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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nmp</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Sklifosovsky Journal "Emergency Medical Care"</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-9022</issn><issn pub-type="epub">2541-8017</issn><publisher><publisher-name>“N.V. Sklifosovsky Research Institute for Emergency Medicine”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23934/2223-9022-2025-14-1-178-185</article-id><article-id custom-type="elpub" pub-id-type="custom">nmp-2075</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Борьба с болевым синдромом травматического генеза при оказании скорой медицинской помощи</article-title><trans-title-group xml:lang="en"><trans-title>Management of Trauma Pain in the Emergency Medicine</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6879-5378</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пиковский</surname><given-names>В. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Pikovskii</surname><given-names>V. J.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пиковский Вадим Юльевич - кандидат медицинских наук, доцент кафедры скорой медицинской помощи ФГБОУ ВО «РосУниМед» МЗ РФ; главный внештатный специалист по анестезиологии и реаниматологии ГБУ города Москвы «ССиНМП им. А.С. Пучкова».</p><p>127006, Москва, ул. Долгоруковская, д. 4; 129090, Москва, 1-й Коптельский пер., д. 3, стр. 1</p></bio><bio xml:lang="en"><p>Vadim Yu. Pikovskii - Candidate of Medical Sciences, Associate Professor, Department of Emergency Medical Care, Russian University of Medicine; Chief Freelance Specialist in Anesthesiology and Resuscitation, A.S. Puchkov Ambulance and Emergency Medical Care Station.</p><p>Dolgorukovskaya Str. 4, Moscow, 127006; 1st Koptelsky per. 3, bldg. 1, Moscow, 129090</p></bio><email xlink:type="simple">pikovskyvadim@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8399-0796</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барклая</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Barklaya</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Барклая Вадим Ильич - кандидат мединских наук, доцент кафедры скорой медицинской помощи ФГБОУ ВО «РосУниМед» МЗ РФ.</p><p>127006, Москва, ул. Долгоруковская, д. 4</p></bio><bio xml:lang="en"><p>Vadim I. Barklaya - Candidate of Medical Sciences, Associate Professor, Department of Emergency Medical Care, Russian University of Medicine.</p><p>Dolgorukovskaya Str. 4, Moscow, 127006</p></bio><email xlink:type="simple">barklaya@rambler.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4063-9648</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Давыдов</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Davidov</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Давыдов Петр Александрович - заместитель главного врача ГБУ города Москвы «ССиНМП им. А.С. Пучкова».</p><p>129090, Москва, 1-й Коптельский пер., д. 3, стр. 1</p></bio><bio xml:lang="en"><p>Petr A. Davidov - Deputy Chief Physician, A.S. Puchkov Ambulance and Emergency Medical Care Station.</p><p>1st Koptelsky per. 3, bldg. 1, Moscow, 129090</p></bio><email xlink:type="simple">peotr.davidov@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУ ВО «Российский университет медицины» МЗ РФ; ГБУ города Москвы «Станция скорой и неотложной медицинской помощи им. А.С. Пучкова» ДЗМ<country>Россия</country></aff><aff xml:lang="en">Russian University of Medicine; A.S. Puchkov Ambulance and Emergency Medical Care Station<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБОУ ВО «Российский университет медицины» МЗ РФ<country>Россия</country></aff><aff xml:lang="en">Russian University of Medicine<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">ГБУ города Москвы «Станция скорой и неотложной медицинской помощи им. А.С. Пучкова» ДЗМ<country>Россия</country></aff><aff xml:lang="en">A.S. Puchkov Ambulance and Emergency Medical Care Station<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>14</day><month>04</month><year>2025</year></pub-date><volume>14</volume><issue>1</issue><fpage>178</fpage><lpage>185</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Пиковский В.Ю., Барклая В.И., Давыдов П.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Пиковский В.Ю., Барклая В.И., Давыдов П.А.</copyright-holder><copyright-holder xml:lang="en">Pikovskii V.J., Barklaya V.I., Davidov P.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jnmp.ru/jour/article/view/2075">https://www.jnmp.ru/jour/article/view/2075</self-uri><abstract><p>Обзор литературы посвящён современным принципам борьбы с болевым синдромом травматического генеза в практике скорой медицинской помощи. Описаны возможности оценки интенсивности боли, отражены доступные методы аналгезии, в том числе актуальные данные об ингаляционной аналгезии метоксифлураном.</p></abstract><trans-abstract xml:lang="en"><p>The literature review is devoted to modern principles of acute pain management of traumatic genesis in the practice of emergency medical care. It describes the capability of pain intensity evaluation, and available methods of analgesia and pain relief medication. Special emphasis is laid on current data on inhaled methoxyflurane analgesia.