<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nmp</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Sklifosovsky Journal "Emergency Medical Care"</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-9022</issn><issn pub-type="epub">2541-8017</issn><publisher><publisher-name>“N.V. Sklifosovsky Research Institute for Emergency Medicine”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23934/2223-9022-2023-12-4-690-696</article-id><article-id custom-type="elpub" pub-id-type="custom">nmp-1735</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group></article-categories><title-group><article-title>Опыт использования вено-венозной экстракорпоральной мембранной оксигенации при тяжелой сочетанной травме</article-title><trans-title-group xml:lang="en"><trans-title>Venovenous Extracorporeal Membrane Oxygenation in Severe Polytrauma</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6581-8722</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Власов</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vlasov</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пётр Алексеевич Власов, врач анестезиолог-реаниматолог</p><p>отделение анестезиологии-реанимации № 5</p><p>170036</p><p>Петербургское шоссе, д. 105</p><p>Тверь</p></bio><bio xml:lang="en"><p>Pyotr A. Vlasov, Anesthesiologist and Resuscitator</p><p>Department of Anesthesiology and Resuscitation No. 5</p><p>170036</p><p>105, Peterburgskoye Hw.</p><p>Tver</p></bio><email xlink:type="simple">thomas.d.shelby@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6118-6273</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кудряшова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kudryashova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена Александровна Кудряшова, врач анестезиолог-реаниматолог</p><p>отделение анестезиологии-реанимации № 5</p><p>170036</p><p>Петербургское шоссе, д. 105</p><p>Тверь</p></bio><bio xml:lang="en"><p>Elena A. Kudryashova, Anesthesiologist and Resuscitator</p><p>Department of Anesthesiology and Resuscitation No. 5</p><p>170036</p><p>105, Peterburgskoye Hw.</p><p>Tver</p></bio><email xlink:type="simple">kudryashowa.elena2012@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8947-0989</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мельниченко</surname><given-names>П. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Melnichenko</surname><given-names>P. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Павел Игоревич Мельниченко, заведующий отделением, врач анестезиолог-реаниматолог</p><p>отделение анестезиологии-реанимации № 5</p><p>170036</p><p>Петербургское шоссе, д. 105</p><p>Тверь</p></bio><bio xml:lang="en"><p>Pavel I. Melnichenko, Head of Department, Anesthesiologist and Resuscitator</p><p>Department of Anesthesiology and Resuscitation No. 5</p><p>170036</p><p>105, Peterburgskoye Hw.</p><p>Tver</p></bio><email xlink:type="simple">ya@melnicaa13.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9769-7953</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никифоров</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikiforov</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Игорь Сергеевич Никифоров, врач анестезиолог-реаниматолог</p><p>отделение анестезиологии-реанимации № 5</p><p>170036</p><p>Петербургское шоссе, д. 105</p><p>Тверь</p></bio><bio xml:lang="en"><p>Igor S. Nikiforov, Anesthesiologist and Resuscitator</p><p>Department of Anesthesiology and Resuscitation No. 5</p><p>170036</p><p>105, Peterburgskoye Hw.</p><p>Tver</p></bio><email xlink:type="simple">nikiforov.i.s@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2780-5138</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петрушин</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrushin</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Максим Александрович Петрушин, главный внештатный анестезиолог-реаниматолог Тверской области, руководитель службы</p><p>отделение анестезиологии-реанимации № 5</p><p>служба анестезиологии-реанимации</p><p>170036</p><p>Петербургское шоссе, д. 105</p><p>Тверь</p></bio><bio xml:lang="en"><p>Maksim A. Petrushin, Chief External Anesthesiologist and Resuscitator of the Tver region, Head of the Service</p><p>Department of Anesthesiology and Resuscitation No. 5</p><p>Anesthesiology and Resuscitation Service</p><p>170036</p><p>105, Peterburgskoye Hw.