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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nmp</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Sklifosovsky Journal "Emergency Medical Care"</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-9022</issn><issn pub-type="epub">2541-8017</issn><publisher><publisher-name>“N.V. Sklifosovsky Research Institute for Emergency Medicine”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23934/2223-9022-2023-12-3-448-457</article-id><article-id custom-type="elpub" pub-id-type="custom">nmp-1677</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Роль экстракорпоральной мембранной оксигенации в комплексном лечении острых химических отравлений</article-title><trans-title-group xml:lang="en"><trans-title>The Role of Extracorporeal Membrane Oxygenation in the Complex Treatment of Acute Chemical Poisoning</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4736-1068</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Симонова</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Simonova</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Симонова Анастасия Юрьевна - кандидат медицинских наук, ведущий научный сотрудник отделения острых отравлений и соматопсихиатрических расстройств, 129090, Москва, Б. Сухаревская пл., д. 3;</p><p>старший научный сотрудник, 125993, Москва, Баррикадная ул., д. 2/1, стр. 1;</p><p>ассистент кафедры клинической токсикологии, 129090, Москва, Б. Сухаревская пл., д. 3, стр. 7</p></bio><bio xml:lang="en"><p>Anastasia Yu. Simonova - Candidate of Medical Sciences, Leading Researcher, Department of Acute Poisonings and Somatopsychiatric Disorders, 3, B. Sukharevskaya Sq., 129090, Moscow;</p><p>Assistant, Department of Clinical Toxicology, bldg. 1, 2/1, Barrikadnaya St., 125993, Moscow;</p><p>Senior Researcher, bldg. 7, 3, B. Sukharevskaya Sq., 129090, Moscow</p></bio><email xlink:type="simple">simonovaau@sklif.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0117-8663</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Поцхверия</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Potskhveriya</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Поцхверия Михаил Михайлович - кандидат медицинских наук, заведующий научным отделением острых отравлений и соматопсихиатрических расстройств, 129090, Москва, Б. Сухаревская пл., д. 3;</p><p>доцент кафедры клинической токсикологии, 125993, Москва, Баррикадная ул., д. 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Mikhail M. Potskhveriya - Candidate of Medical Sciences, Head, Department of Acute Poisonings and Somatopsychiatric Disorders, 3, B. Sukharevskaya Sq., 129090, Moscow;</p><p>Associate Professor, Department of Clinical Toxicology, bldg. 1, 2/1, Barrikadnaya St., 125993, Moscow</p></bio><email xlink:type="simple">potskhveriya@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9992-9260</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Журавель</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhuravel</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Журавель Сергей Владимирович - доктор медицинских наук, заведующий научным отделением анестезиологии,</p><p>129090, Москва, Б. Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Sergey V. Zhuravel - Doctor of Medical Sciences, Head, Department of Anesthesiology,</p><p>3, B. Sukharevskaya Sq., 129090, Moscow</p></bio><email xlink:type="simple">zhsergey5@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3292-8789</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петриков</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrikov</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петриков Сергей Сергеевич - член-корреспондент РАН, директор,</p><p>129090, Москва, Б. Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Sergey S. Petrikov - Corresponding Member of the Russian Academy of Sciences, Professor, Doctor of Medical Sciences, Director,</p><p>3, B. Sukharevskaya Sq., 129090, Moscow</p></bio><email xlink:type="simple">petrikovss@sklif.mos.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0830-2313</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Талызин</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Talyzin</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Талызин Алексей Михайлович - заведующий отделением анестезиологии № 3,</p><p>129090, Москва, Б. Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Alexey M. Talyzin - Head, Department of Anesthesiology No. 3,</p><p>3, B. Sukharevskaya Sq., 129090, Moscow</p></bio><email xlink:type="simple">talyzinam@sklif.mos.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»;&#13;
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» МЗ РФ;&#13;
ФГБУ «Научно-практический токсикологический центр ФМБА России»<country>Россия</country></aff><aff xml:lang="en">N.V. Sklifosovsky Research Institute for Emergency Medicine;&#13;
Russian Medical Academy of Continuous Professional Education;&#13;
Research and Applied Toxicology Center of the Federal Medical-Biological Agency<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»;&#13;
