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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nmp</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Sklifosovsky Journal "Emergency Medical Care"</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-9022</issn><issn pub-type="epub">2541-8017</issn><publisher><publisher-name>“N.V. Sklifosovsky Research Institute for Emergency Medicine”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23934/2223-9022-2020-9-4-646-652</article-id><article-id custom-type="elpub" pub-id-type="custom">nmp-1020</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРАКТИКА ОКАЗАНИЯ НЕОТЛОЖНОЙ МЕДИЦИНСКОЙ ПОМОЩИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PRACTICE OF EMERGENCY MEDICAL CARE</subject></subj-group></article-categories><title-group><article-title>Острая гемолитическая реакция после трансфузии эритроцитсодержащих компонентов крови: причины, профилактика, клинические случаи</article-title><trans-title-group xml:lang="en"><trans-title>Acute Hemolytic Reaction After Transfusion of Erythrocyte-containing Blood Components: Causes, Prevention, Clinical Cases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1981-5173</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Андреева</surname><given-names>Я. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Andreyeva</surname><given-names>Ya. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Андреева Ярослава Сергеевна, врач анестезиолог-реаниматолог, трансфузиолог</p><p>Российская Федерация, 115516, Москва, ул. Поликарпова, д. 14</p></bio><bio xml:lang="en"><p>Yaroslava S. Andreeva, anesthesiologist-resuscitator, transfusiologist</p><p>14 Polikarpova St., Moscow 115516, Russian Federation</p></bio><email xlink:type="simple">ketalain@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8589-7122</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Майорова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mayorova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Майорова Ольга Андреевна доктор медицинских наук, профессор, главный врач</p><p>Российская Федерация, 115516, Москва, ул. Поликарпова, д. 14</p></bio><bio xml:lang="en"><p>Olga A. Mayorova Doctor of Medical Sciences, Professor, Chief Physician</p><p>14 Polikarpova St., Moscow 115516, Russian Federation</p></bio><email xlink:type="simple">olgamai@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6999-8145</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Буланов</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Bulanov</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Буланов Андрей Юльевич доктор медицинских наук, заведующий отделением, выездная реанимационная гематологическая бригада, главный внештатный специалист-трансфузиолог Департамента здравоохранения города Москвы</p><p>Российская Федерация, 123182, Москва, ул. Пехотная, д. 3</p></bio><bio xml:lang="en"><p>Andrey Yu. Bulanov Doctor of Medical Sciences, chief freelance transfusion specialist of the Moscow Department of Health</p><p>3 Pehotnaya St., Moscow 123182, Russian Federation</p></bio><email xlink:type="simple">buldoc68@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Момотюк</surname><given-names>К. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Momotyuk</surname><given-names>K. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Момотюк Кира Сергеевна кандидат медицинских наук, заместитель главного врача</p><p>Российская Федерация, 115516, Москва, ул. Поликарпова, д. 14</p></bio><bio xml:lang="en"><p>Kira S. Momotyuk Candidate of Medical Sciences, Deputy Chief Physician</p><p>14 Polikarpova St., Moscow 115516, Russian Federation</p></bio><email xlink:type="simple">donnadomna@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зинкин</surname><given-names>В. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Zinkin</surname><given-names>V. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зинкин Владимир Юрьевич кандидат медицинских наук, врач клинической лабораторной диагностики, заведующий лабораторией</p><p>Российская Федерация, 115516, Москва, ул. Поликарпова, д. 14</p></bio><bio xml:lang="en"><p>Vladimir Yu. Zinkin Candidate of Medical Sciences, Doctor of Clinical Laboratory Diagnostics, Head of Laboratory </p><p>14 Polikarpova St., Moscow 115516, Russian Federation</p></bio><email xlink:type="simple">ldip-su@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белякова</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Belyakova</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Белякова Вера Владимировна кандидат медицинских наук, врач клинической лабораторной диагностики, заведующая </p><p>Российская Федерация, 115516, Москва, ул. Поликарпова, д. 14</p></bio><bio xml:lang="en"><p>Vera V. Belyakova Candidate of Medical Sciences, Doctor of Clinical Laboratory Diagnostics, Head</p><p>14 Polikarpova St., Moscow 115516, Russian Federation</p></bio><email xlink:type="simple">karnas@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7781-2424</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ватагина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vatagina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ватагина Екатерина Александровна врач-трансфузиолог</p><p>Российская Федерация, 115516, Москва, ул. Поликарпова, д. 14</p></bio><bio xml:lang="en"><p>Ekaterina A. Vatagina Doctor-transfusiologist</p><p>14 Polikarpova St., Moscow 115516, Russian Federation</p><p> </p></bio><email xlink:type="simple">ekaterina.vatagina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Центр организации и обеспечения качества трансфузиологической помощи,  ГБУЗ «Центр крови имени О.