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>боль травматического генеза</kwd><kwd>обезболивание</kwd><kwd>скорая медицинская помощь</kwd><kwd>метоксифлуран</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute pain</kwd><kwd>analgesia</kwd><kwd>emergency medical care</kwd><kwd>methoxyflurane</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Калюжный Л.В. Физиологические механизмы регуляции болевой чувствительности. Москва: Медицина; 1984.</mixed-citation><mixed-citation xml:lang="en">Kalyuzhnyy LV. Fiziologicheskie mekhanizmy regulyatsii bolevoy chuvstvitel’nosti. Moscow: Meditsina Publ.; 1984. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Шухов В.С. Боль. Клинические рекомендации по ведению больных с различными болевыми синдромами. Русский медицинский журнал. 2004;(7):437–444.</mixed-citation><mixed-citation xml:lang="en">Shukhov VS. Bol’. Klinicheskie rekomendatsii po vedeniyu bol’nykh s razlichnymi bolevymi sindromami. RMJ. 2004;(7):437–444 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">European Society for Emergency Medicine. Guidelines for the management of acute pain in emergence situations; 2020. Available from: https://www.eusem.org/images/EUSEM_EPI_GUIDELINES_MARCH_2020.pdf. (Accessed February 28, 2025.)</mixed-citation><mixed-citation xml:lang="en">European Society for Emergency Medicine. Guidelines for the management of acute pain in emergence situations; 2020. Available from: https://www.eusem.org/images/EUSEM_EPI_GUIDELINES_MARCH_2020.pdf. (Accessed February 28, 2025.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Boonstra AM, Stewart RE, Köke AJ, Oosterwijk RF, Swaan JL, Schreurs KM, et al. Cut-off points for mild, moderate and severe pain on numeric rating scale for pain in patients with chronic musculoskeletal pain: variability and influence of sex and catastrophizing. Front Psychol. 2016;7:1466. PMID: 27746750 https://doi.org/10.3389/fpsyg.2016.01466 eCollection 2016.</mixed-citation><mixed-citation xml:lang="en">Boonstra AM, Stewart RE, Köke AJ, Oosterwijk RF, Swaan JL, Schreurs KM, et al. Cut-off points for mild, moderate and severe pain on numeric rating scale for pain in patients with chronic musculoskeletal pain: variability and influence of sex and catastrophizing. Front Psychol. 2016;7:1466. PMID: 27746750 https://doi.org/10.3389/fpsyg.2016.01466 eCollection 2016.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Lynch ME. The need for a Canadian pain strategy. Pain Res Manag. 2011;16(2):77–80. PMID: 21499581 https://doi.org/10.1155/2011/654651</mixed-citation><mixed-citation xml:lang="en">Lynch ME. The need for a Canadian pain strategy. Pain Res Manag. 2011;16(2):77–80. PMID: 21499581 https://doi.org/10.1155/2011/654651</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Dale J, Bjornsen LP. Assessment of pain in a Norwegian emergency department. Scand J Trauma Resusc Emerg Med. 2015;23:86. PMID: 26514633 https://doi.org/10.1186/s13049-015-0166-3</mixed-citation><mixed-citation xml:lang="en">Dale J, Bjornsen LP. Assessment of pain in a Norwegian emergency department. Scand J Trauma Resusc Emerg Med. 2015;23:86. PMID: 26514633 https://doi.org/10.1186/s13049-015-0166-3</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Mura P, Serra E, Marinangeli F, Patti S, Musu M, Piras I, et al. Prospective study on prevalence, intensity, type, and therapy of acute pain in a second-level urban emergency department. J Pain Res. 2017;10:2781–2788. PMID: 29263692 https://doi.org/10.2147/JPR.S137992 eCollection 2017.</mixed-citation><mixed-citation xml:lang="en">Mura P, Serra E, Marinangeli F, Patti S, Musu M, Piras I, et al. Prospective study on prevalence, intensity, type, and therapy of acute pain in a second-level urban emergency department. J Pain Res. 2017;10:2781–2788. PMID: 29263692 https://doi.org/10.2147/JPR.S137992 eCollection 2017.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Wilson JE, Pendleton JM. Oligoanalgesia in the emergency department. Am J Emerg Med. 1989;7(6):620–623. PMID: 2803357 https://doi.org/10.1016/0735-6757(89)90286-6</mixed-citation><mixed-citation xml:lang="en">Wilson JE, Pendleton JM. Oligoanalgesia in the emergency department. Am J Emerg Med. 1989;7(6):620–623. PMID: 2803357 https://doi.org/10.1016/0735-6757(89)90286-6</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Tainter CR. An evidence-based approach to traumatic pain management in the emergency department. Emerg Med Pract. 2012;14(8):1–26. PMID: 22916717</mixed-citation><mixed-citation xml:lang="en">Tainter CR. An evidence-based approach to traumatic pain management in the emergency department. Emerg Med Pract. 2012;14(8):1–26. PMID: 22916717</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Berben SA, Schoonhoven L, Meijs TH, van Vugt AB, van Grunsven PM. Prevalence and relief of pain in trauma patients in emergency medical services. Clin J Pain. 2011;27(7):587–592. PMID: 21505324 https://doi.org/10.1097/AJP.0b013e3182169036</mixed-citation><mixed-citation xml:lang="en">Berben SA, Schoonhoven L, Meijs TH, van Vugt AB, van Grunsven PM. Prevalence and relief of pain in trauma patients in emergency medical services. Clin J Pain. 2011;27(7):587–592. PMID: 21505324 https://doi.org/10.1097/AJP.0b013e3182169036</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Hall JK, Boswell MV. Ethics, law, and pain management as a patient right. Pain Physician. 