nmpЖурнал им. Н.В. Склифосовского «Неотложная медицинская помощь»Russian Sklifosovsky Journal "Emergency Medical Care"2223-90222541-8017“N.V. Sklifosovsky Research Institute for Emergency Medicine”10.23934/2223-9022-2024-13-3-492-500nmp-1938Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSСиндром обратимой церебральной вазоконстрикцииReversible Cerebral Vasoconstriction Syndromehttps://orcid.org/0000-0001-6824-4114РамазановГ. Р.RamazanovG. R.

Рамазанов Ганипа Рамазанович, кандидат медицинских наук, заместитель директора — руководитель регионального сосудистого центра ГБУЗ «НИИ СП им. Н.В. Склифосовского ДЗМ», заведующий научным отделением неотложной неврологии и восстановительного лечения

129090, Москва, Б. Сухаревская пл., д. 3

Ganipa R. Ramazanov, Candidate of Medical Sciences, Deputy Director – Head, Regional Vascular Center; Head, Scientific Department of Emergency Neurology and Rehabilitation

Bolshaya Sukharevskaya Sq. 3, Moscow, 129090

ramasanovgr@sklif.mos.ruhttps://orcid.org/0000-0002-0804-3190МагомедовТ. А.MagomedovT. A.

Магомедов Тимур Абдурахманович, врач-невролог неврологического отделения для больных с острыми нарушениями мозгового кровообращения ГБУЗ «НИИ СП им. Н.В. Склифосовского ДЗМ»

129090, Москва, Б. Сухаревская пл., д. 3

Timur A. Magomedov, Neurologist, Neurological Department for Patients with Acute Cerebrovascular Accidents

Bolshaya Sukharevskaya Sq. 3, Moscow, 129090

magomedovta@sklif.mos.ruhttps://orcid.org/0000-0001-7698-5385СоловцоваМ. С.SolovtsovaM. S.

Соловцова Маргарита Сергеевна, врач-невролог неврологического отделения для больных с острыми нарушениями мозгового кровообращения ГБУЗ «НИИ СП им. Н.В. Склифосовского ДЗМ»

129090, Москва, Б. Сухаревская пл., д. 3

Margarita S. Solovtsova, Neurologist, Neurological Department for Patients with Acute Cerebrovascular Accidents

Bolshaya Sukharevskaya Sq. 3, Moscow, 129090

solovtsovams@sklif.mos.ruhttps://orcid.org/0000-0001-9750-3509ШевченкоЕ. В.ShevchenkoE. V.

Шевченко Евгений Владимирович, кандидат медицинских наук, заведующий неврологическим отделением для больных с острыми нарушениями мозгового кровообращения, старший научный сотрудник научного отделения неотложной неврологии и восстановительного лечения ГБУЗ «НИИ СП им. Н.В. Склифосовского ДЗМ»

129090, Москва, Б. Сухаревская пл., д. 3

Evgeny V. Shevchenko, Candidate of Medical Sciences, Head, Neurological Department for Patients with Acute Cerebrovascular Accidents; Senior Researcher, Scientific Department of Emergency Neurology and Rehabilitation

Bolshaya Sukharevskaya Sq. 3, Moscow, 129090

shevchenkoev@sklif.mos.ruhttps://orcid.org/0000-0002-8490-1417КовалеваЭ. А.KovalevaE. A.

Ковалева Элла Александровна, кандидат медицинских наук, старший преподаватель учебного отдела, старший научный сотрудник научного отделения неотложной неврологии и восстановительного лечения ГБУЗ «НИИ СП им. Н.В. Склифосовского ДЗМ»

129090, Москва, Б. Сухаревская пл., д. 3

Ella A. Kovaleva, Candidate of Medical Sciences, Senior Lecturer, Educational Department; Senior Researcher, Scientific Department of Emergency Neurology and Rehabilitation

Bolshaya Sukharevskaya Sq. 3, Moscow, 129090

kovalevaea@sklif.mos.ruГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»РоссияN.V. Sklifosovsky Research Institute for Emergency MedicineRussian Federation202415102024133492500Copyright © Рамазанов Г.Р., Магомедов Т.А., Соловцова М.С., Шевченко Е.В., Ковалева Э.А., 20242024Рамазанов Г.Р., Магомедов Т.А., Соловцова М.С., Шевченко Е.В., Ковалева Э.А.Ramazanov G.R., Magomedov T.A., Solovtsova M.S., Shevchenko E.V., Kovaleva E.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jnmp.ru/jour/article/view/1938

Синдром обратимой церебральной вазоконстрикции (СОЦВ, reversible cerebral vasoconstriction syndrome) — собирательный термин, применимый для описания патологических состояний со схожей клинической и радиологической картиной, которая характеризуется остро возникающей громоподобной головной болью и обратимой сегментарной (мультифокальной) констрикцией церебральных артерий. Статья посвящена вопросам терминологии, генетическим и клиническим особенностям СОЦВ, а также рассматриваются факторы риска, дифференциальный диагноз, осложнения и прогноз. Представлены современные патогенетические механизмы и возможные подходы к лечению данного состояния.

