nmpЖурнал им. Н.В. Склифосовского «Неотложная медицинская помощь»Russian Sklifosovsky Journal "Emergency Medical Care"2223-90222541-8017“N.V. Sklifosovsky Research Institute for Emergency Medicine”10.23934/2223-9022-2023-12-4-658-666nmp-1730Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSВлияние SARS-CoV-2 на кишечник и его микробиом: что мы знаем и что хотели бы знатьThe Effect of SARS-CoV-2 on the Gut and Its Microbiome: What We Know and What We Would Like to Knowhttps://orcid.org/0000-0001-7473-8727ЕвдокимоваН. В.EvdokimovaN. V.

Наталья Витальевна Евдокимова, кандидат биологических наук, старший научный сотрудник

лаборатория клинической микробиологии

129090

Б. Сухаревская пл., д. 3

Москва

Natalya V. Evdokimova, Candidate of Biological Sciences, Senior Researcher

Laboratory of Clinical Microbiology

129090

3, Bolshaya Sukharevskaya Sq.

Moscow

env1111@yandex.ruhttps://orcid.org/0000-0002-6167-7117ЧерненькаяТ. В.ChernenkayaT. V.

Татьяна Витальевна Черненькая, кандидат медицинских наук, заведующая лабораторией

лаборатория клинической микробиологии

129090

Б. Сухаревская пл., д. 3

Москва

Tatyana V. Chernenkaya, Candidate of Medical Sciences, Head of the Laboratory

Laboratory of Clinical Microbiology

129090

3, Bolshaya Sukharevskaya Sq.

Moscow

chernenkayat@rambler.ruГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»РоссияN.V. Sklifosovsky Research Institute for Emergency MedicineRussian Federation202323012024124658666Copyright © Евдокимова Н.В., Черненькая Т.В., 20242024Евдокимова Н.В., Черненькая Т.В.Evdokimova N.V., Chernenkaya T.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jnmp.ru/jour/article/view/1730

   В обзоре рассмотрены теоретические предпосылки и результаты первых исследований влияния SARS­CoV­2 на кишечник и его микробиом. Полученные данные свидетельствуют о длительной персистенции вируса в клетках слизистой оболочки кишечника. Также выявлено усиление процессов транслокации микробных клеток и микробных метаболитов, связанное с вызванными вирусом воспалительными процессами в эндотелиальных клетках слизистой оболочки кишечника. У пациентов с COVID-19 структура и функциональная активность микробиома кишечника значительно изменяются в течение заболевания. Происходит снижение видового разнообразия, начинают доминировать виды, которые не обнаруживаются в микробиоме здоровых людей. Полученные результаты позволяют предполагать, что состояние микробиома кишечника может сильно влиять на течение и исход ковидной инфекции.

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The authors declare that there are no conflicts of interest present.