nmpЖурнал им. Н.В. Склифосовского «Неотложная медицинская помощь»Russian Sklifosovsky Journal "Emergency Medical Care"2223-90222541-8017“N.V. Sklifosovsky Research Institute for Emergency Medicine”10.23934/2223-9022-2021-10-4-642-648nmp-1261Research ArticleНОВОЕ О COVID-19NEW ABOUT COVID-19Применение Антитромбина-III при новой коронавирусной инфекции (Covid-19) в условиях экстракорпоральной мембранной оксигенации (клиническое наблюдение)Antithrombin-III for New Coronavirus Infection (COVID-19) Under Conditions of Extracorporeal Membrane Oxygenation (Clinical Observation)https://orcid.org/0000-0002-9992-9260ЖуравельС. В.ZhuravelS. V.

доктор медицинских наук, профессор, руководитель научного отделения анестезиологии, реаниматологии и интенсивной терапии,

129090, Москва, Б. Сухаревская пл., д. 3

Doctor of Medical Sciences, Professor, Head of the Scientific Department of Anesthesiology, Resuscitation and Intensive Care,

3, B. Sukharevskaya Sq., Moscow 129090

sjuravel@rambler.ruhttps://orcid.org/0000-0002-4026-8082ВладимировВ. В.VladimirovV. V.

кандидат медицинских наук, врач сердечно-сосудистый хирург отделения неотложной кардиохирургии, вспомогательного кровообращения и трансплантации сердца,

129090, Москва, Б. Сухаревская пл., д. 3

Candidate of Medical Sciences, Cardiovascular Surgeon, Department of Emergency Cardiac Surgery, Assisted Circulation and Heart Transplantation, 

3, B. Sukharevskaya Sq., Moscow 129090

VladimirovVV@sklif.mos.ruhttps://orcid.org/0000-0001-9640-201XГавриловП. В.GavrilovP. V.

младший научный сотрудник отделения анестезиологии, врач анестезиолог-реаниматолог,

129090, Москва, Б. Сухаревская пл., д. 3

Junior Researcher of the Department of Anesthesiology, Anesthesiologist-resuscitator,

3, B. Sukharevskaya Sq., Moscow 129090

likesport10@mail.ruhttps://orcid.org/0000-0002-6648-9385ИвановИ. В.IvanovI. V.

врач анестезиолог-реаниматолог, научный сотрудник отделения анестезиологии,

129090, Москва, Б. Сухаревская пл., д. 3

Anesthesiologist-resuscitator, Researcher of the Scientific Department of Anesthesiology, 

3, B. Sukharevskaya Sq., Moscow 129090

mb4sb@mail.ruhttps://orcid.org/0000-0003-3292-8789ПетриковС. С.PetrikovS. S.

член-корреспондент РАН, профессор, доктор медицинских наук, директор,

129090, Москва, Б. Сухаревская пл., д. 3

Doctor of Medical Sciences, Professor, Corresponding Member of RAS, Director,

3, B. Sukharevskaya Sq., Moscow 129090

petrikovss@sklif.mos.ruhttps://orcid.org/0000-0002-6240-820XПопугаевК. А.PopugayevK. A.

доктор медицинских наук, заместитель директора, руководитель регионального сосудистого центра,

129090, Москва, Б. Сухаревская пл., д. 3

Doctor of Medical Sciences, Deputy Director, Head of the Regional Vascular Center,

3, B. Sukharevskaya Sq., Moscow 129090

stan.popugaev@yahoo.comhttps://orcid.org/0000-0003-0830-2313ТалызинА. М.TalyzinA. M.

заведующий отделением анестезиологии и реанимации №3,

129090, Москва, Б. Сухаревская пл., д. 3

Head of the Department of Anesthesiology and Resuscitation No. 3, 

3, B. Sukharevskaya Sq., Moscow 129090

tripo33@mail.ruНаучное отделение анестезиологии ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»РоссияN.V. Sklifosovsky Research Institute for Emergency MedicineRussian Federation202115012022104642648Copyright © Журавель С.В., Владимиров В.В., Гаврилов П.В., Иванов И.В., Петриков С.С., Попугаев К.А., Талызин А.М., 20222022Журавель С.В., Владимиров В.В., Гаврилов П.В., Иванов И.В., Петриков С.С., Попугаев К.А., Талызин А.М.Zhuravel S.V., Vladimirov V.V., Gavrilov P.V., Ivanov I.V., Petrikov S.S., Popugayev K.A., Talyzin A.M.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jnmp.ru/jour/article/view/1261

COVID-19 является заболеванием, приводящим помимо дыхательной недостаточности к тромбозам и кровотечениям вследствие нарушений в системе гемостаза. Экстракорпоральная мембранная оксигенация (ЭКМО), требующаяся при снижении газообменной функции легких, вносит свой вклад в изменения показателей свертывания крови, что ведет к увеличению риска осложнений геморрагического характера и тромбозов. В статье представлен клинический случай тяжелого течения COVID-19, потребовавший проведения ЭКМО. В ходе лечения был использован Антитромбин-III, что позволило избежать жизнеугрожающих осложнений и успешно завершить процедуру. 

COVID-19 is a disease that, in addition to respiratory failure, leads to thrombosis and bleeding due to coagulation disorders. Extracorporeal membrane oxygenation (ECMO), required in cases of a deterioration of gas exchange function of the lungs, contributes to changes in blood coagulation indicators, which leads to an increased risk of hemorrhagic complications and thrombosis. In the article, a clinical case of a severe course of COVID-19 is reported, which required ECMO. During the treatment, antithrombin-III was used, which allowed avoiding life-threatening complications and successfully completing the procedure. 

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The authors declare that there are no conflicts of interest present.