Reversible cerebral vasoconstriction syndrome (RCVS) is a collective term used to describe pathological conditions with a similar clinical and radiological picture which is characterized by thunderclap headaches with a sudden onset and reversible segmental (multifocal) constriction of the cerebral arteries. The article is devoted to issues of terminology, genetic and clinical features of RSCV, and also discusses risk factors, differential diagnosis, complications and prognosis. Modern pathogenetic mechanisms and possible approaches to the treatment of this condition are presented.

синдром обратимой церебральной вазоконстрикциицеребральный вазоспазмгромоподобная головная больreversible cerebral vasoconstriction syndromecerebral vasospasmthunderclap headacheReferencesSinghal AB. Posterior reversible encephalopathy syndrome and reversible cerebral vasoconstriction syndrome as syndromes of cerebrovascular dysregulation. Continuum (Minneap Minn). 2021;27(5):1301–1320. PMID: 34618761 https://doi.org/10.1212/CON.0000000000001037Singhal AB. Posterior reversible encephalopathy syndrome and reversible cerebral vasoconstriction syndrome as syndromes of cerebrovascular dysregulation. Continuum (Minneap Minn). 2021;27(5):1301–1320. PMID: 34618761 https://doi.org/10.1212/CON.0000000000001037Call GK, Fleming MC, Sealfon S, Levine H, Kistler JP, Fisher CM. Reversible cerebral segmental vasoconstriction. Stroke. 1988;19(9):1159–1170. PMID: 3046073 https://doi.org/10.1161/01.str.19.9.1159Call GK, Fleming MC, Sealfon S, Levine H, Kistler JP, Fisher CM. Reversible cerebral segmental vasoconstriction. Stroke. 1988;19(9):1159–1170. PMID: 3046073 https://doi.org/10.1161/01.str.19.9.1159Burton TM, Bushnell CD. Reversible Cerebral Vasoconstriction Syndrome. Stroke. 2019;50(8):2253–2258. PMID: 31272323 https://doi.org/10.1161/STROKEAHA.119.024416Burton TM, Bushnell CD. Reversible Cerebral Vasoconstriction Syndrome. Stroke. 2019;50(8):2253–2258. PMID: 31272323 https://doi.org/10.1161/STROKEAHA.119.024416Афанасьева М.Ю., Голдобин В.В., Клочева Е.Г. Клинические проявления, факторы риска и церебральные ангиодисплазии при синдроме обратимой церебральной вазоконстрикции. Медицинский алфавит. 2020;(22):22–26. https://doi.org/10.33667/2078-5631-2020-22-22-26Afanasyeva MYu, Goldobin VV, Klocheva EG. Clinical manifestations and pathogenesis of reversible cerebral vasoconstriction syndrome. Medical alphabet. 2020;(22):22–26. (In Russ.) https://doi.org/10.33667/2078-5631-2020-22-22-26Boitet R, Gaillard N, Bendiab E, Corti L, Roos C, Reynes J, et al. Concomitant reversible cerebral vasoconstriction syndrome and transient global amnesia. J Neurol. 2020;267(2):390–394. PMID: 31650256 https://doi.org/10.1007/s00415-019-09594-5Boitet R, Gaillard N, Bendiab E, Corti L, Roos C, Reynes J, et al. Concomitant reversible cerebral vasoconstriction syndrome and transient global amnesia. J Neurol. 2020;267(2):390–394. PMID: 31650256 https://doi.org/10.1007/s00415-019-09594-5Kim T, Ahn S, Sohn CH, Seo DW, Kim WY. Reversible cerebral vasoconstriction syndrome at the emergency department. Clin Exp Emerg Med. 2015;2(4):203–209. PMID: 27752599 https://doi.org/10.15441/ceem.15.099Kim T, Ahn S, Sohn CH, Seo DW, Kim WY. Reversible cerebral vasoconstriction syndrome at the emergency department. Clin Exp Emerg Med. 2015;2(4):203–209. PMID: 27752599 https://doi.org/10.15441/ceem.15.099Singhal AB. Reversible cerebral vasoconstriction syndrome: A review of pathogenesis, clinical presentation, and treatment. Int J Stroke. 2023 Jun 12:17474930231181250. PMID: 37246916 https://doi.org/10.1177/17474930231181250 Online ahead of print.Singhal AB. Reversible cerebral vasoconstriction syndrome: A review of pathogenesis, clinical presentation, and treatment. Int J Stroke. 2023 Jun 12:17474930231181250. PMID: 37246916 https://doi.org/10.1177/17474930231181250 Online ahead of print.Chen SP, Fuh JL, Lirng JF, Chang FC, Wang SJ. Recurrent primary thunderclap headache and benign CNS angiopathy: spectra of the same disorder? Neurology. 