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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nmp</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Sklifosovsky Journal "Emergency Medical Care"</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-9022</issn><issn pub-type="epub">2541-8017</issn><publisher><publisher-name>“N.V. Sklifosovsky Research Institute for Emergency Medicine”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23934/2223-9022-2024-13-3-375-384</article-id><article-id custom-type="elpub" pub-id-type="custom">nmp-1923</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Применение диагностической транскраниальной магнитной стимуляции в качестве предиктора функционального исхода ишемического инсульта</article-title><trans-title-group xml:lang="en"><trans-title>The Use of Diagnostic Transcranial Magnetic Stimulation as a Predictor of the Functional Outcome in Ischemic Stroke</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5123-5991</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Погонченкова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pogonchenkova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Погонченкова Ирэна Владимировна доктор медицинских наук, директор ГАУЗ МНПЦ МРВСМ им. С.И. Спасокукоцкого ДЗМ»</p><p>127206, Москва, ул. Вучетича, д. 21</p></bio><bio xml:lang="en"><p>Irena V. Pogonchenkova, Doctor of Medical Sciences, Director</p><p>Vucheticha Str. 21, Moscow, 127206</p></bio><email xlink:type="simple">pogonchenkovaiv@zdrav.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3292-8789</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петриков</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrikov</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петриков Сергей Сергеевич член-корреспондент РАН, профессор, доктор медицинских наук, директор ГБУЗ «НИИ СП им. Н.В. Склифосовского ДЗМ»</p><p>129090, Москва, Большая Сухаревская площадь, д. 3</p></bio><bio xml:lang="en"><p>Sergey S. Petrikov, Corresponding Member of the Russian Academy of Sciences, Full Professor, Doctor of Medical Sciences, Director</p><p>Bolshaya Sukharevskaya Sq. 3, Moscow, 129090</p></bio><email xlink:type="simple">petrikovss@sklif.mos.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0629-9659</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Костенко</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kostenko</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Костенко Елена Владимировна доктор медицинских наук, профессор, главный научный сотрудник, заместитель директора по научной работе ГАУЗ «МНПЦ МРВСМ им. С.И. Спасокукоцкого ДЗМ»; врач-невролог, профессор кафедры неврологии, нейрохирургии и медицинской генетики ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России</p><p>127206, Москва, ул. Вучетича, д. 21; 119571, Москва, Ленинский проспект, д. 117</p></bio><bio xml:lang="en"><p>Elena V. Kostenko, Doctor of Medical Sciences, Full Professor, Deputy Director for Research; Neurologist, Professor, Department of Neurology, Neurosurgery and Medical Genetics</p><p>Vucheticha Str. 21, Moscow, 127206;Leninsky Prospekt 117, Moscow, 119571</p></bio><email xlink:type="simple">ekostenko58@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7483-1796</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кашежев</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kashezhev</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кашежев Алим Гумарович кандидат медицинских наук, старший научный сотрудник ГАУЗ «МНПЦ МРВСМ им. С.И. Спасокукоцкого ДЗМ»</p><p>127206, Москва, ул. Вучетича, д. 21</p></bio><bio xml:lang="en"><p>Alim G. Kashezhev, Candidate of Medical Sciences, Senior Researcher</p><p>Vucheticha Str. 21, Moscow, 127206</p></bio><email xlink:type="simple">kashezhevalim@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0353-553X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петрова</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrova</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петрова Людмила Владимировна кандидат медицинских наук, врач-невролог, заведующий отделением, старший научный сотрудник ГАУЗ «МНПЦ МРВСМ им. С.