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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nmp</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Sklifosovsky Journal "Emergency Medical Care"</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-9022</issn><issn pub-type="epub">2541-8017</issn><publisher><publisher-name>“N.V. Sklifosovsky Research Institute for Emergency Medicine”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23934/2223-9022-2021-10-3-438-451</article-id><article-id custom-type="elpub" pub-id-type="custom">nmp-1204</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НОВОЕ О COVID-19</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NEW ABOUT COVID-19</subject></subj-group></article-categories><title-group><article-title>COVID-19 и сердечно-сосудистая система. Часть III. Подходы к лечению COVID-19: обзор современной доказательной базы</article-title><trans-title-group xml:lang="en"><trans-title>COVID-19 and Cardiovascular System. Part 3. COVID-19 Current Treatment Approaches: Evidence-Based Review</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4831-7977</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васильченко</surname><given-names>М. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasilchenko</surname><given-names>M. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p> клинический ординатор по специальности «кардиология»</p><p> Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3 </p></bio><bio xml:lang="en"><p> Cardiology Clinical Resident </p><p> 3 B. Sukharevskaya square, Moscow, 129090, Russian Federation </p></bio><email xlink:type="simple">maryvasil25@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9738-1801</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванников</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivannikov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>клинический ординатор по специальности «кардиология»</p><p> Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3 </p></bio><bio xml:lang="en"><p>Cardiology Clinical Resident</p><p>3 B. Sukharevskaya square, Moscow, 129090, Russian Federation </p></bio><email xlink:type="simple">ivannikov_a95@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4940-9574</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эсауленко</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Yesaulenko</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>клинический ординатор по специальности «кардиология»</p><p> Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3 </p></bio><bio xml:lang="en"><p>Cardiology Clinical Resident</p><p> 3 B. Sukharevskaya square, Moscow, 129090, Russian Federation </p></bio><email xlink:type="simple">aesaulenko95@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6229-8629</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алиджанова</surname><given-names>Х. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Alidzhanova</surname><given-names>Kh. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p> доктор медицинских наук, старший преподаватель учебного центра</p><p> Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3 </p></bio><bio xml:lang="en"><p>Doctor of Medical Sciences, Senior Lecturer, Training Center</p><p> 3 B. Sukharevskaya square, Moscow, 129090, Russian Federation </p></bio><email xlink:type="simple">doctorhafiza@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3292-8789</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петриков</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrikov</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>член-корреспондент РАН, доктор медицинских наук, директор  </p><p> Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3 </p></bio><bio xml:lang="en"><p>Сorresponding Member of RAS, Doctor of Medical Sciences, Director </p><p> 3 B. Sukharevskaya square, Moscow, 129090, Russian Federation </p></bio><email xlink:type="simple">petrikovss@sklif.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»<country>Россия</country></aff><aff xml:lang="en">N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare Department<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>16</day><month>11</month><year>2021</year></pub-date><volume>10</volume><issue>3</issue><fpage>438</fpage><lpage>451</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Васильченко М.К., Иванников А.А., Эсауленко А.Н., Алиджанова Х.Г., Петриков С.С., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Васильченко М.К., Иванников А.А., Эсауленко А.Н., Алиджанова Х.Г., Петриков С.С.</copyright-holder><copyright-holder xml:lang="en">Vasilchenko M.K., Ivannikov A.A., Yesaulenko A.N., Alidzhanova K.G., Petrikov S.S.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jnmp.ru/jour/article/view/1204">https://www.jnmp.ru/jour/article/view/1204</self-uri><abstract><p>Единая тактика ведения и лечения пациентов с COVID-19 до сих пор отсутствует. На данный момент зарегистрировано большое количество исследований по изучению медикаментозной и немедикаментозной терапии COVID-19. В статье представлен обзор результатов крупных клинических исследований в области лечения COVID-19, рассмотрены потенциальные механизмы действия некоторых препаратов, описаны особенности основных подходов к терапии новой коронавирусной инфекции, а также методы немедикаментозной терапии.</p></abstract><trans-abstract xml:lang="en"><p>Unified management plan and treatment strategy for COVID-19 patients are yet to be discovered. Many trials on COVID-19 interventions have been registered or are ongoing. In this article the results of large-scale clinical trials on COVID-19 treatment are presented, the potential mechanism of action of some drugs is discussed, the features of the main pharmacological and non-pharmacological therapeutic options for COVID-19 patients are described.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>лечение COVID-19</kwd><kwd>клинические исследования</kwd><kwd>подходы к терапии COVID-19</kwd><kwd>терапия на основе антител</kwd><kwd>противовирусная терапия</kwd><kwd>иммуномодулирующая терапия</kwd><kwd>антитромботическая терапия</kwd><kwd>немедикаментозное лечение COVID-19</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19 treatment</kwd><kwd>clinical trials</kwd><kwd>therapeutic options for COVID-19</kwd><kwd>anti-SARS-CoV-2 antibody products</kwd><kwd>antiviral therapy</kwd><kwd>immunomodulators</kwd><kwd>antithrombotic therapy</kwd><kwd>non-pharmacological interventions</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Global Coronavirus COVID-19 Clinical Trial Tracker. 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