2006;67(12):2164–2169. PMID: 17190937 https://doi.org/10.1212/01.wnl.0000249115.63436.6dChen SP, Fuh JL, Lirng JF, Chang FC, Wang SJ. Recurrent primary thunderclap headache and benign CNS angiopathy: spectra of the same disorder? Neurology. 2006;67(12):2164–2169. PMID: 17190937 https://doi.org/10.1212/01.wnl.0000249115.63436.6dКлочева Е.Г., Голдобин В.В. Диагностика синдрома обратимой церебральной вазоконстрикции: клинические проявления и данные методов лучевой диагностики. Лучевая диагностика и терапия. 2018;(3):50–55. https://doi.org/10.22328/2079-5343-2018-9-3-50-55Klocheva EG, Goldobin VV. Diagnostics of Reversible Cerebral Vasoconstriction Syndrome: Clinical Manifestation and Imaging Patterns. Diagnostic radiology and radiotherapy. 2018;(3):50–55. (In Russ.). https://doi.org/10.22328/2079-5343-2018-9-3-50-55Caria F, Zedde M, Gamba M, Bersano A, Rasura M, Adami A, et al.; Italian Project on Stroke at Young Age (IPSYS) Investigators. The clinical spectrum of reversible cerebral vasoconstriction syndrome: The Italian Project on Stroke at Young Age (IPSYS). Cephalalgia. 2019;39(10):1267–1276. PMID: 31060368 https://doi.org/10.1177/0333102419849013Caria F, Zedde M, Gamba M, Bersano A, Rasura M, Adami A, et al.; Italian Project on Stroke at Young Age (IPSYS) Investigators. The clinical spectrum of reversible cerebral vasoconstriction syndrome: The Italian Project on Stroke at Young Age (IPSYS). Cephalalgia. 2019;39(10):1267–1276. PMID: 31060368 https://doi.org/10.1177/0333102419849013Patel SD, Topiwala K, Otite Oliver F, Saber H, Panza G, Mui G, et al. Outcomes among patients with reversible cerebral vasoconstriction syndrome: a nationwide United States analysis. Stroke. 2021;52(12):3970–3977.Patel SD, Topiwala K, Otite Oliver F, Saber H, Panza G, Mui G, et al. Outcomes among patients with reversible cerebral vasoconstriction syndrome: a nationwide United States analysis. Stroke. 2021;52(12):3970–3977.Erhart DK, Ludolph AC, Althaus K. RCVS: by clinicians for clinicians-a narrative review. J Neurol. 2023;270(2):673–688. PMID: 36305970 https://doi.org/10.1007/s00415-022-11425-zErhart DK, Ludolph AC, Althaus K. RCVS: by clinicians for clinicians-a narrative review. J Neurol. 2023;270(2):673–688. PMID: 36305970 https://doi.org/10.1007/s00415-022-11425-zLin PT, Wang YF, Fuh JL, Lirng JF, Ling YH, Chen SP, et al. Diagnosis and classification of headache associated with sexual activity using a composite algorithm: a cohort study. Cephalalgia. 2021;41(14):1447–1457. PMID: 34275353 https://doi.org/10.1177/03331024211028965Lin PT, Wang YF, Fuh JL, Lirng JF, Ling YH, Chen SP, et al. Diagnosis and classification of headache associated with sexual activity using a composite algorithm: a cohort study. Cephalalgia. 2021;41(14):1447–1457. PMID: 34275353 https://doi.org/10.1177/03331024211028965Kato Y, Hayashi T, Sano H, Kato R, Tanahashi N, Takao M. Cough headache presenting with reversible cerebral vasoconstriction syndrome. Intern Med. 2018;57(10):1459–1461. PMID: 29321411 https://doi.org/10.2169/internalmedicine.0061-17Kato Y, Hayashi T, Sano H, Kato R, Tanahashi N, Takao M. Cough headache presenting with reversible cerebral vasoconstriction syndrome. Intern Med. 2018;57(10):1459–1461. PMID: 29321411 https://doi.org/10.2169/internalmedicine.0061-17Hu CM, Lin YJ, Fan YK, Chen SP, Lai TH. Isolated thunderclap headache during sex: orgasmic headache or reversible cerebral vasoconstriction syndrome? J Clin Neurosci. 2010;17(10):1349–1351. PMID: 20655230 https://doi.org/10.1016/j.jocn.2010.01.052Hu CM, Lin YJ, Fan YK, Chen SP, Lai TH. Isolated thunderclap headache during sex: orgasmic headache or reversible cerebral vasoconstriction syndrome? J Clin Neurosci. 2010;17(10):1349–1351. PMID: 20655230 https://doi.org/10.1016/j.jocn.2010.01.052Ribas MZ, Paticcié GF, de Medeiros SDP, de Oliveira Veras A, Noleto FM, Dos Santos JCC. Reversible cerebral vasoconstriction syndrome: literature review. Egypt J Neurol Psychiatr Neurosurg. 2023;59(1):5. PMID: 36647436 https://doi.org/10.1186/s41983-023-00607-9Ribas MZ, Paticcié GF, de Medeiros SDP, de Oliveira Veras A, Noleto FM, Dos Santos JCC. Reversible cerebral vasoconstriction syndrome: literature review. Egypt J Neurol Psychiatr Neurosurg. 