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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nmp</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Sklifosovsky Journal "Emergency Medical Care"</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-9022</issn><issn pub-type="epub">2541-8017</issn><publisher><publisher-name>“N.V. Sklifosovsky Research Institute for Emergency Medicine”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23934/2223-9022-2022-11-1-186-190</article-id><article-id custom-type="elpub" pub-id-type="custom">nmp-1354</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group></article-categories><title-group><article-title>Гипербарическая оксигенация при рецидивирующих ректальных кровотечениях на фоне лучевого проктита</article-title><trans-title-group xml:lang="en"><trans-title>Hyperbaric Oxygenation in Recurrent Rectal Bleeding in the Background of Radiation Proctitis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3363-6841</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Леонтьев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Leontev</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Леонтьев Александр Владимирович - кандидат медицинских наук, врач-колопроктолог ГБУЗ «МКНЦ им. А.С. Логинова ДЗМ».</p><p>111123, Москва, шоссе Энтузиастов, д. 86</p></bio><bio xml:lang="en"><p>Alexander V. Leontev - Сoloproctologist, Department of Coloproctology.</p><p>86, Shosse Entuziastov, Moscow, 111123</p></bio><email xlink:type="simple">a.leontev@mknc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4811-0845</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Левина</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Levina</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Левина Ольга Аркадьевна - кандидат медицинских наук, ведущий научный сотрудник отделения неотложной нейрохирургии ГБУЗ «НИИ СП им. Н.В. Склифосовского ДЗМ».</p><p>129090, Москва, Большая Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Olga A . Levina - Leading Researcher, Department of Emergency Neurosurgery.</p><p>3 Bolshaya Sukharevskaya Sq., Moscow, 129090</p></bio><email xlink:type="simple">levinaoa@sklif.mos.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1265-8382</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гришина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Grishina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гришина Елена Александровна - врач-эндоскопист ГБУЗ «МКНЦ им. А.С. Логинова ДЗМ».</p><p>111123, Москва, шоссе Энтузиастов, д. 86</p></bio><bio xml:lang="en"><p>Elena A. Grishina – Endoscopist.</p><p>86, Shosse Entuziastov, Moscow, 111123</p></bio><email xlink:type="simple">a.grishina@mknc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9439-9873</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Данилов</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Danilov</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Данилов Михаил Александрович - кандидат медицинских наук, заведующий колопроктологическим отделением ГБУЗ МКНЦ им. А.С. Логинова ДЗМ.</p><p>111123, Москва, шоссе Энтузиастов, д. 86</p></bio><bio xml:lang="en"><p>Mikhail A. Danilov - Head of Coloproctology Department.</p><p>86, Shosse Entuziastov, Moscow, 111123</p></bio><email xlink:type="simple">m.danilov@mknc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0010-5294</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шишин</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shishin</surname><given-names>K. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шишин Кирилл Вячеславович - доктор медицинских наук, руководитель отдела эндоскопии ГБУЗ «МКНЦ им. А.С. Логинова ДЗМ».</p><p>111123, Москва, шоссе Энтузиастов, д. 86</p></bio><bio xml:lang="en"><p>Kirill V. Shishin - Head of Endoscopy Department.</p><p>3 Bolshaya Sukharevskaya Sq., Moscow, 129090</p></bio><email xlink:type="simple">k.shishin@mknc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5342-8268</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бабкина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Babkina</surname><given-names>А. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бабкина Анна Васильевна - кандидат медицинских наук, врач-гинеколог отделения экстренной гинекологии ГБУЗ «НИИ СП им. Н.В. Склифосовского ДЗМ».