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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nmp</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Sklifosovsky Journal "Emergency Medical Care"</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-9022</issn><issn pub-type="epub">2541-8017</issn><publisher><publisher-name>“N.V. Sklifosovsky Research Institute for Emergency Medicine”</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">nmp-114</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS OF LITERATURE</subject></subj-group></article-categories><title-group><article-title>ПСЕВДОМЕМБРАНОЗНЫЙ КОЛИТ: ДИАГНОСТИКА, ЛЕЧЕНИЕ И ПРОФИЛАКТИКА (ОБЗОР ЛИТЕРАТУРЫ)</article-title><trans-title-group xml:lang="en"><trans-title>PSEUDOMEMBRANOUS COLITIS: DIAGNOSIS, TREATMENT AND PREVENTION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черненькая</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Chyornenkaya</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., заведующая научной лабораторией</p></bio><email xlink:type="simple">chernenkayat@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">НИИ скорой помощи им. Н.В. Склифосовского ДЗ г. Москвы, Москва, Российская Федерация<country>Россия</country></aff><aff xml:lang="en">N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare Department, Moscow, Russian Federation<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>27</day><month>03</month><year>2016</year></pub-date><volume>0</volume><issue>1</issue><fpage>33</fpage><lpage>39</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Черненькая Т.В., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Черненькая Т.В.</copyright-holder><copyright-holder xml:lang="en">Chyornenkaya T.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jnmp.ru/jour/article/view/114">https://www.jnmp.ru/jour/article/view/114</self-uri><abstract><p>В последние годы Clostridium difficile стала одним из распространенных и агрессивных внутрибольничных возбудителей. Токсигенный штамм C. difficile является этиологическим агентом псевдомембранозного колита. При отсутствии своевременной адекватной терапии данное заболевание приводит к развитию жизнеугрожающих осложнений. Для предупреждения развития C. difficile-инфекции необходимы оптимизация политики применения антибиотиков в стационаре и строгое соблюдение принципов инфекционного контроля. В настоящем обзоре литературы представлены современные подходы к диагностике, лечению и профилактике инфекции, вызванной C. difficile.</p></abstract><trans-abstract xml:lang="en"><p>In recent years, Clostridium difficile has become one of the most common and aggressive nosocomial pathogens. The toxigenic strain of C. difficile is the etiological agent of pseudomembranous colitis. This disease leads to the development of dangerous complications without proper therapy. To prevent the C. difficile infection, optimization of in-hospital antibiotics usage and strict compliance with principles of infection control are required. The review of literature presents modern approaches to diagnosis, treatment and prevention of infections, caused by C. difficile.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>псевдомембранозный колит</kwd><kwd>Clostridium difficile</kwd><kwd>антибиотик-ассоциированная диарея</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pseudomembranous colitis</kwd><kwd>Clostridium difficile</kwd><kwd>antibiotic-associated diarrhea.</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Four-fold difference in antibiotic consumption across the European Region — new WHO report. 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