2023;59(1):5. PMID: 36647436 https://doi.org/10.1186/s41983-023-00607-9Valencia-Mendoza M, Ramírez-Rodríguez N, Vargas-Avila N, Peña-Ortiz A, Corzo-Villamizar M, Serna-Ramírez L, et al. Fatal reversible cerebral vasoconstriction syndrome: a systematic review of case series and case reports. J Clin Neurosci. 2019;70:183–188. PMID: 31416730 https://doi.org/10.1016/j.jocn.2019.08.014Valencia-Mendoza M, Ramírez-Rodríguez N, Vargas-Avila N, Peña-Ortiz A, Corzo-Villamizar M, Serna-Ramírez L, et al. Fatal reversible cerebral vasoconstriction syndrome: a systematic review of case series and case reports. J Clin Neurosci. 2019;70:183–188. PMID: 31416730 https://doi.org/10.1016/j.jocn.2019.08.014Kato Y, Fujita S, Osada T, Takahashi S, Takao M. Reversible cerebral vasoconstriction syndrome triggered by typhoon Hagibis in 2019: report of 2 cases. Headache. 2020;60(4):781–786. PMID: 32100287 https://doi.org/10.1111/head.13775.Kato Y, Fujita S, Osada T, Takahashi S, Takao M. Reversible cerebral vasoconstriction syndrome triggered by typhoon Hagibis in 2019: report of 2 cases. Headache. 2020;60(4):781–786. PMID: 32100287 https://doi.org/10.1111/head.13775.Lozupone E, Distefano M, Calandrelli R, Della Marca G, Pedicelli A, Pilato F. Reversible cerebral vasoconstriction syndrome: a severe neurological complication in postpartum period. Neurol India. 2020;68(1):192. PMID: 32129278 https://doi.org/10.4103/0028-3886.279674Lozupone E, Distefano M, Calandrelli R, Della Marca G, Pedicelli A, Pilato F. Reversible cerebral vasoconstriction syndrome: a severe neurological complication in postpartum period. Neurol India. 2020;68(1):192. PMID: 32129278 https://doi.org/10.4103/0028-3886.279674Chen SP, Wang SJ. Pathophysiology of reversible cerebral vasoconstriction syndrome. J Biomed Sci. 2022;29(1):72. PMID: 36127720 https://doi.org/10.1186/s12929-022-00857-4Chen SP, Wang SJ. Pathophysiology of reversible cerebral vasoconstriction syndrome. J Biomed Sci. 2022;29(1):72. PMID: 36127720 https://doi.org/10.1186/s12929-022-00857-4Chen SP, Chang YA, Chou CH, Juan CC, Lee HC, Chen LK, et al. Circulating microRNAs associated with reversible cerebral vasoconstriction syndrome. Ann Neurol. 2021;89(3):459–473. PMID: 33314303 https://doi.org/10.1002/ana.25965Chen SP, Chang YA, Chou CH, Juan CC, Lee HC, Chen LK, et al. Circulating microRNAs associated with reversible cerebral vasoconstriction syndrome. Ann Neurol. 2021;89(3):459–473. PMID: 33314303 https://doi.org/10.1002/ana.25965Hsu WH, Wang SJ, Chao YM, Chen CJ, Wang YF, Fuh JL, et al. Urine metabolomics signatures in reversible cerebral vasoconstriction syndrome. Cephalalgia. 2020;40(7):735–747. PMID: 31910660 https://doi.org/10.1177/0333102419897621Hsu WH, Wang SJ, Chao YM, Chen CJ, Wang YF, Fuh JL, et al. Urine metabolomics signatures in reversible cerebral vasoconstriction syndrome. Cephalalgia. 2020;40(7):735–747. PMID: 31910660 https://doi.org/10.1177/0333102419897621Шнякин П.Г., Лосева А.С. Развитие синдрома обратимой церебральной вазоконстрикции после клипирования асимптомной аневризмы средней мозговой артерии. Российский нейрохирургический журнал им. проф. А.Л. Поленова. 2023;15(2):134–139. https://doi.org/10.56618/2071-2693_2023_15_2_134.Shnyakin PG, Loseva AS. Development of the syndrome of reversible cerebral vasoconstriction after clipping of an asymptomatic aneurysm of the middle cerebral artery. Russian Neurosurgical Journal named after Professor A. L. Polenov. 2023;15(2):134–139. (In Russ.). https://doi.org/10.56618/2071-2693_2023_15_2_134Arrigan MT, Heran MK, Shewchuk JR. Reversible cerebral vasoconstriction syndrome: an important and common cause of thunderclap and recurrent headaches. Clin Radiol. 2018;73(5):417–427. PMID: 29274685 https://doi.org/10.1016/j.crad.2017.11.017Arrigan MT, Heran MK, Shewchuk JR. Reversible cerebral vasoconstriction syndrome: an important and common cause of thunderclap and recurrent headaches. Clin Radiol. 2018;73(5):417–427. PMID: 29274685 https://doi.org/10.1016/j.crad.2017.11.017Wolff V, Ducros A. Reversible Cerebral Vasoconstriction Syndrome without Typical Thunderclap Headache. Headache. 