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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nmp</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Sklifosovsky Journal "Emergency Medical Care"</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-9022</issn><issn pub-type="epub">2541-8017</issn><publisher><publisher-name>“N.V. Sklifosovsky Research Institute for Emergency Medicine”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23934/2223-9022-2020-9-4-539-544</article-id><article-id custom-type="elpub" pub-id-type="custom">nmp-1000</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Морфологические аспекты острого почечного повреждения в кардиохирургии</article-title><trans-title-group xml:lang="en"><trans-title>Morphological Aspects of Acute Renal Injury in Cardiac Surgery</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2517-7537</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зимина</surname><given-names>Л. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Zimina</surname><given-names>L. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зимина Лариса Николаевна, ведущий научный сотрудник</p><p>Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Larisa N. Zimina Doctor of Medical Sciences, Leading Researcher</p><p>3 Bolshaya Sukharevskaya Square, Moscow 129090, Russian Federation</p></bio><email xlink:type="simple">lara.zimina.40@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3726-3256</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бердников</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Berdnikov</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бердников Геннадий Анатольевич кандидат медицинских наук, старший научный сотрудник отделения неотложной хирургии, эндоскопии и интенсивной терапии</p><p>Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Gennady A. Berdnikov Candidate of Medical Sciences, Senior Researcher of the Department of Emergency Surgery, Endoscopy and Intensive Care</p><p>3 Bolshaya Sukharevskaya Square, Moscow 129090, Russian Federation</p></bio><email xlink:type="simple">polina1905@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7802-2283</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рей</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Rey</surname><given-names>S. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рей Сергей Игоревич кандидат медицинских наук, старший научный сотрудник отделения неотложной хирургии, эндоскопии и интенсивной терапии</p><p>Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Sergey I. Rey Candidate of Medical Sciences, Senior Researcher of the Department of Emergency Surgery, Endoscopy and Intensive Care</p><p>3 Bolshaya Sukharevskaya Square, Moscow 129090, Russian Federation</p></bio><email xlink:type="simple">fanwal@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3283-0562</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Камбаров</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kambarov</surname><given-names>S. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Камбаров Сергей Юрьевич доктор медицинских наук, заведующий отделом неотложной кардиологии и сердечно-сосудистой хирургии</p><p>Российская Федерация, 129090, Москва, Б. Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Sergey Yu. Kambarov Doctor of Medical Sciences, Head of the Department of Emergency Cardiology and Cardiovascular Surgery</p><p>3 Bolshaya Sukharevskaya Square, Moscow 129090, Russian Federation</p></bio><email xlink:type="simple">kambarovsy@sklif.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Лаборатория патоморфологии с гистохимией, ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»<country>Россия</country></aff><aff xml:lang="en">Pathomorphology laboratory with histochemistry, N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare Department<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>19</day><month>01</month><year>2021</year></pub-date><volume>9</volume><issue>4</issue><fpage>539</fpage><lpage>544</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Зимина Л.Н., Бердников Г.А., Рей С.И., Камбаров С.Ю., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Зимина Л.Н., Бердников Г.А., Рей С.И., Камбаров С.Ю.</copyright-holder><copyright-holder xml:lang="en">Zimina L.N., Berdnikov G.A., Rey S.I., Kambarov S.Y.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jnmp.ru/jour/article/view/1000">https://www.jnmp.ru/jour/article/view/1000</self-uri><abstract><sec><title>Резюме</title><p>Резюме. Острое почечное повреждение является частым осложнением у пациентов, перенесших операцию на сердце в условиях искусственного кровообращения (ИК).</p></sec><sec><title>Цель работы</title><p>Цель работы. Улучшить результаты хирургического лечения пациентов с артериальной гипертонией с помощью гипертонического солевого раствора.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Проведен клинико-анатомический анализ материала от 27 умерших, находившихся на лечении в кардиохирургическом отделении института. Протезирование клапанов было выполнено 11 пациентам, протезирование аорты — 2, клапаны и аорты — 7, сочетанные операции — 7. Изучены карты стационарного больного, протоколы вскрытий, результаты гистологического исследования операционного и аутопсийного материала. Уже на следующие сутки после операции в условиях ИК отмечено повышение сывороточного креатинина более чем на 25%. При морфологическом исследовании почек обнаружены острые патологические процессы — некроз нефроцитов извитых канальцев в 59,3% наблюдений и дистрофические изменения в 40,7% случаев на фоне хронической патологии (нефросклероз, атеросклероз сосудов, гломерулосклероз, пиелонефрит, вторично сморщенная почка). После коронарографии с рентгеноконтрастным средством (РКС) отмечены признаки выделительного нефроза, часто с фиксацией РКС в петле Генле, с тубулорексисом и формированием клеточных цилиндров.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Summary</title><p>Summary. The use of endoscopic transsphenoidal access is an effective and safe method for the surgical treatment of pituitary adenomas (PA). In endoscopic transsphenoidal surgeries, there is a need to control intracranial pressure (ICP) for reposition and expansion of the tumor capsule. Currently, the main method for reducing ICP in transsphenoidal surgery is installation of an external lumbar drainage, which is associated with a number of complications.</p></sec><sec><title>Aim of study</title><p>Aim of study. To improve the results of surgical treatment of patients with arterial hypertension using hypertonic saline solution.</p></sec><sec><title>Material and methods</title><p>Material and methods. A clinical and anatomical analysis of material from 27 deceased patients who were treated in the cardiac surgery department of the Institute was carried out. Valve replacement was performed in 11 patients, aortic replacement - 2, valves and aorta - 7, combined operations - 7. The patient’s records, autopsy protocols, results of histological examination of surgical and autopsy material were studied. Already on the next day after surgery, an increase in serum creatinine by more than 25% was noted under the conditions of CBR. Morphological examination of the kidneys revealed acute pathological processes - necrosis of nephrocytes of the convoluted tubules in 59.3% of cases and dystrophic changes in 40.7% of cases against the background of chronic pathology (nephrosclerosis, vascular atherosclerosis, glomerulosclerosis, pyelonephritis, secondary contracted kidney). After coronary angiography with a radiopaque contrast agent (RCA), signs of excretory nephrosis were noted, often with fixation of the RCA in the loop of Henle, with tubulorexis and the formation of cell casts.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>острое почечное повреждение</kwd><kwd>кардиохирургия</kwd><kwd>морфология</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute renal injury</kwd><kwd>cardiac surgery</kwd><kwd>morphology</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Y, Bellomo R. 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