К. Гаврилова ДЗМ»<country>Россия</country></aff><aff xml:lang="en">Center for the Organization and Quality Assurance of Transfusiological Care, Blood Center named after O.K. Gavrilov of the Moscow City Health Department<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ГБУЗ «Городская клиническая больница № 52 ДЗМ»<country>Россия</country></aff><aff xml:lang="en">City Clinical Hospital No. 52 of the Moscow City Health Department<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>21</day><month>01</month><year>2021</year></pub-date><volume>9</volume><issue>4</issue><fpage>646</fpage><lpage>652</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Андреева Я.С., Майорова О.А., Буланов А.Ю., Момотюк К.С., Зинкин В.Ю., Белякова В.В., Ватагина Е.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Андреева Я.С., Майорова О.А., Буланов А.Ю., Момотюк К.С., Зинкин В.Ю., Белякова В.В., Ватагина Е.А.</copyright-holder><copyright-holder xml:lang="en">Andreyeva Y.S., Mayorova O.A., Bulanov A.Y., Momotyuk K.S., Zinkin V.Y., Belyakova V.V., Vatagina E.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jnmp.ru/jour/article/view/1020">https://www.jnmp.ru/jour/article/view/1020</self-uri><abstract><p>Статья затрагивает проблему изучения причин развития гемолитических реакций после трансфузий эритроцитсодержащих компонентов крови. Рассмотрены пути предотвращения гемолиза в результате гемотрансфузий. Описаны клинические случаи.</p></abstract><trans-abstract xml:lang="en"><p>The article concerns the problem of studying the causes of the development of hemolytic reactions after transfusion of erythrocyte-containing blood components. The ways of preventing hemolysis as a result of blood transfusions are considered. Clinical cases are described.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гемолиз</kwd><kwd>иммунный механизм развития</kwd><kwd>неиммунный механизм развития острой гемолитической реакции</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hemolysis</kwd><kwd>immune development mechanism</kwd><kwd>non-immune mechanism for the development of an acute hemolytic reaction</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Serious Hazards of Transfusion (SHOT). Annual Report. Manchester, UK: SHOT office; 2018. Available at: https://www.shotuk.org/wp-content/uploads/myimages/SHOT-Report-2018_Web_Version-1.pdf [Accessed November 02, 2020].</mixed-citation><mixed-citation xml:lang="en">Serious Hazards of Transfusion (SHOT). Annual Report. Manchester, UK: SHOT office; 2018. Available at: https://www.shotuk.org/wp-content/uploads/myimages/SHOT-Report-2018_Web_Version-1.pdf [Accessed 02 Nov, 2020].</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Рагимов А.А. (ред.) Трансфузиология: национальное руководство. Москва: ГЭОТАР-Медиа; 2018.</mixed-citation><mixed-citation xml:lang="en">Ragimov AA (ed.) Transfuziologiya. Moscow: GEOTAR-Media Publ.; 2018. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Эйхлер О.В., Чечеткин А.В., Бурдинская Е.А., Власов И.Б, Данильченко В.В., Минеева Н.В. и др. Частота и структура осложнений, возникших после переливания донорской крови и ее компонентов в медицинских организациях Российской Федерации в 2014–2017 годах. Трансфузиология. 2018;19(4):4–14.</mixed-citation><mixed-citation xml:lang="en">Eihler OV, Chechetkin AV, Burdinskaya EA, Vlasov IB, Danilchenko VV, Mineeva NV, et al. Rate and Structure of Complications Occurring After Transfusion of Donor Blood and Its Components, in Medical Esteblishments of the Russian Federation in 2014–2017. Transfusiology. 2018;19(4):4–14. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Vamvakas EC, Blajchmam MA. Transfusion-related mortality: the ongoing risk of allogeneic blood transfusion and the available for their prevention. Blood. 2009;113(15):3406–3417. PMID: 19188662 https://doi.org/10.1182/blood-2008-10-167643</mixed-citation><mixed-citation xml:lang="en">Vamvakas EC, Blajchmam MA. Transfusion-related mortality: the ongoing risk of allogeneic blood transfusion and the available for their prevention. Blood. 2009; 113(15):3406–3417. PMID: 19188662 https://doi.org/10.1182/blood-2008-10-167643</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Serious Hazards of Transfusion (SHOT). Annual Report. Manchester, UK: SHOT office; 2017. Available at: https://www.shotuk.org/wp-content/uploads/myimages/SHOT-Report-2017-WEB-Final-v4-25-9-18.pdf [Accessed November 02, 2020].