2016;56(4):674–687. PMID: 27016378 https://doi.org/10.1111/head.12794Wolff V, Ducros A. Reversible Cerebral Vasoconstriction Syndrome without Typical Thunderclap Headache. Headache. 2016;56(4):674–687. PMID: 27016378 https://doi.org/10.1111/head.12794Arnold M, Camus-Jacqmin M, Stapf C, Ducros A, Viswanathan A, Berthet K, et al. Postpartum cervicocephalic artery dissection. Stroke. 2008;39(8):2377–2379. PMID: 18535274 https://doi.org/10.1161/STROKEAHA.107.510107Arnold M, Camus-Jacqmin M, Stapf C, Ducros A, Viswanathan A, Berthet K, et al. Postpartum cervicocephalic artery dissection. Stroke. 2008;39(8):2377–2379. PMID: 18535274 https://doi.org/10.1161/STROKEAHA.107.510107Sheikh HU, Mathew PG. Reversible cerebral vasoconstriction syndrome: updates and new perspectives. Curr Pain Headache Rep. 2014;18(5):414. PMID: 24658747 https://doi.org/10.1007/s11916-014-0414-7Sheikh HU, Mathew PG. Reversible cerebral vasoconstriction syndrome: updates and new perspectives. Curr Pain Headache Rep. 2014;18(5):414. PMID: 24658747 https://doi.org/10.1007/s11916-014-0414-7Kulkarni M, Chauhan V, Shetty S. Reversible cerebral vasoconstriction syndrome. J Assoc Physicians India. 2016;64(6):76–78. PMID: 27739275Kulkarni M, Chauhan V, Shetty S. Reversible cerebral vasoconstriction syndrome. J Assoc Physicians India. 2016;64(6):76–78. PMID: 27739275Perdices M, Herkes G. Reversible cerebral vasoconstriction syndrome. Neuropsychol Rehabil. 2018;28(2):223–233. PMID: 27915588 https://doi.org/10.1080/09602011.2016.1257434Perdices M, Herkes G. Reversible cerebral vasoconstriction syndrome. Neuropsychol Rehabil. 2018;28(2):223–233. PMID: 27915588 https://doi.org/10.1080/09602011.2016.1257434Ling YH, Chen SP. Narrative review: headaches after reversible cerebral vasoconstriction syndrome. Cerr Pain Headache Rep. 2020;24(12):74. PMID: 33161482 https://doi.org/10.1007/s11916-020-00908-1Ling YH, Chen SP. Narrative review: headaches after reversible cerebral vasoconstriction syndrome. Cerr Pain Headache Rep. 2020;24(12):74. PMID: 33161482 https://doi.org/10.1007/s11916-020-00908-1Boitet R, de Gaalon S, Duflos C, Marin G, Mawet J, Burcin C, et al. Long-term outcomes after reversible cerebral vasoconstriction syndrome. Stroke. 2020;51(2):670–673. PMID: 31842705 https://doi.org/10.1161/STROKEAHA.119.027703Boitet R, de Gaalon S, Duflos C, Marin G, Mawet J, Burcin C, et al. Long-term outcomes after reversible cerebral vasoconstriction syndrome. Stroke. 2020;51(2):670–673. PMID: 31842705 https://doi.org/10.1161/STROKEAHA.119.027703Ramineni KK, Jakkani RK, Girgani S, Balani A, Satyanarayan S. Triptan-induced reversible cerebral vasoconstriction syndrome presenting with thunderclap headache and paraparesis. Neurologist. 2018;23(5):160–162. PMID: 30169369 https://doi.org/10.1097/NRL.0000000000000193Ramineni KK, Jakkani RK, Girgani S, Balani A, Satyanarayan S. Triptan-induced reversible cerebral vasoconstriction syndrome presenting with thunderclap headache and paraparesis. Neurologist. 2018;23(5):160–162. PMID: 30169369 https://doi.org/10.1097/NRL.0000000000000193Garg A, Starr M, Rocha M, Ortega-Gutierrez S. Predictors and outcomes of ischemic stroke in reversible cerebral vasoconstriction syndrome. J Neurol. 2021;268(8):3020–3025. PMID: 33646329 https://doi.org/10.1007/s00415-021-10456-2Garg A, Starr M, Rocha M, Ortega-Gutierrez S. Predictors and outcomes of ischemic stroke in reversible cerebral vasoconstriction syndrome. J Neurol. 2021;268(8):3020–3025. PMID: 33646329 https://doi.org/10.1007/s00415-021-10456-2Topcuoglu MA, Singhal AB. Hemorrhagic Reversible Cerebral Vasoconstriction Syndrome: Features and Mechanisms. Stroke. 2016;47(7):1742–1747. PMID: 27272485 https://doi.org/10.1161/STROKEAHA.116.013136.Topcuoglu MA, Singhal AB. Hemorrhagic Reversible Cerebral Vasoconstriction Syndrome: Features and Mechanisms. Stroke. 2016;47(7):1742–1747. PMID: 27272485 https://doi.org/10.1161/STROKEAHA.116.013136.Patel SD, Topiwala K, Saini V, Patel N, Pervez M, Al-Mufti F, et al. Hemorrhagic reversible cerebral vasoconstriction syndrome: a retrospective observational study. J Neurol. 