И. Спасокукоцкого ДЗМ»</p><p>127206, Москва, ул. Вучетича, д. 21</p></bio><bio xml:lang="en"><p>Lyudmila V. Petrova, Candidate of Medical Sciences, Neurologist, Head of the Department, Senior Researcher</p><p>Vucheticha Str. 21, Moscow, 127206</p></bio><email xlink:type="simple">ludmila.v.petrova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5026-0060</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Синкин</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sinkin</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Cинкин Михаил Владимирович доктор медицинских наук, ведущий научный сотрудник отделения нейрохирургии ГБУЗ «НИИ СП им. Н.В. Склифосовского ДЗМ»</p><p>129090, Москва, Большая Сухаревская площадь, д. 3</p></bio><bio xml:lang="en"><p>Mikhail V. Sinkin, Doctor of Medical Sciences, Leading Researcher, Department of Neurosurgery</p><p>Bolshaya Sukharevskaya Sq. 3, Moscow, 129090</p></bio><email xlink:type="simple">sinkinmv@sklif.mos.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ГАУЗ «Московский научно-практический центр медицинской реабилитации, восстановительной и спортивной медицины им. С.И. Спасокукоцкого ДЗМ»<country>Россия</country></aff><aff xml:lang="en">Moscow Research and Practice Center for Medical Rehabilitation, Restorative and Sports Medicine named after S.I. Spasokukotsky<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»<country>Россия</country></aff><aff xml:lang="en">N.V. Sklifosovsky Research Institute for Emergency Medicine<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">ГАУЗ «Московский научно-практический центр медицинской реабилитации, восстановительной и спортивной медицины им. С.И. Спасокукоцкого ДЗМ»; ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» МЗ РФ<country>Россия</country></aff><aff xml:lang="en">Moscow Research and Practice Center for Medical Rehabilitation, Restorative and Sports Medicine named after S.I. Spasokukotsky; N.I. Pirogov Russian National Research Medical University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>14</day><month>10</month><year>2024</year></pub-date><volume>13</volume><issue>3</issue><fpage>375</fpage><lpage>384</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Погонченкова И.В., Петриков С.С., Костенко Е.В., Кашежев А.Г., Петрова Л.В., Синкин М.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Погонченкова И.В., Петриков С.С., Костенко Е.В., Кашежев А.Г., Петрова Л.В., Синкин М.В.</copyright-holder><copyright-holder xml:lang="en">Pogonchenkova I.V., Petrikov S.S., Kostenko E.V., Kashezhev A.G., Petrova L.V., Sinkin M.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jnmp.ru/jour/article/view/1923">https://www.jnmp.ru/jour/article/view/1923</self-uri><abstract><sec><title>АКТУАЛЬНОСТЬ</title><p>АКТУАЛЬНОСТЬ. Определение реабилитационного потенциала (РП) необходимо для подбора оптимальной реабилитационной стратегии и комплекса реабилитационных мероприятий. В качестве одного из методов определения РП может рассматриваться навигационная транскраниальная магнитная стимуляция (нТМС).</p></sec><sec><title>ЦЕЛЬ</title><p>ЦЕЛЬ. Изучить значимость навигационной диагностической транскраниальной магнитной стимуляции как нейрофункционального предиктора восстановления двигательных функций после перенесенного ишемического инсульта.</p></sec><sec><title>МАТЕРИАЛ И МЕТОДЫ</title><p>МАТЕРИАЛ И МЕТОДЫ. В исследование включены 28 пациентов, перенесших ИИ, проходивших стационарную медицинскую реабилитацию (МР) в ГАУЗ МНПЦ МРВСМ им. С.И. Спасокукоцкого ДЗМ. Из них было 19 мужчин и 9 женщин, средний возраст — 60,07±5,67 года. При поступлении и по завершении курса МР проводился клинический осмотр и оценка с помощью шкалы комитета медицинских исследований (MRC), теста «Кубики в коробке» (BBT), модифицированной шкалы Рэнкина (mRS); шкалы реабилитационной маршрутизации (ШРМ). На базе НИИ СП им. Н.В. Склифосовского проводилась нТМС с определением параметров вызванного моторного ответа (ВМО) с мышц верхних и нижних конечностей.