</p><p>Tver</p></bio><email xlink:type="simple">maxi.petrushin@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ГБУЗ Тверской области «Областная клиническая больница»<country>Россия</country></aff><aff xml:lang="en">Regional Clinical Hospital<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>24</day><month>01</month><year>2024</year></pub-date><volume>12</volume><issue>4</issue><fpage>690</fpage><lpage>696</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Власов П.А., Кудряшова Е.А., Мельниченко П.И., Никифоров И.С., Петрушин М.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Власов П.А., Кудряшова Е.А., Мельниченко П.И., Никифоров И.С., Петрушин М.А.</copyright-holder><copyright-holder xml:lang="en">Vlasov P.A., Kudryashova E.A., Melnichenko P.I., Nikiforov I.S., Petrushin M.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jnmp.ru/jour/article/view/1735">https://www.jnmp.ru/jour/article/view/1735</self-uri><abstract><sec><title>   АКТУАЛЬНОСТЬ</title><p>   АКТУАЛЬНОСТЬ. Дорожно-транспортный травматизм (ДТТ) является ведущей причиной смертности трудоспособного населения в настоящее время. Зачастую тяжелая сочетанная травма сопровождается значительным повреждением грудной клетки с развитием выраженных респираторных расстройств. Стандартные методы интенсивной терапии дыхательной недостаточности часто оказываются неэффективны. Применение метода экстракорпоральной мембранной оксигенации (ЭКМО) может быть эффективным методом снижения смертности у данной категории пациентов, даже в условиях невозможности применения системной антикоагуляции.</p></sec><sec><title>   ЦЕЛЬ ИССЛЕДОВАНИЯ</title><p>   ЦЕЛЬ ИССЛЕДОВАНИЯ. Рассмотреть возможности применения ЭКМО у пациентов с тяжелой сочетанной травмой и высоким риском геморрагических осложнений.</p></sec><sec><title>   МАТЕРИАЛ И МЕТОДЫ</title><p>   МАТЕРИАЛ И МЕТОДЫ. Пациент Р., 43 года, получил тяжелую сочетанную травму в дорожно-транспортном происшествии, в связи с прогрессирующей острой дыхательной недостаточностью была применена вено-венозная ЭКМО (ВВ-ЭКМО), которую проводили в течение 11 суток.</p></sec><sec><title>   РЕЗУЛЬТАТЫ</title><p>   РЕЗУЛЬТАТЫ. В данном сообщении рассмотрено клиническое наблюдение успешного применения ВВ-ЭКМО у пациента с тяжелым острым респираторным дистресс-синдромом в результате политравмы в ДТП. Ввиду высокого риска геморрагических осложнений процедуру проводили без применения системной антикоагуляции, что является довольно редким случаем в современной интенсивной терапии. На 11-е сутки процедура ВВ-ЭКМО была прекращена. На 7-е сутки ВВ-ЭКМО развилось осложнение в виде интенсивного геморрагического синдрома, которое было успешно купировано. На 13-е сутки после отлучения пациент был переведен из отделения интенсивной терапии в реабилитационный центр.</p></sec><sec><title>   ВЫВОДЫ</title><p>   ВЫВОДЫ.  Метод вено-венозной экстракорпоральной мембранной оксигенации может быть рассмотрен в рамках лечения тяжелого острого респираторного дистресс-синдрома в результате тяжелой травмы грудной клетки при неэффективности стандартных методов респираторной поддержки. При высоком риске геморрагических осложнений, который зачастую наблюдается у пациентов данной категории, возможно применение вено-венозной экстракорпоральной мембранной оксигенации без системной антикоагуляции.