2021;268(2):632–639. PMID: 32894331 https://doi.org/10.1007/s00415-020-10193-yPatel SD, Topiwala K, Saini V, Patel N, Pervez M, Al-Mufti F, et al. Hemorrhagic reversible cerebral vasoconstriction syndrome: a retrospective observational study. J Neurol. 2021;268(2):632–639. PMID: 32894331 https://doi.org/10.1007/s00415-020-10193-yDucros A, Fiedler U, Porcher R, Boukobza M, Stapf C, Bousser MG. Hemorrhagic manifestations of reversible cerebral vasoconstriction syndrome: frequency, features, and risk factors. Stroke. 2010;41(11):2505–2511. PMID: 20884871 https://doi.org/10.1161/strokeaha.109.572313Ducros A, Fiedler U, Porcher R, Boukobza M, Stapf C, Bousser MG. Hemorrhagic manifestations of reversible cerebral vasoconstriction syndrome: frequency, features, and risk factors. Stroke. 2010;41(11):2505–2511. PMID: 20884871 https://doi.org/10.1161/strokeaha.109.572313Muehlschlegel S, Kursun O, Topcuoglu MA, Fok J, Singhal AB. Differentiating reversible cerebral vasoconstriction syndrome with subarachnoid hemorrhage from other causes of subarachnoid hemorrhage. JAMA Neurol. 2013;70(10):1254–1260. PMID: 23939614 https://doi.org/10.1001/jamaneurol.2013.3484Muehlschlegel S, Kursun O, Topcuoglu MA, Fok J, Singhal AB. Differentiating reversible cerebral vasoconstriction syndrome with subarachnoid hemorrhage from other causes of subarachnoid hemorrhage. JAMA Neurol. 2013;70(10):1254–1260. PMID: 23939614 https://doi.org/10.1001/jamaneurol.2013.3484Singhal AB, Topcuoglu MA, Fok JW, Kursun O, Nogueira RG, Frosch MP, et al. Reversible cerebral vasoconstriction syndromes and primary angiitis of the central nervous system: clinical, imaging, and angiographic comparison. Ann Neurol. 2016;79(6):882–894. PMID: 27043703 https://doi.org/10.1002/ana.24652Singhal AB, Topcuoglu MA, Fok JW, Kursun O, Nogueira RG, Frosch MP, et al. Reversible cerebral vasoconstriction syndromes and primary angiitis of the central nervous system: clinical, imaging, and angiographic comparison. Ann Neurol. 2016;79(6):882–894. PMID: 27043703 https://doi.org/10.1002/ana.24652Chen SP, Fuh JL, Wang SJ, Chang FC, Lirng JF, Fang YC, et al.Magnetic resonance angiography in reversible cerebral vasoconstriction syndromes. Ann Neurol. 2010;67(5):648–656. PMID: 20437562 https://doi.org/10.1002/ana.21951Chen SP, Fuh JL, Wang SJ, Chang FC, Lirng JF, Fang YC, et al.Magnetic resonance angiography in reversible cerebral vasoconstriction syndromes. Ann Neurol. 2010;67(5):648–656. PMID: 20437562 https://doi.org/10.1002/ana.21951Mills JN, Mehta V, Russin J, Amar AP, Rajamohan A, Mack WJ. Advanced imaging modalities in the detection of cerebral vasospasm. Neurol Res Int. 2013;2013:415960. PMID: 23476766 https://doi.org/10.1155/2013/415960Mills JN, Mehta V, Russin J, Amar AP, Rajamohan A, Mack WJ. Advanced imaging modalities in the detection of cerebral vasospasm. Neurol Res Int. 2013;2013:415960. PMID: 23476766 https://doi.org/10.1155/2013/415960Perillo T, Paolella C, Perrotta G, Serino A, Caranci F, Manto A. Reversible cerebral vasoconstriction syndrome: review of neuroimaging findings. Radiol Med. 2022;127(9):981–990. PMID: 35932443 https://doi.org/10.1007/s11547-022-01532-2Perillo T, Paolella C, Perrotta G, Serino A, Caranci F, Manto A. Reversible cerebral vasoconstriction syndrome: review of neuroimaging findings. Radiol Med. 2022;127(9):981–990. PMID: 35932443 https://doi.org/10.1007/s11547-022-01532-2Fifi JT, Meyers PM, Lavine SD, Cox V, Silverberg L, Mangla S, et al. Complications of modern diagnostic cerebral angiography in an academic medical center. J Vasc Interv Radiol. 2009;20(4):442–447. PMID: 19246211 https://doi.org/10.1016/j.jvir.2009.01.012Fifi JT, Meyers PM, Lavine SD, Cox V, Silverberg L, Mangla S, et al. Complications of modern diagnostic cerebral angiography in an academic medical center. J Vasc Interv Radiol. 2009;20(4):442–447. PMID: 19246211 https://doi.org/10.1016/j.jvir.2009.01.012Shen J, Karki M, Jiang T, Zhao B. Complications associated with diagnostic cerebral angiography: a retrospective analysis of 644 consecutive cerebral angiographic cases. Neurol India. 