</p><p>129090, Москва, Большая Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Annа V. Babkina - Gynecologist of the Department of Emergency Gynecology.</p><p>3 Bolshaya Sukharevskaya Sq., Moscow, 129090</p></bio><email xlink:type="simple">babkina.anya@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ГБУЗ Московский клинический научно-практический центр им. А.С. Логинова ДЗМ<country>Россия</country></aff><aff xml:lang="en">A.S. Loginov Moscow Clinical Scientific Center<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ГБУЗ Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ<country>Россия</country></aff><aff xml:lang="en">N.V. Sklifosovsky Research Institute for Emergency Medicine<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>09</day><month>04</month><year>2022</year></pub-date><volume>11</volume><issue>1</issue><fpage>186</fpage><lpage>190</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Леонтьев А.В., Левина О.А., Гришина Е.А., Данилов М.А., Шишин К.В., Бабкина А.В., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Леонтьев А.В., Левина О.А., Гришина Е.А., Данилов М.А., Шишин К.В., Бабкина А.В.</copyright-holder><copyright-holder xml:lang="en">Leontev A.V., Levina O.A., Grishina E.A., Danilov M.A., Shishin K.V., Babkina А.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jnmp.ru/jour/article/view/1354">https://www.jnmp.ru/jour/article/view/1354</self-uri><abstract><p>Лучевой проктит — это осложнение лучевой терапии, применяемой в лечении злокачественных опухолей тазовой локализации. Ведущим клиническим симптомом данного рода поздних лучевых осложнений являются рецидивирующие прямокишечные кровотечения, приводящие к развитию анемии. Несмотря на наличие современных лекарственных препаратов, консервативные методы лечения остаются неэффективными, а малоинвазивные эндоскопические технологии применимы не во всех случаях и могут приводить к развитию осложнений в виде язв и свищей. Около 20 лет назад мировым научным сообществом гипербарическая оксигенация (ГБО) была рекомендована как способ лечения поздних лучевых повреждений прямой кишки. Однако данная методика не получила широкого применения.</p><p>Нами представлен опыт успешного применения ГБО в лечении пациентки 50 лет с хроническим лучевым проктитом, осложненным рецидивирующими прямокишечными кровотечениями. Консервативные и эндоскопические методы лечения у данной пациентки были неэффективны. Данное клиническое наблюдение демонстрирует, что ГБО является эффективным методом лечения прямокишечного кровотечения на фоне лучевого проктита.</p></abstract><trans-abstract xml:lang="en"><p>Radiation proctitis is a complication of radiation therapy used in the treatment of pelvic malignant tumors. The leading clinical symptom of this kind of late radiation complications is recurrent rectal bleeding, leading to the development of anemia. Despite the availability of modern drugs, conservative treatment methods remain ineffective, and minimally invasive endoscopic technologies are not applicable in all cases and can lead to the development of complications in the form of ulcers and ﬁ stulas. About 20 years ago, the world scientiﬁ c community recommended hyperbaric oxygenation (HBO) as a method of treating late radiation damage to the rectum. However, this technique has not been widely used.  We have presented the experience of treating the successful use of HBO in the treatment of a 50-year-old patient with chronic radiation proctitis complicated by recurrent rectal bleeding. Conservative and endoscopic methods of treatment in this patient were ineffective. This clinical observation demonstrates that HBO is an effective method of treating rectal bleeding associated with radiation proctitis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>лучевой проктит</kwd><kwd>гипербарическая оксигенация</kwd><kwd>прямокишечное кровотечение</kwd><kwd>аргоноплазменная коагуляция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>radiation proctitis</kwd><kwd>hyperbaric oxygenation</kwd><kwd>rectal bleeding</kwd><kwd>argon plasma coagulation</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Исследование не имеет спонсорской поддержки</funding-statement></funding-group><funding-group xml:lang="en"><funding-statement>The study had no sponsorship</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гришина Е.А., Шишин К.В., Недолужко И.Ю., Курушкина Н.