</p></sec><sec><title>РЕЗУЛЬТАТЫ</title><p>РЕЗУЛЬТАТЫ. У пациентов с определяемым вызванным моторным ответом отмечался статистически значимый прирост силы паретичной конечности по шкале MRC — c 4,00 (2,94–4,06) до 4,22 (3,83–4,89) балла (р&lt;0,001) для верхней конечности и с 4,00 (3,67–4,00) до 4,44 (3,83–4,61) (p&lt;0,001) для нижней конечности. В случаях сохранности ВМО отмечено увеличение числа пациентов с оценкой по mRS в 2 балла на 26,1%, достигли значений в 1 балл 13,0% пациентов и на 8,7% уменьшилось число пациентов с оценкой степени инвалидизации и способности к самообслуживанию в 4 балла.</p></sec><sec><title>ВЫВОДЫ</title><p>ВЫВОДЫ. Навигационная транскраниальная магнитная стимуляция может служить одним из методов оценки реабилитационного потенциала у пациентов, перенесших ишемический инсульт. Использование ее как единственного источника информации для определения тактики медицинской реабилитации не имеет убедительных доказательств. Оценка реабилитационного потенциала должна носить комплексный характер и опираться на всю совокупность полученных данных.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>ABSTRACT</title><p>ABSTRACT. Determination of rehabilitation potential (RP) is necessary for optimal rehabilitation strategy and the best rehabilitation measures. Navigational transcranial magnetic stimulation (nTMS) has been proposed as a method for PR determination in after-stroke patients.</p></sec><sec><title>THE AIM</title><p>THE AIM. was to study the importance of navigational diagnostic transcranial magnetic stimulation as a neurofunctional predictor of motor function recovery after ischemic stroke.</p></sec><sec><title>MATERIAL AND METHODS</title><p>MATERIAL AND METHODS. The study included 28 after-stroke patients, 19 men and 9 women, the mean age was 60.07±5.67 years, who underwent a course of inpatient medical rehabilitation at the Moscow Research and Practice Center for Medical Rehabilitation, Restorative and Sports Medicine named after S.I. Spasokukotsky in 2022–2023. Clinical examination and assessment were conducted before and after the rehabilitation course using validated scales and questionnaires — the Medical Research Committee (MRCs) scale, the Box and Block Test (BBT), the modified Rankin scale (mRS); the rehabilitation routing scale (RRS). The patients were also examined using nTMS at the N.V. Sklifosovsky Research Institute for Emergency Medicine with the determination of motor evoked potential (MEP) parameters from the muscles of the upper and lower extremities.</p></sec><sec><title>RESULTS</title><p>RESULTS. In patients with preserved MEP, there was a significant increase in the strength of the paretic limb on the MRCs scale from 4.00 (2.94–4.06) to 4.22 (3.83–4.89) points (p &lt;0.001) for the upper limb and from 4.00 (3.67–4.00) to 4.44 (3.83–4.61) (p&lt;0.001) for the lower limb. Improvements were revealed according to the mRS scale — the number of patients with an mRS score of 2 points in the group of patients with defined MEP increased by 26.1%, reached values of 1 point — 13.0% of patients, and the number of patients with an assessment of disability and self-care ability of 4 points decreased by 8.7%.</p></sec><sec><title>CONCLUSION</title><p>CONCLUSION. Navigational transcranial magnetic stimulation is one of the methods for assessing the rehabilitation potential in patients with ischemic stroke. But TMS should not be used as the only method of evaluating rehabilitation potential. The assessment of RP should be comprehensive and based on the complex data obtained.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>нейрореабилитация</kwd><kwd>транскраниальная магнитная стимуляция</kwd><kwd>реабилитационный потенциал</kwd><kwd>ишемический инсульт</kwd></kwd-group><kwd-group xml:lang="en"><kwd>neurorehabilitation</kwd><kwd>transcranial magnetic stimulation</kwd><kwd>rehabilitation potential</kwd><kwd>ischemic stroke</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Грант Правительства г. Москвы № 1503-7/23.</funding-statement></funding-group><funding-group xml:lang="en"><funding-statement>The study was supported by the Grant of the Government of Moscow No. 1503-7/23.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Feigin VL, Brainin M, Norrving B, Martins S, Sacco RL, Hacke W, et al. 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