2009;12(3):499–506. PMID: 19461819</mixed-citation><mixed-citation xml:lang="en">Hall JK, Boswell MV. Ethics, law, and pain management as a patient right. Pain Physician. 2009;12(3):499–506. PMID: 19461819</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Farrar JT, Berlin JA, Strom BL. Clinically important changes in acute pain outcome measures: a validation study. J Pain Symptom Manage. 2003;25(5):406–411. PMID: 12727037 https://doi.org/10.1016/s0885-3924(03)00162-3</mixed-citation><mixed-citation xml:lang="en">Farrar JT, Berlin JA, Strom BL. Clinically important changes in acute pain outcome measures: a validation study. J Pain Symptom Manage. 2003;25(5):406–411. PMID: 12727037 https://doi.org/10.1016/s0885-3924(03)00162-3</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Gallagher EJ, Liebman M, Bijur PE. Prospective validation of clinically important changes in pain severity measured on a visual analog scale. Ann Emerg Med. 2001;38:633–638. PMID: 11719741 https://doi.org/10.1067/mem.2001.118863</mixed-citation><mixed-citation xml:lang="en">Gallagher EJ, Liebman M, Bijur PE. Prospective validation of clinically important changes in pain severity measured on a visual analog scale. Ann Emerg Med. 2001;38:633–638. PMID: 11719741 https://doi.org/10.1067/mem.2001.118863</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Gausche-Hill M, Brown KM, Oliver ZJ, Sasson C, Dayan PS, Eschmann NM, et al. An evidence-based guideline for prehospital analgesia in trauma. Prehosp Emerg Care. 2014;18(Suppl 1):25–34. PMID: 24279813 https://doi.org/10.3109/10903127.2013.844873</mixed-citation><mixed-citation xml:lang="en">Gausche-Hill M, Brown KM, Oliver ZJ, Sasson C, Dayan PS, Eschmann NM, et al. An evidence-based guideline for prehospital analgesia in trauma. Prehosp Emerg Care. 2014;18(Suppl 1):25–34. PMID: 24279813 https://doi.org/10.3109/10903127.2013.844873</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Fabbri A, Voza A, Riccardi A, Serra S, Iaco F; Study and Research Center of the Italian Society of Emergency Medicine (SIMEU). The Pain Management of Trauma Patients in the Emergency Department. J Clin Med. 2023;12(9):3289. PMID: 37176729. https://doi.org/10.3390/jcm12093289.</mixed-citation><mixed-citation xml:lang="en">Fabbri A, Voza A, Riccardi A, Serra S, Iaco F; Study and Research Center of the Italian Society of Emergency Medicine (SIMEU). The Pain Management of Trauma Patients in the Emergency Department. J Clin Med. 2023;12(9):3289. PMID: 37176729. https://doi.org/10.3390/jcm12093289.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Hatherley C, Jennings N, Cross R. Time to analgesia and pain score documentation best practice standards for the emergency department – a literature review. Australas Emerg Nurs J. 2016;19(1):26–36. PMID: 26718064 https://doi.org/10.1016/j.aenj.2015.11.001</mixed-citation><mixed-citation xml:lang="en">Hatherley C, Jennings N, Cross R. Time to analgesia and pain score documentation best practice standards for the emergency department – a literature review. Australas Emerg Nurs J. 2016;19(1):26–36. PMID: 26718064 https://doi.org/10.1016/j.aenj.2015.11.001</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Приказ Минздрава России от 20 июня 2013 года № 388н «Об утверждении Порядка оказания скорой, в том числе скорой специализированной, медицинской помощи (с изменениями на 21 февраля 2020 года)». Москва; 2020. URL: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/053/356/original/388í.pdf?1608118780 (Дата обращения 03.03.2025)</mixed-citation><mixed-citation xml:lang="en">Prikaz Minzdrava Rossii ot 20 iyunya 2013 goda No 388n “Ob utverzhdenii Poryadka okazaniya skoroy, v tom chisle skoroy spetsializirovannoy, meditsinskoy pomoshchi (s izmeneniyami na 21 fevralya 2020 goda)”. Moscow; 2020. (In Russ.) Available at: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/053/356/original/388í.pdf?1608118780 (Accessed 03.03.2025)</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Приказ Минтруда России от 14.03.2018 № 133н «Об утверждении профессионального стандарта «Врач скорой медицинской помощи». Москва; 2018. URL: http://publication.pravo.gov.ru/Document/View/0001201804090002 (Дата обращения 03.03.2025)</mixed-citation><mixed-citation xml:lang="en">Prikaz Mintruda Rossii ot 14.03.2018 No 133n “Ob utverzhdenii professional’nogo standarta “Vrach skoroy meditsinskoy pomoshchi”. Moscow; 2018. (In Russ.) Available at: http://publication.pravo.gov.ru/Document/View/0001201804090002 (Accessed 03.03.2025)</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Приказ Минтруда России от 27.08.2018 № 554н «Об утверждении профессионального стандарта «Врач анестезиолог-реаниматолог». Москва; 2018. URL: http://publication.pravo.gov.ru/Document/View/0001201809170020 (Дата обращения 03.03.2025)</mixed-citation><mixed-citation xml:lang="en">Prikaz Mintruda Rossii ot 27.08.2018 No 554n “Ob utverzhdenii professional’nogo standarta “Vrach