2018;66(4):1154–1158. PMID: 30038108 https://doi.org/10.4103/0028-3886.237018Shen J, Karki M, Jiang T, Zhao B. Complications associated with diagnostic cerebral angiography: a retrospective analysis of 644 consecutive cerebral angiographic cases. Neurol India. 2018;66(4):1154–1158. PMID: 30038108 https://doi.org/10.4103/0028-3886.237018Marder CP, Donohue MM, Weinstein JR, Fink KR. Multimodal imaging of reversible cerebral vasoconstriction syndrome: a series of 6 cases. AJNR Am J Neuroradiol. 2012;33(7):1403–1410. PMID: 22422190 https://doi.org/10.3174/ajnr.A2964Marder CP, Donohue MM, Weinstein JR, Fink KR. Multimodal imaging of reversible cerebral vasoconstriction syndrome: a series of 6 cases. AJNR Am J Neuroradiol. 2012;33(7):1403–1410. PMID: 22422190 https://doi.org/10.3174/ajnr.A2964Miller TR, Shivashankar R, Mossa-Basha M, Gandhi D. Reversible cerebral vasoconstriction syndrome, part 2: diagnostic work-up, imaging evaluation, and differential diagnosis. AJNR Am J Neuroradiol. 2015;36(9):1580–1588. PMID: 25614476 https://doi.org/10.3174/ajnr.A4215Miller TR, Shivashankar R, Mossa-Basha M, Gandhi D. Reversible cerebral vasoconstriction syndrome, part 2: diagnostic work-up, imaging evaluation, and differential diagnosis. AJNR Am J Neuroradiol. 2015;36(9):1580–1588. PMID: 25614476 https://doi.org/10.3174/ajnr.A4215Mandell DM, Matouk CC, Farb RI, Krings T, Agid R, terBrugge K, et al. Vessel wall MRI to differentiate between reversible cerebral vasoconstriction syndrome and central nervous system vasculitis: preliminary results. Stroke. 2012;43:860–862. https://doi.org/10.1161/STROKEAHA.111.626184Mandell DM, Matouk CC, Farb RI, Krings T, Agid R, terBrugge K, et al. Vessel wall MRI to differentiate between reversible cerebral vasoconstriction syndrome and central nervous system vasculitis: preliminary results. Stroke. 2012;43:860–862. https://doi.org/10.1161/STROKEAHA.111.626184Pilato F, Distefano M, Calandrelli R. Posterior Reversible Encephalopathy Syndrome and Reversible Syndrome: Clinical and Radiological Considerations. Front Neurol. 2020;11:34. PMID: 32117007 https://doi.org/10.3389/fneur.2020.00034 eCollection 2020.Pilato F, Distefano M, Calandrelli R. Posterior Reversible Encephalopathy Syndrome and Reversible Syndrome: Clinical and Radiological Considerations. Front Neurol. 2020;11:34. PMID: 32117007 https://doi.org/10.3389/fneur.2020.00034 eCollection 2020.Merli N, Padroni M, Azzini C, Bernardoni A, Marcialis C, Tugnoli V, et al. Reversible cerebral vasoconstriction syndrome: strategies to early diagnosis and the role of transcranial color-coded doppler ultrasonography (TCCD). Neurol Sci. 2023;44(7):2541–2545. PMID: 37014565 https://doi.org/10.1007/s10072-023-06755-3Merli N, Padroni M, Azzini C, Bernardoni A, Marcialis C, Tugnoli V, et al. Reversible cerebral vasoconstriction syndrome: strategies to early diagnosis and the role of transcranial color-coded doppler ultrasonography (TCCD). Neurol Sci. 2023;44(7):2541–2545. PMID: 37014565 https://doi.org/10.1007/s10072-023-06755-3Liu L, Tan Q, Huang R, Hu Z. Analysis of postpartum reversible cerebral vasoconstriction syndrome in China. Medicine (Baltimore). 2019;98(45):e17170. PMID: 31702607 https://doi.org/10.1097/MD.0000000000017170Liu L, Tan Q, Huang R, Hu Z. Analysis of postpartum reversible cerebral vasoconstriction syndrome in China. Medicine (Baltimore). 2019;98(45):e17170. PMID: 31702607 https://doi.org/10.1097/MD.0000000000017170Ducros A. Reversible cerebral vasoconstriction syndrome. Lancet Neurol. 2012;11(10):906–917. PMID: 22995694 https://doi.org/10.1016/S1474-4422(12)70135-7Ducros A. Reversible cerebral vasoconstriction syndrome. Lancet Neurol. 2012;11(10):906–917. PMID: 22995694 https://doi.org/10.1016/S1474-4422(12)70135-7Saini M, Jeerakathil T, Butcher K. Reversible cerebral vasoconstriction syndrome. Neurol India. 2009;57(1):63–65. PMID: 19305081 https://doi.org/10.4103/0028-3886.48816Saini M, Jeerakathil T, Butcher K. Reversible cerebral vasoconstriction syndrome. Neurol India. 2009;57(1):63–65. PMID: 19305081 https://doi.org/10.4103/0028-3886.48816Hajj-Ali RA, Singhal AB, Benseler S, Molloy E, Calabrese LH. Primary angiitis of the CNS. Lancet Neurol. 