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» МЗ РФ<country>Россия</country></aff><aff xml:lang="en">N.V. Sklifosovsky Research Institute for Emergency Medicine;&#13;
Russian Medical Academy of Continuous Professional Education<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»<country>Россия</country></aff><aff xml:lang="en">N.V. Sklifosovsky Research Institute for Emergency Medicine<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>24</day><month>11</month><year>2023</year></pub-date><volume>12</volume><issue>3</issue><fpage>448</fpage><lpage>457</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Симонова А.Ю., Поцхверия М.М., Журавель С.В., Петриков С.С., Талызин А.М., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Симонова А.Ю., Поцхверия М.М., Журавель С.В., Петриков С.С., Талызин А.М.</copyright-holder><copyright-holder xml:lang="en">Simonova A.Y., Potskhveriya M.M., Zhuravel S.V., Petrikov S.S., Talyzin A.M.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jnmp.ru/jour/article/view/1677">https://www.jnmp.ru/jour/article/view/1677</self-uri><abstract><sec><title>Цель</title><p>Цель. Анализ данных литературы по применению экстракорпоральной мембранной оксигенации (ЭКМО) при острых отравлениях химической этиологии.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Поиск отечественных публикаций проводился в базе данных eLibrary, зарубежных — в базах MEDLINE/PubMed, Google Scholar за период 2010–февраль 2023 г. В качестве поискового запроса использовались термины согласно официальным терминам MeSH: “Extracorporeal Membrane Oxygenation” or “Membrane Oxygenation, Extracorporeal” or “ECMO Treatment” and “poisoning”.</p></sec><sec><title>Результаты</title><p>Результаты. В данном обзоре приведены сведения о результатах применения вено-артериальной (ВА ЭКМО) и вено-венозной экстракорпоральной мембранной оксигенации (ВВ ЭКМО) при развитии рефрактерного кардиогенного шока, остановки сердечной деятельности и тяжелого острого респираторного дистресс-синдрома при острых химических отравлениях.</p></sec><sec><title>Выводы</title><p>Выводы. Анализ данных показал, что у пациентов с острыми химическими отравлениями ниже частота осложнений и летальность при включении в комплексную терапию экстракорпоральной мембранной оксигенации/ЭКМО-сердечно-легочной реанимации по сравнению с больными, у которых показаниями к использованию данной методики послужили другие причины. Вероятно, это связано с тем, что пациенты в группе с острыми отравлениями моложе, у них меньше сопутствующих заболеваний, а экстракорпоральная мембранная оксигенация требуется, как правило, на более короткий период времени до выведения токсиканта из организма с помощью применения методов их элиминации и восстановления нарушенных функций.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim of study</title><p>Aim of study. Analysis of literature data on the use of extracorporeal membrane oxygenation in acute chemical poisoning.</p></sec><sec><title>Material and methods</title><p>Material and methods. The search for domestic publications was carried out in the Elibrary database, foreign publications — in the MEDLINE / PubMed, Google Scholar databases for the period of 2010–2023. The terms used as a search query were according to the official MeSH terms: “Extracorporeal Membrane Oxygenation” OR “Membrane Oxygenation, Extracorporeal” OR “ECMO Treatment” AND “poisoning”.</p></sec><sec><title>Results</title><p>Results. This review provides information on the outcomes of the use of veno-arterial and veno-venous extracorporeal membrane oxygenation (ECMO) for refractory cardiogenic shock, cardiac arrest and severe ARDS in acute chemical poisoning.</p></sec><sec><title>Conclusion</title><p>Conclusion. Data analysis showed that in patients with acute chemical poisoning, the incidence of complications and mortality was lower when ECMO/ECMOCPR was included in the complex therapy compared with patients in whom other reasons (not related to acute poisoning) served as indications for the use of this technique. This is probably due to the fact that patients in the group with acute poisoning are younger, they have fewer concomitant diseases; and ECMO is required, as a rule, for a shorter period of time before the toxicant is eliminated from the body using the methods of their elimination and restoration of disturbed functions.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>острое отравление</kwd><kwd>токсикология</kwd><kwd>экстракорпоральная мембранная оксигенация</kwd><kwd>ЭКМО</kwd><kwd>ЭКМОСЛР</kwd><kwd>ВА ЭКМО</kwd><kwd>ВВ ЭКМО</kwd><kwd>острое отравление химической этиологии</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute poisoning</kwd><kwd>toxicology</kwd><kwd>extracorporeal membrane oxygenation</kwd><kwd>ECMO</kwd><kwd>ECPR</kwd><kwd>VAECMO</kwd><kwd>VVECMO</kwd><kwd>acute poisoning of chemical etiology</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Хоффман Р.С., Хауланд М.-Э., Нельсон Л.С. 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