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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nmp</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Sklifosovsky Journal "Emergency Medical Care"</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-9022</issn><issn pub-type="epub">2541-8017</issn><publisher><publisher-name>“N.V. Sklifosovsky Research Institute for Emergency Medicine”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23934/2223-9022-2020-9-4-670-676</article-id><article-id custom-type="elpub" pub-id-type="custom">nmp-1024</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group></article-categories><title-group><article-title>Опыт применения гипербарической оксигенации при лечении радионекроза, развившегося как осложнение стереотаксически ориентированного радиохирургического лечения менингиомы на примере клинического случая</article-title><trans-title-group xml:lang="en"><trans-title>Experience of Using Hyperbaric Oxygenation in the Treatment of Radionecrosis That Developed as a Complication of Stereotactic Radiosurgical Treatment of Meningioma on the Example of a Clinical Case</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8415-5602</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Токарев</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Tokarev</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Токарев Алексей Сергеевич кандидат медицинских наук, врач-нейрохирург</p><p>Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Aleksey S. Tokarev Candidate of Medical Sciences, neurosurgeon of the Center for Radiosurgery</p><p>3 B. Suharevskaya Sq., Moscow 129090, Russian Federation</p></bio><email xlink:type="simple">alex_am_00@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0007-8054</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Степанов</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Stepanov</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Степанов Валентин Николаевич рентгенолог</p><p>Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Valentin N. Stepanov Radiologist</p><p>3 B. Suharevskaya Sq., Moscow 129090, Russian Federation</p></bio><email xlink:type="simple">valentin.st534@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4534-8719</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рак</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rak</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рак Вячеслав Августович врач-нейрохирург</p><p>Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Vyacheslav A. Rak Neurosurgeon</p><p>3 B. Suharevskaya Sq., Moscow 129090, Russian Federation</p></bio><email xlink:type="simple">rakva@sklif.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8099-9544</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Евдокимова</surname><given-names>О. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Yevdokimova</surname><given-names>O. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Евдокимова Ольга Ливерьевна врач-радиолог высшей категории, заведующая</p><p>Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Olga L. Yevdokimova Doctor-radiologist of the highest category, Head</p><p>3 B. Suharevskaya Sq., Moscow 129090, Russian Federation</p></bio><email xlink:type="simple">liveryevna@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8502-7792</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Терехин</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Terekhin</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Терехин Иван Андреевич врач-рентгенолог</p><p>Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Ivan A. Terekhin Radiologist</p><p>3 B. Suharevskaya Sq., Moscow 129090, Russian Federation</p></bio><email xlink:type="simple">ivan79206260182@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0635-6783</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Незнанова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Neznanova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Незнанова Мария Викторовна, врач рентгенолог</p><p>Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Maria V. Neznanova Radiologist</p><p>3 B. Suharevskaya Sq., Moscow 129090, Russian Federation</p></bio><email xlink:type="simple">mashaneznanova@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4811-0845</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Левина</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Levina</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Левина Ольга Аркадьевна ведущий научный сотрудник отделения неотложной нейрохирургии</p><p>Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Olga A. Levina Leading Researcher, Department of Emergency Neurosurgery</p><p>3 B. Suharevskaya Sq., Moscow 129090, Russian Federation</p></bio><email xlink:type="simple">levinaoa@sklif.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Центр радиохирургии, ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»<country>Россия</country></aff><aff xml:lang="en">Radiosurgery Center, N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>22</day><month>01</month><year>2021</year></pub-date><volume>9</volume><issue>4</issue><fpage>670</fpage><lpage>676</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Токарев А.