nmpЖурнал им. Н.В. Склифосовского «Неотложная медицинская помощь»Russian Sklifosovsky Journal "Emergency Medical Care"2223-90222541-8017“N.V. Sklifosovsky Research Institute for Emergency Medicine”10.23934/2223-9022-2025-14-2-398-405nmp-2185Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSИсторические аспекты применения кардиоплегического раствора по Del NidoHistorical Aspects of the Application of a Cardioplegic Solution Del Nidohttps://orcid.org/0000-0002-3904-6415КомаровР. Н.KomarovR. N.

Комаров Роман Николаевич - профессор, доктор медицинских наук, заведующий кафедрой сердечно-сосудистой хирургии Института профессионального образования.

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Roman N. Komarov - Full Professor, Doctor of Medical Sciences, Head, Department of Cardiovascular Surgery, Institute of Professional Education.

Trubetskaya Str. 8, bldg. 2, Moscow, 119991

rnkomarov@mail.ruhttps://orcid.org/0000-0002-2252-7773ТкачёвМ. И.TkachevM. I.

Ткачёв Максим Игоревич - кандидат медицинских наук, доцент кафедры сердечно-сосудистой хирургии Института профессионального образования.

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Maxim I. Tkachev - Candidate of Medical Sciences, Associate Professor, Department of Cardiovascular Surgery, Institute of Professional Education.

Trubetskaya Str. 8, bldg. 2, Moscow, 119991

maximtkachev1997@gmail.comhttps://orcid.org/0009-0006-4043-9116ШумаховаА. О.ShumakhovaA. O.

Шумахова Ариана Османовна - студентка 6-го курса.

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Ariana O. Shumakhova - 6th-year Student.

Trubetskaya Str. 8, bldg. 2, Moscow, 119991

arianashumahova@yandex.ruhttps://orcid.org/0009-0002-4132-2113ПанешЕ. Б.PaneshE. B.

Панеш Елена Батырбиевна - студентка 5-го курса.

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Elena B. Panesh - 5th-year Sudent.

Trubetskaya Str. 8, bldg. 2, Moscow, 119991

apanesh96@mail.ruhttps://orcid.org/0000-0002-9599-8154ОрешинаЯ. С.OreshinaY. S.

Орешина Яна Сергеевна - студентка 6-го курса.

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Yana S. Oreshina - 6th-year Student.

Trubetskaya Str. 8, bldg. 2, Moscow, 119991

oreshyana07@mail.ruhttps://orcid.org/0009-0001-7596-6374ТроеглазоваП. В.TroeglazovaP. V.

Троеглазова Полина Витальевна - студентка 6-го курса.

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Polina V. Troeglazova - 6th-year Student.

Trubetskaya Str. 8, bldg. 2, Moscow, 119991

polinatroeglazova@yandex.ruhttps://orcid.org/0009-0002-6221-8219БелованецА. А.BelovanetsA. A.

Белованец Артём Андреевич - студент 6-го курса.

119991, Москва, ул. Трубецкая, д. 8, стр. 2

abelovanets@mail.ruhttps://orcid.org/0009-0000-2060-9057МихайловМ. В.MikhailovM. V.

Михайлов Михаэль Вадимович - студент 6-го.

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Mikhail V. Mikhailov - 6th-year Student.

Trubetskaya Str. 8, bldg. 2, Moscow, 119991

simantov@yandex.ruФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» МЗ РФ (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University)Russian Federation202506092025142398405Copyright © Комаров Р.Н., Ткачёв М.И., Шумахова А.О., Панеш Е.Б., Орешина Я.С., Троеглазова П.В., Белованец А.А., Михайлов М.В., 20252025Комаров Р.Н., Ткачёв М.И., Шумахова А.О., Панеш Е.Б., Орешина Я.С., Троеглазова П.В., Белованец А.А., Михайлов М.В.Komarov R.N., Tkachev M.I., Shumakhova A.O., Panesh E.B., Oreshina Y.S., Troeglazova P.V., Belovanets A.A., Mikhailov M.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jnmp.ru/jour/article/view/2185

Кардиоплегия является неотъемлемым и важным методом защиты миокарда у пациентов всех возрастов, нуждающихся в кардиохирургическом вмешательстве, при котором необходимо остановить сердце. Для этого были разработаны многочисленные растворы и методы доставки. Раствор Del Nido используется уже 30 лет в Бостонской детской больнице. Это уникальный раствор, состоящий из четырёх частей кристаллоида и одной части цельной крови, который обычно используется в разовой дозировке. Несмотря на то, что изначально препарат был разработан для использования в педиатрии и у младенцев, в последнее время расширяется его использование в кардиохирургии для взрослых.

Cardioplegia is an integral and important method of myocardial protection in patients of all ages requiring cardiac surgery in which cardiac arrest is necessary. Numerous solutions and delivery methods have been developed. Del Nido solution has been used for 30 years at Boston Children’s Hospital. It is a unique solution consisting of four parts crystalloid and one part whole blood that is typically used in a single dose. Although the drug was originally developed for use in pediatrics and infants, its use in adult cardiac surgery has recently been expanding.

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The authors declare that there are no conflicts of interest present.