2011;10(6):561–572. PMID: 21601163 https://doi.org/10.1016/s1474-4422(11)70081-3Hajj-Ali RA, Singhal AB, Benseler S, Molloy E, Calabrese LH. Primary angiitis of the CNS. Lancet Neurol. 2011;10(6):561–572. PMID: 21601163 https://doi.org/10.1016/s1474-4422(11)70081-3Rocha EA, Topcuoglu MA, Silva GS, Singhal AB. RCVS2 score and diagnostic approach for reversible cerebral vasoconstriction syndrome. Neurology. 2019;92(7):e639–e647. PMID: 30635475 https://doi.org/10.1212/wnl.0000000000006917Rocha EA, Topcuoglu MA, Silva GS, Singhal AB. RCVS2 score and diagnostic approach for reversible cerebral vasoconstriction syndrome. Neurology. 2019;92(7):e639–e647. PMID: 30635475 https://doi. org/10.1212/wnl.0000000000006917Singhal AB, Rocha EA. Author response: RCVS2 score and diagnostic approach for reversible cerebral vasoconstriction syndrome. Neurology. 2020;94(21):946. https://doi.org/10.1212/WNL.0000000000009500Singhal AB, Rocha EA. Author response: RCVS2 score and diagnostic approach for reversible cerebral vasoconstriction syndrome. Neurology. 2020;94(21):946. https://doi.org/10.1212/WNL.0000000000009500Collins L, Lam L, Kleinig O, Proudman W, Zhang R, Bagster M, et al. Verapamil in the treatment of reversible cerebral vasoconstriction syndrome: A systematic review. J Clin Neurosci. 2023;113:130–141. https://doi.org/10.1016/j.jocn.2023.05.013 PMID: 37267876Collins L, Lam L, Kleinig O, Proudman W, Zhang R, Bagster M, et al. Verapamil in the treatment of reversible cerebral vasoconstriction syndrome: A systematic review. J Clin Neurosci. 2023;113:130–141. https://doi.org/10.1016/j.jocn.2023.05.013 PMID: 37267876Cho S, Lee MJ, Chung CS. Effect of nimodipine treatment on the clinical course of reversible cerebral vasoconstriction syndrome. Front Neurol. 2019;10:644. PMID: 31275233 https://doi.org/10.3389/fneur.2019.00644 eCollection 2019.Cho S, Lee MJ, Chung CS. Effect of nimodipine treatment on the clinical course of reversible cerebral vasoconstriction syndrome. Front Neurol. 2019;10:644. PMID: 31275233 https://doi.org/10.3389/fneur.2019.00644 eCollection 2019.Song TJ, Lee KH, Li H, Kim JY, Chang K, Kim SH, et al. Reversible cerebral vasoconstriction syndrome: a comprehensive systematic review. Eur Rev Med Pharmacol Sci. 2021;25(9):3519–3529. PMID: 34002826 https://doi.org/10.26355/eurrev_202105_25834Song TJ, Lee KH, Li H, Kim JY, Chang K, Kim SH, et al. Reversible cerebral vasoconstriction syndrome: a comprehensive systematic review. Eur Rev Med Pharmacol Sci. 2021;25(9):3519–3529. PMID: 34002826 https://doi.org/10.26355/eurrev_202105_25834Hadhiah KM, Alshagawi ZA, Alzahrani SK, Alrayes MM, Aldandan HW. Reversible cerebral vasoconstriction syndrome in a background of eclampsia responding to milrinone infusion. Am J Case Rep. 2021;22:e934528. PMID: 34784343 https://doi.org/10.12659/AJCR.934528Hadhiah KM, Alshagawi ZA, Alzahrani SK, Alrayes MM, Aldandan HW. Reversible cerebral vasoconstriction syndrome in a background of eclampsia responding to milrinone infusion. Am J Case Rep. 2021;22: e934528. PMID: 34784343 https://doi.org/10.12659/AJCR.934528Zeitouni D, Parish JM, Smith M, Stetler WR, Bernard JD. Reversible cerebral vasoconstriction syndrome successfully treated by intrathecal nicardipine. Clin Neurol Neurosurg. 2021;206:106705 PMID: 34053805 https://doi.org/10.1016/j.clineuro.2021.10670Zeitouni D, Parish JM, Smith M, Stetler WR, Bernard JD. Reversible cerebral vasoconstriction syndrome successfully treated by intrathecal nicardipine. Clin Neurol Neurosurg. 2021;206:106705 PMID: 34053805 https://doi.org/10.1016/j.clineuro.2021.10670Farid H, Tatum JK, Wong C, Halbach VV, Hetts SW. Reversible Cerebral Vasoconstriction Syndrome: Treatment with Combined Intra-Arterial Verapamil Infusion and Intracranial Angioplasty. AJNR Am J Neuroradiol. 2011;32(10):E184–E187. PMID: 21273351 https://doi.org/10.3174/ajnr.A2341Farid H, Tatum JK, Wong C, Halbach VV, Hetts SW. Reversible Cerebral Vasoconstriction Syndrome: Treatment with Combined Intra-Arterial Verapamil Infusion and Intracranial Angioplasty. AJNR Am J Neuroradiol. 2011;32(10):E184–E187. PMID: 21273351 https://doi.org/10.3174/ajnr.A2341

The authors declare that there are no conflicts of interest present.