anesteziolog-reanimatolog”. Moscow; 2018. (In Russ.) Available at: http://publication.pravo.gov.ru/Document/View/0001201809170020 (Accessed 03.03.2025)</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Приказ Минтруда России от 13.01.2021 № 3н «Об утверждении профессионального стандарта «Фельдшер скорой медицинской помощи». Москва; 2021. URL: http://publication.pravo.gov.ru/Document/View/0001202104120032 (Дата обращения 03.03.2025)</mixed-citation><mixed-citation xml:lang="en">Prikaz Mintruda Rossii ot 13.01.2021 No 3n “Ob utverzhdenii professional’nogo standarta “Fel’dsher skoroy meditsinskoy pomoshchi”. Moscow; 2021. (In Russ.) Available at: http://publication.pravo.gov.ru/Document/View/0001202104120032 (Accessed 03.03.2025)</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Приказ Минздрава России от 28.10.2020 № 1165н «Об утверждении требований к комплектации лекарственными препаратами и медицинскими изделиями укладок и наборов для оказания скорой медицинской помощи» (с изменениями и дополнениями)». Москва; 2020. URL: http://publication.pravo.gov.ru/Document/View/0001202011260027 (Дата обращения 03.03.2025)</mixed-citation><mixed-citation xml:lang="en">Prikaz Minzdrava Rossii ot 28.10.2020 No 1165n “Ob utverzhdenii trebovaniy k komplektatsii lekarstvennymi preparatami i meditsinskimi izdeliyami ukladok i naborov dlya okazaniya skoroy meditsinskoy pomoshchi” (s izmeneniyami i dopolneniyami)”. Moscow; 2020. (In Russ.) Available at: http://publication.pravo.gov.ru/Document/View/0001202011260027 (Accessed 03.03.2025)</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Porter KM, Siddiqui MK, Sharma I, Dickerson S, Eberhardt A. Management of trauma pain in the emergency setting: low-dose methoxyflurane or nitrous oxide? A systematic review and indirect treatment comparison. J Pain Res. 2018;11:11–21. PMID: 29302193 https://doi.org/10.2147/JPR.S150600 Collection 2018.</mixed-citation><mixed-citation xml:lang="en">Porter KM, Siddiqui MK, Sharma I, Dickerson S, Eberhardt A. Management of trauma pain in the emergency setting: low-dose methoxyflurane or nitrous oxide? A systematic review and indirect treatment comparison. J Pain Res. 2018;11:11–21. PMID: 29302193 https://doi.org/10.2147/JPR.S150600 Collection 2018.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Михайлович В.А., Мирошниченко А.Г. (ред.) Руководство для врачей скорой медицинской помощи: учебное пособие для системы послевузовского профессионального образования врачей. 4-е изд. Санкт-Петербург; 2007.</mixed-citation><mixed-citation xml:lang="en">Mikhaylovich VA, Miroshnichenko AG. (eds.) Rukovodstvo dlya vrachey skoroy meditsinskoy pomoshchi. 4th ed. Saint Petersburg; 2007. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Багненко С.Ф. (ред.) Скорая медицинская помощь. Клинические рекомендации. Москва; 2023.</mixed-citation><mixed-citation xml:lang="en">Bagnenko SF (ed.) Skoraya meditsinskaya pomoshch’. Klinicheskie rekomendatsii. Moscow; 2023. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Wadlund DL. Local anesthetic systemic toxicity. AORN J. 2017;106(5):367–377. PMID: 29107256 https://doi.org/10.1016/j.aorn.2017.08.015</mixed-citation><mixed-citation xml:lang="en">Wadlund DL. Local anesthetic systemic toxicity. AORN J. 2017;106(5):367–377. PMID: 29107256 https://doi.org/10.1016/j.aorn.2017.08.015</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">McRae PJ, Bendall JC, Madigan V, Middleton PM. Paramedic-performed fascia iliaca compartment block for femoral fractures: a controlled trial. J Emerg Med. 2015;48(5):581–589. PMID: 25661312 https://doi.org/10.1016/j.jemermed.2014.12.016</mixed-citation><mixed-citation xml:lang="en">McRae PJ, Bendall JC, Madigan V, Middleton PM. Paramedic-performed fascia iliaca compartment block for femoral fractures: a controlled trial. J Emerg Med. 2015;48(5):581–589. PMID: 25661312 https://doi.org/10.1016/j.jemermed.2014.12.016</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Slade S, Hanna E, Pohlkamp-Hartt J, Savage DW, Ohle R. Efficacy of Fascia Iliaca Compartment Blocks in Proximal Femoral Fractures in the Prehospital Setting: A Systematic Review and Meta-Analysis. Prehosp Disaster Med. 2023;38(2):252–258. PMID: 36912109 https://doi.org/10.1017/S1049023X23000298</mixed-citation><mixed-citation xml:lang="en">Slade S, Hanna E, Pohlkamp-Hartt J, Savage DW, Ohle R. Efficacy of Fascia Iliaca Compartment Blocks in Proximal Femoral Fractures in the Prehospital Setting: A Systematic Review and Meta-Analysis. Prehosp Disaster Med. 2023;38(2):252–258. PMID: 36912109 https://doi.org/10.1017/S1049023X23000298</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Bakan M, Umutoglu T, Topuz U, Uysal H, Bayram M, Kadioglu H, et al. Opioid-free total intravenous anesthesia with propofol, dexmedetomidine and lidocaine infusions for laparoscopic cholecystectomy: a prospective, randomized, double-blinded study. Rev Bras Anestesiol. 2015;65(3):191–199. PMID: 25925031 https://doi.org/10.1016/j.bjane.2014.05.001</mixed-citation><mixed-citation xml:lang="en">Bakan M, Umutoglu T, Topuz U, Uysal H, Bayram M, Kadioglu H, et al. Opioid-free total intravenous anesthesia with propofol, dexmedetomidine and lidocaine infusions for laparoscopic cholecystectomy: a prospective, randomized, double-blinded study. Rev Bras Anestesiol. 