nmpЖурнал им. Н.В. Склифосовского «Неотложная медицинская помощь»Russian Sklifosovsky Journal "Emergency Medical Care"2223-90222541-8017“N.V. Sklifosovsky Research Institute for Emergency Medicine”10.23934/2223-9022-2023-12-4-637-649nmp-1727Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSРоль оксида азота в ауторегуляции мозгового кровотока и патогенезе церебрального сосудистого спазма у пациентов с разрывом церебральных аневризмThe Role of Nitric Oxide in the Autoregulation of Cerebral Blood Flow and the Pathogenesis of Cerebral Vascular Spasm in Patients with Ruptured Cerebral Aneurysmshttps://orcid.org/0000-0003-2444-8136ПриродовА. В.PrirodovA. V.

Александр Владиславович Природов, доктор медицинских наук, заведующий отделением, ведущий научный сотрудник, профессор

отделение неотложной нейрохирургии

нейрохирургическое отделение

129090

Б. Сухаревская пл., д. 3

кафедра фундаментальной нейрохирургии

117997

ул. Островитянова, д. 1

Москва

Aleksandr V. Prirodov, Doctor of Medical Sciences, Head of the Department, Leading Researcher, Professor, Honored Doctor of Moscow

Neurosurgical Department

Department of Emergency Neurosurgery

129090

3, Bolshaya Sukharevskaya Sq.

Department of Fundamental Neurosurgery

117997

1, Ostrovitianova Str.

Moscow

aprirodov@yandex.ruhttps://orcid.org/0000-0002-9992-9260ЖуравельС. В.ZhuravelS. V.

Сергей Владимирович Журавель, доктор медицинских наук, заведующий отделением, профессор, доцент

отделение неотложной нейрохирургии

научное отделение анестезиологии

129090

Б. Сухаревская пл., д. 3

ЛФ

кафедра анестезиологии, реаниматологии и интенсивной терапии имени профессора В. Д. Малышева

117997

ул. Островитянова, д. 1

кафедра анестезиологии, реаниматологии и неотложной медицины

127473

ул. Делегатская, д. 20, стр. 1

Москва

Sergey V. Zhuravel, Doctor of Medical Sciences, Head of the Department, Professor, Associate Professor

Neurosurgical Department

Scientific Department of Anesthesiology

129090

3, Bolshaya Sukharevskaya Sq.

Department of Anesthesiology, Resuscitation and Intensive Care named after Professor V. D. Malyshev

117997

1, Ostrovitianova Str.

Department of Anesthesiology, Reanimatology and Emergency Medicine

127473

20, bldg. 1, Delegatskaya Str.

Moscow

zhuravelsv@sklif.mos.ruhttps://orcid.org/0000-0003-1525-1585БахаревЕ. Ю.BakharevE. Yu.

Евгений Юрьевич Бахарев, кандидат медицинских наук, врач-нейрохирург, старший научный сотрудник

отделение неотложной нейрохирургии

129090

Б. Сухаревская пл., д. 3

Москва

Evgeniy Yu. Bakharev, Candidate of Medical Sciences, Neurosurgeon, Senior Researcher

Neurosurgical Department

Department of Emergency Neurosurgery

129090

3, Bolshaya Sukharevskaya Sq.

Moscow

ads_nvkz@mail.ruhttps://orcid.org/0000-0002-5685-4916ГончароваИ. И.GoncharovaI. I.

Ирина Игоревна Гончарова, кандидат медицинских наук, врач-анестезиолог-реаниматолог, старший научный сотрудник

отделение неотложной нейрохирургии

отделение анестезиологии

129090

Б. Сухаревская пл., д. 3

Москва

Irina I. Goncharova, Candidate of Medical Sciences, Anesthesiologist-Resuscitator, Senior Researcher

Neurosurgical Department

Department of Anesthesiology

129090

3, Bolshaya Sukharevskaya Sq.