С., Степанов В.Н., Рак В.А., Евдокимова О.Л., Терехин И.А., Незнанова М.В., Левина О.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Токарев А.С., Степанов В.Н., Рак В.А., Евдокимова О.Л., Терехин И.А., Незнанова М.В., Левина О.А.</copyright-holder><copyright-holder xml:lang="en">Tokarev A.S., Stepanov V.N., Rak V.A., Yevdokimova O.L., Terekhin I.A., Neznanova M.V., Levina O.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jnmp.ru/jour/article/view/1024">https://www.jnmp.ru/jour/article/view/1024</self-uri><abstract><p>Стереотаксическая радиохирургия в отличие от обычной микрохирургии имеет преимущество в лечении интракраниальных объемных образований, позволяя избежать тяжелых осложнений, связанных с открытым вмешательством. В редких случаях применение метода связано с развитием радиационно-индуцированных повреждений, одним из которых является лучевой некроз (ЛН). Это позднее осложнение радиохирургии, развивающееся преимущественно через 6 месяцев после облучения. Неврологические проявления данного осложнения зависят от локализации, а клиническая картина очень разнообразна. Метод магнитно-резонансной томографии (МРТ) с внутривенным контрастным усилением достаточно часто является первым звеном нейровизуализации, помогающим предположить наличие данного осложнения на основании рентгенологической картины и уточнить локализацию изменений.</p><p>Нами представлен опыт лечения ЛН, возникшего у пациентки 47 лет, направленной в наше отделение с диагнозом менингиомы лобной области. Больной было проведено стереотаксическое радиохирургическое лечение на аппарате “Elekta Leksell Gamma Knife Perfextion”, а спустя 6 месяцев у женщины стало развиваться постепенное ухудшение состояния, появились жалобы на головную боль, тошноту; развился центральный прозопарез. Учитывая клиническую картину и данные контрольного МРТ, изменения были интерпретированы как радионекроз. В целях контроля над осложнением пациентке провели стандартную терапию глюкокротикостероидами, дополненную гипербарической оксигенацией (ГБО), что позволило добиться регрессии неблагоприятных клинических и рентгенологических проявлений осложнения. Таким образом, на клиническом приме- ре было продемонстрировано, что комбинированное применение глюкокортикостероидов и ГБО имеет высокую эффективность при лечении ЛН.</p></abstract><trans-abstract xml:lang="en"><p>In contrast to conventional microsurgery, stereotactic radiosurgery has an advantage in the treatment of intracranial masses, avoiding severe complications associated with open surgery. In rare cases, the use of the method is associated with the development of radiation-induced injuries, one of which is radiation necrosis (RN). This is a late complication of radiosurgery, developing mainly 6 months after radiation exposure. The neurological manifestations of this complication depend on location, and the clinical picture is very diverse. The method of magnetic resonance imaging (MRI) with intravenous contrast enhancement is quite often the first link in neuroimaging, which helps to suggest the presence of this complication based on the X-ray picture and to clarify the location of changes.</p><p>We presented the experience of radiation necrosis treatment in a 47-year-old patient who was referred to our department with a diagnosis of frontal meningioma. The patient underwent stereotactic radiosurgical treatment using the Elekta Leksell Gamma Knife Perfextion device, and 6 months later the gradual deterioration began, the patient complained of headache, nausea; central prosoparesis developed. Considering the clinical picture and control MRI data, the changes were interpreted as radionecrosis. In order to control the complication, the patient underwent standard glucocroticosteroid therapy, supplemented by hyperbaric oxygenation (HBO), which made it possible to achieve regression of the adverse clinical and radiological manifestations of the complication. Thus, on a clinical example, it was demonstrated that the combined use of glucocorticosteroids and HBOs is highly effective in the treatment of RN.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>стереотаксическое радиохирургическое лечение</kwd><kwd>радионекроз</kwd><kwd>магнитно-резонансная томография</kwd><kwd>менингиома</kwd><kwd>гипербарическая оксигенация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>stereotactic radiosurgical treatment</kwd><kwd>radionecrosis</kwd><kwd>magnetic resonance imaging</kwd><kwd>meningioma</kwd><kwd>hyperbaric oxygenation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Whittle IR, Smith C, Navoo P, Collie D. Meningiomas. Lancet. 2004;363(9420):1535–43. PMID: 15135603 https://doi.org/10.1016/S0140-6736(04)16153-9</mixed-citation><mixed-citation xml:lang="en">Whittle IR, Smith C, Navoo P, Collie D. Meningiomas. 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