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>   BACKGROUND</title><p>   BACKGROUND. Road transport injuries (RTI) are the leading cause of death among the working-age population at present. Often, severe combined trauma is accompanied by significant damage to the chest with the development of severe respiratory disorders. Standard methods of intensive therapy for respiratory failure are often ineffective. The use of extracorporeal membrane oxygenation (ECMO) can be an effective method of reducing mortality in this category of patients, evenin conditions where it is impossible to use systemic anticoagulation.</p></sec><sec><title>   AIM OF THE STUDY</title><p>   AIM OF THE STUDY. Consider the use of ECMO in patients with serious polytrauma trauma and a high risk of hemorrhagic complications.</p></sec><sec><title>   MATERIAL AND METHODS</title><p>   MATERIAL AND METHODS. Patient R., 43 years old, got a severe combined injury in a traffic accident; due to progressive acute respiratory failure, veno-venous ECMO (VV-ECMO) was performed for 11 days.</p></sec><sec><title>   RESULTS</title><p>   RESULTS. This report reviews a clinical observation of the successful use of VV-ECMO in a patient with severe acute respiratory distress syndrome as a result of polytrauma in a road accident. Due to the high risk of hemorrhagic complications, the procedure was performed without the use of systemic anticoagulation, which is a rather rare case in modern intensive care. On the 11th day, the VV-ECMO procedure was stopped. On the 7th day of VV-ECMO, an intense hemorrhagic syndrome developed as a complication, which was successfully treated. On the 13th day after weaning, the patient was transferred from the intensive care unit to the rehabilitation center.</p></sec><sec><title>   CONCLUSIONS</title><p>   CONCLUSIONS. The venovenous extracorporeal membrane oxygenation method can be considered as part of the treatment of severe acute respiratory distress syndrome as a result of severe chest trauma when standard methods of respiratory support are ineffective. With a high risk of hemorrhagic complications, which is often observed in patients in this category, it is possible to use venovenous extracorporeal membrane oxygenation without systemic anticoagulation.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>тяжелая сочетанная травма</kwd><kwd>ОРДС</kwd><kwd>вено-венозная ЭКМО</kwd><kwd>системная антикоагуляция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>severe combined trauma</kwd><kwd>ARDS</kwd><kwd>venovenous ECMO</kwd><kwd>systemic anticoagulation</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Исследование не имеет спонсорской поддержки</funding-statement></funding-group><funding-group xml:lang="en"><funding-statement>The study has no sponsorship</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ried M, Bein T, Philipp A, Müller T, Graf B, Schmid C, et al. Extracorporeal lung support in trauma patients with severe chest injury and acute lung failure: a 10-year institutional experience. Crit Care. 2013;17(3):R110. PMID: 23786965 doi: 10.1186/cc12782</mixed-citation><mixed-citation xml:lang="en">Ried M, Bein T, Philipp A, Müller T, Graf B, Schmid C, et al. Extracorporeal lung support in trauma patients with severe chest injury and acute lung failure: a 10-year institutional experience. Crit Care. 2013;17(3):R110. PMID: 23786965 doi: 10.1186/cc12782</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Chrysou K, Halat G, Hoksch B, Schmid RA, Kocher GJ. Lessons from a large trauma center: impact of blunt chest trauma in polytrauma patients-still a relevant problem? Scand J Trauma Resusc Emerg Med. 2017;25(1):42. PMID: 28427480 doi: 10.1186/s13049-017-0384-y</mixed-citation><mixed-citation xml:lang="en">Chrysou K, Halat G, Hoksch B, Schmid RA, Kocher GJ. Lessons from a large trauma center: impact of blunt chest trauma in polytrauma patients-still a relevant problem? Scand J Trauma Resusc Emerg Med. 2017;25(1):42. PMID: 28427480 doi: 10.1186/s13049-017-0384-y</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Haider T, Halat G, Heinz T, Hajdu S, Negrin LL. Thoracic trauma and acute respiratory distress syndrome in polytraumatized patients: a retrospective analysis. Minerva Anestesiol. 