Moscow

goncharovaii@sklif.mos.ruhttps://orcid.org/0009-0003-9157-2943ЗоринП. Д.ZorinP. D.

Павел Дмитриевич Зорин, врач-анестезиолог-реаниматолог, аспирант

отделение неотложной нейрохирургии

отделение анестезиологии и реаниматологии № 1

129090

Б. Сухаревская пл., д. 3

ЛФ

кафедра анестезиологии, реаниматологии и интенсивной терапии имени профессора В. Д. Малышева

117997

ул. Островитянова, д. 1

Москва

Pavel D. Zorin, Anesthesiologist-Resuscitator, postgraduate student

Neurosurgical Department

Department of Anesthesiology and Resuscitation No 1

129090

3, Bolshaya Sukharevskaya Sq.

Department of Anesthesiology, Reanimatology and Intensive Care named after Professor V. D. Malyshev

117997

1, Ostrovitianova Str.

Moscow

zorinpd@mail.ruhttps://orcid.org/0000-0002-3349-0451КлычниковаЕ. В.KlychnikovaE. V.

Елена Валерьевна Клычникова, кандидат медицинских наук, заведующая научным отделением, доцент

отделение неотложной нейрохирургии

отделение клинико-биохимической лаборатории экстренных исследований

129090

Б. Сухаревская пл., д. 3

кафедра общей патологии

117997

ул. Островитянова, д. 1

Москва

Elena V. Klychnikova, Candidate of Medical Sciences, Head of the Department, Associate Professor

Neurosurgical Department

Scientific Department of the Clinical and Biochemical Laboratory of Emergency Research

129090

3, Bolshaya Sukharevskaya Sq.

Medical and Biological Faculty

Department of General Pathology

117997

1, Ostrovitianova Str.

Moscow

klychnikovaev@sklif.mos.ruhttps://orcid.org/0000-0001-6079-1228ТазинаЕ. В.TazinaE. V.

Елизавета Владимировна Тазина, кандидат медицинских наук, старший научный сотрудник

отделение неотложной нейрохирургии

отделение клинико-биохимической лаборатории экстренных исследований

129090

Б. Сухаревская пл., д. 3

Москва

Elizaveta V. Tazina, Candidate of Medical Sciences, Senior Researcher

Neurosurgical Department

Scientific Department of the Clinical and Biochemical Laboratory ofEmergency Research

129090

3, Bolshaya Sukharevskaya Sq.

Moscow

tazinaev@sklif.mos.ruhttps://orcid.org/0000-0003-3515-8329ГриньА. А.GrinA. A.

Андрей Анатольевич Гринь, член-корреспондент РАН, доктор медицинских наук, заведующий отделением, профессор

отделение неотложной нейрохирургии

научное отделение неотложной нейрохирургии

129090

Б. Сухаревская пл., д. 3

кафедра фундаментальной нейрохирургии

117997

ул. Островитянова, д. 1

Москва

Andrey A. Grin, Corresponding Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Head of the Department, Professor

Neurosurgical Department

Scientific Department of Emergency Neurosurgery

129090

3, Bolshaya Sukharevskaya Sq.

Department of Fundamental Neurosurgery

117997

1, Ostrovitianova Str.

Moscow

grinaa@sklif.mos.ruhttps://orcid.org/0000-0003-3292-8789ПетриковС. С.PetrikovS. S.

Сергей Сергеевич Петриков, член-корреспондент РАН, доктор медицинских наук, директор ГБУЗ, врач-анестезиолог-реаниматолог, профессор

отделение неотложной нейрохирургии

129090

Б. Сухаревская пл., д. 3

кафедра анестезиологии, реаниматологии и неотложной медицины

127473

ул. Делегатская, д. 20, стр. 1

Москва

Sergey S. Petrikov, Corresponding Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Director of the Research Institute, Anesthesiologist-Resuscitator, Professor

127473

Neurosurgical Department

129090

3, Bolshaya Sukharevskaya Sq.