</mixed-citation><mixed-citation xml:lang="en">Serious Hazards of Transfusion (SHOT). Annual Report. Manchester, UK: SHOT office; 2017. Available at: https://www.shotuk.org/wp-content/uploads/myimages/SHOT-Report-2017-WEB-Final-v4-25-9-18.pdf [Accessed 02 Nov 2020].</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Донсков С.И., Уртаев Б.М., Дубинкин И.В. Новая тактика гемотрансфузионной терапии – от совместимости к идентичности. Москва: Бином; 2015.</mixed-citation><mixed-citation xml:lang="en">Donskov SI, Urtaev BM, Dubinkin IV. Novaya taktika gemotransfuzionnoy terapii – ot sovmestimosti k identichnosti. Moscow: Binom Publ.; 2015. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Harewood J, Master SR. Hemolytic transfusion reaction. National Center for Biotechnology Information, U.S. National Library of Medicine. Available at: https://www.ncbi.nlm.nih.gov/books/NBK448158/ [Accessed November 02, 2020].</mixed-citation><mixed-citation xml:lang="en">Harewood J, Master SR. Hemolytic transfusion reaction. National Center for Biotechnology Information, U.S. National Library of Medicine. Available at: https://www.ncbi.nlm.nih.gov/books/NBK448158/ [Accessed 02 Nov 2020].</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Robertson D. Hemolytic transfusion reactions. In: Popovsky MA. (ed.) Transfusion reactions. 4th ed. Bethesda, MD: AABB Press; 2012. p. 1–51.</mixed-citation><mixed-citation xml:lang="en">Robertson D. Hemolytic transfusion reactions. In: Popovsky MA. (ed.) Transfusion reactions. 4th ed. Bethesda, MD: AABB Press; 2012: 1–51.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">National Healthcare Safety. Network Biovigilance Component. Hemovigilance Module Surveillance Protocol. Atlanta, GA, USA; 2018. Available at: https://www.cdc.gov/nhsn/pdfs/biovigilance/bv-hvprotocol-current.pdf [Accessed November 02, 2020].</mixed-citation><mixed-citation xml:lang="en">National Healthcare Safety. Network Biovigilance Component. Hemovigilance Module Surveillance Protocol. Atlanta, GA, USA; 2018. Available at: https://www.cdc.gov/nhsn/pdfs/biovigilance/bv-hvprotocol-current.pdf [Accessed 02 Nov 2020].</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Robertson D. Management of transfusion reactions. In: Mintz PD. ( ed.). Transfusion therapy: clinical principles and practice. 3rd ed. Bethesda, MD.: AABB Press; 2011. p. 757–784.</mixed-citation><mixed-citation xml:lang="en">Robertson D. Management of transfusion reactions. In: Mintz PD. (ed.). Transfusion therapy: clinical principles and practice. 3rd ed. Bethesda, MD.: AABB Press; 2011: 757–784.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Maynard K. Administration of Blood Components. In: Fung MK. (ed.) Technical Manual. 18th ed. Bethesda, MD: AABB Press; 2014. p. 545–559.</mixed-citation><mixed-citation xml:lang="en">Maynard K. Administration of Blood Components. In: Fung MK. (ed.) Technical Manual. 18th ed. Bethesda, MD: AABB Press; 2014:545–559.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Panch SR, Montemayor-Garcia C, Klein HG. Hemolytic transfusion reactions. N Engl J Med. 2019; 381(2):150–162. PMID: 31291517 https://doi.org/10.1056/NEJMra1802338</mixed-citation><mixed-citation xml:lang="en">Panch SR, Montemayor-Garcia C, Klein HG. Hemolytic transfusion reactions. N Engl J Med. 2019; 381(2):150–162. PMID: 31291517https://doi.org/10.1056/NEJMra1802338</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Delaney M, Wendel S, Bercovitz RS, Cid J, Cohn C, Dunbar NM, et al. Transfusion reactions: prevention, diagnosis, and treatment. Lancet. 2016; 388(10061):2825–2836. PMID: 27083327 https://doi.org/10.1016/S0140-6736(15)01313-6</mixed-citation><mixed-citation xml:lang="en">Delaney M, Wendel S, Bercovitz RS, Cid J, Cohn C, Dunbar NM, et al. Transfusion reactions: prevention, diagnosis, and treatment. Lancet. 2016; 388(10061):2825–2836. PMID: 27083327 https://doi.org/10.1016/S0140-6736(15)01313-6</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Vamvakas E. Causes of mortality related to allogeneic blood transfusion. In: Vamvakas EC. Decision making in transfusion medicine. Bethesda, MD: AABB Press; 2011. p. 31–86.</mixed-citation><mixed-citation xml:lang="en">Vamvakas E. Causes of mortality related to allogeneic blood transfusion. In: Vamvakas EC. Decision making in transfusion medicine. Bethesda, MD: AABB Press; 2011:31–86.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Delaney M, Dinwiddie S, Nester TN, Aubuchon JA. The immunohematologic and patient safety benefits of a centralized transfusion database. Transfusion. 2013;53(4):771–776. PMID: 22803792 https://doi.org/10.1111/j.1537-2995.2012.03789.x</mixed-citation><mixed-citation xml:lang="en">Delaney M, Dinwiddie S, Nester TN, Aubuchon JA. The immunohematologic and patient safety benefits of a centralized transfusion database. Transfusion. 2013;53(4):771–776. PMID: 22803792 https://doi.org/10.1111/j.1537-2995.2012.03789.x</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