2017;83(10):1026–1033. PMID: 28402091 doi: 10.23736/S0375-9393.17.11728-1</mixed-citation><mixed-citation xml:lang="en">Haider T, Halat G, Heinz T, Hajdu S, Negrin LL. Thoracic trauma and acute respiratory distress syndrome in polytraumatized patients: a retrospective analysis. Minerva Anestesiol. 2017;83(10):1026–1033. PMID: 28402091 doi: 10.23736/S0375-9393.17.11728-1</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Корнелюк Р.А., Шукевич Д.Л. Экстракорпоральная мембранная оксигенация в интенсивной терапии критических состояний. Медицина в Кузбассе. 2016;15(4):3–9.</mixed-citation><mixed-citation xml:lang="en">Kornelyuk RA, Shukevich DL. Extracorporeal Membrane Oxygenation in Intensive Care. Medicine in Kuzbass. 2016;15(4):3–9. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Schmidt M, Stewart C, Bailey M, Nieszkowska A, Kelly J, Murphy L, et al. Mechanical ventilation management during extracorporeal membrane oxygenation for acute respiratory distress syndrome: a retrospective international multicenter study. Crit Care Med. 2015;43(3):654–664. PMID: 25565460 doi: 10.1097/CCM.0000000000000753</mixed-citation><mixed-citation xml:lang="en">Schmidt M, Stewart C, Bailey M, Nieszkowska A, Kelly J, Murphy L, et al. Mechanical ventilation management during extracorporeal membrane oxygenation for acute respiratory distress syndrome: a retrospective international multicenter study. Crit Care Med. 2015;43(3):654–664. PMID: 25565460 doi: 10.1097/CCM.0000000000000753</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hill JD, O’Brien TG, Murray JJ, Dontigny L, Bramson ML, Osborn JJ, et al. Prolonged extracorporeal oxygenation for acute post-traumatic respiratory failure (shock-lung syndrome). Use of the Bramson membrane lung. N Engl J Med. 1972;286(12):629–634. PMID: 5060491 doi: 10.1056/NEJM197203232861204</mixed-citation><mixed-citation xml:lang="en">Hill JD, O’Brien TG, Murray JJ, Dontigny L, Bramson ML, Osborn JJ, et al. Prolonged extracorporeal oxygenation for acute post-traumatic respiratory failure (shock-lung syndrome). Use of the Bramson membrane lung. N Engl J Med. 1972;286(12):629–634. PMID: 5060491 doi: 10.1056/NEJM197203232861204</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Wen PH, Chan WH, Chen YC, Chen YL, Chan CP, Lin PY. Non-heparinized ECMO serves a rescue method in a multitrauma patient combining pulmonary contusion and nonoperative internal bleeding: a case report and literature review. World J Emerg Surg. 2015;10:15. PMID: 25774211 doi: 10.1186/s13017-015-0006-9</mixed-citation><mixed-citation xml:lang="en">Wen PH, Chan WH, Chen YC, Chen YL, Chan CP, Lin PY. Non-heparinized ECMO serves a rescue method in a multitrauma patient combining pulmonary contusion and nonoperative internal bleeding: a case report and literature review. World J Emerg Surg. 2015;10:15. PMID: 25774211 doi: 10.1186/s13017-015-0006-9</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Mahmood I, El-Menyar A, Younis B, Ahmed K, Nabir S, Ahmed MN, et al. Clinical Significance and Prognostic Implications of Quantifying Pulmonary Contusion Volume in Patients with Blunt Chest Trauma. Med Sci Monit. 2017;23:3641–3648. PMID: 28746303 doi: 10.12659/msm.902197</mixed-citation><mixed-citation xml:lang="en">Mahmood I, El-Menyar A, Younis B, Ahmed K, Nabir S, Ahmed MN, et al. Clinical Significance and Prognostic Implications of Quantifying Pulmonary Contusion Volume in Patients with Blunt Chest Trauma. Med Sci Monit. 2017;23:3641–3648. PMID: 28746303 doi: 10.12659/msm.902197</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Кузьков В.В., Лапин К.С., Фот Е.В., Киров М.Ю. Вентилятор-ассоциированное повреждение легких в отделении интенсивной терапии и операционной – что нового? Вестник анестезиологии и реаниматологии. 