2015;65(3):191–199. PMID: 25925031 https://doi.org/10.1016/j.bjane.2014.05.001</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Weibel S, Jelting Y, Pace NL, Helf A, Eberhart LH, Hahnenkamp K, et al. Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery in adults. Cochrane Database Syst Rev. 2018;6(6):CD009642. PMID: 29864216 https://doi.org/10.1002/14651858.CD009642.pub3</mixed-citation><mixed-citation xml:lang="en">Weibel S, Jelting Y, Pace NL, Helf A, Eberhart LH, Hahnenkamp K, et al. Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery in adults. Cochrane Database Syst Rev. 2018;6(6):CD009642. PMID: 29864216 https://doi.org/10.1002/14651858.CD009642.pub3</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Farahmand S, Hamrah H, Arbab M, Sedaghat M, Basir Ghafouri H, Bagheri-Hariri S. Pain management of acute limb trauma patients with intravenous lidocaine in emergency department. Am J Emerg Med. 2018;36(7):1231–1235. PMID: 29254669 https://doi.org/10.1016/j.ajem.2017.12.027</mixed-citation><mixed-citation xml:lang="en">Farahmand S, Hamrah H, Arbab M, Sedaghat M, Basir Ghafouri H, Bagheri-Hariri S. Pain management of acute limb trauma patients with intravenous lidocaine in emergency department. Am J Emerg Med. 2018;36(7):1231–1235. PMID: 29254669 https://doi.org/10.1016/j.ajem.2017.12.027</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Clattenburg EJ, Nguyen A, Yoo T, Flores S, Hailozian C, Louie D, et al. Intravenous lidocaine provides similar analgesia to intravenous morphine for undifferentiated severe pain in the emergency department: a pilot, unblinded randomized controlled trial. Pain Med. 2019;20(4):834–839. PMID: 29741660 https://doi.org/10.1093/pm/pny031</mixed-citation><mixed-citation xml:lang="en">Clattenburg EJ, Nguyen A, Yoo T, Flores S, Hailozian C, Louie D, et al. Intravenous lidocaine provides similar analgesia to intravenous morphine for undifferentiated severe pain in the emergency department: a pilot, unblinded randomized controlled trial. Pain Med. 2019;20(4):834–839. PMID: 29741660 https://doi.org/10.1093/pm/pny031</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Hewes HA, Dai M, Mann NC, Baca T, Taillac P. Prehospital pain management: disparity by age and race. Prehosp Emerg Care. 2018;22(2):189–197. PMID: 28956669 https://doi.org/10.1080/10903127.2017.1367444</mixed-citation><mixed-citation xml:lang="en">Hewes HA, Dai M, Mann NC, Baca T, Taillac P. Prehospital pain management: disparity by age and race. Prehosp Emerg Care. 2018;22(2):189–197. PMID: 28956669 https://doi.org/10.1080/10903127.2017.1367444</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Hoeffe J, Doyon Trottier E, Bailey B, Shellshear D, Lagacé M, Sutter C, et al. Intranasal fentanyl and inhaled nitrous oxide for fracture reduction: the FAN observational study. Am J Emerg Med. 2017;35(5):710–715. PMID: 28190665 https://doi.org/10.1016/j.ajem.2017.01.004</mixed-citation><mixed-citation xml:lang="en">Hoeffe J, Doyon Trottier E, Bailey B, Shellshear D, Lagacé M, Sutter C, et al. Intranasal fentanyl and inhaled nitrous oxide for fracture reduction: the FAN observational study. Am J Emerg Med. 2017;35(5):710–715. PMID: 28190665 https://doi.org/10.1016/j.ajem.2017.01.004</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Vergnion M, Degesves S, Garcet L, Magotteaux V. Tramadol, an alternative to morphine for treating posttraumatic pain in the prehospital situation. Anesth Analg. 2001;92(6):1543–1546. PMID: 11375843 https://doi.org/10.1097/00000539-200106000-00039</mixed-citation><mixed-citation xml:lang="en">Vergnion M, Degesves S, Garcet L, Magotteaux V. Tramadol, an alternative to morphine for treating posttraumatic pain in the prehospital situation. Anesth Analg. 2001;92(6):1543–1546. PMID: 11375843 https://doi.org/10.1097/00000539-200106000-00039</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Beakley BD, Kaye AM, Kaye AD. Tramadol, pharmacology, side effects, and serotonin syndrome: a review. Pain Physician. 2015;18(4):395–400. PMID: 26218943</mixed-citation><mixed-citation xml:lang="en">Beakley BD, Kaye AM, Kaye AD. Tramadol, pharmacology, side effects, and serotonin syndrome: a review. Pain Physician. 2015;18(4):395–400. PMID: 26218943</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Svenson JE, Abernathy MK. Ketamine for prehospital use: new look at an old drug. Am J Emerg Med. 2007;25(8):977–980. PMID: 17920984 https://doi.org/10.1016/j.ajem.2007.02.040</mixed-citation><mixed-citation xml:lang="en">Svenson JE, Abernathy MK. Ketamine for prehospital use: new look at an old drug. Am J Emerg Med. 2007;25(8):977–980. PMID: 17920984 https://doi.org/10.1016/j.ajem.2007.02.040</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Zietlow J, Berns K, Jenkins D, Zietlow S. Prehospital use of ketamine: effectiveness in critically ill and injured patients. Mil Med. 2019;184(Suppl 1):542–544. PMID: 30901477 https://doi.org/10.1093/milmed/usy422</mixed-citation><mixed-citation xml:lang="en">Zietlow J, Berns K, Jenkins D, Zietlow S. Prehospital use of ketamine: effectiveness in critically ill and injured patients. Mil Med. 2019;184(Suppl 1):542–544. PMID: 30901477 https://doi.org/10.1093/milmed/usy422</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Rueda Carrillo L, Garcia KA, Yalcin N, Shah M. Ketamine and its Emergence in the field of neurology. Cureus. 