А., Шумкина Л.В., Леонтьев А.В. Эндоскопические методы лечения хронического лучевого проктита. Тазовая хирургия и онкология. 2020;10(3–4):65–72.</mixed-citation><mixed-citation xml:lang="en">Grishina EA, Shishin KV, Nedoluzhko IYu, Kurushkina NA, Shumkina LV, Leontyev АV. Endoscopic treatment for chronic radiation proctitis. Pelvic Surgery and Oncology. 2020;10(3-4):65–72. (in Russ.) https://doi.org/10.17650/2686-9594-2020-10-3-4-65-72</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Гречин А.И., Пикунов Д.Ю., Майновская О.А., Черных М.В., Рыбаков Е.Г. Хронический лучевой проктит. Современные возможности диагностики и лечения (обзор литературы). Колопроктология. 2018;3(65):66–74.</mixed-citation><mixed-citation xml:lang="en">Grechin AN, Pikunov DYu, Mainovskaya OA, Chernikh MV, Rybakov EG. Chronic Radiation Proctitis. Modern Opportunities of Diagnosis and Treatment (Review). Koloproktologia. 2018;(3):66–74. (in Russ.) https://doi.org/10.33878/2073-7556-2018-0-3-66-74</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Токарев А.С., Степанов В.Н., Рак В.А., Евдокимова О.Л., Терехин И. А., Незнанова М.В., и др. Опыт применения гипербарической оксигенации при лечении радионекроза, развившегося как осложнение стереотаксически ориентированного радиохирургического лечения менингиомы на примере клинического случая. Журнал им. Н.В. Склифосовского Неотложная медицинская помощь. 2020;9(4):670–676.</mixed-citation><mixed-citation xml:lang="en">Tokarev AS, Stepanov VN, Rak VA, Yevdokimova OL, Terekhin IA, Neznanova MV, et al. Experience of Using Hyperbaric Oxygenation in the Treatment of Radionecrosis That Developed as a Complication of Stereotactic Radiosurgical Treatment of Meningioma on the Example of a Clinical Case. Russian Sklifosovsky Journal Emergency Medical Care. 2020;9(4):670–676. https://doi.org/10.23934/2223-9022-2020-9-4-670-676</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">McCarty TR, Garg R, Rustagi T. Efficacy and safety of radiofrequency ablation for treatment of chronic radiation proctitis: A systematic review and meta-analysis. J Gastroenterol Hepatol. 2019;34(9):1479–1485. PMID: 31111527 https://doi.org/10.1111/jgh.14729</mixed-citation><mixed-citation xml:lang="en">McCarty TR, Garg R, Rustagi T. Efficacy and safety of radiofrequency ablation for treatment of chronic radiation proctitis: A systematic review and meta-analysis. J Gastroenterol Hepatol. 2019;34(9):1479–1485. PMID: 31111527 https://doi.org/10.1111/jgh.14729</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Feldmeier J, Carl U, Hartmann K, Sminia P. Hyperbaric oxygen: does it promote growth or recurrence of malignancy? Undersea Hyperb Med. 2003;30(1):1–18. PMID: 12841604</mixed-citation><mixed-citation xml:lang="en">Feldmeier J, Carl U, Hartmann K, Sminia P. Hyperbaric oxygen: does it promote growth or recurrence of malignancy? Undersea Hyperb Med. 2003;30(1):1–18. PMID: 12841604</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ramakrishnaiah NVP, Krishnamachari S. Chronic haemorrhagic radiation proctitis: A review. World J Gastrointest Surg. 2016;8(7):483–491. PMID: 27462390 https://doi.org/10.4240/wjgs.v8.i7.483</mixed-citation><mixed-citation xml:lang="en">Ramakrishnaiah NVP, Krishnamachari S. Chronic haemorrhagic radiation proctitis: A review. World J Gastrointest Surg. 2016;8(7):483–491. PMID: 27462390 https://doi.org/10.4240/wjgs.v8.i7.483</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Thackham JA, McElwain DL, Long RJ. The use of hyperbaric oxygen therapy to treat chronic wounds: a review. Wound Repair Regen. 2008;16(3):321–330. PMID: 18471250 https://doi.org/10.1111/j.1524-475X.2008.00372.x</mixed-citation><mixed-citation xml:lang="en">Thackham JA, McElwain DL, Long RJ. The use of hyperbaric oxygen therapy to treat chronic wounds: a review. Wound Repair Regen. 2008;16(3):321–330. PMID: 18471250 https://doi.org/10.1111/j.1524-475X.2008.00372.x</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ali F, Hu KY. Evaluation and Management of Chronic Radiation Proctitis. Dis Colon Rectum. 2020;63(3):285–287. PMID: 32032142 https://doi.org/10.1097/DCR.0000000000001592</mixed-citation><mixed-citation xml:lang="en">Ali F, Hu KY. Evaluation and Management of Chronic Radiation Proctitis. Dis Colon Rectum. 