Department of Anesthesiology, Reanimatology and Emergency Medicine

20, bldg. 1, Delegatskaya Str.

Moscow

petrikovss@sklif.mos.ruГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»; ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» МЗ РФРоссияN.V. Sklifosovsky Research Institute for Emergency Medicine; N.I. Pirogov Russian National Research Medical UniversityRussian FederationГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»; ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» МЗ РФ; ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» МЗ РФРоссияN.V. Sklifosovsky Research Institute for Emergency Medicine; N.I. Pirogov Russian National Research Medical University; A.I. Yevdokimov Moscow State University of Medicine and DentistryRussian FederationГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»РоссияN.V. Sklifosovsky Research Institute for Emergency MedicineRussian FederationГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»; ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» МЗ РФРоссияN.V. Sklifosovsky Research Institute for Emergency Medicine; A.I. Yevdokimov Moscow State University of Medicine and DentistryRussian Federation202322012024124637649Copyright © Природов А.В., Журавель С.В., Бахарев Е.Ю., Гончарова И.И., Зорин П.Д., Клычникова Е.В., Тазина Е.В., Гринь А.А., Петриков С.С., 20242024Природов А.В., Журавель С.В., Бахарев Е.Ю., Гончарова И.И., Зорин П.Д., Клычникова Е.В., Тазина Е.В., Гринь А.А., Петриков С.С.Prirodov A.V., Zhuravel S.V., Bakharev E.Y., Goncharova I.I., Zorin P.D., Klychnikova E.V., Tazina E.V., Grin A.A., Petrikov S.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jnmp.ru/jour/article/view/1727

   Представленный обзор литературы посвящен роли эндотелиального вазорелаксирующего фактора — оксида азота (NO) в регуляции церебрального мозгового кровотока у пациентов с разрывом внутричерепных аневризм. Описаны современные взгляды на физиологию NO, способы синтеза, участие в ауторегуляции, представлены экспериментальные и клинические данные, посвященные нарушению выработки эндотелиального вазорелаксирующего фактора при субарахноидальном кровоизлиянии.

   The presented literature review is devoted to the role of the endothelial relaxing factor – nitric oxide (NO) – in the regulation of cerebral blood flow in patients with ruptured intracranial aneurysms. Modern views on the physiology of NO, methods of regulation and autoregulation of its synthesis are described, experimental and clinical data on the disruption of the production of the endothelial relaxing factor in subarachnoid hemorrhage are presented.

ангиоспазмсосудистый спазмсубарахноидальное кровоизлияниемонооксид азотацеребральная аневризмаингаляцииangiospasmvascular spasmSAHnitrogen monoxidecerebral aneurysminhalationРабота выполнена при поддержке гранта АНО (Соглашение № 1603-32/23с)This work was supported by an ANO grant (Agreement No. 1603-32/23с)ReferencesMeyer DJ. Enzymatic/non-enzymatic formation of nitric oxide. Nat Med. 1995;1(11):1103–1104. PMID: 7584968 doi: 10.1038/nm1195-1103aMeyer DJ. Enzymatic/non-enzymatic formation of nitric oxide. Nat Med. 1995;1(11):1103–1104. PMID: 7584968 doi: 10.1038/nm1195-1103aZweier JL, Samouilov A, Kuppusamy P. Non-enzymatic nitric oxide synthesis in biological systems. Biochim Biophys Acta. 1999;1411(2–3):250–262. PMID: 10320661 doi: 10.1016/s0005-2728(99)00018-3Zweier JL, Samouilov A, Kuppusamy P. Non-enzymatic nitric oxide synthesis in biological systems. Biochim Biophys Acta. 1999;1411(2–3):250–262. PMID: 10320661 doi: 10.1016/s0005-2728(99)00018-3Граник В.Г., Григорьев Н.Б. 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The authors declare that there are no conflicts of interest present.