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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nmp</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Sklifosovsky Journal "Emergency Medical Care"</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-9022</issn><issn pub-type="epub">2541-8017</issn><publisher><publisher-name>“N.V. Sklifosovsky Research Institute for Emergency Medicine”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23934/2223-9022-2021-10-3-549-557</article-id><article-id custom-type="elpub" pub-id-type="custom">nmp-1218</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Симптоматические эпилептические приступы при глиомах головного мозга</article-title><trans-title-group xml:lang="en"><trans-title>Symptomatic Epileptic Seizures in Patients with Brain Gliomas</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7217-6940</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абзалова</surname><given-names>Д. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Abzalova</surname><given-names>D. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>младший научный сотрудник отделения неотложной нейрохирургии</p><p> Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3 </p></bio><bio xml:lang="en"><p>Junior Researcher, Department of Emergency Neurosurgery</p><p>3 Bolshaya Sukharevskaya Square, Moscow 129090, Russian Federation</p></bio><email xlink:type="simple">Dila1307@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2444-8136</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Природов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Prirodov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p> доктор медицинских наук, врач-нейрохирург, заведующий нейрохирургическим отделением</p><p> Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3 </p></bio><bio xml:lang="en"><p>Doctor of Medicine, Neurosurgeon, Head of the Neurosurgical Department</p><p>3 Bolshaya Sukharevskaya Square, Moscow 129090, Russian Federation</p></bio><email xlink:type="simple">aprirodov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5026-0060</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Синкин</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sinkin</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, старший научный сотрудник неотложной нейрохирургии</p><p> Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3 </p></bio><bio xml:lang="en"><p>Candidate of Medical Sciences, Senior Researcher of Emergency Neurosurgery</p><p>3 Bolshaya Sukharevskaya Square, Moscow 129090, Russian Federation</p></bio><email xlink:type="simple">mvsinkin@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»<country>Россия</country></aff><aff xml:lang="en">N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare Department<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>18</day><month>11</month><year>2021</year></pub-date><volume>10</volume><issue>3</issue><fpage>549</fpage><lpage>557</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Абзалова Д.И., Природов А.В., Синкин М.В., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Абзалова Д.И., Природов А.В., Синкин М.В.</copyright-holder><copyright-holder xml:lang="en">Abzalova D.I., Prirodov A.V., Sinkin M.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jnmp.ru/jour/article/view/1218">https://www.jnmp.ru/jour/article/view/1218</self-uri><abstract><sec><title>Введение</title><p>Введение. Эпилептические приступы являются важной проблемой, значительно ухудшающей качество жизни пациентов как с впервые выявленной, так и рецидивирующей глиомой головного мозга (ГГМ).</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Проведенный анализ отечественной и зарубежной литературы показал, что при глиомах низкой степени злокачественности этот симптом встречается в среднем у 76%, при глиомах высокой степени злокачественности — у 21% пациентов. Несмотря на максимально допустимую резекцию опухоли, вероятно сохранение эпилептических приступов у 18–64% пациентов, а у 5% больных они впервые возникают в послеоперационном периоде. От 15 до 50% эпилептических приступов при ГГМ не поддаются фармакологическому контролю. У пациентов, которым проводят химиотерапию, предпочтительно использовать новые противоэпилептические препараты, поскольку их перекрестное воздействие минимально.</p></sec><sec><title>Заключение</title><p>Заключение. Общепризнанного алгоритма назначения и отмены противоэпилептических препаратов у пациентов с симптоматическими эпилептическими приступами при глиомах головного мозга не существует. Необходимы дальнейшие исследования для определения оптимальных сочетаний и режима дозирования противоэпилептических препаратов, особенно во время проведения химиотерапии.</p></sec></abstract><trans-abstract xml:lang="en"><p>Introduction. Epileptic seizures are an important problem that significantly worsens the quality of patients’ life with both newly diagnosed and recurrent brain gliomas.Review. The analysis of domestic and foreign literature showed that low-grade gliomas, this symptom occurs on average in 76%, with high-grade gliomas – in 21% of patients. Despite the maximum allowable tumor resection, it is likely that epileptic seizures persist in 18-64% of patients, and in 5% of patients they first appear in the postoperative period. From 15 to 50% of epileptic seizures in cerebral gliomas are drug-resistant. In patients undergoing chemotherapy, it is better to use new antiepileptic drugs because their cross-effects are minimal.Conclusion. There is no generally accepted algorithm for prescribing and discontinuing antiepileptic drugs in patients with symptomatic epileptic seizures with cerebral gliomas. Further research is needed to determine the optimal combination and dosage regimen of antiepileptic drugs, especially during chemotherapy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>глиома</kwd><kwd>эпилептические приступы</kwd><kwd>глиобластома</kwd><kwd>судорожные приступы</kwd><kwd>симптоматическая эпилепсия</kwd><kwd>фармакорезистентная эпилепсия</kwd><kwd>опухоль головного мозга</kwd></kwd-group><kwd-group xml:lang="en"><kwd>glioma</kwd><kwd>epileptic seizures</kwd><kwd>glioblastoma</kwd><kwd>convulsive seizures</kwd><kwd>symptomatic epilepsy</kwd><kwd>drug-resistant epilepsy</kwd><kwd>brain tumor</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ostrom QT, Gittleman H, Liao P, Rouse C, Chen Y, Dowling J, et al. CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2007–2011. 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