nmpЖурнал им. Н.В. Склифосовского «Неотложная медицинская помощь»Russian Sklifosovsky Journal "Emergency Medical Care"2223-90222541-8017“N.V. Sklifosovsky Research Institute for Emergency Medicine”10.23934/2223-9022-2023-12-1-92-98nmp-1574Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSПатогенетические механизмы органной дисфункции при тяжелой сочетанной травмеPathogenetic Mechanisms of Organ Dysfunction in Severe Concomitant Traumahttps://orcid.org/0000-0002-1244-2135БулаваГ. В.BulavaG. V.

Булава Галина Владимировна, доктор медицинских наук, научный консультант

129090, Москва, Б. Сухаревская пл., д. 3

Galina V. Bulava, Doctor of Medical Sciences, Scientific Consultant

3 Bolshaya Sukharevskaya Sq., Moscow, 129090

gbulava@mail.ruЛаборатория клинической иммунологии ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»РоссияClinical Immunology Laboratory, N.V. Sklifosovsky Research Institute for Emergency MedicineRussian Federation2023160420231219298Copyright © Булава Г.В., 20232023Булава Г.В.Bulava G.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jnmp.ru/jour/article/view/1574

Тяжелая сочетанная травма на протяжении многих лет представляет собой большую демографическую и медицинскую проблему, являясь причиной высокой смертности трудоспособного населения. Одномоментное образование массива разрушенных тканей «запускает» системную воспалительную реакцию, которая на фоне травматического и геморрагического шока приводит к дисбалансу иммунной реактивности и предрасполагает к развитию септических осложнений. В обзоре представлены основные понятия о посттравматических реакциях и нарушениях баланса клеточных и гуморальных иммунных механизмов, приводящих к развитию осложнений. 

Severe concomitant trauma has been a major demographic and medical problem for many years, being the cause of high mortality of the able-bodied population. The simultaneous formation of an array of destroyed tissues triggers a systemic inflammatory reaction, which, against the background of traumatic and hemorrhagic shock, leads to an imbalance in immune reactivity and predisposes to the development of septic complications. The review presents the basic concepts of post-traumatic reactions and violations of the balance of cellular and humoral immune mechanisms leading to the development of complications. 

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The authors declare that there are no conflicts of interest present.