2022;14(7):e27389. PMID: 36046286 https://doi.org/10.7759/cureus.27389 eCollection 2022 Jul.</mixed-citation><mixed-citation xml:lang="en">Rueda Carrillo L, Garcia KA, Yalcin N, Shah M. Ketamine and its Emergence in the field of neurology. Cureus. 2022;14(7):e27389. PMID: 36046286 https://doi.org/10.7759/cureus.27389 eCollection 2022 Jul.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Reede K, Bartholomew R, Nielsen D, Ahmeti M, Zreik K. Ketamine in Trauma: A Literature Review and Administration Guidelines. Cureus. 2023;15(11):e48099. PMID: 37920424 https://doi.org/10.7759/cureus.48099</mixed-citation><mixed-citation xml:lang="en">Reede K, Bartholomew R, Nielsen D, Ahmeti M, Zreik K. Ketamine in Trauma: A Literature Review and Administration Guidelines. Cureus. 2023;15(11):e48099. PMID: 37920424 https://doi.org/10.7759/cureus.48099</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Верткин А.Л., Тополянский А.В., Вовк Е.И., Наумов А.В. Место кеторолака в терапии острых болевых синдромов на догоспитальном этапе. Врач скорой помощи. 2006;(6):1–6.</mixed-citation><mixed-citation xml:lang="en">Vertkin AL, Topolyanskiy AV, Vovk EI, Naumov AV. Mesto ketorolaka v terapii ostrykh bolevykh sindromov na dogospital’nom etape. Ambulance Doctor. 2006;(6):1–6. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Forrest JB, Camu F, Greer IA, Kehlet H, Abdalla M, Bonnet F, et al.; POINT Investigators. Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery. Br J Anaesth. 2002;88(2):227–233. PMID: 11883386 https://doi.org/10.1093/bja/88.2.227</mixed-citation><mixed-citation xml:lang="en">Forrest JB, Camu F, Greer IA, Kehlet H, Abdalla M, Bonnet F, et al.; POINT Investigators. Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery. Br J Anaesth. 2002;88(2):227–233. PMID: 11883386 https://doi.org/10.1093/bja/88.2.227</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Gobble RM, Hoang HL, Kachniarz B, Orgill DP. Ketorolac does not increase perioperative bleeding: a meta-analysis of randomized controlled trials. Plast Reconstr Surg. 2014;133(3):741–755. PMID: 24572864 https://doi.org/10.1097/01.prs.0000438459.60474.b5</mixed-citation><mixed-citation xml:lang="en">Gobble RM, Hoang HL, Kachniarz B, Orgill DP. Ketorolac does not increase perioperative bleeding: a meta-analysis of randomized controlled trials. Plast Reconstr Surg. 2014;133(3):741–755. PMID: 24572864 https://doi.org/10.1097/01.prs.0000438459.60474.b5</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Motov S, Yasavolian M, Likourezos A, Pushkar I, Hossain R, Drapkin J, et al. Comparison of intravenous ketorolac at three single-dose regimens for treating acute pain in the emergency department: a randomized controlled trial. Ann Emerg Med. 2017;70(2):177–184. PMID: 27993418 https://doi.org/10.1016/j.annemergmed.2016.10.014</mixed-citation><mixed-citation xml:lang="en">Motov S, Yasavolian M, Likourezos A, Pushkar I, Hossain R, Drapkin J, et al. Comparison of intravenous ketorolac at three single-dose regimens for treating acute pain in the emergency department: a randomized controlled trial. Ann Emerg Med. 2017;70(2):177–184. PMID: 27993418 https://doi.org/10.1016/j.annemergmed.2016.10.014</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">McCarthy DT. Prehospital analgesia: multimodal considerations. Br J Anaesth. 2013;110(5):849. PMID: 23599525 https://doi.org/10.1093/bja/aet094</mixed-citation><mixed-citation xml:lang="en">McCarthy DT. Prehospital analgesia: multimodal considerations. Br J Anaesth. 2013;110(5):849. PMID: 23599525 https://doi.org/10.1093/bja/aet094</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Пиковский В.Ю., Барклая В.И. Применение ненаркотического анальгетика кеторола на догоспитальном этапе. Скорая медицинская помощь. 2009;(3):53–57.</mixed-citation><mixed-citation xml:lang="en">Pikovskiy VY, Barklaya VI. Ketorol at a Prehospital Stage. Emergency Medical Care. 2009;(3):53–57. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Coffey F, Dissmann P, Mirza K, Lomax M. Methoxyflurane analgesia in adult patients in the emergency department: a subgroup analysis of a randomized, double-blind, placebo-controlled study (STOP!). Adv Ther. 2016;33:2012–2031. PMID: 27567918 https://doi.org/10.1007/s12325-016-0405-7</mixed-citation><mixed-citation xml:lang="en">Coffey F, Dissmann P, Mirza K, Lomax M. Methoxyflurane analgesia in adult patients in the emergency department: a subgroup analysis of a randomized, double-blind, placebo-controlled study (STOP!). Adv Ther. 2016;33:2012–2031. PMID: 27567918 https://doi.org/10.1007/s12325-016-0405-7</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Ducassé JL, Siksik G, Durand-Béchu M, Couarraze S, Vallé B, Lecoules N, et al. Nitrous oxide for early analgesia in the emergency setting: a randomized, double-blind multicenter prehospital trial. Acad Emerg Med. 2013;20(2):178–184. PMID: 23406077 https://doi.org/10.1111/acem.12072</mixed-citation><mixed-citation xml:lang="en">Ducassé JL, Siksik G, Durand-Béchu M, Couarraze S, Vallé B, Lecoules N, et al. Nitrous oxide for early analgesia in the emergency setting: a randomized, double-blind multicenter prehospital trial. Acad Emerg Med. 2013;20(2):178–184. PMID: 23406077 https://doi.org/10.1111/acem.12072</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Калви Т.