2020;17(5):47–61. doi: 10.21292/2078-5658-2020-17-5-47-61</mixed-citation><mixed-citation xml:lang="en">Kuzkov VV, Lapin KS, Fot EV, Kirov MYu. Ventilator-associated lung injury in the intensive care unit and operating room – what’s new? Messenger of Anesthesiology and Resuscitation. 2020;17(5):47–61. (In Russ.) doi: 10.21292/2078-5658-2020-17-5-47-61</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Кузьков В.В., Суборов Е.В., Фот Е.В., Родионова Л.Н., Соколова М. М., Лебединский К.М., и др. Послеоперационные дыхательные осложнения и ОРДС легче предупредить, чем лечить. Анестезиология и реаниматология. 2016;(6):461–468.</mixed-citation><mixed-citation xml:lang="en">Kuz’kov VV, Suborov EV, Fot EV, Rodionova LN, Sokolova MM, Lebedinskiy KM, et al. Postoperative Pulmonary Complications and Acute Respiratory Distress Syndrome – Better Prevent Then Treat! Russian Journal of Anesthesiology and Reanimatology. 2016;(6):461–468. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Chen CY, Hsu TY, Chen WK, Muo CH, Chen HC, Shih HM. The use of extracorporeal membrane oxygenation in trauma patients: A national case-control study. Medicine (Baltimore). 2018;97(36):e12223. PMID: 30200143 doi: 10.1097/MD.0000000000012223</mixed-citation><mixed-citation xml:lang="en">Chen CY, Hsu TY, Chen WK, Muo CH, Chen HC, Shih HM. The use of extracorporeal membrane oxygenation in trauma patients: A national case-control study. Medicine (Baltimore). 2018;97(36):e12223. PMID: 30200143 doi: 10.1097/MD.0000000000012223</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care. 2007;13(6):680-685. PMID: 17975390 doi: 10.1097/MCC.0b013e3282f1e78f</mixed-citation><mixed-citation xml:lang="en">Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care. 2007;13(6):680-685. PMID: 17975390 doi: 10.1097/MCC.0b013e3282f1e78f</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hess JR, Brohi K, Dutton RP, Hauser CJ, Holcomb JB, Kluger Y, et al. The coagulopathy of trauma: a review of mechanisms. J Trauma. 2008;65(4):748–754. PMID: 18849786 doi: 10.1097/TA.0b013e3181877a9c</mixed-citation><mixed-citation xml:lang="en">Hess JR, Brohi K, Dutton RP, Hauser CJ, Holcomb JB, Kluger Y, et al. The coagulopathy of trauma: a review of mechanisms. J Trauma. 2008;65(4):748–754. PMID: 18849786 doi: 10.1097/TA.0b013e3181877a9c</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Mesher AL, McMullan DM. Extracorporeal life support for the neonatal cardiac patient: outcomes and new directions. Semin Perinatol. 2014;38(2):97–103. PMID: 24580765 doi: 10.1053/j.semperi.2013.11.006</mixed-citation><mixed-citation xml:lang="en">Mesher AL, McMullan DM. Extracorporeal life support for the neonatal cardiac patient: outcomes and new directions. Semin Perinatol. 2014;38(2):97–103. PMID: 24580765 doi: 10.1053/j.semperi.2013.11.006</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ogawa F, Sakai T, Takahashi K, Kato M, Yamaguchi K, Okazaki S, et al. A case report: Veno-venous extracorporeal membrane oxygenation for severe blunt thoracic trauma. J Cardiothorac Surg. 2019;14(1):88. PMID: 31060587 doi: 10.1186/s13019-019-0908-9</mixed-citation><mixed-citation xml:lang="en">Ogawa F, Sakai T, Takahashi K, Kato M, Yamaguchi K, Okazaki S, et al. A case report: Veno-venous extracorporeal membrane oxygenation for severe blunt thoracic trauma. J Cardiothorac Surg. 2019;14(1):88. PMID: 31060587 doi: 10.1186/s13019-019-0908-9</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Скопец А.А., Жаров А.С., Потапов С.И., Афонин Е.С., Утегулов М.Г., Козлов Д.В. и др. Применение вено-венозной экстракорпоральной мембранной оксигенации без гепарина у пациентки с сочетанной травмой. Политравма. 2020;(1):56–66.</mixed-citation><mixed-citation xml:lang="en">Skopets AA, Zharov AS, Potapov SI, Afonin ES, Utegulov MG, Kozlov DV, et al Application of Veno-Venous Extracorporeal Membrane Oxygenation Without Heparin in a Patient With Combined Trauma. Polytrauma. 2020;(1):56–66. (In Russ.)</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
