaya anesteziya i lechenie ostroy boli. 2013; 4: 35–43. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Chandrakantan A., Glass P.S. Multimodal therapies for postoperative nausea and vomiting, and pain // Brit. J. Anesth. – 2011. – Vol. 107, Suppl. 1. – P. 27–40.</mixed-citation><mixed-citation xml:lang="en">Chandrakantan A., Glass P.S. Multimodal therapies for postoperative nausea and vomiting, and pain // Brit. J. Anesth. – 2011. – Vol. 107, Suppl. 1. – P. 27–40.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Dullenkopf A., Müller R., Dillmann F., et al. An intraoperative pre-incision single dose of intravenous ketamine does not have an effect on postoperative analgesic requirements under clinical conditions // Anaesth. Intens. Care. – 2009. – Vol. 37, N. 5.– P. 753–757.</mixed-citation><mixed-citation xml:lang="en">Dullenkopf A., Müller R., Dillmann F., et al. An intraoperative pre-incision single dose of intravenous ketamine does not have an effect on postoperative analgesic requirements under clinical conditions // Anaesth. Intens. Care. – 2009. – Vol. 37, N. 5.– P. 753–757.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hughes M.J., Ventham N.T., McNally S., et al. Analgesia after Open Abdominal Surgery in the Setting of Enhanced Recovery Surgery. A Systematic Review and Meta-analysis. // J.A.M.A. – 2014. – Vol. 149, N. 12. – P. 1224–1230.</mixed-citation><mixed-citation xml:lang="en">Hughes M.J., Ventham N.T., McNally S., et al. Analgesia after Open Abdominal Surgery in the Setting of Enhanced Recovery Surgery. A Systematic Review and Meta-analysis. // J.A.M.A. – 2014. – Vol. 149, N. 12. – P. 1224–1230.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Долгунов А.М., Шуматов В.Б., Полежаев А.А., Силин Н.В. Упреждающая мультимодальная аналгезия кетопрофеном и морфином в торакальной хирургии // Pacific. Med. J. – 2010. – № 3. – С. 59–61. Dolgunov A.M., Shumatov V.B., Polezhaev A.A., Silin N.V. Uprezhdayushchaya mul’timodal’naya analgeziya ketoprofenom i morfinom v torakal’noy khirurgii [Pre-emptive multimodal analgesia with Ketoprofenand morphine inthoracic surgery]. Pacific Med J. 2010; 3: 59–61. (In Russian).</mixed-citation><mixed-citation xml:lang="en">Долгунов А.М., Шуматов В.Б., Полежаев А.А., Силин Н.В. Упреждающая мультимодальная аналгезия кетопрофеном и морфином в торакальной хирургии // Pacific. Med. J. – 2010. – № 3. – С. 59–61. Dolgunov A.M., Shumatov V.B., Polezhaev A.A., Silin N.V. Uprezhdayushchaya mul’timodal’naya analgeziya ketoprofenom i morfinom v torakal’noy khirurgii [Pre-emptive multimodal analgesia with Ketoprofenand morphine inthoracic surgery]. Pacific Med J. 2010; 3: 59–61. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Elia N., Lysakowski C., Tramer M. Concomitant use of non-opioid analgesic sand morphine after major surgery – is the clinically relevant morphine sparing effect? A meta–analysis of randomized trials // Europ. J. Anaesth. – 2005. – Vol. 22, Suppl. 34. – P. 187. – A726.</mixed-citation><mixed-citation xml:lang="en">Elia N., Lysakowski C., Tramer M. Concomitant use of non-opioid analgesic sand morphine after major surgery – is the clinically relevant morphine sparing effect? A meta–analysis of randomized trials // Europ. J. Anaesth. – 2005. – Vol. 22, Suppl. 34. – P. 187. – A726.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Albi-Feldzer A., Mouret-Fourme E., Hamouda S., et al. A double-blind randomized trial of wound and intercostal space infiltration with ropivacaine during breast cancer surgery: effects on chronic postoperative pain // Anesthesiology. – 2013. – Vol. 118, N. 2. – P. 318–326.</mixed-citation><mixed-citation xml:lang="en">Albi-Feldzer A., Mouret-Fourme E., Hamouda S., et al. A double-blind randomized trial of wound and intercostal space infiltration with ropivacaine during breast cancer surgery: effects on chronic postoperative pain // Anesthesiology. – 2013. – Vol. 118, N. 2. – P. 318–326.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