Н., Уильямс Н.Е. Фармакология для анестезиолога. Москва; 2007.</mixed-citation><mixed-citation xml:lang="en">Kalvi TN, Uil’yams NE. Farmakologiya dlya anesteziologa. Moscow; 2007. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Davies DM, Ferner RE, de Glanville H. Davies’ textbook of adverse drug reactions. 5th edition. London, Chapman and Hall Medical; 1998.</mixed-citation><mixed-citation xml:lang="en">Davies DM, Ferner RE, de Glanville H. Davies’ textbook of adverse drug reactions. 5th edition. London, Chapman and Hall Medical; 1998.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Cousins ML, Mazze RI. Methoxyflurane nephrotoxicity. A study of dose-response in man. JAMA. 1973;225:1611–1616. PMID: 4740737 https://doi.org/10.1001/jama.225.13.1611</mixed-citation><mixed-citation xml:lang="en">Cousins ML, Mazze RI. Methoxyflurane nephrotoxicity. A study of dose-response in man. JAMA. 1973;225:1611–1616. PMID: 4740737 https://doi.org/10.1001/jama.225.13.1611</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Dayan AD. Analgesic use of inhaled methoxyflurane: evaluation of its potential nephrotoxicity. Hum Exp Toxicol. 2016;35(1):91–100. PMID: 25926525 https://doi.org/10.1177/0960327115578743</mixed-citation><mixed-citation xml:lang="en">Dayan AD. Analgesic use of inhaled methoxyflurane: evaluation of its potential nephrotoxicity. Hum Exp Toxicol. 2016;35(1):91–100. PMID: 25926525 https://doi.org/10.1177/0960327115578743</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Spruyt O, Westerman D, Milner A, Bressel M, Wein S. A randomised, double-blind, placebo-controlled study to assess the safety and efficacy of methoxyflurane for procedural pain of a bone marrow biopsy. BMJ Support Palliat Care. 2014;4(4):342–348. PMID: 24644183 https://doi.org/10.1136/bmjspcare-2013-000447</mixed-citation><mixed-citation xml:lang="en">Spruyt O, Westerman D, Milner A, Bressel M, Wein S. A randomised, double-blind, placebo-controlled study to assess the safety and efficacy of methoxyflurane for procedural pain of a bone marrow biopsy. BMJ Support Palliat Care. 2014;4(4):342–348. PMID: 24644183 https://doi.org/10.1136/bmjspcare-2013-000447</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Jacobs IG. Health effects of patients given methoxyflurane in the pre-hospital setting: a data linkage study. Open Emerg Med J. 2010;3:7–13. https://doi.org/10.2174/1876542401003010007</mixed-citation><mixed-citation xml:lang="en">Jacobs IG. Health effects of patients given methoxyflurane in the pre-hospital setting: a data linkage study. Open Emerg Med J. 2010;3:7–13. https://doi.org/10.2174/1876542401003010007</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Coffey F, Wright J, Hartshorn S, Hunt P, Locker T, Mirza K, et al. STOP!: a randomised, double-blind, placebo-controlledstudy of the efficacy and safety of methoxyflurane for the treatment of acute pain. Emerg Med J. 2014;31(8):613–618. PMID: 24743584 https://doi.org/10.1136/emermed-2013-202909</mixed-citation><mixed-citation xml:lang="en">Coffey F, Wright J, Hartshorn S, Hunt P, Locker T, Mirza K, et al. STOP!: a randomised, double-blind, placebo-controlledstudy of the efficacy and safety of methoxyflurane for the treatment of acute pain. Emerg Med J. 2014;31(8):613–618. PMID: 24743584 https://doi.org/10.1136/emermed-2013-202909</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Blair HA, Frampton JE. Methoxyflurane: a review in trauma pain. Clin Drug Investig. 2016;36(12):1067–1073. PMID: 27738897 https://doi.org/10.1007/s40261-016-0473-0</mixed-citation><mixed-citation xml:lang="en">Blair HA, Frampton JE. Methoxyflurane: a review in trauma pain. Clin Drug Investig. 2016;36(12):1067–1073. PMID: 27738897 https://doi.org/10.1007/s40261-016-0473-0</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Johnston S, Wilkes GJ, Thompson JA, Ziman M, Brightwell R. Inhaled methoxyflurane and intranasal fentanyl for prehospital management of visceral pain in an Australian ambulance service. Emerg Med J. 2011;28(1):57–63. PMID: 20466829 https://doi.org/10.1136/emj.2009.078717</mixed-citation><mixed-citation xml:lang="en">Johnston S, Wilkes GJ, Thompson JA, Ziman M, Brightwell R. Inhaled methoxyflurane and intranasal fentanyl for prehospital management of visceral pain in an Australian ambulance service. Emerg Med J. 2011;28(1):57–63. PMID: 20466829 https://doi.org/10.1136/emj.2009.078717</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Oxer HF. Effects of Penthrox (methoxyflurane) as an analgesic on cardiovascular and respiratory functions in the pre-hospital setting. J Mil Veterans Health. 2016;24:14–20. https://doi-ds.org/doilink/05.2021-18784211/JMVHVol24No2</mixed-citation><mixed-citation xml:lang="en">Oxer HF. Effects of Penthrox (methoxyflurane) as an analgesic on cardiovascular and respiratory functions in the pre-hospital setting. J Mil Veterans Health. 