2020;63(3):285-287. PMID: 32032142 https://doi.org/10.1097/DCR.0000000000001592</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Woo TC, Joseph D, Oxer H. Hyperbaric oxygen treatment for radiation proctitis. Int J Radiat Oncol Biol Phys. 1997;38(3):619–622. PMID: 9231688 https://doi.org/10.1016/s0360-3016(97)00017-5</mixed-citation><mixed-citation xml:lang="en">Woo TC, Joseph D, Oxer H. Hyperbaric oxygen treatment for radiation proctitis. Int J Radiat Oncol Biol Phys. 1997;38(3):619–622. PMID: 9231688 https://doi.org/10.1016/s0360-3016(97)00017-5</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kitta T, Shinohara N, Shirato H, Otsuka H, Koyanagi T. The treatment of chronic radiation proctitis with hyperbaric oxygen in patients with prostate cancer. BJU Int. 2000;85(3):372–374. PMID: 10671898 https://doi.org/10.1046/j.1464-410x.2000.00404.x</mixed-citation><mixed-citation xml:lang="en">Kitta T, Shinohara N, Shirato H, Otsuka H, Koyanagi T. The treatment of chronic radiation proctitis with hyperbaric oxygen in patients with prostate cancer. BJU Int. 2000;85(3):372–374. PMID: 10671898 https://doi.org/10.1046/j.1464-410x.2000.00404.x</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Jones K, Evans AW, Bristow RG, Levin W. Treatment of radiation proctitis with hyperbaric oxygen. Radiother Oncol. 2006;78(1):91–94. PMID: 16337705 https://doi.org/10.1016/j.radonc.2005.11.004</mixed-citation><mixed-citation xml:lang="en">Jones K, Evans AW, Bristow RG, Levin W. Treatment of radiation proctitis with hyperbaric oxygen. Radiother Oncol. 2006;78(1):91–94. PMID: 16337705 https://doi.org/10.1016/j.radonc.2005.11.004</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Gill AL, Bell CAN. Hyperbaric oxygen: its uses, mechanisms of action and outcomes. QJM. 2004;97(7):385–395. PMID: 15208426 https://doi.org/10.1093/qjmed/hch074</mixed-citation><mixed-citation xml:lang="en">Gill AL, Bell CAN. Hyperbaric oxygen: its uses, mechanisms of action and outcomes. QJM. 2004;97(7):385–395. PMID: 15208426 https://doi.org/10.1093/qjmed/hch074</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Oscarsson N, Arnell P, Lodding P, Ricksten SE, Seeman-Lodding H. Hyperbaric oxygen treatment in radiation-induced cystitis and proctitis: a prospective cohort study on patient-perceived quality of recovery. Int J Radiat Oncol Biol Phys. 2013;87(4):670–675. PMID: 24035333 https://doi.org/10.1016/j.ijrobp.2013.07.039</mixed-citation><mixed-citation xml:lang="en">Oscarsson N, Arnell P, Lodding P, Ricksten SE, Seeman-Lodding H. Hyperbaric oxygen treatment in radiation-induced cystitis and proctitis: a prospective cohort study on patient-perceived quality of recovery. Int J Radiat Oncol Biol Phys. 2013;87(4):670–675. PMID: 24035333 https://doi.org/10.1016/j.ijrobp.2013.07.039</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Tang H, Sun Y, Xu C, Zhou T, Gao X, Wang L Effects of hyperbaric oxygen therapy on tumor growth in murine model of PC-3 prostate cancer cell line. Urology. 2009;73(1):205–208. PMID: 18579187 https://doi.org/10.1016/j.urology.2008.04.057</mixed-citation><mixed-citation xml:lang="en">Tang H, Sun Y, Xu C, Zhou T, Gao X, Wang L Effects of hyperbaric oxygen therapy on tumor growth in murine model of PC-3 prostate cancer cell line. Urology. 2009;73(1):205–208. PMID: 18579187 https://doi.org/10.1016/j.urology.2008.04.057</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Kalns J, Krock L, Piepmeier E Jr. The effect of hyperbaric oxygen on growth and chemosensitivity of metastatic prostate cancer. Anticancer Res. 1998;18(1A):363–367. PMID: 9568104</mixed-citation><mixed-citation xml:lang="en">Kalns J, Krock L, Piepmeier E Jr. The effect of hyperbaric oxygen on growth and chemosensitivity of metastatic prostate cancer. Anticancer Res. 1998;18(1A):363–367. PMID: 9568104</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Holmquist L, Lofstedt T, Pahlman S. Effect of hypoxia on the tumor phenotype: the neuroblastoma and breast cancer models. Adv Exp Med Biol. 2006;587:179–193. PMID: 17163166 https://doi.org/10.1007/978-1-4020-5133-3_16</mixed-citation><mixed-citation xml:lang="en">Holmquist L, Lofstedt T, Pahlman S. Effect of hypoxia on the tumor phenotype: the neuroblastoma and breast cancer models. Adv Exp Med Biol. 2006;587:179–193. PMID: 17163166 https://doi.org/10.1007/978-1-4020-5133-3_16</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