2016;24:14–20. https://doi-ds.org/doilink/05.2021-18784211/JMVHVol24No2</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Frangos J, Mikkonnen., Down C. Derivation of an occupational exposure limit for an inhalation analgesic methoxyflurane (Penthrox). Regul Toxicol Pharmacol. 2016;80:210–225. PMID: 27181451 https://doi.org/10.1016/j.yrtph.2016.05.012</mixed-citation><mixed-citation xml:lang="en">Frangos J, Mikkonnen., Down C. Derivation of an occupational exposure limit for an inhalation analgesic methoxyflurane (Penthrox). Regul Toxicol Pharmacol. 2016;80:210–225. PMID: 27181451 https://doi.org/10.1016/j.yrtph.2016.05.012</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Ruff R, Kerr S, Kerr D, Zalcberg D, Stevens J. Occupational exposure to methoxyflurane administered for procedural sedation: an observational study of 40 exposures. Br J Anaesth. 2018;120(6):1435–1437. PMID: 29793614 https://doi.org/10.1016/j.bja.2018.01.029</mixed-citation><mixed-citation xml:lang="en">Ruff R, Kerr S, Kerr D, Zalcberg D, Stevens J. Occupational exposure to methoxyflurane administered for procedural sedation: an observational study of 40 exposures. Br J Anaesth. 2018;120(6):1435–1437. PMID: 29793614 https://doi.org/10.1016/j.bja.2018.01.029</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Borland M, Jacobs I, King B, O’Brien D. A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department. Ann Emerg Med. 2007;49(3):335–340. PMID: 17067720 https://doi.org/10.1016/j.annemergmed.2006.06.016</mixed-citation><mixed-citation xml:lang="en">Borland M, Jacobs I, King B, O’Brien D. A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department. Ann Emerg Med. 2007;49(3):335–340. PMID: 17067720 https://doi.org/10.1016/j.annemergmed.2006.06.016</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Tvieta T, Thoner J, Klepstad P, Dale O, Jystad A, Borchgrevink PC. A controlled comparison between single doses of intravenous and intramuscular morphine with respect to analgesic effects and patient safety. Acta Anaesthesiol Scand. 2008;52(7):920–925. PMID: 18702754 https://doi.org/10.1111/j.1399-6576.2008.01608.x</mixed-citation><mixed-citation xml:lang="en">Tvieta T, Thoner J, Klepstad P, Dale O, Jystad A, Borchgrevink PC. A controlled comparison between single doses of intravenous and intramuscular morphine with respect to analgesic effects and patient safety. Acta Anaesthesiol Scand. 2008;52(7):920–925. PMID: 18702754 https://doi.org/10.1111/j.1399-6576.2008.01608.x</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Middleton PM, Simpson PM, Sinclair G, Dobbins TA, Math B, Bendall JC. Effectiveness of morphine, fentanyl, and methoxyflurane in the prehospital setting. Prehosp Emerg Care. 2010;14(4):439–447. PMID: 20809687 https://doi.org/10.3109/10903127.2010.497896</mixed-citation><mixed-citation xml:lang="en">Middleton PM, Simpson PM, Sinclair G, Dobbins TA, Math B, Bendall JC. Effectiveness of morphine, fentanyl, and methoxyflurane in the prehospital setting. Prehosp Emerg Care. 2010;14(4):439–447. PMID: 20809687 https://doi.org/10.3109/10903127.2010.497896</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Lim KJ, Koh ZX, Ng YY, Fook-Chong S, Ho AFW, Doctor NE, et al. Comparison of inhalational methoxyflurane (Penthrox®) and intramuscular tramadol for prehospital analgesia. Singapore Med J. 2021;62(6):281–286. PMID: 32179922 https://doi.org/10.11622/smedj.2020035</mixed-citation><mixed-citation xml:lang="en">Lim KJ, Koh ZX, Ng YY, Fook-Chong S, Ho AFW, Doctor NE, et al. Comparison of inhalational methoxyflurane (Penthrox®) and intramuscular tramadol for prehospital analgesia. Singapore Med J. 2021;62(6):281–286. PMID: 32179922 https://doi.org/10.11622/smedj.2020035</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Verdier J, Leduc A, Duteille F, Bertrand-Vasseur A, Perrot P. Use of methoxyflurane on acute pain during burn dressing in adult consultation. Ann Chir Plast Esthet. 2020;65(2):141–146. PMID: 31300241 https://doi.org/10.1016/j.anplas.2019.06.007</mixed-citation><mixed-citation xml:lang="en">Verdier J, Leduc A, Duteille F, Bertrand-Vasseur A, Perrot P. Use of methoxyflurane on acute pain during burn dressing in adult consultation. Ann Chir Plast Esthet. 2020;65(2):141–146. PMID: 31300241 https://doi.org/10.1016/j.anplas.2019.06.007</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Smith MD, Rowan E, Spaight R, Siriwardena AN. Evaluation of the effectiveness and costs of inhaled methoxyflurane versus usual analgesia for prehospital injury and trauma: non-randomised clinical study. BMC Emerg Med. 2022;22(1):122. PMID: 35799131 https://doi.org/10.1186/s12873-022-00664-y</mixed-citation><mixed-citation xml:lang="en">Smith MD, Rowan E, Spaight R, Siriwardena AN. Evaluation of the effectiveness and costs of inhaled methoxyflurane versus usual analgesia for prehospital injury and trauma: non-randomised clinical study. BMC Emerg Med. 2022;22(1):122. PMID: 35799131 https://doi.org/10.1186/s12873-022-00664-y</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
